Gene SRPK_c (S.moellendorffii)

SRPK_c

Species: S.moellendorffii
Alias: SRPK_c
External Links:
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SRPK_c.AA Protein None 545 None Fasta, JSON
SRPK_c.NA RNA None 1638 None Fasta, JSON
SRPK_c.kin_dom Protein Kinase Domain None 404 None Fasta, JSON

Protein domain

Protein domains of SRPK_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SRPK_c.AA SRPK 309-474 57 2.4e-137 356.2 In-house 389-554 (554) Show / Hide 
Range on Protein: 309-474
Range on HMM: 389-554/554
Sequence Identity: 57% (96 aa)

DVDLRCKIVDLGNACWTYKQFTADIQTRQYRCPEVLVGSKYSTPADMWSLACVVFELATGDVLFDPHTGEDYDRDEDHLALTMELLGRMPRKVALGGRYS
| ... ||.|||||||... || |||||||| |||..|..|.|||| ||.|| .||||||| ||.|| |||| ||.||.|.  ||.|. |...|| |.||
DHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYS

HDYFNRHGDLRHIRKLRFWPLKRVLVEKYDFSEVDAQDLSSFLCPILEFVPEKRLTAAQALQHSWL
 ..||. |.|||| || .|||..||.|||..|. .|.. ..|| | |...|||| ||...||| ||
REFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase SRPK_c.AA SRPK 71-213 50 1.6e-112 290.73 In-house 1-165 (554) Show / Hide 
Range on Protein: 71-213
Range on HMM: 1-165/554
Sequence Identity: 50% (84 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKNIALKIQKSAQHYTEAAMDEITILTQISKGDPE-----------------------NKKCVVKLLDHFRHTGPN
| | .||||||||||||. |    ... |.||.|||.||||.| ||| .| ...| ||                        |...||.|||||.|.|||
YHVIRKLGWGHFSTVWLCWD-MQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPN

GQHVCLVFELLGDNLLTLIKRHNCRGLPLQVVREISAQVLVGLDYLHRELSIIHTDLKPENILLTM
|.|.|.|||.||.||| .||..| .|.|.  |. |. ||| |||||||. .|||||.||||.||..
GNHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCV
Kinase SRPK_c.AA CMGC 71-474 17 2.8e-98 323.56 In-house 1-513 (513) Show / Hide 
Range on Protein: 71-474
Range on HMM: 1-513/513
Sequence Identity: 17% (106 aa)

YLVRKKLGWGHFSTVWLSSDR-------------HNENKNIALKIQKSAQHYTEAAM-------------DEITILTQIS-KGDPEN----------KKC
| . ||.|.|....|.   |.             |. |. .|.|. |... |.| |              .|| || ... ..|| |          .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-VVKLLDHFRHTGPNGQ-------------HVCLVFELLGDNLLTLIKRHN--------------------------CRGLPLQVVREISAQVLVGLD--
 .|||.|.|.| ...|.             |..||||... .|. .||...                          .. ...  .| .. |.| ||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YLHRE-LSIIHTDLKPENILLTMP-----------LPKARVFDHKKKSRAEENTDATGKEGGDEFDGIATNKSMKDREPGKAEIEAFQDAWKNIGLDKSC
|.|.  ..|||.||||||||..                                                                              
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSE----------------------------------------------------------------

LEDAPSDVEKLICEVKKPPPVASNCKTSHDVDLRCKIVDLGNACWTYKQ------------------------FTADIQTRQYRCPEVLVGSK-------
                    . ..|    ... | || | |.|.|. .                         .| ...|| || ||.|.|.|       
------------------D-W-NPC----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNY

---YSTPADMWSLACVVFELATG--------DVLFDPHTGE-----DYDRDEDHLALTMELLGRMPRKVALGGR-------YSHDYFNRHGDLRHIRKL-
   |.|| ||||..|. .|. ||        . || .|...     ..... |.|.. ...||  . ...  |.       .. ...|. . .... .. 
SMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPK

------------------------RFWPLKRVLVEKYDFSEV--------------------------------DAQDLSSFLCPILEFVPEKRLTAAQA
                          |. .. . ... ..                                  . ...  .|. .|.. |.||.||.||
KWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQA

LQHSWL
||| ..
LQHPYF
Kinase SRPK_c.AA CLK 71-398 25 9.2e-65 192.82 In-house 1-268 (350) Show / Hide 
Range on Protein: 71-398
Range on HMM: 1-268/350
Sequence Identity: 25% (88 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKNIALKIQKSAQHYTEAAMDEIT-ILTQISKG-DPENKKC--VVKLLDHFRH-TGPNGQHVCLVFELLGDNLLTL
| . ..|| | |..|    |. |..| .|||| ...  |.|||  ||. |. .| .  ||.||.   ..|..| | .  |    |.|.||||.| ..  .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIYDF

IKRHN------CRGLPLQVVREISAQVLVGLDYLHRELSIIHTDLKPENILLTMP-LPKARVFDHKKKSRAEENTDATGKEGGDEFDGIATNKSMKDREP
.|  |       ...|.. .|....| .  .  || .....|||||||||... . .     || . |   . ...                        
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRF---THFDCTFKYNHKKKIN------------------------

GKAEIEAFQDAWKNIGLDKSCLEDAPSDVEKLICEVKKPPPVASNCKTSHDVDLRCKIVDLGNAC---WTYKQFTADIQTRQYRCPEVLVGSKYSTPADM
                                     |    .. |. .| ...  ...| |.|      .   .. ..||.|| |||  |  .|.| | 
-------------------------------------KKS-NNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDV

WSLACVVFELATGDVLFDPHTGEDYDRDEDHLALTMELLG-RMP
|| .|. ||| ||. ||. |         .|||.  ...|   |
WSIGCILFELYTGFTLFQTHD------NREHLAMMERIMGMPIP
Kinase SRPK_c.AA S_TKc 71-474 18 1.4e-58 201.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 71-474
Range on HMM: 1-231/231
Sequence Identity: 18% (77 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKNIALKIQKSAQHYTEAAMDEITILTQISKGDPENKKCVVKLLDHFRHTGPNGQHVCLVFELLGD---NLLTLIK
| . .|.| | |..|..  ...  ..  |.|| |      | .. || || .       . . .|||.|.|..     .|...|.|...    .|...||
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIK

RHNCRG----LPLQVVREISAQVLVGLDYLHRELSIIHTDLKPENILLTMPLPK------ARVFDHKKKSRAEENTDATGKEGGDEFDGIATNKSMKDRE
.....|    .|  ..| . .|.. .|.|.|.   ||| |||||||||.    |      ||..                                    
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL------------------------------------

PGKAEIEAFQDAWKNIGLDKSCLEDAPSDVEKLICEVKKPPPVASNCKTSHDVDLRCKIVDLGNACWTYKQFTADIQTRQYRCPEVLVGSKYST-PADMW
                                                                        |  . |. |. ||||   .|.. ..|.|
------------------------------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWW

SLACVVFELATGDVLFDPHTGEDYDRDEDHLALTMELLGRMPRKVALGGRYSHDYFNRHGDLRHIRKLRFWPLKRVLVEKYDFSEVDAQDLSSFLCPILE
|. |...|...|  .|.            .........|                                                 ... .|.. .|.
SCGCILYEMLCGYPPFP------------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQ

FVPEKRLTAAQALQ-------HSWL
. ||||.|| .|||       | |.
KDPEKRPTA-EALQDEWDIKCHPWF
Kinase SRPK_c.AA DYRK 71-211 36 4.4e-40 139.49 In-house 1-137 (320) Show / Hide 
Range on Protein: 71-211
Range on HMM: 1-137/320
Sequence Identity: 36% (52 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKNIALKIQKSAQHYTEAAMDEITILTQISKGDPENKKCVVKLLDHFRHTGPNGQHVCLVFELLGDNLLTLIKRHN
| . . .| | |. |    |. . |. .|.|| .. . .   |..|| ||  ... ||..|. .|...|.| |     .|.|.|||||  ||  ..|...
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHR----NHLCIVFELLSMNLYEFLKNNH

