Gene ERK-p1_a-1 (S.moellendorffii)

ERK-p1_a-1

Species: S.moellendorffii
Alias: ERK-p1_a-1
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK-p1_a-1.AA Protein None 374 None Fasta, JSON
ERK-p1_a-1.NA RNA None 1125 None Fasta, JSON
ERK-p1_a-1.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of ERK-p1_a-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK-p1_a-1.AA ERK 32-319 56 2.3e-191 642.05 In-house 1-307 (307) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-307/307
Sequence Identity: 56% (174 aa)

YVPIRPLGKGAYGVVCSADNLE-----TGDKVAIKKIGNAFENSIDALRTLREMRLLRYLQ-HENVVGLLDIMKPVGRYTFNDVYLVYELMDTDLHQIIR
|  | ..|.||||||||| . |     ||.||||||| |||.. |.. ||||| .|||..  |||...|.|||.|. .  .||.|.| |||.|||||||.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SSQPLTDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLAR---TGREKG-----QFMTEYVVTRWYRAPELLLSCEDYTSAIDI
|.|.|.|.|.|.|.||.|.||||||||||.||||||.|.|.| ||||||.||||||   .. ...     .||||||.||||||||..|| ..||.|.||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCIFAELLGRKPIFPGKNYINQLKLIIDVIGSP-KESQLGFISNHKARSYIRSLPP--TPRVPLSRLYPHAN--PQALQLIERMLAFDPKERITVSE
||.||||||.|||||.||||.|..|. .|...||.|  | .|  | . .|. ||..||    | .|.. ..| ||  |||. |.|.||.|||..|||| |
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALDHPYF
.| ||||
CLEHPYF
Kinase ERK-p1_a-1.AA MAPK 32-319 53 1.9e-188 632.33 In-house 1-328 (328) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-328/328
Sequence Identity: 53% (174 aa)

YVPIRPLGKGAYGVVCSADNLE------TGDKVAIKKIGNAFENSIDALRTLREMRLLRYL-QHENVVGLLDIMKP------VGRYTFNDVYLVYELMDT
|....|.|.|||||||||.  .      .|.||||||| ..|.| ... ||.|| .|||.. .|||...||||..|        .  |||.|.| |||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQIIRSSQPLTDEHYQFFIYQLLRG--LKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLARTGREK----GQ----------FMTEYVVTRWYRAP
||||||.| |||.|.| |.|.||.|||  |||||||||.||||||.|.|.| ||||||.||||||.   .    .|          .|||||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLLS--CEDYTSAIDIWSVGCIFAELLG-RKPIFPGKNYINQLKLIIDVIGSPKESQLGFIS-NHKARSYIRSL---PPTPRVPLSRLYP----HANPQ
|..|.    .|| |.|.|||||||||.|. |||.||||.||.|..||..|.|.|.|  . .|. ...||.||.||   |..|..|.. ..|    .||||
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALQLIERMLAFDPKERITVSEALDHPYF
|. |.|.||.|||..|||| ||| ||||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ERK-p1_a-1.AA p38 32-319 49 1.8e-151 509.48 In-house 1-289 (289) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-289/289
Sequence Identity: 49% (145 aa)

YVPIRPLGKGAYGVVCSADNLETGDK---VAIKKIGNAFENSIDALRTLREMRLLRYLQHENVVGLLDIMKP--VGRYTFNDVYLVYELMDTDLHQIIRS
|. ..|.|.|||| ||.|   .||.|   |||||.   |.  |.| || ||.|||. ..||||..|||.  |    .  |.|||.| ..|..||..|...
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

SQPLTDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLARTGREKGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAE
 . |.|.| || .||.||||||||||.. ||||||.|. .| .|.|.| ||||||   .. . ||.||.|||||||| .|.  .|| ..|||||||| ||
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAE

LLGRKPIFPGKNYINQLKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
|. ... |||...|.||. |. |.|.|.|  .  |....||.||.|.|..||  ...... |||||. |.|.||  ||  |||..||. ||||
LITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase ERK-p1_a-1.AA CMGC 32-319 28 8.10000000001e-148 489.38 In-house 1-513 (513) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-513/513
Sequence Identity: 28% (147 aa)

YVPIRPLGKGAYGVVCSADN--------------LETGDKVAIKKIGNAFENSIDAL----------RTLREMRLLRYLQ-----------------HEN
|  |...|.|.||||... .               ||. .|||||| |.| . ..|.          |.||| ..|..|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVGLLDIMKPVG-RYT-----------FNDVYLVYELMDTDLHQIIRSSQ---------PLTDEH------------YQFFI------YQLLRGLK--YI
.|.|.|| .. . . .           ||..||| |.||.||.|.|.. |         ||.. |             ..|.      ||.|||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDLKPGNLLLNANCDL--------------------KIADFGLAR-TGREKGQ--------------------FMTEYVVTRWYRAPELLL
||..  ..|||||| |.|.| ||.|                    ||.|||||| .. ....                    ..|.|||||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SCEDYT---------SAIDIWSVGCIFAELLGR--------KPIFP-----------GKNYINQLKLIIDVIGSP----------------KESQLGFIS
....||         ..||.|||||||||.. .        ||.||           ||..|.||..|..|.|.|                .|   ..|.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------NHKARSYIRS---LPPTPRVPLSRLYPH-----------------------------------ANPQALQLIERMLAFDP
                    ...|| ||.|   .|. |. |...|.|                                    ..|||. |...|| .||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

KERITVSEALDHPYF
..|||...||.||||
DKRITAEQALQHPYF
Kinase ERK-p1_a-1.AA ERK5 32-319 52 2e-145 489.4 In-house 1-295 (295) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-295/295
Sequence Identity: 52% (156 aa)

YVPIRPLGKGAYGVVCSADNLETGDKVAIKKIGNAFENSIDALRTLREMRLLRYLQHENVVGLLDIMKPVGRYT-FNDVYLVYELMDTDLHQIIRSSQPL
| .|  .| ||||||||| .  .|..|||||| |||.    | ||.||...||  .|.|.. . ||..|   |  . ||| |..||. |||||| |.||.
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLAR---T--GREKGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFA
| ||  .|.||.||||||.|||.|.|||||| ||| | ||.||| |||.||   |    ..  |||||| |||||||||..| .||| |||.||||||| 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELLGRKPIFPGKNYINQLKLIIDVIGSPKESQLGFISNHKARSYIRS-LPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
|...|. .|||||||.||.||..|.| |    .  .|  . . |. . .|.   ......|| | .|||.|. ||| |.| ||||| .|| ||. 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase ERK-p1_a-1.AA ERK1 32-319 53 4.5e-129 435.1 In-house 1-289 (289) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-289/289
Sequence Identity: 53% (155 aa)

YVPIRPLGKGAYGVVCSADNLETGDKVAIKKIGNAFENSIDALRTLREMRLLRYLQHENVVGLLDIMKPVGRYTFNDVYLVYELMDTDLHQIIRSSQPLT
|. .. .|.||||.||||.   ....||||||   ||      |||||...|   .|||.... ||..      . |||.| .||.||| .... .|.| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLK-TQHLS

DEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLART---GREKGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELL
 .|  .|.||.||||||||||||||||||| |||||  ||||| ||||||    . .   |.|||| ||||||||..|    || .||||||||| ||.|
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

GRKPIFPGKNYINQLKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
  .|||||| |. || .|. |.||| .  |  | |.|||.|..|||  |.||. ||.|.| ..|| |...||.| |..|||| ||| ||| 
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase ERK-p1_a-1.AA ERK7 32-319 43 1.5e-119 403.5 In-house 1-292 (292) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-292/292
Sequence Identity: 43% (128 aa)

YVPIRPLGKGAYGVVCSADNLETGDKVAIKKIGNAFENSIDALRTLREMRLLRYLQ-HENVVGLLDIMKPVGRYTFNDVYLVYELMDTDLHQIIRSSQPL
|  .. |||||||.|  |    |.. ||.|||  || |..|| || ||. .|. .. |.|.. |.....        |.|||.| |.|||| .||  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADND---RDIYLVFEFMETDLHAVIRKGNIL

TDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLAR--TGRE----KGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIF
 | | |. .||||| .||.||.||.|||||| |.||...| .|..||||||  . .|    . . .|||| |||||||| ||. . || ..| ||.||| 
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AELLGRKPIFPGKNYINQLKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALDHPYF
.|.|  ||.|||   .||. .|...|. |..  .  |  | | . . ... ..| .|. ..|.. ..|. |. |.|.| ||.|.|. .|| ||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase ERK-p1_a-1.AA nmo 33-319 47 8.8e-117 360.81 In-house 2-292 (292) Show / Hide 
Range on Protein: 33-319
Range on HMM: 2-292/292
Sequence Identity: 47% (138 aa)

VPIRPLGKGAYGVVCSADNLETGDKVAIKKIGNAFENSIDALRTLREMRLLRYLQHENVVGLLDIMKPVGRYTFNDVYLVYELMDTDLHQIIRSSQPLTD
 | ||.| ||.||| |      | .||.||. | | | . . |  ||...| . .|.||. .|||..|     |...| | |||  |||.|| | |.|. 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

EHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLART-GREKGQFMTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGRK
.| . |.||.||||||.||||.||||.||||||.|.|| ||| ||||||.  ... . ||. ||| .|||||.|.    ||||.|||||||||||||||.
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR

PIFPGKNYINQLKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVP-LSRLYP--HANPQALQLIERMLAFDPKERITVSEALDHPYF
 .|  .. |.||..|.|..| |   .. .  .      .|  .  | .. | .|    ||.  | .|. ||| |||  || . .|| ||| 
ILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ERK-p1_a-1.AA CDK 32-319 35 4.7e-110 353.33 In-house 1-284 (284) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-284/284
Sequence Identity: 35% (117 aa)

YVPIRPLGKGAYGVVCSADNLETG-----DKVAIKKIGNAF-----ENSIDALRTLREMRLLRYLQHENVVGLLDIMKPVGRYTF-----------NDVY
|  .  .| |.||||  | ...||     . ||.|||         |       ..||  ||. | |.|.| |.|.      .|            | .|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVC-----HTKNMDRNNKDKHENKLY

LVYELMDTDLHQIIRSSQPLTDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCD-----LKIADFGLARTGRE------KGQFMTEYVVTRWY
.| | ||.|| ....          . ...|||||| |.|| ...|||||| |.|.| |       ||||||||||          . . .|  |||.||
MVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELLLSCEDYT--SAIDIWSVGCIFAELLG---RKPIFPGKNYINQLKLIIDVIGSPKESQL-GFISNHKARSYIRSLPPTPRVPLSRLYPHANPQAL
||||||| ...|.   .||.|||||||||..    |||.|||.. |.||..|....|.| |..  |. .                               
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------

QLIERMLAFDPKERITVSEALDHPYF
.|...||..||| ||. ..||.||||
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase ERK-p1_a-1.AA S_TKc 32-319 30 6.5e-101 342.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

YVPIRPLGKGAYGVVCSADNLETGDKVAIKKIGNAFENSIDALRTLREMRLLRYLQHENVVGLLDIMKPVGRYTFNDVYLVYELMDT---DLHQIIRSSQ
|  .|..||||.|.|. . . .|| .||||.|           ...||...|.  .|.|.| |.|..        ...|.| |..|.   ||...|.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

P------LTDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLARTGREKGQFMTEYVVTRWYRAPELLLSCEDYTS-AIDIWSVG
.      ..  | .|..||....|.|.|| ...|||||| |.||.    .||.||||||         | ...|.||.|||.|     |.  ..|.||.|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

CIFAELLGRKPIFPGKNYINQLKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVSEALD------
||..|.| ..| ||      |.......||                                      |.|...|...| .||..|.|. |||       
CILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYF
 ||.|
CHPWF
Kinase ERK-p1_a-1.AA Pkinase 32-319 29 1.5e-97 335.22 Pfam 1-293 (293) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YVPIRPLGKGAYGVVCSADNLETGDKVAIKKIGNAFENSIDALRTLR--EMRLLRYLQHENVVGLLDIMKPVGRYTFNDVYLVYELMDT-----DLHQII
|. .|..|.|..|.|. . .  ||..||.|.|    |.|    . .|  | .... |.|.|.| |.|..        ...|.| |...      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

R--SSQPL--TDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDL----KIADFGLARTG-REKGQFMTEYVVTRWYRAPELLLSCEDYTSAI
.  .. ..  .... .|..||.||||.|.|| ...|||||| |.|.. |...    ||.|||||.     ... || ...|.||.|||.......|....
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSVGCIFAELLGRKPIFPGK----NYINQLKLIIDVIGSPKESQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIERMLAFDPKERITVS
|.||.|||..|.| ..|.|||.    | ..|...|  . | | ...    ..   .. .|  . .    .... . ... ....|...|..|||.|.|  
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

EALDHPYF
..| ||.|
QILQHPWF
Kinase ERK-p1_a-1.AA MAPK-Unclassified 32-181 47 2.3e-75 256.69 In-house 1-157 (575) Show / Hide 
Range on Protein: 32-181
Range on HMM: 1-157/575
Sequence Identity: 47% (74 aa)

YVPIRPLGKGAYGVVCSADNLET-GDKVAIKKIGNAFENSIDALRTLREMRLLRYLQHENVVGLLDIMKPVGRYT--FNDVYLVYELMDT---DLHQIIR
| ..  .| ||||.|| |    . . .|||||.  .|.| .|. |.||| |.|||| |.|.. . ||  . .     | |.|.| ..| |   ||||||.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SSQ-PLTDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLAR
| | .. ..| | |.||.||||||.|||...|||||| |||.| .| ..|.|||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase ERK-p1_a-1.AA MAPK-Unclassified 190-319 35 8.6e-60 204.96 In-house 405-575 (575) Show / Hide 
Range on Protein: 190-319
Range on HMM: 405-575/575
Sequence Identity: 35% (60 aa)

MTEYVVTRWYRAPELLLSCEDYTSAIDIWSVGCIFAELLGR-----------KPIFPGKN--------------------YINQLKLIIDVIGSPKESQL
||.|||||||||||..||  .|. ..||||.||||||.. .           .|.|||..                    .. |.|.|.|. |.|.|  .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

GFISNHKARSYIRSLPPTPRVPLSRLYPHANP----------QALQLIERMLAFDPKERITVSEALDHPYF
 || . .|| ||.|. . ..|. . |.. ..|          ... ..  ||.|.|. |||  .|| ||||
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase ERK-p1_a-1.AA TyrKc 32-319 22 1.3e-14 13.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 32-319
Range on HMM: 1-280/280
Sequence Identity: 22% (74 aa)

YVPIRPLGKGAYGVVCSADNLETGDKVAIKKIG-NAFENSIDALRTLREMRLLRYL--QHENVVGLLDIMKPVGRYTF---NDVYLVYELMDT-DLHQII
 . .. || ||.|.|. .       .||.|..  .|    . ..  .||.|... |  .|.|.| |. .    ||  |     ...| |.|.  ||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDF--MREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYL

RSSQP-LTDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLARTGREK-------GQFMT-----EY--VVTRWYRAPELLLSCE
|...| |. ..   | .|  .|  |.|| |. ||||   | |...|   ||.||||.| . ..          ..     .   .  ||. ||| .  ..
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGK

DYTSAIDIWSVGCIFAEL--LGRKPIFP------GKNYINQLKLIIDVIGSPKE----SQLGFISNHKARSYIRSLPPTPRVPLSRLYPHANPQALQLIE
 .|.. |.|| |    |.  .| .|             . ..    .    |..    |                         .   ... .   |...
-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------F---VCCPDEMYQIMK

RMLAFDPKERITVSEALDHPYF
.  ..||..| | ||   | .|
QCWHEDPEDRPTFSEI--HECF
Kinase ERK-p1_a-1.AA Pkinase_Tyr 32-219 27 1.3e-12 43.34 Pfam 1-199 (270) Show / Hide 
Range on Protein: 32-219
Range on HMM: 1-199/270
Sequence Identity: 27% (58 aa)

YVPIRPLGKGAYGVVCSADNL----ETGDKVAIKKIGNAFENSID--ALRTLREMRLLRYL-QHENVVGLLDIMKPVGRYTFNDVYLVYELMDT-DLHQI
 . .. ||.||.|.|. .       .|. .||.|.. .    . .      .||..... | .|.|.| |. .  . |.     .|.| |.|   ||.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDY

IRS----SQPLTDEHYQFFIYQLLRGLKYIHSANVLHRDLKPGNLLLNANCDLKIADFGLARTGREKGQFMTEY-VVT-------RWYRAPELLLSCEDY
 |.     |||| ..   . .|  .|. | .| |  ||||   | |.. |   ||.||||||.     .   .| ...       .|. ||| .  .. .
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI----YNDDYYYRKRGGGKLPIKWM-APECINYGK-F

TSAIDIWS
|.. |.||
TTKSDVWS