Gene PRP4_a (S.moellendorffii)

PRP4_a

Species: S.moellendorffii
Alias: PRP4_a
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: PRP4

Sequence

Name Sequence Type Origin Length Description Download
PRP4_a.AA Protein None 761 None Fasta, JSON
PRP4_a.NA RNA None 2286 None Fasta, JSON
PRP4_a.kin_dom Protein Kinase Domain None 755 None Fasta, JSON

Protein domain

Protein domains of PRP4_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PRP4_a.AA PRP4 424-685 60 1.9e-155 522.73 In-house 1-261 (320) Show / Hide 
Range on Protein: 424-685
Range on HMM: 1-261/320
Sequence Identity: 60% (159 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEEVAIKIIRSNETMFKAGQMELIILNKLAGA--DLENKRHCVRLLSSFEYRNHLCLVFESLHMNLREILKKF
|.. .  | ||||.|.|.||.  |.   |.|||||||.|| | | |  || || ||  |  | . | ||||.  .|..|.|.||||| . |||||.|||.
YRVYGYCGQGVFSNVCRCRDQTRGN---EMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKY

GRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKNLLKLCDFGSAMFAGENEITPYLVSRFYRAPEIILGLPYDHALDMWSVGCCLYE
|...| .| ||||||.||| ||||| .|. || ||||||.||| ||| ||.||||||    |||||||||||||||||||.| ||| . |||||||.|||
GKDVGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

LYTGKVLFPGSTNNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQDLNFHAIEEDPVTKKVQFCI
|||||..|||.|||.||.| |..|| .|.||.||  |  .|||| .||  .| | ||....  .
LYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQEVDKVTEREKVTV
Kinase PRP4_a.AA DYRK 424-759 36 8.8e-135 454.07 In-house 1-320 (320) Show / Hide 
Range on Protein: 424-759
Range on HMM: 1-320/320
Sequence Identity: 36% (127 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEEVAIKIIRSNETMFKAGQMELIILNKLAGADLENKRHCVRLLSSFEYRNHLCLVFESLHMNLREILKKFGR
||| .  |.|.|. ||...|.| .    | |||||||.|. ... .| |. || .|  .| ..| |||... .| .|||||.||| | |||.| ||. . 
YEILEYIGKGSFGQVVKCWDHKTN----EMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHF

NIGISLAAVRSYARQLFTALKHLRNC-GVLHCDIKPDNMLVND--SKNLLKLCDFGSAMFAGENEITPYLVSRFYRAPEIILGLPYDHALDMWSVGCCLY
. ..|| .||..|.|..|.||.| ..   .|||.||.| ....  .|. .|..||||. | .. .|..|..||||||||.|||.||. | ||||.||.|.
QGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILA

ELYTGKVLFPGSTNNDMLRLHMELKGPFPKKMLRKA--MFTAQHFDQDLNFHAIEEDPVTKKVQFCIFPVYSFLHLL-SFQTINRMITNVKPKDISTLI-
||.||..||||....|.|.. ||..|..||.|..|.   .. ..||.                    .. . .     .. |  .|. . .|... . . 
ELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-------------------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRR

---SSSGGSDEDAKNLLNFKLLLEKIFILDPEKRLTVSQALNHPFI
   ......  . .. ..|| ...| ...||.||.| ||||.||..
PPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase PRP4_a.AA CMGC 424-759 19 3.2e-97 320.04 In-house 1-513 (513) Show / Hide 
Range on Protein: 424-759
Range on HMM: 1-513/513
Sequence Identity: 19% (103 aa)

YEIASSHGRGVFSTVVRARDTKAG----------RGEPEEVAIKIIRSNETMFKAGQ-------------MELIILNKL--AGADLE----------NKR
||| .  |.| ...|...||.. .          .   |.||||.|.... .   ..              |. || .|  ..   .          .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

HCVRLLSSFEYRN-----------------HLCLVFESLHMNLREILKKFGR-------------------------NIGISLAAVRSYARQLFTALK--
..|.|. .| ..|                 ||.|||| . ..| ...|.  .                            ... ..| |..|....||  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