CRGL-PLQVVREISAQVLVGLDYLHRELSIIHTDLKPENILL
 .|. .|..|| .  |.|..|..||.. .||| |||||||.|
FQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIML
Kinase SRPK_c.AA Ciliate-E2 71-474 14 3e-32 108.01 In-house 1-365 (365) Show / Hide 
Range on Protein: 71-474
Range on HMM: 1-365/365
Sequence Identity: 14% (79 aa)

YLVRKKLGWGHFSTVWLSSDRHNEN----------------------KNIALKIQKSAQHYTEAAMDEITILTQISKGD-----------PENKKCVVKL
| . ||.| | |..|.. ... . .                      | .|.||.|  |   |. . || |. .|   .             | . ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQ--IEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKM

LDHFR--HTGPNGQHVCLVFELLGD-NLLTLIK--RHNCRGLPL-------QVVREISAQVLV---------------GLDYLHRELSIIHTDLKPENIL
 ..|    .    ... ||.|..   .|. .||  ....   .        . ...|..|.|                .| ||| . .||| |.||||||
YECFQEKDD----NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

LTMPLPKARVFDHKKKSRAEENTDATGKEGGDEFDGIATNKSMKDREPGKAEIEAFQDAWKNIGLDKSCLEDAPSDVEKLICEVKKPPPVASNCKTSHDV
.                                                                                                   
F---------------------------------------------------------------------------------------------------

DLRCKIVDLGNA-----------------CWTYKQ------------------FTADIQTRQYRCPEVLVGSK---------YSTPADMWSLACVVFELA
   .||.|.|..                  ... .                  |   . |  | .||.| | |         |.. .|.||| .. .|. 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGDVLFDPHTGEDYDRDEDHLALTMELLGRMPRKVALGGRYSHDYFNRHGDLRHIRKLRFWPLKRVLVEKYDFSEV--------------DAQDLSSF--
.|   |                                                        ..  .  |.||..               . ...|    
FGKPPF--------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECK

-LCP-----ILEFVPEKRLT-AAQALQHSWL
 |.      .|.  ||||.| . |.|.| |.
DLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase SRPK_c.AA DYRK2 71-211 36 3.3e-32 101.78 In-house 1-135 (318) Show / Hide 
Range on Protein: 71-211
Range on HMM: 1-135/318
Sequence Identity: 36% (52 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKNIALKIQKSAQHYTEAAMDEITILTQISKGDPENKKCVVKLLDHFRHTGPNGQHVCLVFELLGDNLLTLIKRHN
| . . .| | |  |    | |  .. .|.|.    . . . |  || ||  |.. |. |   .|..|| |   .    |.|..||||. ||  .||...
YEILEVIGKGSFGQVVKCYD-HKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKNH

CRGLPLQVVREISAQVLVGLDYLHRELSIIHTDLKPENILL
  |. || ||   ...| .|. ||..  ||| |||||||||
FQGFSLQLVRRFAHSILQCLRFLHKN-NIIHCDLKPENILL
Kinase SRPK_c.AA Pkinase 71-396 18 6.6e-31 110.36 Pfam 1-233 (293) Show / Hide 
Range on Protein: 71-396
Range on HMM: 1-233/293
Sequence Identity: 18% (64 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKNIALKIQKSAQHYTEAAMD-----EITILTQISKGDPENKKCVVKLLDHFRHTGPNGQHVCLVFELLGD-----
| . .|.| | |..|..  .. ..    |.|| |      .  .      || |.  ..       ...|.|.| |.     ..|...|.|...      
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFED----KDHIYMVMEYCEGGLYVM

NLLTLIKRHNCRGL--PLQVVREISAQVLVGLDYLHRELSIIHTDLKPENILLT-MPLPKARVFDHKKKSRAEENTDATGKEGGDEFDGIATNKSMKDRE
 | ..|.... ...  . .... .  |.| ||.|.|.  .||| ||||||||.   . ..|                                       
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDA---------------------------------------

