Gene PEKb (S.moellendorffii)
PEKb
Species: S.moellendorffii
Alias: PEKb
External Links:
Annotation:
Sequence
Protein domains of PEKb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Pkinase | PEKb.AA | Pkinase | 41-189 | 30 | 5.8e-39 | 138.85 | Pfam | 1-160 (293) | Show / Hide |
Range on Protein: 41-189
Range on HMM: 1-160/293
Sequence Identity: 30% (51 aa)
YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFCGR-----SLQ--
|... ..|.|..|.||||. | ...|.|.|.||.|.. .. || .. | ....|. |||||...|.. . |...|.|||.|. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDY
-----SVLL-GGESPPADAFRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRI----KLGDFGLAK
. . . | . ..|.|..... |.. .|||. | ||.. ..| | |..||||||
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
|
|||||||||
| S_TKc | PEKb.AA | S_TKc | 41-291 | 24 | 1.1e-33 | 119.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 41-291 Range on HMM: 1-231/231 Sequence Identity: 24% (68 aa) YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFCGR---SLQSVLL ||.| .|.|| ||||||| |.. .|.|||.|| . .| ..|.. ||||||..|.. . ...|.|||.|. .| ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIK GGESPP---------ADAFRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKNKESMLETENIKKGRAVYYSPQRRSNST-YTDMLALGVI ... . ..|...|... |.. .|||. | ||.... .||..|||||. . | | .| . .. |. ..|.| KRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCI LFELHWRCPPDQERESVLIDVRDGVLPADWAYQHPSIAPK--VLELVAARRDQRPSARDILC-------DPAW |.|. ..|| . . ..... | | . . ..||.| ..| .| LYEMLCGYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | PEKb.AA | CAMK | 46-197 | 18 | 2.9e-33 | 104.01 | In-house | 1-278 (425) | Show / Hide |
Range on Protein: 46-197 Range on HMM: 1-278/425 Sequence Identity: 18% (51 aa) CVGQGASGKVYKCRSKEDE------------QIYAIKVIKVRTATKS-----------------------RDQDVALVFKEGEMLQRCE-------HPNI |.|. |||..|. |.. | .|||.|. . .... |..| . |..| |..... |||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKYFDMWKEEG------EPG---------KSKVYIVM---EFCGR-----SLQSVLLG----------------GESPPADA---FRQLLQAVAHVHDNV .| .... . . . ....|.|| |.| | . . | . ..| |||...||.. |.. IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN GVHRDIAPHNIFVTDD-----------------GRIKLGDFGLAKNKES--------------------------MLET ||||. | || ..|. . ||. |||.|. ... ...| IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT |
|||||||||
| Kinase | PEKb.AA | CMGC | 41-189 | 19 | 4e-32 | 102.13 | In-house | 1-252 (513) | Show / Hide |
Range on Protein: 41-189 Range on HMM: 1-252/513 Sequence Identity: 19% (49 aa) YEVLACVGQGASGKVYKCRS--------------KEDEQIYAIKVIKVRTATKSR-----DQDVAL--VFKEGEMLQRCE-----------------HPN ||.. .|.|. |.||||| .|...|.||| || . . |. . | ..|.. |.| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IVKYFDMWKEEGEPGKS------------KVYIVMEFCGRSLQSVLLGGES--------PPADAF-----------------------RQLLQAVA--HV ||| .|. . ... |. ..|.|.|... .| .. | . .|.|.... . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HDNV--GVHRDIAPHNIFVTDD--------------------GRIKLGDFGLAK | . .|||. | || .... ||.|..|||||. HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLAR |
|||||||||
| Kinase | PEKb.AA | STE | 41-190 | 24 | 4.9e-32 | 110.46 | In-house | 1-196 (359) | Show / Hide |
Range on Protein: 41-190 Range on HMM: 1-196/359 Sequence Identity: 24% (49 aa) YEVLACVGQGASGKVYKCRSKE---------------DEQIYAIKVIKVRTATKSRDQ-------------DVALVFKEGEMLQRCE--HPNIVKYFDMW .| . ..|.||.|.|||.. .. .|.|||...... ... . .. . || .....| |||||||... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY KEEGEP--GKSKVYIVMEFCG-RSLQSVLL---GG---------------ESPPADAFRQLLQA-VAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLA ||.. .....|.||... || ... | || | ||.|.. .. |.. .|||| | ||.. .|| |||.. FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC KN .. GQ |
|||||||||
| Kinase | PEKb.AA | WEE | 41-190 | 25 | 7.3e-32 | 104.21 | In-house | 1-181 (297) | Show / Hide |
Range on Protein: 41-190 Range on HMM: 1-181/297 Sequence Identity: 25% (48 aa) YEVLACVGQGASGKVYKCRSKEDEQIYAIKVI-KVRTATKSRDQDVALVFKEGEMLQ---RCE-HPNIVKYFDMWKEEGEPGKSKVYIVMEFCGRS---- .... .|.| .|.|||||...| .|||||.. . . ...|.. . | . . | |. ||.||.|. |.| ... ||.||.| .. FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREV-YAHMVLGQIMDCDHHPHIVRYYSAWEE-----DDHMYIQMEYCNGGSNLL --LQSVLLG-----GESPPADAFRQLLQAVAHVHDN-VGVHRDIAPHNIFVTDDG--------------------RIKLGDFGLAKN ... . |. . .....|...|.|.| || || | |||.. .. ..|.||||.... QFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTD |
|||||||||
| Kinase | PEKb.AA | CAMKL | 41-197 | 25 | 7.7e-32 | 98.78 | In-house | 1-192 (297) | Show / Hide |
Range on Protein: 41-197 Range on HMM: 1-192/297 Sequence Identity: 25% (50 aa) YEVLACVGQGASGKVYKCRS-KEDEQIYAIKVIKVRTAT------------KSRDQDVALVFKEGEMLQRCE---HPNIVKYFDMWKEEGE--PGKSKVY |... |.|. ||| .. . .. .|||.|. . .. |. ..|. ...| . ... ||||.| .... . .|.| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH-ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIY IVMEFCGRS---LQSVL--LGGES---PPADA---FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDG--RIKLGDFGLA-------KNKESMLET .||| |. |. . |. |. .| |||.. ||.. |.. ||||| | || ....| ||. |||.. .... .|.| LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKT |
|||||||||
| Kinase | PEKb.AA | PEK | 147-291 | 24 | 2.9e-28 | 95.0 | In-house | 433-655 (655) | Show / Hide |
Range on Protein: 147-291
Range on HMM: 433-655/655
Sequence Identity: 24% (54 aa)
FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGR-----IKLGDFGLAKNKE--------------SMLETENIKK-------------------------
|||.| .....| . .|||. |.|||...||. .| ||||||.| | | .. .....
FRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYH
------------------GRAVYYSPQRRSNS-----TYT---DMLALGVILFELHWRCPPDQ-ERESVLIDVRD------GVLP-ADWAYQHPSIAPKV
|.. | ||. |.. |. || .||.|.||.. . . || .| |.|| | .| ... .| | .
IQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFI
LELVAARRDQRPSARDILCDPAW
. .. .||||| .|| .
QWMLSHDPQQRPSAQQILQHEFF
|
|||||||||
| Kinase | PEKb.AA | STE20 | 41-129 | 33 | 1.6e-24 | 86.72 | In-house | 1-91 (288) | Show / Hide |
Range on Protein: 41-129 Range on HMM: 1-91/288 Sequence Identity: 33% (31 aa) YEVLACVGQGASGKVYKCRSKEDEQI----YAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFCG || | ..|||..|||||.. |. .. .|||....... . ... ...|| ....| |||||||.. . .. .. .||||.|| YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTC-DDELWIVMEYCG |
|||||||||
| Kinase | PEKb.AA | NEK | 41-128 | 35 | 2.3e-20 | 68.7 | In-house | 1-88 (286) | Show / Hide |
Range on Protein: 41-128 Range on HMM: 1-88/286 Sequence Identity: 35% (34 aa) YEVLACVGQGASGKVYKCRSKEDEQI-----YAIKVIKVRTATKSRDQD--VALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFC ||.. .|||. |||||.|.|.|... |..| |.. . |. .| |.. |||||||.| . ||. ... .||||.| YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQN----NEVRILKQLKHPNIVKYYDSFIEEQ---NNCLCIVMEYC |
|||||||||
| Kinase | PEKb.AA | NEK1 | 41-128 | 36 | 3e-19 | 63.55 | In-house | 1-82 (276) | Show / Hide |
Range on Protein: 41-128 Range on HMM: 1-82/276 Sequence Identity: 36% (32 aa) YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFC |... .|.|. ||... ..||| | |.|| |.| .|. ... . .|. |.. .|||||||.. |.| |||||.| YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINV---MKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGC---GILYIVMEYC |
|||||||||
| Kinase | PEKb.AA | GCN2 | 121-201 | 33 | 3.5e-19 | 63.48 | In-house | 282-370 (511) | Show / Hide |
Range on Protein: 121-201 Range on HMM: 282-370/511 Sequence Identity: 33% (30 aa) VYIVMEFCG-RSLQSVLLGGESPPADA-----FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKN--KESMLETENIK .||.||.|. ..| . . . .... |||.| .....|.. .|||. | |||.. .|..| ||||||.| .|| .. | LYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQK |
|||||||||
| Kinase | PEKb.AA | PEK | 41-117 | 32 | 6.8e-17 | 54.68 | In-house | 1-90 (655) | Show / Hide |