HLRNCG--VLHCDIKPDNMLVNDSKNL-------------------LKLCDFGSAMFAGEN-----------------------EITPYLVSRFYRAPEI
..   .  ..|.|.|| | |.|. . |                   ||.||||.| . ...                        .|.| |.|.||||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGLP----------YDHALDMWSVGCCLYELYTG--------KVLFPGSTN-----------NDMLRLHMELKGPFPKKMLRKAMFT-------AQHFD
.|| .          |. . ||||||| ..|.|||        | ||||...            |.| . ... |... .|..|..          . . 
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFNFCKHEEEWP

QDLNFHAIEEDPV-----------TKKVQFCI-----FPVYSFLHLLSFQTI------------NRMITNVKPKDISTLISSSGGSDEDAKNL-------
. ..    . .|            .....  |     || . . .. ..               ..  . ..              .|..|.        
NMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF-NW-IY--------------EEKFKSHKFNHQFK

-----LNFKLLLEKIFILDPEKRLTVSQALNHPFI
       .  ||.|....||.||.|..|||.||..
RKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase PRP4_a.AA S_TKc 424-759 22 3e-74 253.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 424-759
Range on HMM: 1-231/231
Sequence Identity: 22% (79 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEEVAIKIIRSNETMFKAGQMELIILNKLAGADLENKRHCVRLLSSFEYRNHLCLVFESLHM---NLREILKK
|||    |.| |..| ..|..|      ..||||||.      .  . |. || |       .  . |.|. .|.  .||..|.| .     .|....||
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

FGR---NIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKNLLKLCDFGSAMFAGENEITPYLVSRFYRAPEIILGLPYDH-ALDMWSVG
 ||   . ...   .|.|..|.. ||... . |..|.|.||.| |...    .|.||||.| .      | . ....|.|||..   .|.. . |.||.|
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

CCLYELYTGKVLFPGSTNNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQDLNFHAIEEDPVTKKVQFCIFPVYSFLHLLSFQTINRMITNVKPKDISTLI
|.|||...|. .||  . . |... .                                                                          
CILYEMLCGYPPFP--QMQMMFKKIG--------------------------------------------------------------------------

SSSGGSDEDAKNLLNFKLLLEKIFILDPEKRLTVSQALN-------HPFI
               .| ...|..  |||||.|. .||.       ||..
------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PRP4_a.AA DYRK2 424-663 40 9.9e-69 222.54 In-house 1-240 (318) Show / Hide 
Range on Protein: 424-663
Range on HMM: 1-240/318
Sequence Identity: 40% (99 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEEVAIKIIRSNETMFKAGQMELIILNKLAGADLENKRHCVRLLSSFEYRNHLCLVFESLHMNLREILKKFGR
||| .  |.| |  ||.. | | .    . ||||.||      .  ..|..|| ..   |  |   ||..| .| .|||.|..|| | ||| | .||   
YEILEVIGKGSFGQVVKCYDHKTK----QHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHF

NIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDN-MLVNDSKNLLKLCDFGSAMFAGENEITPYLVSRFYRAPEIILGLPYDHALDMWSVGCCLYEL
. |.||. ||  |... ..|. |.   . ||| || | .|    .. .|. ||||  |. .  |  |  ||||||||.|||..|. | |||| || . ||
Q-GFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAEL

YTGKVLFPGSTNNDMLRLHMELKGPFPKKMLRKA----MFTAQHF
|||. ||||.  || . . ||. |  |||.. ..     | .. |
YTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYF
Kinase PRP4_a.AA DYRK1 424-666 41 1.3e-58 201.04 In-house 1-240 (321) Show / Hide 
Range on Protein: 424-666
Range on HMM: 1-240/321
Sequence Identity: 41% (101 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEEVAIKIIRSNETMFKAGQMELIILNKLAGADLENKRHCVRLLSSFEYRNHLCLVFESLHMNLREILKKFGR
||| |. |.| |  ||.| |..    | |.||||||.   . .   |.|. .|  .  .| |.| . |.|   | .||||||||| |  || ..|.    
YEIDSLIGKGSFGQVVKAYDHQ----EQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNT-H

