Gene ERK5_c (S.moellendorffii)

ERK5_c

Species: S.moellendorffii
Alias: ERK5_c
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK5_c.AA Protein None 408 None Fasta, JSON
ERK5_c.NA RNA None 1227 None Fasta, JSON
ERK5_c.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of ERK5_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK5_c.AA MAPK 12-303 47 5.4e-160 537.81 In-house 1-328 (328) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-328/328
Sequence Identity: 47% (155 aa)

YKVLEVIGKGSYGVVCSAIDTR------TNEKVAIKKINDIFEHVSDATRILREIKLLRLL-RHPDVVEIKHILLP------PSRREFKDIYVVFELMES
|. |. ||.|.|||||||||.|      ...||||||| . |... .. |..||||||| . .|. .. ...|. |      .|. ||.|||.|.||||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQVIKANDDLMPEHYQFFLYQLLRG--LKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFND------------APTAIFWTDYVATRWYRA
||||.|| .. |  .| |.|.||.|||  ||.|| ||| |||||| |.| | || ||||||||||.. ..            .  . . |.|||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCF-QKMHMTEYVATRWYRA

PELCGSF-FSRYTPAIDIWSIGCIFAETIT-RKPLFPGKNVTHQLELITDLLGTPSQDVISRVR-NEKARRYLSTM---SKKSPVPFSEKFKN----IDP
||.  .    .|| |.|.||.|||||| .| ||||||||.  .|..||...|||||...|...  .|.|| |.. .    |. ..|... |.|     .|
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

LARNLLQKMLAFDPKDRPSATEALADPYF
.|..||.|||.|||..| .. |||. |||
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ERK5_c.AA ERK 12-303 48 3.1e-155 522.0 In-house 1-307 (307) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-307/307
Sequence Identity: 48% (150 aa)

YKVLEVIGKGSYGVVCSAIDTR-----TNEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HPDVVEIKHILLPPSRREFKDIYVVFELMESDLHQVIK
|. .. ||.|.|||||||||.      |..||||||| ..|.|  ...|.||||||||... |. .. ...|..| |. ...|||.|.||||.||||.|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

ANDDLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLAR---VAFNDAP--TAIFWTDYVATRWYRAPELCGSFFSRYTPAID
    | ..|.|.|.||.|.|||.|| |||.||||||.|.| | || ||||||||||   . ... .  .. | |.|||||||||||.  | .. || |.|
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLS-WQKYTKAMD

IWSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTP-SQDVISRVRNEKARRYLSTMSK--KSPVPFSEKFKN--IDPLARNLLQKMLAFDPKDRPSAT
|||.|||||| . ||||||||.  ||...|....||| |.. ...  .|.|. |.. ...  . |.|... |.|  . |.| .||.|||.|||..| .. 
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

EALADPYF
|.|. |||
ECLEHPYF
Kinase ERK5_c.AA CMGC 12-303 27 4.1e-127 420.08 In-house 1-513 (513) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-513/513
Sequence Identity: 27% (140 aa)

YKVLEVIGKGSYGVVCSAIDTRTN--------------EKVAIKKINDIFEHVSDAT----------RILREIKLLRLLR----------------HPD-
|.....||.|.||||....|.|||              |.||||||   | .  .|           |.|||||.|. |.                |.  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVEIKHILLPP-SRRE-----------FKDIYVVFELMESDLHQVIKAND---------DLMPEH------------YQFFL------YQLLRGLK--FI
.| .. |. .. |...           |...| |||.|. ||.|.|| |           | . |             ..|.      ||.|||||  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HTAN--VFHRDLKPKNVLANANCKL--------------------KICDFGLAR-VAFNDAPTAI-----------------FWTDYVATRWYRAPE-LC
| ..  ..|||||| |.| | ||.|                    ||||||||| .  .. ...                  . |.||.|||||||| |.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GS-------FFSRYTPAIDIWSIGCIFAETITR--------KPLFPGKNV-----------THQLELITDLLGTP----------------SQDVISRVR
|.       ..  ||..||.||.|||||| .|.        ||||||..             .||..| ..||||                ... .... 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------NEKARRYLST---MSKKSPVPFSEKFKN-----------------------------------IDPLARNLLQKMLAFDP
                    .|.||.|..      .. | |....|..                                   .||.|..||.||| .||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