Range on Protein: 41-117 Range on HMM: 1-90/655 Sequence Identity: 32% (29 aa) YEVLACVGQGAS-GKVYKCRSKEDEQIYAIKVIKVRTATKS------------RDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPG .|...|.|.|. | |||...| |.. |||| ||. .... . . |..| | |..||||| |. .| |. | . FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEK |
|||||||||
| Kinase | PEKb.AA | NEK | 149-189 | 38 | 4.9e-14 | 46.18 | In-house | 122-171 (286) | Show / Hide |
Range on Protein: 149-189 Range on HMM: 122-171/286 Sequence Identity: 38% (19 aa) QLLQAVAHVHDN-----VGVHRDIAPHNIFVTDDGR----IKLGDFGLAK |.. |. ..||. .|||| | ||| |.... .|.||||..| QMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISK |
|||||||||
| Kinase | PEKb.AA | NEK1 | 147-189 | 36 | 4.8e-11 | 34.72 | In-house | 110-169 (276) | Show / Hide |
Range on Protein: 147-189 Range on HMM: 110-169/276 Sequence Identity: 36% (22 aa) FRQLLQAVAHVHDNVGVHRDIAPHNIFVT--DDG---------------RIKLGDFGLAK | |. |. |.|| |||| . ||| | ..| .|||||| |. FCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIAR |
|||||||||
| Kinase | PEKb.AA | TyrKc | 41-289 | 18 | 5e-11 | -44.36 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 41-289 Range on HMM: 1-280/280 Sequence Identity: 18% (53 aa) YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRC--EHPNIVKYFDMWKEEGEPGK---SKVYIVMEFC-GRSLQS . . | || |.|||.. | . |.|..| . .. .| ... . .|||||. . ..|. ..||||.. . .|.. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKD VLLGGESPPADAFRQLLQAVAHV-------HDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKNKESM----LETENIKK-----GRAV----YYSP---Q | . ..||. . |.. .|||.| |. |......| .||||... .. ... ..| |... ..| . YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN RRSNSTYTDMLALGVILFELHWRCPPDQERE----SVLIDVRDGVLPADWAYQHPS--------IAPKVLELV----AARRDQRPSARDILCDP . .| .| . || ..|. .. . . . ..|. | . | |. ... .. .. ..||. ..| . YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | PEKb.AA | GCN2 | 41-107 | 27 | 5.5e-10 | 30.73 | In-house | 1-67 (511) | Show / Hide |
Range on Protein: 41-107 Range on HMM: 1-67/511 Sequence Identity: 27% (19 aa) YEVLACVGQGASGKVYK-CRSKEDEQIYAIKVIKVRTATKSRDQDVAL--VFKEGEMLQRCEHPNIVKYF |...|.|.|. |.|.| |.. |...|||| .... . .. . . ..| . | |. |...| |. FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRK---LPCKHKIMREVKLLCRLHHQHVVRYY |
|||||||||
| Kinase | PEKb.AA | STE20 | 148-188 | 46 | 1e-06 | 20.89 | In-house | 124-164 (288) | Show / Hide |
Range on Protein: 148-188 Range on HMM: 124-164/288 Sequence Identity: 46% (19 aa) RQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLA |..||. .. | | .|||| || .|.||..|| |||.. REVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVC |
|||||||||
| Kinase | PEKb.AA | Pkinase_Tyr | 163-189 | 48 | 7e-06 | 20.52 | Pfam | 133-159 (270) | Show / Hide |
Range on Protein: 163-189 Range on HMM: 133-159/270 Sequence Identity: 48% (13 aa) VHRDIAPHNIFVTDDGRIKLGDFGLAK .|||.| |. ||... .| .|||||. IHRDLAARNCLVTENNVVKICDFGLAR |
|||||||||
| Kinase | PEKb.AA | Pkinase_Tyr | 41-128 | 26 | 2.7e-05 | 18.58 | Pfam | 1-89 (270) | Show / Hide |
Range on Protein: 41-128 Range on HMM: 1-89/270 Sequence Identity: 26% (25 aa) YEVLACVGQGASGKVYKCRSK----EDEQIYAIKVIKVRTATKSRDQD--VALVFKEGEMLQRC-EHPNIVKYFDMWKEEGEPGKSKVYIVMEFC . . |.|| |.|||.. | .... |.|..| .. ... . ..| ... |||||.. ..|||. ..|||||.. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYM |
|||||||||
| Kinase | PEKb.AA | GCN2 | 220-249 | 34 | 0.018447 | 3.93 | In-house | 434-465 (511) | Show / Hide |
Range on Protein: 220-249 Range on HMM: 434-465/511 Sequence Identity: 34% (11 aa) DMLAL-GVILFELHWR-CPPDQERESVLIDVR || .| |.|.||. . .. || ..| . | DMYSLGGIIFFEMWYPPFCTQMERVQILKQLR |
|||||||||
| Kinase | PEKb.AA | NEK | 277-291 | 46 | 0.046358 | 3.52 | In-house | 272-286 (286) | Show / Hide |
Range on Protein: 277-291 Range on HMM: 272-286/286 Sequence Identity: 46% (7 aa) DQRPSARDILCDPAW .||||...|| .| EQRPSCNQILEMPFI |
|||||||||