NIGISLAAVRSYARQLFTALKHLR--NCGVLHCDIKPDN-MLVNDSKNLLKLCDFGSAMFAGENEITPYLVSRFYRAPEIILGLPYDHALDMWSVGCCLY
  |.||  .| .|.|. |||  .      ..|||.||.| .|.|  .  .|. ||||.  .|.  |  |. |||||.||..||..|| |.||||.|| | 
FRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILV

ELYTGKVLFPGSTNNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQD
|. ||  || ||   | .   .|  |  ||.|. .|  . ..|..|
EMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKD
Kinase PRP4_a.AA HIPK 424-668 37 9.3e-54 167.43 In-house 1-242 (329) Show / Hide 
Range on Protein: 424-668
Range on HMM: 1-242/329
Sequence Identity: 37% (93 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEEVAIKIIRSNETMFKAGQMELIILNKLAGADLENKRHCVRLLSSFEYRNHLCLVFESLHMNLREILKKFGR
||.    ||| |  ||..      ||  | |||||.. .    . ||.|. ||..| . . ..  | || .  |. .|| ||||| |  || . .|.  .
YEVLEFLGRGTFGQVVKCWK----RGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQN-K

NIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDN-MLVNDSKN--LLKLCDFGSAMFAGENEITPYLVSRFYRAPEIILGLPYDHALDMWSVGCCLY
   . | ..|    |  |||..|.. |..| |.||.| |||  ..     |  |||||    .    .|| ||.|||||||||||.  . |||| || . 
FMPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIA

ELYTGKVLFPGSTNNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQDLN
||. |  |.||. . |  |   .  .   . .| .|. . . ||.| .
ELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQ
Kinase PRP4_a.AA GSK 424-640 31 3.7e-47 141.72 In-house 1-230 (328) Show / Hide 
Range on Protein: 424-640
Range on HMM: 1-230/328
Sequence Identity: 31% (74 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEE----VAIKIIRSNETMFKAGQMELIILNKLAGADLENKRHCVRLLSSFE-YRNH--------LCLVFESL
||.   .|.|.|..|..| ..  .  . |.    |||| .   .. .|  ..|| |. .|. .|  |   .|||. .|. . .         .|||.| .
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQ-DKRYK-CNRELQIMKMLGKLDHPN---IVRLKYFFYMHYEKKDENHVYCNCLVMEYM

HMNLREILKKF---GRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKNLLKLCDFGSAM-FAG--ENEITPYLVSRFYRAPEIILGL
 ..| ......   ...  ...  .. |. |.| .|..|   |. | ||||.|.||....  ||.||||||         . ..| .||.||||| |.| 
PQTLYQVIRHYVKNKQQ--MPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGC

-PYDHALDMWSVGCCLYELYTGKVLFPGSTNNDMLRL
  |... |.||.||.. |. .|..|||| . .|.|..
TNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVE
Kinase PRP4_a.AA Pkinase 424-647 27 1.5e-46 165.65 Pfam 1-233 (293) Show / Hide 
Range on Protein: 424-647
Range on HMM: 1-233/293
Sequence Identity: 27% (69 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEEVAIKIIRSNETMFKAGQM-----ELIILNKLAGADLENKRHC--VRLLSSFEYRNHLCLVFESLHM----
|.| .  |.| |..| .... . |.    .||.|||.  ..  .  |      |. |...| .       |.  |||. .||...|...|.| . .    
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYV

-NLREILK--KFGRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKNL---LKLCDFGSAMF--AGENEITPYLVSRFYRAPEIIL-G
  | ....  . |. .  |   ...|..|.. .|... ..|..|.|.||.| |...  ..   .|.||||.| .     |. | . ....|.|||.|. |
MDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGG

LPYDHALDMWSVGCCLYELYTGKVLFPGS----TNNDMLRLHMELKGP
 .|... ||||.|| |||...|. .|||.    . .|.. .. . .||
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGP
Kinase PRP4_a.AA YAK 454-663 33 2e-39 131.39 In-house 27-239 (347) Show / Hide 
Range on Protein: 454-663
Range on HMM: 27-239/347
Sequence Identity: 33% (73 aa)