PGKAEIEAFQDAWKNIGLDKSCLEDAPSDVEKLICEVKKPPPVASNCKTSHDVDLRCKIVDLGNAC---WTYKQFTADIQTRQYRCPEVLV-GSKYSTPA
                                                       . || | | |.   . .  .|    |. |. |||.  |..|....
-------------------------------------------------------CVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DMWSLACVVFELATGDVLFDPHTGEDYDRDEDHLALTMELLGR
||||. |...|...|  .|. . . . |.  |....  . .|.
DMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGP
Kinase SRPK_c.AA DYRK 315-474 31 1.9e-27 97.54 In-house 147-320 (320) Show / Hide 
Range on Protein: 315-474
Range on HMM: 147-320/320
Sequence Identity: 31% (57 aa)

KIVDLGNACWTYKQFTADIQTRQYRCPEVLVGSKYSTPADMWSLACVVFELATGDVLFDPHTGEDYDRDEDHLALTMELLGRMPRKVALGG--RYSHDYF
|..| | .|   ....  || | || |||..| .|... ||||| |.. || || .||    ||..    | ||. ||.|| .|...   |  |. | .|
KVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFP---GENEY---DQLACIMEVLGMPPKWMIDKGRCRRKHKFF

NR--------HGDLRHIRKLRFW----PLKRVLVEKYDFSE-------VDAQDLSSFLCPILEFVPEKRLTAAQALQHSWL
..          . ..| . ..     | ||  ....  ..        | ...  |.   |.. |.||.|..|||||.|.
DCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase SRPK_c.AA DYRK1 71-214 38 5.9e-27 91.35 In-house 1-140 (321) Show / Hide 
Range on Protein: 71-214
Range on HMM: 1-140/321
Sequence Identity: 38% (56 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKNIALKIQKSAQHYTEAAMDEITILTQISKGDPENKKCVVKLLDHFRHTGPNGQHVCLVFELLGDNLLTLIKRHN
|..   .| | |  |    | | | . .|.|| |  . . . |  || .|  . | |.|.|  .|.|  || .      |.|||||||  ||  |..  .
YEIDSLIGKGSFGQVVKAYD-HQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNTH

CRGLPLQVVREISAQVLVGLDYLHR-ELSIIHTDLKPENILLTMP
 ||  | ..| .  |..  | ..   ||.||| |||||||||  |
FRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP
Kinase SRPK_c.AA Ciliate-E2-Unclassified 71-373 17 1.3e-26 89.3 In-house 1-271 (352) Show / Hide 
Range on Protein: 71-373
Range on HMM: 1-271/352
Sequence Identity: 17% (65 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKN----IALKIQKSAQHYTEAA---MDEITILTQISKGDPENKK---------------CVVKLLDHFRHTGPNG
| . |..| | |..|..  .. .  .     .. |||. .|.. .     | |.... ...| .  . |               ..||....|. .    
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-KYNKIMQQILLNHPHPFIVKMFYCFQDK----

QHVCLVFELL-GDNLLTLIKR------------HNCRG---LPLQVVR-----EISAQVLVGLDYLHRELSIIHTDLKPENILLT---MPLPKARVFDHK
|....| |.. | .|.  ||             ||..    .. | ..      . ||.|.||.|||... ||| |.||||||..   .           
QNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-----------

KKSRAEENTDATGKEGGDEFDGIATNKSMKDREPGKAEIEAFQDAWKNIGLDKSCLEDAPSDVEKLICEVKKPPPVASNCKTSHDVDLRCKIVDLGNA--
                                                                                       ...|| |.|..  
--------------------------------------------------------------------------------------NYYIKIIDFGISKK

----------------CWTYKQFTADIQTRQYR----CPEVLVGSKYSTP----ADMWSLACVVFELATGDVLFD
                 | .. ..  ..| .|      |||| | .|...    .|.||| .. .|. .|   |.
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY
Kinase SRPK_c.AA DYRK2 315-416 36 1e-22 70.43 In-house 144-245 (318) Show / Hide 
Range on Protein: 315-416
Range on HMM: 144-245/318
Sequence Identity: 36% (40 aa)

KIVDLGNACWTYK-QFTADIQTRQYRCPEVLVGSKYSTPADMWSLACVVFELATGDVLFDPHTGEDYDRDEDHLALTMELLGRMPRKVALGG------RY
|..| |  |  .  ..  .||.| || ||| .| ||... ||||. |.. || ||  ||    ||...   | .|. ||.|| || |. .        ..
KVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENEN---DQFACMMEVLG-MPPKKFFDTWFYIHCFR

