Gene PRP4_e (S.moellendorffii)

PRP4_e

Species: S.moellendorffii
Alias: PRP4_e
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: PRP4

Sequence

Name Sequence Type Origin Length Description Download
PRP4_e.AA Protein None 447 None Fasta, JSON
PRP4_e.NA RNA None 1344 None Fasta, JSON
PRP4_e.kin_dom Protein Kinase Domain None 315 None Fasta, JSON

Protein domain

Protein domains of PRP4_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PRP4_e.AA PRP4 128-442 43 4.8e-117 395.15 In-house 1-320 (320) Show / Hide 
Range on Protein: 128-442
Range on HMM: 1-320/320
Sequence Identity: 43% (140 aa)

YQVKASIGSGMFSTVFLAKSLFPECEQEVAIKIPRKNDLMLRSAKSELQILKKVAEP-EATNKDNHCVKLLDSFVYREHLCLVMESLDLNLRQITNKYGR
|.|   .|.| ||.|  .. .     ..||||| | |..| ..   || ||.|  .     |   |||.. ..| .| |.||| | .  |||..  |||.
YRVYGYCGQGVFSNVCRCRDQT-RGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGK

NRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHAIDMWSAGCCL
. |  || . .|| ||..||.||  |.||| |||||||.|  |.  .|.|||| |    ..     ||||||  |||||||.|. ..  .|||||.||.|
DVGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHEN---EITPYLVSRFYRAPEIIIGHPYD-YQIDMWSVGCTL

YELYTGKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEFR--QLDPVTKLETLRSMASFNVKTSCISDLTGE-------DGALMARFKN
|||||||..||  |||  ||  |..||..|. |..|| |   ||..|. |     | ||. |    |.  . .    ..| ..       .   .  || 
YELYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQEVDKVTEREKVTVMTYIKPTKDIYQELIECNQRIPEDQMKKVHQFKD

LLERMLTLDPSKRITPDEALKHPFL
||...| |||.||||. |||||||.
LLDKCLMLDPKKRITCNEALKHPFI
Kinase PRP4_e.AA DYRK 128-442 33 2.9e-100 339.4 In-house 1-320 (320) Show / Hide 
Range on Protein: 128-442
Range on HMM: 1-320/320
Sequence Identity: 33% (111 aa)

YQVKASIGSGMFSTVFLAKSLFPECEQEVAIKIPRKNDLMLRSAKSELQILKKVAEPEATNKDNHCVKLLDSFVYREHLCLVMESLDLNLRQITNKYGRN
|..   ||.| |. |. ..       . ||||| |.|  ..|.|. |..||..  .    .   |||...|.|..|.|||.| | |. ||..   ... .
YEILEYIGKGSFGQVVKCWDH--KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQ

RGINLKTICVYAHQLMVALQHLAHC-GILHCDIKPDNIMVTK--SRRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHAIDMWSAGC
 ...|. . ..|.|. ..| .|. .  |.|||.||.|||. .  ..  ||..||| . |  .      ..|..|  |||||.|||  ||. |||||| ||
GFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ----RIYTYIQSRFYRAPEVILGC-PYCYAIDMWSLGC

CLYELYTGKFLFPVATNNGLLKQQMELKGAFPKAMLKKG--AFTGMHFNENFEFRQLDPVTK--LETLRSMASFNVKTSCISDLTGEDG-------ALMA
.|.||.||. ||| .... .|.  ||..|..|| |..||   ..  .|.. |.....| .||   .| ..|  ....|. .. ....         .   
ILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDH

RFKNLLERMLTLDPSKRITPDEALKHPFL
 ||......|..||.||||| .||.||..
QFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase PRP4_e.AA CMGC 128-442 18 6.9e-82 268.7 In-house 1-513 (513) Show / Hide 
Range on Protein: 128-442
Range on HMM: 1-513/513
Sequence Identity: 18% (96 aa)

YQVKASIGSGMFSTVFLAKSLFPE------------CEQEVAIKIPRKNDLMLRSAK-------------SELQILKKVA-EPEATN----------KDN
|..   ||.| ...|. ..    .             ...||||. ...  . . ||              |..|||..  . .. |          ..|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