VAIKIIRSNETMFKAGQMELIILNKL-AGADLENKR---HCVRLLSSFEYRNHLCLVFESLHMNLREILK--KFGRNIGISLAAVRSYARQLFTALKHLR
.|.|.| .    |  .  |  ||  |    | .||    | .|.. .| ..||.||||| | .|| | ||  ||    | |   .| .  |   ..  | 
FAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF---CGFSFQLIRQWTKQILDGMCVLE

NCGVLHCDIKPDNMLVND-SKNLLKLCDFGSAMFAGENEITPYLVSRFYRAPEIILGLPYDHALDMWSVGCCLYELYTGKVLFPGSTNNDMLRLHMELKG
|  . ||| || | .     |  .|. ||||.       .. |  .|.||.||||.. .|  . |||| || . ||. |  .|||    . .    .  |
NKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSC-QEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQIKRIIDMLG

PFPKKMLRKAMFTAQHF
 .|  |. .  |  . |
YPPSWMIDQGRFKNKYF
Kinase PRP4_a.AA CDK 505-633 30 2.4e-32 100.65 In-house 95-229 (284) Show / Hide 
Range on Protein: 505-633
Range on HMM: 95-229/284
Sequence Identity: 30% (45 aa)

LVFESLHMNLREILKKFGRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKN----LLKLCDFGSAMFAGE--------NEITPYLVS
.||| ... | ....            ...| .||  .| ..   ...| |.|| | |.|.  .     ||. ||| |   |         .. |.  | 
MVFEYMDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRAPEIIL-GLPYD--HALDMWSVGCCLYELYT---GKVLFPGST
. |||||. |    |.   . ||||||| ..|..|   .| ||||..
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDS
Kinase PRP4_a.AA CLK 424-566 32 2.8e-31 90.47 In-house 1-150 (350) Show / Hide 
Range on Protein: 424-566
Range on HMM: 1-150/350
Sequence Identity: 32% (49 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEEVAIKIIRSNETMFKAGQMELI-ILNKLAGA-DLENKRH--CVRLLSSFEY-RNHLCLVFESLHMNLREIL
||| .  | |.|..||. .|.| |   .  ||.||||. |    | . |.  |. |.. . | .||.   |......|.|  .| |.||| .  .. . .
YEIVCTLGEGTFGKVVECWDHKNG---KKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFM

KKFG-----RNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDS
|. .     . |.  ....|. |.|| .|.| |   .  | | || | .  ||
KSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDS
Kinase PRP4_a.AA CLK 571-666 37 2.3e-26 75.43 In-house 187-288 (350) Show / Hide 
Range on Protein: 571-666
Range on HMM: 187-288/350
Sequence Identity: 37% (39 aa)

KLCDFGSAM---FAGENEITPYLVS-RFYRAPEIILGLPYDHALDMWSVGCCLYELYTGKVLFPGSTNNDMLRLHMELKG-PFPKKMLRKAM---FTAQH
.. |||||    |  ..|  . .|| | |||||.||||..    | ||.|| |.|||||  ||..  | . | .  .. | |.|. | ..      .  .
CVIDFGSATKIRF--DHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKY

FDQD
| ..
FYHN
Kinase PRP4_a.AA PRP4 704-759 40 6.5e-15 51.08 In-house 262-320 (320) Show / Hide 
Range on Protein: 704-759
Range on HMM: 262-320/320
Sequence Identity: 40% (24 aa)

ITNVKP-KDISTLISSS--GGSDEDAKNLLNFKLLLEKIFILDPEKRLTVSQALNHPFI
.|..|| ||| ..      . .... | .. || ||.|...|||.|| |. .|| ||||
MTYIKPTKDIYQELIECNQRIPEDQMKKVHQFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase PRP4_a.AA CDK 735-759 48 3.1e-10 28.79 In-house 260-284 (284) Show / Hide 
Range on Protein: 735-759
Range on HMM: 260-284/284
Sequence Identity: 48% (12 aa)

LLEKIFILDPEKRLTVSQALNHPFI
||.| . .||.||.. .|||.||. 
LLNKMLCYDPKKRISAEQALQHPYF
Kinase PRP4_a.AA CLK 735-759 48 6.9e-10 25.09 In-house 326-350 (350) Show / Hide 
Range on Protein: 735-759
Range on HMM: 326-350/350
Sequence Identity: 48% (12 aa)

LLEKIFILDPEKRLTVSQALNHPFI
|..|... || ||.| ..|| ||| 
LIRKMLEYDPSKRITCKDALQHPFF
Kinase PRP4_a.AA TyrKc 424-676 17 3.4e-09 -73.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 424-676
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

YEIASSHGRGVFSTVVRARDTKAGRGEPEEVAIKIIRSNETMFKAGQMELIILNKL-AGADLENKRHCVRLLSSFEYR-------NHLCLVFESLHM-NL
 .     |.| | .|.... .       ..||.| ....    ..   |. |. ||       .  . |||.               |..|.|     .|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

REILKKFGRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKNLLKLCDFGSAMFAGEN----EITPYLV------SR-----FYRAPE
.. |.| ...  ....   |.. |      .|   .. | |.   | ||.. .   | .||| . . ..     | . | .      ..        |||
KDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

IILGLPYDHALDMWSVGCCLYELYT-GKVLFPG-----STNNDMLRLHMELKGPFPKKM--------LRKAMFT------AQHFDQDLNFHAIEEDP
 |    . .. | || | |..|..| |.   ||      .| ..... .. . . . .           ..|..      .   ..  .| .| |. 
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PRP4_a.AA Pkinase 731-759 34 1.5e-07 27.81 Pfam 265-293 (293) Show / Hide 
Range on Protein: 731-759
Range on HMM: 265-293/293
Sequence Identity: 34% (10 aa)

NFKLLLEKIFILDPEKRLTVSQALNHPFI
..| ...... .||.||.|  |.|.||..
ECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PRP4_a.AA DYRK2 743-759 64 1.7e-07 20.09 In-house 302-318 (318) Show / Hide 
Range on Protein: 743-759
Range on HMM: 302-318/318
Sequence Identity: 64% (11 aa)

DPEKRLTVSQALNHPFI
||..|.| ||||.||.|
DPSERMTPSQALKHPWI
Kinase PRP4_a.AA YAK 742-759 50 1e-06 18.22 In-house 330-347 (347) Show / Hide 
Range on Protein: 742-759
Range on HMM: 330-347/347
Sequence Identity: 50% (9 aa)

LDPEKRLTVSQALNHPFI
|.| .| . .||  ||||
LNPRERWKPMQAMQHPFI
Kinase PRP4_a.AA GSK 735-759 44 6e-06 13.41 In-house 304-328 (328) Show / Hide 
Range on Protein: 735-759
Range on HMM: 304-328/328
Sequence Identity: 44% (11 aa)

LLEKIFILDPEKRLTVSQALNHPFI
|. |... ||.|||.  .|. ||| 
LISKCLVYDPKKRLSPLEACAHPFF
Kinase PRP4_a.AA HIPK 735-759 48 1.1e-05 13.29 In-house 305-329 (329) Show / Hide 
Range on Protein: 735-759
Range on HMM: 305-329/329
Sequence Identity: 48% (12 aa)

LLEKIFILDPEKRLTVSQALNHPFI
.| |.  .|..||.| ..||||||.
VLKKMCTWDAHKRITPCEALNHPFV
Kinase PRP4_a.AA CDK 424-460 36 8.7e-05 11.06 In-house 1-38 (284) Show / Hide 
Range on Protein: 424-460
Range on HMM: 1-38/284
Sequence Identity: 36% (14 aa)

YEIASSHGRGVFSTVVRARDTKAG-RGEPEEVAIKIIR
||.    |.| . .| .|||.. | .   . ||.| ||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR
Kinase PRP4_a.AA DYRK1 730-759 40 0.000105 11.89 In-house 292-321 (321) Show / Hide 
Range on Protein: 730-759
Range on HMM: 292-321/321
Sequence Identity: 40% (12 aa)

LNFKLLLEKIFILDPEKRLTVSQALNHPFI
| || |.... . ||..|.|  .|| |.|.
LKFKDLIKRMLQYDPKQRITPYYALQHSFF