Gene CLK_c (S.moellendorffii)

CLK_c

Species: S.moellendorffii
Alias: CLK_c
External Links:
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
CLK_c.AA Protein None 378 None Fasta, JSON
CLK_c.NA RNA None 1137 None Fasta, JSON
CLK_c.kin_dom Protein Kinase Domain None 330 None Fasta, JSON

Protein domain

Protein domains of CLK_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CLK_c.AA CLK 47-376 43 2.7e-172 521.52 In-house 1-350 (350) Show / Hide 
Range on Protein: 47-376
Range on HMM: 1-350/350
Sequence Identity: 43% (155 aa)

YKIIGKMGEGTFGRVLECWDRDT-QEYVAIKLIRNVQKYRDAAMIEID-VLNELARY-DRNGSRR--CVQLKRWFDF-RNHICMVFEKLGPSLYDFLRKN
|.|. . ||||||.|.||||.     |||.| |||| |||.|| .||. ..  ..   | |. ..  |...  |||.  .|||.|||..| |.|||...|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

E------YRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSP------DHVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSAT---FN
       |.|| || .|....||.|.|  .||. |.|||||||||..|..        .|  . | . ..|    |.....   .|..|||||||   | 
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

SHYHCSVISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIG-PLPAHMIEKAD--RRAEKYF-KNKVELNWPEGAVS
  .|  ..|||||||||||||||||. ||.|||||||.|| .| ||||||.|.||||||||| | |.| .|| . .  .  .||| .|..  .| . . .
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDW-HNSDG

RESVRAVRKLPRLRNMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
| . . .  | ...    .  .|    | ||.. .| |.|. |...|.||.||||
RYVMENCKPLKQYMDCKDPEHRQ----LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase CLK_c.AA CMGC 47-376 20 1.3e-104 344.76 In-house 1-513 (513) Show / Hide 
Range on Protein: 47-376
Range on HMM: 1-513/513
Sequence Identity: 20% (109 aa)

YKIIGKMGEGTFGRVLECWD--------------RDTQEYVAIKLIRNVQKYRDAAM-------------IEIDVLNELARYDRNGS-----------RR
|.||.| ||||.| | .|.|              ..|.|.|||| |.|.. | . |               ||  | .| ... .             . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-CVQLKRWFDFRN-----------------HICMVFEKLGPSLYDFLRKNE--YRP------------------------YAIDLVREFGRQLLESVA--
 .|.|. .| ..|                 |...||| .. .||.....|   |..                        . | ..| . .|.|....  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YMHDLT--LIHTDLKPENILLVSPDHV-------KVPDFKGLYQRSGPGRCYVRVPRTSE----------IKLIDFGSAT-FNSH---------------
|.|      ||.||||||||. .   .       .                        |          .|..|||.|. ...|               
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKS------------------------EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNV

--------YHCSVISTRHYRAPEVILGLG----------WSYSCDIWSIGCILVELCSG--------STLFQTHEN-----------LEHLAMMERIIGP
         . . ..||.|||||..|| .          .....|.||.|||. |.  |         .||..| .           ...|... ...|.
NKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGT

LPAHMIEKADRRA------EKYFKNKVELN-----------------WPEGAVSRESV---RAVRKLPRLRNMILQHVD---------------------
 . .||.|.. |       |. . |...|                  |.|.|    .       .. . ..|..  | .                     
PT-WMIQKGK-RHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKS

----------QYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
          . .  ..|||...|.|.|..|..|.|||.||.|
HKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CLK_c.AA S_TKc 47-376 23 1.2e-80 275.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 47-376
Range on HMM: 1-231/231
Sequence Identity: 23% (81 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGP---SLYDFLRKNEYR
|.|. | |.|.||.|  |....|...|||| |.      . .. ||..| .       .    |.|. .|.  .|..||.| ..    .|.|...|. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

P----YAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDHVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSATFNSHYHCSVISTRHYR
.    .    .| . .|... ..|.|..  || ||||||||| .                             .||..|||.|..      ... |..|.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------------------------HIKICDFGLARQL----TTFCGTPWYM

APEVILGLGWSY-SCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYFKNKVELNWPEGAVSRESVRAVRKLPRLRNMI
||||.   |... .||.||.|||| |...| ..|.      ...|| ..||                                                 
APEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------------------

LQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALS-------HPFF
       .  ..|.....|...|..|..| .||        ||.|
-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CLK_c.AA Pkinase 47-376 23 1.3e-72 252.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 47-376
Range on HMM: 1-293/293
Sequence Identity: 23% (83 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMI-----EIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGP-----SLYDF
|.|..| |.|.||.| .| ...|.. ||.| |. . .  .  ..     || ....| .     .   |.|..||  ..||.||.| ..      .|.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRKNEYRPY--AIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDHVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSA----TFNSHYHC
..  .....    . .. . .|.|. ..|.|.   || ||||||||... .|..                         .|..|||.|    . |..   
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----------------------CVKICDFGLAKQFDY-NNS-MT

SVISTRHYRAPEVIL-GLGWSYSCDIWSIGCILVELCSGSTLFQTH----ENLEHLAMMERIIGPLPAHMIEKADRRA---EKYFKNKVELNWPEGAVSR
..  |..|.|||||. | ......|.||.|||| |...| ..|. |    . .....|..|| || .   ... ...     .. . .            
TFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H------------

ESVRAVRKLPRLRNMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
                .. ..  .  ..|.. ..|.. |..|..|.|.| ||.|
--------------F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CLK_c.AA DYRK 47-192 42 1.3e-55 191.09 In-house 1-151 (320) Show / Hide 
Range on Protein: 47-192
Range on HMM: 1-151/320
Sequence Identity: 42% (64 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEYRPY-
|.|..  | |.|| |  |||. |.|.||||.||| ... . |.|||  |  | . |.. . .||.... | .||| |.||| |  .||.||..|  ... 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

AIDLVREFGRQLLESVAYMHDL-TLIHTDLKPENILLVSP---DHVKVPDF
 . ||| |..|.|..  ..| .  .|| |||||||.|..|     .|| ||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDF
Kinase CLK_c.AA DYRK2 47-192 39 1.3e-49 159.36 In-house 1-148 (318) Show / Hide 
Range on Protein: 47-192
Range on HMM: 1-148/318
Sequence Identity: 39% (59 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEYRPYA
| |   .| | || |..| |  |...||||.||| ...   | .|| .| .. | |....  || ..  | ||||.|..|| |. .||....||..  ..
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

IDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDH--VKVPDF
  ||| |....|..    |   .|| ||||||||| ..    .|| ||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDF
Kinase CLK_c.AA Ciliate-E2 47-376 16 1.6e-46 157.7 In-house 1-365 (365) Show / Hide 
Range on Protein: 47-376
Range on HMM: 1-365/365
Sequence Identity: 16% (76 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIK---------------------LIRNVQKYRDAAMIEIDVLNELARYD-----------RNGSRRCVQLKR
||.| | |.|.|| | .| .. .|. .|||                     . .. ..   . . ||....|.   .           .. .   .... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

WFD--FRNHICMVFEKL-GPSLYDFLRKN----------EYRPYAIDLVREFGRQLLE---------------SVAYMHDLT-LIHTDLKPENILLVSPD
.|    .|.| .|.| . | .|.|....|          .  .. .  .... .|.|.                . |.|     || |.||||||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

HVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSATFNS----------------------------------HYHCSVISTRHYRAPEVILGLG---
                            ||.|||| .....                                  . . ... | .| |||.. | .   
----------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDN

------WSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYFKNKVELNWPEGAVSRESVRAVRKLPRLRNMILQHV
      ..|.|||||.|.|| |...| . |                                                               . |.|  
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------------------------------------------QQQIKQCK

DQYPNVL----------------------LDLLQG----LLRYEPTERLS-AKQALSHPFF
 ..|.                         ||..     .| ..| .|.. ..|.| ||.|
IDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CLK_c.AA DYRK 209-376 33 7e-43 148.79 In-house 140-320 (320) Show / Hide 
Range on Protein: 209-376
Range on HMM: 140-320/320
Sequence Identity: 33% (61 aa)

P-RTSEIKLIDFGSATFNSHYHCSV-ISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKA-DRRAEK
|   |.||.|||||..| .. ...  |  |.|||||||||.  .|. |.|| ||||.||  |  ||.   . . ||..  ..|. | .||.|.  ||..|
PRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHK

YFKN---KVELNWPEGAV----------SRESVRAVRKLPRLRNMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
.|..    .  .|... .           ...   .|..|  || .  |  .    ..|.....| ..|..|....||| ||.|
FFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase CLK_c.AA DYRK1 47-184 43 9.5e-40 137.04 In-house 1-140 (321) Show / Hide 
Range on Protein: 47-184
Range on HMM: 1-140/321
Sequence Identity: 43% (61 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEYRPYA
|.|.  .| | || |   .|. .|||||||.|.| . . . | ||| .|  . . |..   . |.||| | ||||.|.||| |   ||| ||  ..|  .
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