HCVKLLDSFVYRE-----------------HLCLVMESLDLNLRQITNKYGR-------------------------NRGINLKTICVYAHQLMVALQ--
..|||.|.|....                 ||.||.| .| .| |.  .. .                          . . .  |  |..|.  .|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

HLAHCG--ILHCDIKPDNIMVTKSRRS-------------------IKLCDFGVAM-FARDQTPSAE-------------------TPYLVSPSYRAPEI
..   .  |.|.|.|| ||....  ..                   .|.|||| |  .   . . ..                   |.| |.  ||||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGV---------APYSHAIDMWSAGCCLYELYTG--------KFLFP-----------VATNNGLLKQQMELKGAFPKAMLKKG---------AFTGMH
.||            |. .|||||.|| ..|.|||        | |||            . .   |.. ... | ..  |..||           . . 
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

FNENFEF-----------------------------RQLDPVTKLETLRSMASF---------NVKTSCISDLTGEDGA----------------LMARF
.... ..                              .  |  ... |   ...         .  .. |.                        .   .
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF-NW-IY-------EEKFKSHKFNHQFKRKCCDPQA

KNLLERMLTLDPSKRITPDEALKHPFL
 .||..||..||.||||...||.||..
IDLLKKMLQYDPDKRITAEQALQHPYF
Kinase PRP4_e.AA S_TKc 128-442 24 1.1e-74 255.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 128-442
Range on HMM: 1-231/231
Sequence Identity: 24% (82 aa)

YQVKASIGSGMFSTVFLAKSLFPECEQEVAIKIPRKNDLMLRSAKSELQILKKVAEPEATNKDNHCVKLLDSFVYREHLCLVMESLDL---NLRQITNKY
|..   ||.| |..|....       ..||||| .      .....|.|||||        .  . |||.|.|.  .||..||| .|    .|...  |.
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

GRNRG---INLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSH-AIDMW
||...   ..  ... |..|.  ||...   ||.|.|.||.||....    ||.||||.| .         | . ..| |.|||..    .|.. ..|.|
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWW

SAGCCLYELYTGKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEFRQLDPVTKLETLRSMASFNVKTSCISDLTGEDGALMARFKNLLE
| ||.|||...|. .||  . . ..|. .                                                                 .|....
SCGCILYEMLCGYPPFP--QMQMMFKKIG--------------------------------------------------------------SPEAKDFIR

RMLTLDPSKRITPDEALK-------HPFL
..|. ||.||.|  |||.       ||..
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PRP4_e.AA Ciliate-E2 128-442 17 1e-43 147.9 In-house 1-365 (365) Show / Hide 
Range on Protein: 128-442
Range on HMM: 1-365/365
Sequence Identity: 17% (76 aa)

YQVKASIGSGMFSTVFLAKSLFPECE---------------------QEVAIKIPRKNDLMLRSAKSELQILKKVAEPE----------ATNKDNHCVKL
| .   ||.| |..|...|     ..                     ...|.|| .||..     |.|..|.... . .           ... .. .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQI--KQEIHIMREINC-FYKKINEKNILEQLNHPNIIKM

LDSFV--YREHLCLVMESLDL-NLRQITNKYGRNR--------GINLKTICVYAHQLMV---------------ALQHLAHCG-ILHCDIKPDNIMVTKS
 ..|    .... |||| ..  .|... ..   .|         ...| |. .  |.                 ||..|   . |.| ||||.||..   
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

RRSIKLCDFGVAMFARDQ-------TPSAETPYLV------------------------SPSYRAPEIILGVAP--------YSHAIDMWSAGCCLYELY
   ||..||| . .. |.         . . ..                          .| | ||||. |           |....|.||.|..|||. 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEFRQLDPVTKLETLRSMASFNVKTSCISDLTGEDGA---------------LMARF
.||. |                                                         .. .  |  |.  ..                 .    
FGKPPF---------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQEC

KNLLER----MLTLDPSKRIT-PDEALKHPFL
|.|. .    ||  ||.|||| ....|.||..
KDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PRP4_e.AA DYRK2 128-337 38 4.7e-43 137.66 In-house 1-203 (318) Show / Hide 
Range on Protein: 128-337
Range on HMM: 1-203/318
Sequence Identity: 38% (81 aa)

YQVKASIGSGMFSTVFLAKSLFPECEQEVAIKIPRKNDLMLRSAKSELQILKKVAEPEATNKDNHCVKLLDSFVYREHLCLVMESLDLNLRQITNKYGRN
| ..  ||.| |  |.  | .    .| ||||. |     .. |  |..||..  .   .|  | ||..||.|..| |.|.. | |..||     |   .
YEILEVIGKGSFGQVV--KCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMN-CVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQ

RGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRRS-IKLCDFGVAMFARD-QTPSAETPYLVSPSYRAPEIILGVAPYSHAIDMWSAGCC
 |..|. .   ||... .|. |    | ||| || ||.  .  || ||. |||   |.   .       |  |  |||||.|||  .|. |||||| || 
-GFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYT----YIQSRFYRAPEVILGG-KYGMAIDMWSFGCI

LYELYTGKFLFP
. |||||. |||
MAELYTGYPLFP
Kinase PRP4_e.AA Ciliate-E2-Unclassified 128-442 17 1.2e-42 145.71 In-house 1-352 (352) Show / Hide 
Range on Protein: 128-442
Range on HMM: 1-352/352
Sequence Identity: 17% (69 aa)

YQVKASIGSGMFSTVFLAKSLFPECEQEVAIKIPRKNDLMLRSAKS---------ELQILKKVAEPE----------ATNKDNHCVKLLDSFVYREHLCL
| .   ||.| |..|....      .. .   .  ... . .. ..         |....||    .            ... . ||... |  ......
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMESL-DLNLRQITNKYGR--------------NRGINLKTIC-----VYAHQLMVALQHLAHCG-ILHCDIKPDNIMVTKSRR--SIKLCDFGVAMFAR
||| . ...|.|. .|..               .. .  . ..      |. |. ..|..| | . |.| ||||.||..... .   ||..||| ...  
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

D-------------QTPSAETPYLV-SPSYR----APEIILGVAPYS---HAIDMWSAGCCLYELYTGKFLFPVATNNG----------------LLKQQ
.             .... ..   . .|.|     |||.. |  ..    ...|.|| |..|||. .|.. |.  . .                 |....
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

MELKGAFPKAML----KKGAFTGMHFNENFEFRQLDPVTKLETLRSMASFNVKTSCISDLTGEDGALMARFKNLLERMLTLDPSKRITPDEALKHPFL
.. .  |||.      |.  ... .| .                                            .|| .||  .|.||||....|.||..
KQKNIQFPKFPWQQIPKHWSPEAKDFIN--------------------------------------------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase PRP4_e.AA Pkinase 128-337 28 6.7e-38 135.1 Pfam 1-213 (293) Show / Hide 
Range on Protein: 128-337
Range on HMM: 1-213/293
Sequence Identity: 28% (67 aa)

YQVKASIGSGMFSTVFLAKSLFPECEQEVAIKI---PRKNDLMLRSAKS--ELQILKKVAEPEATNKDNHC--VKLLDSFVYREHLCLVMESLDL-----
|...  |||| |..|....    ..  .||.||   ..... .....    |.||.|..          |.  |.|.|.| .. |...||| ..      
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM

NLR----QITNKYGRNRGI--NLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRRSI----KLCDFGVA-MFARDQTPSAETPYLVSPSYRAP
 |            |....    .... |. |.  .|...  .||.|.|.||.||..  ..  |    |.||||.|  |      |  | . ..| |.||
DLFDYIST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAP

EIILGVAPYSHAIDMWSAGCCLYELYTGKFLFP
|.|.|  .|....||||.|| |||...|...||
EVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP
Kinase PRP4_e.AA DYRK1 128-371 32 6e-37 127.05 In-house 1-238 (321) Show / Hide 
Range on Protein: 128-371
Range on HMM: 1-238/321
Sequence Identity: 32% (81 aa)