KDRPSATEALADPYF
..|..| .||. |||
DKRITAEQALQHPYF
Kinase ERK5_c.AA ERK5 12-303 48 2.2e-124 419.51 In-house 1-295 (295) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-295/295
Sequence Identity: 48% (143 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPS-RREFKDIYVVFELMESDLHQVIKANDDL
||..| || | |||||||.  .. ..||||||   |. |  | | .||.|.||  ||  .. |. || |     |.||.||||.||||||||.| .|  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

MPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLAR--VAFNDAPTAIFWTDYVATRWYRAPELCGSFFSRYTPAIDIWSIGCIF
  ||  .||||.|||||..| |.| |||||| |.| | || ||| |||.||    |  .   .| |.||||||||||||  |    || |||.||.||||
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFS-SHDYTQAIDVWSVGCIF

AETITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLST-MSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRPSATEALADPYF
 | |.|. .|||||  |||.|| . ||.|.  .|  |  .. . |.   .. . |..... .   |. | .|| .|| |.| .| .. .||  |. 
GEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase ERK5_c.AA p38 12-303 42 8.4e-117 394.34 In-house 1-289 (289) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-289/289
Sequence Identity: 42% (126 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEK---VAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLP--PSRREFKDIYVVFELMESDLHQVIKA
|. |. .|.|.|| ||.|.|.||..|   |||||..  |. . .| |. ||..||...||  |...  .  |   |...|.|.|.| ..|..||....| 
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NDDLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFNDAPTAIFWTDYVATRWYRAPELCGSFFSRYTPAIDIWSIGC
   |  .| || .||.|||||.|| |.. |||||| |.  | .| |.| ||||||      ...   |.|||||||||||   .    || ..||||.||
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR------HCDDEMTGYVATRWYRAPEIMLNWMH-YTQTVDIWSVGC

IFAETITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRPSATEALADPYF
| || ||...||||..  .||. |. ..|||.. ..... .|.|| |.  ...     |.. |.. .|.| .|| |||  ||  | .| ||.. |||
IMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase ERK5_c.AA ERK1 12-303 49 1.3e-111 377.11 In-house 1-289 (289) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-289/289
Sequence Identity: 49% (145 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPSRREFKDIYVVFELMESDLHQVIKANDDLM
|  |. ||.| ||.||||.||.....||||||   |||     | |||||.|   .|  ...|. |.  ..  ...|.|.| .||| || ...|.   | 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

PEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFNDAPTAIFWTDYVATRWYRAPELCGSFFSR-YTPAIDIWSIGCIFAE
 .|  .||||.|||||.|| ||| |||||| |.| |  | ||||||||||.|  .     | |.|||||||||||.     |. || .|||||.||| ||
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM--LNSKGYTKSIDIWSVGCILAE

TITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRPSATEALADPYF
 .  .|.||||    || .|  .|| |||| .  . ||||| ||  .  |. ||. . | . |. |  ||.|||.| |. |    |||| || 
MLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase ERK5_c.AA ERK7 12-303 41 4.3e-101 342.14 In-house 1-292 (292) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-292/292
Sequence Identity: 41% (123 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HPDVVEIKHILLPPSRREFKDIYVVFELMESDLHQVIKANDDL
|.... .||| ||.|  |.| || . ||.||| | |    || |  ||| .|. .. || .. .  ..        .|||.||| ||.||| ||.  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI---RADNDRDIYLVFEFMETDLHAVIRKGNIL

MPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLAR-VAFND--APTAIFWTDYVATRWYRAPE-LCGSFFSRYTPAIDIWSIGC
   | |. .||||| .|..| .|| |||||| |.| ...| .|.||||||| .|  .  ..     |.||||||||||| | ||   |||...| |||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGS--HRYTKGVDMWSIGC

IFAETITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRPSATEALADPYF
| .| .. ||.|||    .|.|.| .... |.|  |  .  . |   |. | .. . .... ...  . | .||...|.| || | .|..||. || 
ILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase ERK5_c.AA nmo 13-303 43 3.5e-99 305.68 In-house 2-292 (292) Show / Hide 
Range on Protein: 13-303
Range on HMM: 2-292/292
Sequence Identity: 43% (130 aa)

KVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPSRREFKDIYVVFELMESDLHQVIKANDDLMP
.    || | .||| |  | |   .||.||. ..|  .  . |. ||.|.|   .|  |.  . || ||    |..|||| ||| ||||..| .   | .
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

EHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFNDAPTAIFWTDYVATRWYRAPE-LCGSFFSRYTPAIDIWSIGCIFAET
.| . ||||.|||||..|.||. |||.|| |.| |.|| |||||||||||   .  ..   |  | | .||||| | |.   .|| |.||||.|||||| 
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVW--EQDQSKHMTQEVVTQYYRAPEILMGA--RHYTSAVDIWSVGCIFAEL

ITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNID-----PLARNLLQKMLAFDPKDRPSATEALADPYF
. |. ||  ..  .||..|||||||||.. . .   | |.  .  |..| |  ..  ..          | .||..|| |||  | |...||| || 
LGRRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPPC-LQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ERK5_c.AA CDK 12-303 35 8.4e-94 300.49 In-house 1-284 (284) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-284/284
Sequence Identity: 35% (117 aa)

YKVLEVIGKGSYGVVCSAIDTRTN-----EKVAIKKINDIF---EHVSDATRI--LREIKLLRLLRHPDVVEIKHILLPP-----SRREF--KDIYVVFE
|. || || |.||||  |.|..|.     . ||.|||       |   .   |  .|||.||. | || .| .. . .         . .  . .| |||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

LMESDLHQVIKANDDLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCK-----LKICDFGLARVAFNDA-----PTAIFWTDYVATRWYRA
 |. || ....          . ...|||||| ..|  .. |||||| | | | | .     ||| |||||| ||.       |.  . |  | |.||||
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR-AFGIPHQMSEPNRTY-THEVVTLWYRA

PELCGSFF--SRYT--PAIDIWSIGCIFAETIT---RKPLFPGKNVTHQLELITDLLGTPSQDV---ISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDP
|||    .  ..|.  ..||.||.|||||| .|   |||||||.. ..||..| ...|||. |.   ..   .                           
PEL---LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------

LARNLLQKMLAFDPKDRPSATEALADPYF
   .||.|||..||| | ||..|| .|||
---DLLNKMLCYDPKKRISAEQALQHPYF
Kinase ERK5_c.AA S_TKc 12-303 27 1.2e-93 318.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPSRREFKDIYVVFELMES---DLHQVIKAND
|..|..||||..|.|. .....|...||||.|.          .|.|||..|.  .|| .| .. .         ...|.|.|...    ||...|| . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

D------LMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFNDAPTAIFWTDYVATRWYRAPELCGSFFSRYTP-AIDI
       . . | .|..||....|...|  .. |||||| |.| .    .|||||||||.           | .. |.||.|||..      |.. ..|.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-----GYGKCKCDW

WSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRPSATEALA--
||.|||..| ....|.||      |.... ...|                                     .| |.....|.| .||..||.| |||.  
WSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----DPYF
     .|.|
WDIKCHPWF
Kinase ERK5_c.AA Pkinase 12-303 28 1.1e-79 275.81 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-303
Range on HMM: 1-293/293
Sequence Identity: 28% (89 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILR--EIKLLRLLRHPDVVEIKHILLPPSRREFKDIYVVFELMES-----DLHQVI
|.....||.||.|.|. ...  |...||.|.|.   |. .   . .|  ||.... |.|| .|.....         ..||.|.|..|      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K--ANDDL--MPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKL----KICDFGLARVAFNDAPTAIFWTDYVATRWYRAPELCGSFFSRYT
.  ..  .   ... .|..||.||||...|  .. |||||| |.| . |. .    ||||||||...          |... |.||.|||..  . . |.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR-GGQYYG