IDLVREFGRQLLESVAYMH--DLTLIHTDLKPENILLVSP
. |.| | .|.. .. .|   .| .|| |||||||||. |
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP
Kinase CLK_c.AA HIPK 47-192 39 2.6e-39 121.14 In-house 1-149 (329) Show / Hide 
Range on Protein: 47-192
Range on HMM: 1-149/329
Sequence Identity: 39% (59 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEYRPYA
| ..  .| |||| |  || | |.| ||||...|   |     ||. .|. |   . .     |     |. .||.|.||| |   ||||...|.. |  
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

IDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDH----VKVPDF
.  .|    | |   . . .| ||| |||||||.|| | .    ||| ||
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDF
Kinase CLK_c.AA YAK 47-185 35 5.2e-34 112.67 In-house 1-143 (347) Show / Hide 
Range on Protein: 47-185
Range on HMM: 1-143/347
Sequence Identity: 35% (51 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNEL-ARYDRNGSR---RCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKNEY
|..    | |||| |  |   || | .|.| | | | |   |  || .|  |  . | |.     . . .   | ..|| |.||| |  .||..|  | .
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPD
.   . |.| .  | |..     .  .|| |||||||.|  |.
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPN
Kinase CLK_c.AA DYRK2 212-376 27 1.6e-30 96.19 In-house 141-318 (318) Show / Hide 
Range on Protein: 212-376
Range on HMM: 141-318/318
Sequence Identity: 27% (50 aa)

SEIKLIDFGSATFNSHYHCSV-ISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKA----DRRAEKY
| ||.||||| .|   |.  . | .| |||||||||.  . . |.|| |||..|| .|  ||      . .|.|  ..|  |.......     .|.. .
SGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYF

FK----------NKVELNWPEGAVSRESVRAVRKLPRLR--NMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
|.          .  . . ... ...   .  |. |  .  ...|.  ....  ..| ..  .  .|.||....||| ||..
FNSHCFEWYCTFMTDHSMEIPKHYKNR--HGKRRPPGSKSWKSVLKGCEDEN--FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase CLK_c.AA DyrkP 213-310 42 2e-24 76.77 In-house 146-242 (323) Show / Hide 
Range on Protein: 213-310
Range on HMM: 146-242/323
Sequence Identity: 42% (42 aa)

EIKLIDFGSATFNSHYHCSVISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYFKNK
..|.|||||. |      | .  | |||||||.|  . |  |.||.|||| ||  |  |||  .    || .  ||||.|  |. .  |  . .| .|
QVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMM-QEGRLVQNFFTRK
Kinase CLK_c.AA PRP4 47-180 32 2.6e-24 85.91 In-house 1-138 (320) Show / Hide 
Range on Protein: 47-180
Range on HMM: 1-138/320
Sequence Identity: 32% (45 aa)

YKIIGKMGEGTFGRVLECWDRD-TQEYVAIKLIRNVQKYRDAAMIEIDVLNELARY--DRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFLRKN-EY
|...|. |.| |. |  | | . ..| |||| |||    ..  . |. .|  |     |.|    ||...| | .|.|.|.||| .  .| . | |    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENIL
    .. || . .||.     .  .  .| |.|| |||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL
Kinase CLK_c.AA DYRK1 209-315 38 9.4e-22 72.78 In-house 140-245 (321) Show / Hide 
Range on Protein: 209-315
Range on HMM: 140-245/321
Sequence Identity: 38% (41 aa)

PRTSEIKLIDFGSATFNSHYHCSVISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYFK
|. | ||.|||||.    .     |  | ||.|||.||. .. . |.||.||||||.  |  ||   . .. .  .  ..|  |.|||..|  .|.|||.
PKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAP-KAHKYFE

NKVELNW
 . .  |
KDPDNTW
Kinase CLK_c.AA DyrkP 47-192 30 5.6e-18 55.16 In-house 1-152 (323) Show / Hide 
Range on Protein: 47-192
Range on HMM: 1-152/323
Sequence Identity: 30% (47 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRNGSRRCVQLKRWFDFRNHICMVFEKLGPSLYDFL---RKNEYR
|.|.  .|   | . . | |. |   . .|.| | . | | .. || .|  .        .  ..   .|  . |. .. | |   ||.|    | ||  
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

PY-AIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPD--HVKVPDF
.|  .  .     |.| .. |.| | ||| ||||||||. |    .||. ||
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDF
Kinase CLK_c.AA HIPK 214-376 25 4.5e-16 46.65 In-house 144-329 (329) Show / Hide 
Range on Protein: 214-376
Range on HMM: 144-329/329
Sequence Identity: 25% (47 aa)

