Gene BUB_a-2 (S.moellendorffii)

BUB_a-2

Species: S.moellendorffii
Alias: BUB_a-2
External Links:
Annotation:

Classification

Group: Other
Family: BUB

Sequence

Name Sequence Type Origin Length Description Download
BUB_a-2.AA Protein None 439 None Fasta, JSON
BUB_a-2.NA RNA None 1317 None Fasta, JSON
BUB_a-2.kin_dom Protein Kinase Domain None 130 None Fasta, JSON

Protein domain

Protein domains of BUB_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Mad3_BUB1_I BUB_a-2.AA Mad3_BUB1_I 54-104 34 1.4e-17 63.36 Pfam 80-134 (134) Show / Hide 
Range on Protein: 54-104
Range on HMM: 80-134/134
Sequence Identity: 34% (19 aa)

ADCCA----DPLHIFELLEAKRIGQTHSLFYEAYAMILELRGDITKANQIYELGI
...|.    .|..||. .... ||....||||..|  ||..|   ||.....|||
MNYCNNNFDEPRDIFQYMYNQGIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI
Mad3_BUB1_I BUB_a-2.AA Mad3_BUB1_I 1-104 27 1.5e-11 31.0 SMART 11-133 (133) Show / Hide 
Range on Protein: 1-104
Range on HMM: 11-133/133
Sequence Identity: 27% (39 aa)

EL------------------------------------CPLLEFCTKAFLDDPRYREDLRYLRIWLRYVSLLLCLVLLYSYFPSLQPLQADCC----ADP
|.                                    ..||| ||..|.||.||. | |||.||. |                     .|.|     .|
EIQDDSYEGDDPLDVWYRYIKWTEQNYPQGQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWY---------------------MDMCYNYFDEP

LHIFELLEAKRIGQTHSLFYEAYAMILELRGDITKANQIYELGI
..||. .....||. ..||||..|  .| .|.  ||..||.|||
REIFQYMYRHGIGTQCALFYEEWAQWYENMGNYQKADEIYQLGI
Mad3_BUB1_I BUB_a-2.AA Mad3_BUB1_I 2-33 56 6e-10 36.74 Pfam 49-80 (134) Show / Hide 
Range on Protein: 2-33
Range on HMM: 49-80/134
Sequence Identity: 56% (18 aa)

LCPLLEFCTKAFLDDPRYREDLRYLRIWLRYV
|..||| |.|.|..|.||..| |||.||| |.
LPTLLERCVKYFWHDERYKNDPRYLKIWLWYM
Kinase BUB_a-2.AA BUB 178-413 34 1.5e-76 260.62 In-house 42-311 (311) Show / Hide 
Range on Protein: 178-413
Range on HMM: 42-311/311
Sequence Identity: 34% (93 aa)

CKIQKPPCPWEFYIYYQLDKRIPV----EERDSFGSARKMYVFSDCSILVAGYG-QHGTLQDVVNAYL---AHS-LKMDELLCMYYTIEMLRMLEVLHGV
|| ||||.||||||  |. .|.      .   .|  .   ....| |...  |    |||.||.| .    . .   |.| ..|  ...||.|.| || .
CKVQKPPNPWEFYICDQMHERLKERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYGTLLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRC

GIIHADFKPDNLLIRNESRG--LCLA--LQG-------LCLIDWGRSIDMRLFPEGTEFLADSKTSA--FRCIEMM----EERPWTYQVDGYGLCCIVHC
.|||.| ||||....|.  .   | .   .|       | |||.||||||.|||.|. | .  .|..  | |.||     . .||||||| .|..  .||
EIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQRFKFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHC

MLHGSYMELEEERSPDGGRVHKPKASLKRYWNTN-------VWDKFFKTLLN----ASPPLPLSSLREMLEQT
|| |.||..    .   |.. |.. ...|||          .| ||| ..||    ..    |... |. .| 
MLFGKYMQVKQKWD---GQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQTLPMWHELRQQF
Kinase BUB_a-2.AA PDK1 247-282 47 1.6e-08 21.67 In-house 108-143 (307) Show / Hide 
Range on Protein: 247-282
Range on HMM: 108-143/307
Sequence Identity: 47% (17 aa)

DELLCMYYTIEMLRMLEVLHGVGIIHADFKPDNLLI
|.. | .|. | .  || ||. |||| | ||.|.|.
DMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILL
Kinase BUB_a-2.AA CK2 253-302 44 3.4e-08 19.76 In-house 99-141 (288) Show / Hide 
Range on Protein: 253-302
Range on HMM: 99-141/288
Sequence Identity: 44% (22 aa)

YYTIEMLRMLEVLHGVGIIHADFKPDNLLIRNESRGLCLALQGLCLIDWG
|| .|.|. |.  |  ||.| | || | .|  | |        | |||||
YYMFELLKALDYCHSMGIMHRDVKPHNIMIDHEKR-------KLRLIDWG
Kinase BUB_a-2.AA MASTL 247-285 53 3.6e-08 23.82 In-house 98-136 (283) Show / Hide 
Range on Protein: 247-285
Range on HMM: 98-136/283
Sequence Identity: 53% (21 aa)