YQVKASIGSGMFSTVFLAKSLFPECEQEVAIKIPRKNDLMLRSAKSELQILKKVAEPEATNKDNHCVKLLDSFVYREHLCLVMESLDLNLRQITNKYGRN
|.. ..|| | |  |  .|    . ...||||| .     .  |. |...|  . . .. .| .  |.|   |..|.|||||.| |  ||  .  .    
YEIDSLIGKGSFGQV--VKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYY-IVHLKRHFMFRNHLCLVFELLSYNLYDLL-RNTHF

RGINLKTICVYAHQLMVALQHLA--HCGILHCDIKPDNIMVTKSRRS-IKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHAIDMWSAGC
||. |  .  .|.|.. ||  ..     |.|||.||.||..  ..|| ||. ||| .     |.      |. |  ||.||..||.. |. |||||| ||
RGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSC----QLGQRIYQYIQSRFYRSPEVLLGIE-YDMAIDMWSLGC

CLYELYTGKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFN
 | |. ||  ||  .     ... .|  |  ||.|. ..  .  .|.
ILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase PRP4_e.AA YAK 171-370 33 2.8e-34 113.58 In-house 42-239 (347) Show / Hide 
Range on Protein: 171-370
Range on HMM: 42-239/347
Sequence Identity: 33% (68 aa)

AKSELQILKKVAEPEATNKDN---HCVKLLDSFVYREHLCLVMESLDLNLRQITNKYGRNRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVT
|| | |||.   . .  |  |   | ....|.||.. |.||| | | .||     |  . .|     | ..  |   ..  |.   | ||| || |||  
AKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYL-KQNKFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLC

K-SRRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHAIDMWSAGCCLYELYTGKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFT
|  .  ||. ||| .     |. .  . |  .  ||.||||... .|. .||||| || . ||. |  .|| .     .|   .  | .|  |. .| | 
KPNKPEIKIIDFGSSC----QEKKMVYTYIQQRHYRSPEIIVWM-IYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFK

GMHF
   |
NKYF
Kinase PRP4_e.AA CAMK 133-334 16 8e-33 102.55 In-house 1-332 (425) Show / Hide 
Range on Protein: 133-334
Range on HMM: 1-332/425
Sequence Identity: 16% (56 aa)

SIGSGMFSTVFLAKSLFPECE----------QEVAIKIPRKN-----------------------------DLMLRSAKSELQILKKVAEPEATNKDNHC
 .|.| |..|.|..     ..          |.|||||  |.                             . .... ..|..|.||. . .   .  . 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLLDSFV-----------------YRE---HLCLVM---ESLDLN------LRQITNK------------YGRNRGINLKTICVYAHQLMVALQHLAHC
.||.. .                  . .   |...||   |  .        .  |. .              ... .. .  . | .|.  |....  .
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

GILHCDIKPDNIMVTKSR----------------RSIKLCDFGVAMFARDQTPSA--------------ETP--------YLVSPSYRA-PEIILG----
.| |.|.||.||.....                   ||..||| | . ..   .                ||        .  .|.| | ||...|    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------VAPYSHAIDMWSAGCCLYELYTGKF
           .|. ..||||.|. || . .|..
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP
Kinase PRP4_e.AA ULK 128-333 24 3.1e-28 95.73 In-house 1-253 (329) Show / Hide 
Range on Protein: 128-333
Range on HMM: 1-253/329
Sequence Identity: 24% (62 aa)

YQVKASIGSGMFSTVFLA----KSLFPECEQEVAIKI-P-----RKNDL-----MLRSAKSELQILKKVAEPEATNKDNH----CVKLLDSFVYREH--L
|...  .|.| | .|. .    .    .  . ||.|. .     .||..     |. . |.| .|.||   |   |. ..    .|||.| |    |  .
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSP---NRHKNHHPNIVKLYDWFETSNHNNI