SHDYFNRHG
   .||.|.
RKYFFNSHC
Kinase SRPK_c.AA PRP4 71-210 32 4.5e-22 77.63 In-house 1-138 (320) Show / Hide 
Range on Protein: 71-210
Range on HMM: 1-138/320
Sequence Identity: 32% (47 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKNIALKIQKSAQHYTEAAMDEITILTQISKG--DPENKKCVVKLLDHFRHTGPNGQHVCLVFELLGDNLLTLIKR
| |  . | | ||.|    |  . |...| ||  .        . |. ||  ..    |.. |. .|.. .|| |     || ||||| .  ||  ..|.
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHR----QHMCLVFECMSMNLREVLKK

H-NCRGLPLQVVREISAQVLVGLDYLHRELSIIHTDLKPENIL
     || | .||  . | .. |  | . . |.| |.|| |||
YGKDVGLHLKAVRSYAQQLFLALKHLKK-CNILHADIKPDNIL
Kinase SRPK_c.AA YAK 98-211 38 3.5e-20 64.92 In-house 27-139 (347) Show / Hide 
Range on Protein: 98-211
Range on HMM: 27-139/347
Sequence Identity: 38% (45 aa)

IALKIQKSAQHYTEAAMDEITILTQI-SKGDPENKK---CVVKLLDHFRHTGPNGQHVCLVFELLGDNLLTLIKRHNCRGLPLQVVREISAQVLVGLDYL
.| |. |. | |   |  || ||     . ||.||     .....| | |      | |||||.|  ||  ..|  . .|.  |..|    |.| |.  |
FAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHK----NHFCLVFEMLSNNLYEYLKQNKFCGFSFQLIRQWTKQILDGMCVL

HRELSIIHTDLKPENILL
  .  ||| |||||||.|
-ENKQIIHCDLKPENIML
Kinase SRPK_c.AA DYRK1 315-417 35 6.3e-16 51.98 In-house 146-242 (321) Show / Hide 
Range on Protein: 315-417
Range on HMM: 146-242/321
Sequence Identity: 35% (37 aa)

KIVDLGNACWTYKQFTADIQTRQYRCPEVLVGSKYSTPADMWSLACVVFELATGDVLFDPHTGEDYDRDEDHLALTMELLGRMPRKVALGGRYSHDYFNR
||.| | .| . .     || | || ||||.| .|..  ||||| |.. |. ||. ||   .| .   . | .   .| ||  |...   .  .| ||..
KIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SGSN---EVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEK

HGD
. |
DPD
Kinase SRPK_c.AA YAK 315-365 49 1e-15 49.53 In-house 148-198 (347) Show / Hide 
Range on Protein: 315-365
Range on HMM: 148-198/347
Sequence Identity: 49% (25 aa)

KIVDLGNACWTYKQFTADIQTRQYRCPEVLVGSKYSTPADMWSLACVVFEL
||.| | .| . |  .  || | || ||..|.  |.|  ||||| |.| ||
KIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL
Kinase SRPK_c.AA PRP4 334-413 33 1.3e-12 42.61 In-house 167-240 (320) Show / Hide 
Range on Protein: 334-413
Range on HMM: 167-240/320
Sequence Identity: 33% (27 aa)

QTRQYRCPEVLVGSKYSTPADMWSLACVVFELATGDVLFDPHTGEDYDRDEDHLALTMELLGRMPRKVALGGRYSHDYFN
. | || ||...| .|    |||| .|  .||.|| ..|.  |        . | | |.. | ||.|    | .   .|.
VSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKT------NNHMLKLFMDYKGKMPNKMIRKGQFKDNHFD
Kinase SRPK_c.AA DYRK2 450-474 40 1.9e-07 19.89 In-house 294-318 (318) Show / Hide 
Range on Protein: 450-474
Range on HMM: 294-318/318
Sequence Identity: 40% (10 aa)

FLCPILEFVPEKRLTAAQALQHSWL
|.   .|  |..|.|..|||.| |.
FIKRCFEWDPSERMTPSQALKHPWI
Kinase SRPK_c.AA CLK 454-474 47 3.1e-07 16.97 In-house 330-350 (350) Show / Hide 
Range on Protein: 454-474
Range on HMM: 330-350/350
Sequence Identity: 47% (10 aa)

ILEFVPEKRLTAAQALQHSWL
.||. | ||.|...|||| . 
MLEYDPSKRITCKDALQHPFF
Kinase SRPK_c.AA Pkinase 436-474 22 8.2e-07 25.17 Pfam 236-293 (293) Show / Hide 
Range on Protein: 436-474
Range on HMM: 236-293/293
Sequence Identity: 22% (13 aa)

KYDFSEVDA-------------------QDLSSFLCPILEFVPEKRLTAAQALQHSWL
..|... .                    ... .|.. .|.. |.||.||.|.||| |.
HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SRPK_c.AA TyrKc 71-474 12 1e-06 -114.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 71-474
Range on HMM: 1-280/280
Sequence Identity: 12% (56 aa)

YLVRKKLGWGHFSTVWLSSDRHNENKNIALKIQKSAQHYTEAAMDEITILTQI-SKGDPENKKCVVKLLDHFRHTGPNG---QHVCLVFELL-GDNLLTL
    |||| |.| .|..   .     . | |  |.     |. |.|. |....       . ...|.|.   .. | |    . ...|.|.  . .|.  
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKRHNCRGLPLQVVREISAQVLVGLDYLHRELSIIHTDLKPENILLTMPLPKARVFDHKKKSRAEENTDATGKEGGDEFDGIATNKSMKDREPGKAEIEA
...|  . |...   ... |.  | .|||.   .|| ||   |.|.. ..                                                  
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH--------------------------------------------------

FQDAWKNIGLDKSCLEDAPSDVEKLICEVKKPPPVASNCKTSHDVDLRCKIVDLGNACWTYKQ----FTADIQTRQY--RCP----------EVLVGSKY
                                               ..|| | | .   |         |  . .    .           |..  .|.
-----------------------------------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

STPADMWSLACVVFELATGDVLFDPHTGEDYDR-----DEDHLALTMELLGRMPRKVAL----GGRYSHDYFNRHGDLRHIRKLRFWPLKRVLVEKYDFS
.|  | ||   . .|. |         .. |        ..  ..     |..... .                                        | 
TTKSDVWSFGVCMWEIFTY-------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------F-

EVDAQDLSSFLCPILEFVPEKRLTAAQALQHSWL
    ... .      .. ||.| | ..   |. .
VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SRPK_c.AA Ciliate-E2-Unclassified 444-474 37 2e-06 18.1 In-house 321-352 (352) Show / Hide 
Range on Protein: 444-474
Range on HMM: 321-352/352
Sequence Identity: 37% (12 aa)

AQDLSS-FLCPILEFVPEKRLTAAQALQHSWL
|.|. . .|. .|.  |.||.|. |.|.| |.
AKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase SRPK_c.AA PRP4 459-474 43 0.00031 11.5 In-house 305-320 (320) Show / Hide 
Range on Protein: 459-474
Range on HMM: 305-320/320
Sequence Identity: 43% (7 aa)

PEKRLTAAQALQHSWL
|.|| |  .||.|. .
PKKRITCNEALKHPFI
Kinase SRPK_c.AA DYRK1 454-474 42 0.001492 7.78 In-house 301-321 (321) Show / Hide 
Range on Protein: 454-474
Range on HMM: 301-321/321
Sequence Identity: 42% (9 aa)

ILEFVPEKRLTAAQALQHSWL
.|.. |..|.|  .|||||..
MLQYDPKQRITPYYALQHSFF
Kinase SRPK_c.AA YAK 450-474 32 0.003452 6.24 In-house 323-347 (347) Show / Hide 
Range on Protein: 450-474
Range on HMM: 323-347/347
Sequence Identity: 32% (8 aa)

FLCPILEFVPEKRLTAAQALQHSWL
|.  .|.  | .| .. || ||  .
FINQLLQLNPRERWKPMQAMQHPFI