IKLIDFGSATFNSHYHCSV-ISTRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYF---KN
.| ||||||   |.  |.  .  |.|||||.||||    . |.|| ||.. ||  |  |.   .. .    ..   . ||.  . .| ......|   |.
VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQH-LPHEHLLHAACKKHRFFDRDKQ

KVELNWPEGAVSRESVRAVRKLPRLRNMILQHVDQYPNVLL--------------------DLLQGLLRYEPTERLSAKQALSHPFF
     |.   .      .  |. ..| .|. ..|  |.| .                    ..|  ..  .. .|..  .|| ||| 
SKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase CLK_c.AA YAK 213-265 47 5.9e-16 50.32 In-house 146-198 (347) Show / Hide 
Range on Protein: 213-265
Range on HMM: 146-198/347
Sequence Identity: 47% (25 aa)

EIKLIDFGSATFNSHYHCSVISTRHYRAPEVILGLGWSYSCDIWSIGCILVEL
|||.|||||.          |  ||||.||.|..   . | | || |||..||
EIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL
Kinase CLK_c.AA PRP4 214-272 46 7.3e-11 36.06 In-house 146-205 (320) Show / Hide 
Range on Protein: 214-272
Range on HMM: 146-205/320
Sequence Identity: 46% (29 aa)

IKLIDFGSATFNSHYHCSVIS----TRHYRAPEVILGLGWSYSCDIWSIGCILVELCSGSTLF
.|..|||||   || | . |      | |||||.|.|    |. |.||.|| | ||  |  .|
LKMCDFGSA---SHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMF
Kinase CLK_c.AA YAK 348-376 37 2.9e-09 27.22 In-house 319-347 (347) Show / Hide 
Range on Protein: 348-376
Range on HMM: 319-347/347
Sequence Identity: 37% (11 aa)

VLLDLLQGLLRYEPTERLSAKQALSHPFF
...|.. .||  .| || .. ||  ||| 
CFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase CLK_c.AA TyrKc 47-376 14 6.1e-08 -94.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 47-376
Range on HMM: 1-280/280
Sequence Identity: 14% (54 aa)

YKIIGKMGEGTFGRVLECWDRDTQEYVAIKLIRNVQKYRDAAMIEIDVLNELARYDRN--GSRRCVQLKRWFDFR-------NHICMVFE--KLGPSLYD
 . . | ||| ||.| ..  .   . ||.| ...          . | ..|.    .        |.|                ...|.|  ..| .| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG-DLKD

FLRKNEYRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDHVKVPDFKGLYQRSGPGRCYVRVPRTSEIKLIDFGSATFNSHY-HC----
.|||.. .    .   .|  |  .  .| |.  .|| ||   |.|. ..                             .|  ||| . .  .. ..    
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------------------TVKISDFGLSRDIYDDDQQGESK

SVISTR---HYR--------APEVILGLGWSYSCDIWSIGCILVELCS-------G-----STLFQTHENLEHLAMMERIIGPLPAHMIEKADRRAEKYF
......   . .        |||.|     .   |.|| |  . |...       |      . .. .|....  .|..   ..   |            
DYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-----------

KNKVELNWPEGAVSRESVRAVRKLPRLRNMILQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF
                                      |  . .. .   ...| .| . ..   | .|
----------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CLK_c.AA DyrkP 348-376 37 9e-06 14.32 In-house 295-323 (323) Show / Hide 
Range on Protein: 348-376
Range on HMM: 295-323/323
Sequence Identity: 37% (11 aa)

VLLDLLQGLLRYEPTERLSAKQALSHPFF
. .|  . .|  . | | .|| ||.||.|
MFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase CLK_c.AA PRP4 351-376 42 1.2e-05 16.7 In-house 295-320 (320) Show / Hide 
Range on Protein: 351-376
Range on HMM: 295-320/320
Sequence Identity: 42% (11 aa)

DLLQGLLRYEPTERLSAKQALSHPFF
||| ..|   |  | .  .|| |||.
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase CLK_c.AA DYRK1 351-376 42 1.4e-05 15.05 In-house 296-321 (321) Show / Hide 
Range on Protein: 351-376
Range on HMM: 296-321/321
Sequence Identity: 42% (11 aa)

DLLQGLLRYEPTERLSAKQALSHPFF
||.. .|.|.| .|..  .|| |.||
DLIKRMLQYDPKQRITPYYALQHSFF