CLVMESLDL-NLRQITNKYGR-------NRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRRS-----------IKLCDFGVAMFAR-D
 ..||  .  .|.|. .|...       .. .. . .  . .|.. ....|   .| |.||||.||....   .           .|..||| | .   |
YIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDND

QTPSAETPYLV-------SPSYRAPEIIL---GVAPYS-HAIDMWSAGCCLYELYTGK
.   . . . |       .| | ||.|.    .  ||. .  |.|| || .||. .||
NMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK
Kinase PRP4_e.AA CAMK 416-442 44 4.8e-12 34.39 In-house 399-425 (425) Show / Hide 
Range on Protein: 416-442
Range on HMM: 399-425/425
Sequence Identity: 44% (12 aa)

KNLLERMLTLDPSKRITPDEALKHPFL
|.|. .||. ||.||.| ...|.||..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PRP4_e.AA ULK 415-442 39 6.5e-11 34.42 In-house 302-329 (329) Show / Hide 
Range on Protein: 415-442
Range on HMM: 302-329/329
Sequence Identity: 39% (11 aa)

FKNLLERMLTLDPSKRITPDEALKHPFL
.|.|. |||. |...||. .| ..||..
CKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase PRP4_e.AA DYRK1 414-442 55 2.7e-10 31.85 In-house 293-321 (321) Show / Hide 
Range on Protein: 414-442
Range on HMM: 293-321/321
Sequence Identity: 55% (16 aa)

RFKNLLERMLTLDPSKRITPDEALKHPFL
.|| |..|||  || .|||| .||.|.|.
KFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase PRP4_e.AA DYRK2 415-442 46 6.6e-10 28.05 In-house 291-318 (318) Show / Hide 
Range on Protein: 415-442
Range on HMM: 291-318/318
Sequence Identity: 46% (13 aa)

FKNLLERMLTLDPSKRITPDEALKHPFL
| . . | .. |||.|.||..|||||..
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase PRP4_e.AA TyrKc 128-442 14 6.8e-10 -62.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 128-442
Range on HMM: 1-280/280
Sequence Identity: 14% (52 aa)

YQVKASIGSGMFSTVFLAKSLFPECEQEVAIKIPRKNDLMLRSAKSELQILKKV-AEPEATNKDNHCVKLLDSFVYR--------EHLCLVMESLDL-NL
 . .  .|.| | .|....       ..||.|  ...   ..   .|..|..|.        .  . |.|.   .          | |..|||  .. .|
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGG------HHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDL

RQITNKYGRNRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRRSIKLCDFGVAMFARDQ---TPSAETPYLVS---PSYR--------A
..   |....  ...|. . ...|     ..|.. .. | |.   |..|.. .  .| .||| . .  |       ... | ..    . .        |
KDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMA

PEII-LGVAPYSHAIDMWSAGCCLYELYTGKFLFPVA-----TNNGLLKQQMELKGAFPKAML----KKGAFTGMHFNENFEFRQLDPVTKLETLRSMAS
|| |  |.  .... | || | |..|..|     .        .|  . .. .  .  |.                                        
PECINYGK--FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------

FNVKTSCISDLTGEDGALMARFKNLLERMLTLDPSKRITPDEALKHPFL
        .      ..  . .. . ..    ||..| |  |   | ..
--------F-----VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase PRP4_e.AA Pkinase 415-442 35 1.6e-09 34.74 Pfam 266-293 (293) Show / Hide 
Range on Protein: 415-442
Range on HMM: 266-293/293
Sequence Identity: 35% (10 aa)

FKNLLERMLTLDPSKRITPDEALKHPFL
.| .....|..||.||.|....|.||..
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PRP4_e.AA YAK 415-442 35 3.8e-07 19.9 In-house 320-347 (347) Show / Hide 
Range on Protein: 415-442
Range on HMM: 320-347/347
Sequence Identity: 35% (10 aa)

FKNLLERMLTLDPSKRITPDEALKHPFL
|  ..  .| |.| .| .|  | .|||.
FIDFINQLLQLNPRERWKPMQAMQHPFI