DELLCMYYTIEMLRMLEVLHGVGIIHADFKPDNLLIRNE
||   ..|  ||   |. ||  |||| | ||||.|| ||
DEEMAIKYISEMVMALDYLHRHGIIHRDIKPDNMLISNE
Kinase BUB_a-2.AA AGC 239-282 32 9.1e-08 14.61 In-house 133-188 (395) Show / Hide 
Range on Protein: 239-282
Range on HMM: 133-188/395
Sequence Identity: 32% (18 aa)

YLA---HSLKMDELLCMYYTIE-------MLRMLEVLHG-VGIIHAD-FKPDNLLI
.|    .. ..||  . .|. |       ..  || ||   |||| |  ||.|.|.
HLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILL
Kinase BUB_a-2.AA ROCK 234-298 36 1.9e-07 21.1 In-house 85-146 (263) Show / Hide 
Range on Protein: 234-298
Range on HMM: 85-146/263
Sequence Identity: 36% (24 aa)

DVVNAYLAHSLKMDELLCMYYTIEMLRMLEVLHGVGIIHADFKPDNLLIRNESRGLCLALQGLCL
|.||  |  .  . |    .||.|.   |. .| .| || | ||||.|. ...  | ||  | |.
DLVN--LMSNYDVPEKWARFYTMEVVLALDAIHSMGFIHRDVKPDNMLL-DKYGHLKLADFGTCM
Kinase BUB_a-2.AA MAST 262-282 66 6e-07 16.57 In-house 115-135 (337) Show / Hide 
Range on Protein: 262-282
Range on HMM: 115-135/337
Sequence Identity: 66% (14 aa)

LEVLHGVGIIHADFKPDNLLI
|| ||  ||.| | ||||.||
LEYLHSYGIVHRDLKPDNMLI
Kinase BUB_a-2.AA Ciliate-E1 232-343 18 6.6e-07 19.02 In-house 93-202 (202) Show / Hide 
Range on Protein: 232-343
Range on HMM: 93-202/202
Sequence Identity: 18% (21 aa)

LQDVVNAYLAHSLKMDELLCMYYTIEMLRMLEVLHGVGIIHADFKPDNLLIRNESRGLCLALQGLCLIDWGRSIDMRLFPEGTEFLA-DSKTSAFRCIEM
| . .. .     ..... .|. .. ..  |. ||  .||| | ||.|.|| |.   . .. .|....    ...   .   |. ..   .   .   |.
L-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EH

MEERPWTYQVDGY
... ...|..| |
NKNQKINYKSDIY
S_TKc BUB_a-2.AA S_TKc 147-435 13 2e-06 -81.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 147-435
Range on HMM: 1-231/231
Sequence Identity: 13% (43 aa)

DRRDRKI---------EFVDPWDETLVADLLKKLAPPLQTCKIQKPPCPWEFYIYYQLDKRIPVEERDSFGSARKMYVFS-DCSILVAGYGQH--GTLQD
 .  |||           ..  .  .||  .|..                   .  .   .|  .  .     .  .||  |.  .|  |  .  |.| |
YEILRKIGKGAFGKVYKCRHKKTGRIVA--IKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFD

VVNAYLAHSLK--MDELLCMYYTIEMLRMLEVLHGVGIIHADFKPDNLLIRNESRGLCLALQGLCLIDWGRSIDMRLFPEGTEFLADSKTSAFRCIEMME
.   .  | |.  ..|  . .|. .... || .|  |||| | ||.|.|. .           . ..| | .  .              |  ..  |.. 
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL---------TTFCGTPWYMAPEVL-

ERPWTY-QVDGYGLCCIVHCMLHGSYMELEEERSPDGGRVHKPKASLKRYWNTNVWDKFFKTLLNASPPLPLSSLREMLEQTIVSNAA---HPRRLKE--
  ....  .| . . ||.  || |                      ... ..  .                 .........  . . .       . .  
--GYGKCKCDWWSCGCILYEMLCGYPPFP----------------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

LLIKQTVMM
..||.   .
WDIKCHPWF
Kinase BUB_a-2.AA RSKL 257-282 44 2e-06 9.62 In-house 281-307 (436) Show / Hide 
Range on Protein: 257-282
Range on HMM: 281-307/436
Sequence Identity: 44% (12 aa)

EMLRMLEVLHGVG-IIHADFKPDNLLI
||.  |..||. | .|  |. |||.|.
EMVVALHALHAEGHVICRDLNPDNILL
Kinase BUB_a-2.AA MAST 262-282 66 2e-06 16.42 In-house 112-132 (334) Show / Hide 
Range on Protein: 262-282
Range on HMM: 112-132/334
Sequence Identity: 66% (14 aa)

LEVLHGVGIIHADFKPDNLLI
|| ||  ||.| | ||||.||
LEYLHSHGIVHRDLKPDNMLI