PAIDIWSIGCIFAETITRKPLFPGK----NVTHQLELITDLLGTPSQDVISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKMLAFDPKDRP
|..|.||.|||..| ....|.|||.    |   |...|   .|.|    ..  ...  .  ...   .    .... .|... .. .. ..|..|||.||
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRP

SATEALADPYF
.|...| .|.|
TAEQILQHPWF
Kinase ERK5_c.AA MAPK-Unclassified 12-161 46 6.5e-75 255.19 In-house 1-157 (575) Show / Hide 
Range on Protein: 12-161
Range on HMM: 1-157/575
Sequence Identity: 46% (73 aa)

YKVLEVIGKGSYGVVCSAIDTRT-NEKVAIKKINDIFEHVSDATRILREIKLLRLLRHPDVVEIKHILLPPSRRE--FKDIYVVFELMES---DLHQVIK
| . ..|| |.||.|| |.|... | .|||||.| ||. ..|. |.|||| .|| | || .. |. |. . .     |.|||.| ..|..   ||||.||
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

AND-DLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLAR
 |   .. .| | |.||.||||| .| |.. |||||| |.|.| .| ..|||||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase ERK5_c.AA MAPK-Unclassified 174-303 32 2e-46 160.54 In-house 406-575 (575) Show / Hide 
Range on Protein: 174-303
Range on HMM: 406-575/575
Sequence Identity: 32% (56 aa)

TDYVATRWYRAPELCGSFFSRYTPAIDIWSIGCIFAETITR-----------KPLFPGKN--------------------VTHQLELITDLLGTPSQDVI
| ||.||||||||.  |  . |. ..||||||||||| . .           .|||||..                    .  |. .| | ||.| . ..
TQYVVTRWYRAPEIMLS-MHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

SRVRNEKARRYLSTMSKKSPVPFS-EKFKNID---------PLARNLLQKMLAFDPKDRPSATEALADPYF
..... .|| |...  .| ||.|.   | .           .......||||.|.|. | .| .||  |||
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase ERK5_c.AA TyrKc 12-309 20 5.7e-16 35.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-309
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YKVLEVIGKGSYGVVCSAIDTRTNEKVAIKKINDIFEHVSDATRILREIKLLRLL--RHPDVVEIKHILLPPSRREF---KDIYVVFELMES-DLHQVIK
 . ....| | .|.|. .. .   ..||.|....          ..||..... |  .|| .| .  . . ..|. |   . ...|.|.|.  ||.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

ANDD-LMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFND------APTAIF----WTDY-VATRWYRAPELCGSFFS
.. . | ...   | .|  .|  ..|  |. ||||   |.| ..|   ||.||||.|   .|        .        ... .  ||. |||    ...
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI--NYG

RYTPAIDIWSIGCIFAETITR-KPLFPG-----KNVTHQLELITDLLGTPSQDV---ISRVRNEKARRYLSTMSKKSPVPFSEKFKNIDPLARNLLQKML
..|.. |.|| |    |  |. ..  ||     .. .. .|.. .    |  .    .|                         |    .   .. ..  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCW

AFDPKDRPSATEALADPYFQSMSHL
..||.|||. .|          . .
HEDPEDRPTFSEI--------HECF
Kinase ERK5_c.AA Pkinase_Tyr 12-166 26 1.1e-14 50.39 Pfam 1-164 (270) Show / Hide 
Range on Protein: 12-166
Range on HMM: 1-164/270
Sequence Identity: 26% (44 aa)

YKVLEVIGKGSYGVVCSAIDT----RTNEKVAIKKINDIFEHVSDA---TRILREIKLLRLL-RHPDVVEIKHILLPPSRREFKDIYVVFELMES-DLHQ
 . ....|.|..|.|. .. .     |. .||.|....   . ...      .||.|... | .|| .|    . .. ..     ||.|.|.|.  ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

VIKA----NDDLMPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNVLANANCKLKICDFGLARVAFND
  ..    .. | ...   . .|  .|. . .  |  ||||  .|.| . | . |||||||||  .||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYND