Gene MAK_e (S.moellendorffii)

MAK_e

Species: S.moellendorffii
Alias: MAK_e
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
MAK_e.AA Protein None 434 None Fasta, JSON
MAK_e.NA RNA None 1305 None Fasta, JSON
MAK_e.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of MAK_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAK_e.AA RCK 24-304 53 5.9e-182 582.44 In-house 1-298 (298) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-298/298
Sequence Identity: 53% (161 aa)

YQVIKQVGDGTYGSVWKAIDRCTNEFVAIKKMKTKFHGWEECMNLREVKCLQRLD-HPNIVQLKEVIWEHG--ELFLVFEYMECNLYQVMKD---RSKML
||.|||.||||||.| ||..  |.|.|||||||.||. |||||||||.| | .|  ||||..||||| .    .|..|||||. |||| |||   | | |
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

SEER--IRIWSFQVLRALDYMHQHGIFHRDLKPENLLVS----------DEAIKVADFGLAREVYSVAPYTDYVATRW*YRAPEVLLQAPSYSYAIDIWA
.|.   |.   .|.| .|..|| ||.|||||||||....          .. ||.|||||.||..|  |||||| ||| |||||.|| .  |.. .||||
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRW-YRAPECLLRCTYYNSPMDIWA

MGAIMAELFNLQPLFPGASEADEIYKICSVLGSPNYHTWPDGMQLAVRKGFRFPQFAPAGLQSLIPSASPAAVDMISAMLCWDPNRRPTAYQLRQHPFF
.|.||.||  |.|||||.|| |.|.|||.|.|.||  .|||| .||  ..|.|||  . .|..|||..|. ... .  ||.|||. |.||.|. |||.|
VGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase MAK_e.AA MAK 24-304 47 2.5e-166 533.88 In-house 1-352 (352) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-352/352
Sequence Identity: 47% (168 aa)

YQVIKQVGDGTYGSVWKAID------------------------------RCTNEFVAIKKMKTKFHGWEECMNLREVKCLQRLD-HPNIVQLKEVIW--
||.|||.||||||.| .|..                                | | ||||.||.||. ||||||||||| |  |  |||||.|||||   
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

EHGELFLVFEYMECNLYQVMKDRSK-MLSEERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVSD------------------EAIKVADFGLAREVYS
|  .|..|||||. |||| |||| . ...|  ||   .|.| .| .||.|| ||||.||||....                   | ||.||||||||. |
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

VAPYTDYVATRW*YRAPEVLLQAPSYSYAIDIWAMGAIMAELFNLQPLFPGASEADEIYKICSVLGSPNYHT----------------WPDGMQLAVRKG
  |||||| ||| ||||||||   .||  ||.||.|.|||||. . |||||.|| |.|.|||.|||.|.  .                |||| |||   .
KPPYTDYVSTRW-YRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMN

FRFPQFAP---AGLQSLIPSASP-AAVDMISAMLCWDPNRRPTAYQLRQHPFF
|||||  |     |..|||..|.  |....  || ||||.|||| |. ..|.|
FRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase MAK_e.AA CMGC 24-304 25 2e-126 417.79 In-house 1-513 (513) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-513/513
Sequence Identity: 25% (131 aa)

YQVIKQVGDGTYGSVWKAIDRCTN--------------EFVAIKKMKTKFHGWEEC----------MNLREVKCLQRL-----------------DHPNI
|..||..| |||| |.|..|. ||              |.|||||.| .|. ....          . |||.|.|..|                 .|.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQLKEVIWEHG-----------------ELFLVFEYMECNLYQVMKDRSK--------MLSEER------------IRIWS------FQVLRALD--YMH
|.|....  ..                 .|.||||||...|||..|. ..         |||              |.  .      .|.||.|.  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

QHG--IFHRDLKPENLLVSDE---------------------AIKVADFGLAREVYS----------------------VAPYTDYVATRW*YRAPEVLL
.|.  |.||||||||.|....                      .|..|||||| . .                      . |||.||.||| |||||.||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRW-YRAPEILL

QAPSYS---------YAIDIWAMGAIMAELFN--------LQPLFPGASE-----------ADEIYKICSVLGSPN---------------YHTWPDGMQ
 .. |.         ..||.|. | |.||...        ..||||| ||            | ..||. |||.|.                 .||.  .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

-------------------------LAVRKGFRFPQFAPAGLQSLIPS-----------------------------------ASPAAVDMISAMLCWDP
                         .......|||.. |  ...|.|                                    ..| |.| .. ||..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

NRRPTAYQLRQHPFF
..|.|| |  |||.|
DKRITAEQALQHPYF
Kinase MAK_e.AA CDK 24-304 34 2.1e-108 347.95 In-house 1-284 (284) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-284/284
Sequence Identity: 34% (110 aa)

YQVIKQVGDGTYGSVWKAIDRCTN-----EFVAIKKMKTKFHG---WEECMN---LREVKCLQRLDHPNIVQLKEVIWEH-----------GELFLVFEY
|. ....| |||| | ||.|. |.     ..||.|| ..   |    .| ..   .||...|. | |||||.|..|.  .             |..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MECNLYQVMKDRSKMLSEERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVSDEA------IKVADFGLAREVYS-------VAPYTDYVATRW*YRAP
|.  |...|.          |. . .| ||.|.|.|...| |||||| |.|...        .|.|||||||.  .       . .||  | |.| ||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLW-YRAP

EVLLQAPSYS--YAIDIWAMGAIMAELFN---LQPLFPGASEADEIYKICSVLGSPNYHTWPDGMQLAVRKGFRFPQFAPAGLQSLIPSASPAAVDMISA
|.|| .  ||   .||.|. | |.||.|.    .||||| || | . ||. ..|.|.  .||.  .|                            | .. 
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNK

MLCWDPNRRPTAYQLRQHPFF
||| ||..| .| |  |||.|
MLCYDPKKRISAEQALQHPYF
Kinase MAK_e.AA CDC2 24-304 38 7e-104 320.2 In-house 1-301 (301) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-301/301
Sequence Identity: 38% (117 aa)

YQVIKQVGDGTYGSVWKAIDRCTNEFVAIKKMKTKFHGWEE----CMNLREVKCLQRLD-HPNIVQLKEVIWEHGELFLVFEYMECNLYQVMK-DRS--K
|| |. .| |||| | |..|. ||. ||.|| ... .  |.       .||  ||. |. |||||.|..|| .   |..||||....| . |.   .  |
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLE-QEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNK

MLSEERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVSDE-AIKVADFGLAREV-YSVAPYT--DYVATRW*YRAPEVLLQAPSYSYAIDIWAMGAIMA
 .... ..   .| |..... ||..|.|||||| |.|.... .||.||||||| . . . .||    | |.| |||||.|| .  || ..|.|. | |.|
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLW-YRAPEILLGCKRYSTPVDMWSIGCIFA

EL---FNLQPLFPGASEADEIYKICSVLGSPNYHTWPDGMQLAVRKGFRFPQFAPAGLQSLIPS---------ASPAAVDMISAMLCWDPNRRPTAYQLR
|.    .  |||.| || |...||  .||.||  |||.  ||   |   ||.. | .|....|.         . | ..| .. ||. ||..| .| .  
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

QHPFF
|||.|
QHPYF
Kinase MAK_e.AA CDK7 24-304 36 3.9e-99 264.66 In-house 1-288 (288) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-288/288
Sequence Identity: 36% (106 aa)

YQVIKQVGDGTYGSVWKAIDRCTNEFVAIKKMKTKFHGWE-----ECMNLREVKCLQRLDHPNIVQLKEVIWEHGELFLVFEYMECNLYQVMKDRSKMLS
|. ||..| |... | || |  |.. ||||| | . |  |     .   .||.| || . |.|.. |  ..     . |||..|.  |  | || |  | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

EERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVSDE-AIKVADFGLAREVYS-VAPYTDYVATRW*YRAPEVLLQAPSYSYAIDIWAMGAIMAELFNL
   |  .  ..|. | |.|.. | |||||| |||.. .  .|.|||||||   |    ||  | ||| ||||| |  | .|  ..|.|..| |.|||   
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRW-YRAPELLFGARHYGTGVDMWSVGCIFAELMLR

QPLFPGASEADEIYKICSVLGSPNYHTWPDGMQLAVRKGFR-FPQFAPAGLQSLIPSASPAAVDMISAMLCWDPNRRPTAYQLRQHPFF
 | .|| |. | . .|.. || |.  .||.  ...    |. || ..   |. .   ||  ..|... |.  .| .| |. |  ..|.|
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase MAK_e.AA S_TKc 24-304 30 2.6e-97 330.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-231/231
Sequence Identity: 30% (91 aa)

YQVIKQVGDGTYGSVWKAIDRCTNEFVAIKKMKTKFHGWEECMNLREVKCLQRLDHPNIVQLKEVIWEHGELFLVFEYMEC---NLYQVMKDRSKM----
|......| |..|.|.|.... |.. ||||..|        .. .||...|.. .|||||.|..|. . ..|..|.||..    .|....|.| .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSEERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVSDEAIKVADFGLAREVYSVAPYTDYVATRW*YRAPEVLLQAPSYSY-AIDIWAMGAIMAELF
 ..| ..| .  |...||.|.|.||| ||||||||.|...  ||..||||||..      | .. |.| |.|||||    .|.. ..|.|. | |..|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPW-YMAPEVL----GYGKCKCDWWSCGCILYEML

NLQPLFPGASEADEIYKICSVLGSPNYHTWPDGMQLAVRKGFRFPQFAPAGLQSLIPSASPAAVDMISAMLCWDPNRRPTAYQLRQ-------HPFF
  .|.||   . ....|..                                        || | |.|. .|..||..|||| .. |       ||.|
CGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAK_e.AA MOK 24-304 39 1.2e-94 297.03 In-house 1-283 (283) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-283/283
Sequence Identity: 39% (111 aa)

YQVIKQVGDGTYGSVWKAIDRCTNEFVAIKKMKTKFHGWEECMNLREVKCLQRLD-HPNIVQLKEVIWEH--GELFLVFEYMECNLYQVMKDRSKMLSEE
|. | ..|.||.  | |       .. | |.|| .|   |.  ||||.. ..||. ||||..|.||...   |.| |. | |. |.| ... |   |...
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

RIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVSDEAIKVADFGLAREVYSVAPYTDYVATRW*YRAPEVLLQAPSYSYAIDIWAMGAIMAELFNLQPLF
.|. . .|....|| ||  |||||| ||||.|. .. .|.||||  | |||  |||.|..||| ||||| ||    |.| .|.|. | .  |.  |.|||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHLKLADFGSCRSVYSKQPYTEYISTRW-YRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLF

PGASEADEIYKICSVLGSPNYHTWPDGMQLAVRKGFRFPQFAPAGLQSLIPSASPAAVDMISAMLCWDPNRRPTAYQLRQHPFF
||. | | | ||  |.| |  ..     . .    . ||    .|.. |.| ... ..... .|  .||  | || |  |||.|
PGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase MAK_e.AA Pkinase 24-304 31 3.5e-93 320.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YQVIKQVGDGTYGSVWKAIDRCTNEFVAIKKMKTKFHGWEECMNLR---EVKCLQRLDHPNIVQLKEVIWEHGELFLVFEYMEC-----NLYQVMK-DRS
|......| |..|.|.|.... |.. ||.|..| .   .......|   |.. ..||.|||||.|...  ..... .|.||.|.      |. ... .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KML--SEERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVS-DEAI----KVADFGLARE--VYSVAPYTDYVATRW*YRAPEVLLQAPSYSYAIDIWA
. .  ||. .. .  |.||.|.|.|..|| ||||||||.|.. .  |    |..|||||.     .   .|... |.| |.||||.. .. |....|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW-YMAPEVIRGGQYYGPKVDMWS

MGAIMAELFNLQPLFPGA----SEADEIYKICSVLGSPNYHTWPDGMQLAVRKGFRFPQFAPAGLQSLIPSASPAAVDMISAMLCWDPNRRPTAYQLRQH
.| |..|... .|.|||.    . .|....|| ..| |.   ||       .. ||. . .   .. . . .|... | |. .||.||..|||| |. ||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFF
|.|
PWF
Kinase MAK_e.AA MAPK 24-304 32 2.9e-84 286.26 In-house 1-328 (328) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-328/328
Sequence Identity: 32% (107 aa)

YQVIKQVGDGTYGSVWKAIDRC------TNEFVAIKKMKTKFHGWEECMN-LREVKCLQRL-DHPNIVQLKEVIWEH-----------GELFLVFEYMEC
|| .|..| | || |..|||..      ....|||||.   |.    |   .||.|.|... .|.||. |....  .            .. .|.|.||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLYQVMK-DRSKMLSEERIRIWSFQVLRA--LDYMHQHGIFHRDLKPENLLVSDE-AIKVADFGLAR--EVYSVAPY-------------TDYVATRW*Y
.|.|..| ..  .||...|.   .|.||.  | |.|  .. ||||||.|.||  .   |..||||||  .  .  ..             |.|||||| |
DLHQIIKSQQ--PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRW-Y

RAPEVLLQ--APSYSYAIDIWAMGAIMAELFN-LQPLFPGASEADEIYKICSVLGSPNYHTWPDGM-QLAVRKGFR----FPQFAPAGLQSLIPS----A
||||..|   .  |. |.|.|. | |.||. .  .||||| .  | . .| .|||.|  . .       ..|. ..    .|.  .  .....|     |
RAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNA

SPAAVDMISAMLCWDPNRRPTAYQLRQHPFF
.| |.|... || .||..| |. .  |||.|
NPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase MAK_e.AA CDKL 24-304 37 1.1e-80 274.32 In-house 1-286 (286) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-286/286
Sequence Identity: 37% (108 aa)

YQVIKQVGDGTYGSVWKAIDRCTNEFVAIKKMKT-KFHGWEECMNLREVKCLQRLDHPNIVQLKEVIWEHGELFLVFEYMECNLYQVMKDRSKMLSEERI
|  .  || | || | |  .. |.. ||||| |  .    .    .||.| |  | |.|||.|.||    ..|.|||||.. ..  . . . . . |...
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RIWSFQVLRALDYMHQHGIFHRDLKPENLLVS--DEAIKVADFGLAREVY-SVAPYTDYVATRW*YRAPEVLLQAPSYSYAIDIWAMGAIMAELFNLQPL
|   .|.|.|... |.| . ||| ||||.|..  .  .|  |||.||    . . ||||||||| ||||| |.  ..|. ..|||| | .|||..  |||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRW-YRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGASEADEIYKICSVLGSPNYHTWPDGMQLAVRK----GFRFPQF-APAGLQSLIPSAS-PAAVDMISAMLCWDPNRRPTAYQLRQHPFF
.|| |. |  |.|  .||       |. ...   .    | .||.   .  | .  | .| ..| |.. ..|  || .|.|. || .||.|
WPGQSDIDQLYHIQKCLG----PLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase MAK_e.AA CDK5 24-304 34 3.5e-79 249.73 In-house 1-287 (287) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-287/287
Sequence Identity: 34% (100 aa)

YQVIKQVGDGTYGSVWKAIDRCTNEFVAIKKMKTKFH-GWEECMNLREVKCLQRLDHPNIVQLKEVIWEHGELFLVFEYMECNLYQVMKDRSKMLSEERI
|. .  .|.|||| |.|| .. | |.||.|. .         .  .||.  |. | |.||| |  ||     | ||||..   |   | ..   .. . |
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RIWSFQVLRALDYMHQHGIFHRDLKPENLLVSDEAI-KVADFGLAREV-YSVAPYTDYVATRW*YRAPEVLLQAPSYSYAIDIWAMGAIMAELF-NLQPL
.   .| |. | . |.| . |||||| |||.. . . | |||||||     |  |.  | | | ||.| ||. .  ||  ||.| .| |.||.  ...||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLW-YRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPL

FPGASEADEIYKICSVLGSPNYHTWPDGMQLAVRK--GFRFPQFAPAG-LQSLIPSASPAAVDMISAMLCWDPNRRPTAYQLRQHPFF
|||... |.  .|  ..|.|.  .||   .|   |     .| . .   .|...|. .    |. . ||  .|| | .| .  .||.|
FPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase MAK_e.AA Pkinase_Tyr 24-171 27 2e-18 63.0 Pfam 1-163 (270) Show / Hide 
Range on Protein: 24-171
Range on HMM: 1-163/270
Sequence Identity: 27% (45 aa)

YQVIKQVGDGTYGSVWKAIDR----CTNEFVAIKKMKTKFHGWE--ECMNLREVKCLQRL-DHPNIVQLKEVIW-EHGE--LFLVFEYMEC-NLYQVMKD
 . .|. | | .|.|.|.. .     |.  ||.|..| . .  .    . .||.| .  | .|||||.|  |.  . .   ...|.|||.. .|.   ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---SKMLSEERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVS-DEAIKVADFGLAREVYS
.    . |. ...  ...|. ....| ..... ||||   | ||. .  .|..|||||| .|.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYN
Kinase MAK_e.AA TyrKc 24-304 22 4.6e-16 36.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-304
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YQVIKQVGDGTYGSVWKAIDRCTNEFVAIKKMK-TKFHGWEECMNLREVKCLQRL--DHPNIVQLKEVIWEH-------GELFLVFEYMEC-NLYQVMKD
 . .|. | | .| |.|.. .   . ||.|..|  .     . . .|| . . .|  .|||||.|  |. ..       . |..|.|||.  .| .  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RSKMLSEERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVSDEA-IKVADFGLAREVYSV----APYTDYVA-----TR--W*YR--APEVLLQAPSYS
. . |. .    ...|. .  .| |.... ||||   | ||...  .|..||||.|..|.     .    |..     ..  . .|  |||.. .   ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

YAIDIWAMGAIMAELFNL-QPLFPG-------ASEADEIYKICSVLGSPNYHTWPDGMQLAVRKGFRFPQFAPAGLQSLIPSASPAAVDMISAMLCWDPN
 . |.|. |  | |.| . |.  ||       ..|. |  |    .  | ..  |  |                   .  . ....  ....     ||.
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P--MS------------------F--VCCPDEMYQIMKQCWHEDPE

RRPTAYQLRQHPFF
 |||  ..  | .|
DRPTFSEI--HECF