Gene PEK-S1_h (S.moellendorffii)

PEK-S1_h

Species: S.moellendorffii
Alias: PEK-S1_h
External Links:
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
PEK-S1_h.AA Protein None 360 None Fasta, JSON
PEK-S1_h.NA RNA None 1083 None Fasta, JSON
PEK-S1_h.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of PEK-S1_h.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase PEK-S1_h.AA Pkinase 106-254 30 1.2e-38 137.75 Pfam 1-160 (293) Show / Hide 
Range on Protein: 106-254
Range on HMM: 1-160/293
Sequence Identity: 30% (51 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVEYFDMWKEEGEPGKSKVYIVMEFCGR-----SLQ--
|... ..|.|..|.||||. | ...|.|.|.||.|.. .. ||  ..   | ....|. |||||...|.. .     |...|.|||.|.      .|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDY

-----SVLL-GGESPPADAFRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRI----KLGDFGLAK
     .  . . |    . ..|.|..... |..  .|||. | ||.. ..| |    |..||||||
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
S_TKc PEK-S1_h.AA S_TKc 106-356 24 5.8e-33 116.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVEYFDMWKEEGEPGKSKVYIVMEFCGR---SLQSVLL
||.|  .|.|| ||||||| |.. .|.|||.||              . .| ..|..  ||||| ..|.. .      ...|.|||.|.    .| ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIK

GGESPP---------ADAFRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKNKESMLETENIKKGRAVYYSPQRRSNST-YTDMLALGVI
   ...         .  ..|...|... |..  .|||. | ||....  .||..|||||.         .   |   | .|   . ..   |. ..|.|
KRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCI

LFELHWRCPPDQERESVLIDVRDGVLPADWAYQHPSIAPK--VLELVAARRDQRPSARDILC-------DPAW
|.|.  ..|| .  . .....              |   |  .  .     ..||.| ..|        .|  
LYEMLCGYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PEK-S1_h.AA CAMK 111-262 17 1.9e-32 101.33 In-house 1-278 (425) Show / Hide 
Range on Protein: 111-262
Range on HMM: 1-278/425
Sequence Identity: 17% (50 aa)

CVGQGASGKVYKCRSKEDE------------QIYAIKVIKVRTATKS-----------------------RDQDVALVFKEGEMLQRCE-------HPNI
  |.|. |||..|. |..             | .|||.|. . ....                       |..| . |..| |.....        ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEYFDMWKEEG------EPG---------KSKVYIVM---EFCGR-----SLQSVLLG----------------GESPPADA---FRQLLQAVAHVHDNV
.  ....  .       . .         ....|.||   |.|        | . .                  |  . ..|   |||...||.. |.. 
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

GVHRDIAPHNIFVTDD-----------------GRIKLGDFGLAKNKES--------------------------MLET
 ||||. | || ..|.                 . ||. |||.|. ...                          ...|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT
Kinase PEK-S1_h.AA STE 106-255 23 1.4e-31 108.83 In-house 1-196 (359) Show / Hide 
Range on Protein: 106-255
Range on HMM: 1-196/359
Sequence Identity: 23% (48 aa)

YEVLACVGQGASGKVYKCRSKE---------------DEQIYAIKVIKVRTATKSRDQ-------------DVALVFKEGEMLQRCE--HPNIVEYFDMW
.| . ..|.||.|.|||.. ..                 .|.|||...... ...  .             ..  . || .....|   |||||.|... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

KEEGEP--GKSKVYIVMEFCG-RSLQSVLL---GG---------------ESPPADAFRQLLQA-VAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLA
  ||..   .....|.||...  || ...    |                ||  |   ||.|..  .. |..  .|||| | ||..     .|| |||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KN
..
GQ
Kinase PEK-S1_h.AA CMGC 106-254 18 2.4e-31 99.56 In-house 1-252 (513) Show / Hide 
Range on Protein: 106-254
Range on HMM: 1-252/513
Sequence Identity: 18% (48 aa)

YEVLACVGQGASGKVYKCRS--------------KEDEQIYAIKVIKVRTATKSR-----DQDVAL--VFKEGEMLQRCE-----------------HPN
||..  .|.|. |.|||||               .|...|.||| || .   .         |.     . | ..|..                   |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVEYFDMWKEEGEPGKS------------KVYIVMEFCGRSLQSVLLGGES--------PPADAF-----------------------RQLLQAVA--HV
||  .|. . ... |.             ..|.|.|... .|  ..             |  .                         .|.|....  . 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HDNV--GVHRDIAPHNIFVTDD--------------------GRIKLGDFGLAK
| .    .|||. | || ....                    ||.|..|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLAR
Kinase PEK-S1_h.AA WEE 106-255 25 5.1e-31 101.32 In-house 1-181 (297) Show / Hide 
Range on Protein: 106-255
Range on HMM: 1-181/297
Sequence Identity: 25% (48 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVI-KVRTATKSRDQDVALVFKEGEMLQ---RCE-HPNIVEYFDMWKEEGEPGKSKVYIVMEFCGRS----
....  .|.| .|.|||||...| .|||||.. . .  ...|.. .  | .  . |     |. ||.|| |.  |.|     ... ||.||.| ..    
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREV-YAHMVLGQIMDCDHHPHIVRYYSAWEE-----DDHMYIQMEYCNGGSNLL

--LQSVLLG-----GESPPADAFRQLLQAVAHVHDN-VGVHRDIAPHNIFVTDDG--------------------RIKLGDFGLAKN
  ...  .       |.   . .....|...|.|.|   || || | |||.. ..                    ..|.||||....
QFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTD
Kinase PEK-S1_h.AA KHS 106-253 37 1.1e-29 96.91 In-house 1-143 (258) Show / Hide 
Range on Protein: 106-253
Range on HMM: 1-143/258
Sequence Identity: 37% (58 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVEYFDMWKEEGEPGKSKVYIVMEFCGR-SLQSV--LL
||.|  || |  | ||| | .. ... |.||||.       ..|.|.. .|  |.. |.||||| ||  .       . |..|.||.||  ||| .  . 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEP-----GDDFAVIQQEIMMMKDCRHPNIVAYFGSYLR-----RDKLWICMEYCGGGSLQDIYHVT

GGESPPADAF--RQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLA
|  |    |.  |. ||.....| .  .||||   || .||.| .|| |||..
GPLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVS
Kinase PEK-S1_h.AA PEK 212-356 24 2.9e-28 95.0 In-house 433-655 (655) Show / Hide 
Range on Protein: 212-356
Range on HMM: 433-655/655
Sequence Identity: 24% (54 aa)

FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGR-----IKLGDFGLAKNKE--------------SMLETENIKK-------------------------
|||.| .....| .  .|||. |.|||...||.     .| ||||||.| |              | .. .....                         
FRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYH

------------------GRAVYYSPQRRSNS-----TYT---DMLALGVILFELHWRCPPDQ-ERESVLIDVRD------GVLP-ADWAYQHPSIAPKV
                  |.. | ||.  |..      |.   || .||.|.||.. .    . ||  .| |.||      | .|  ...  .|  |  .
IQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFI

LELVAARRDQRPSARDILCDPAW
. ..    .||||| .||  .  
QWMLSHDPQQRPSAQQILQHEFF
Kinase PEK-S1_h.AA STE20 106-194 32 2.5e-24 86.04 In-house 1-91 (288) Show / Hide 
Range on Protein: 106-194
Range on HMM: 1-91/288
Sequence Identity: 32% (30 aa)

YEVLACVGQGASGKVYKCRSKEDEQI----YAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVEYFDMWKEEGEPGKSKVYIVMEFCG
|| | ..|||..|||||.. |.  ..    .|||.......   . ... ...||  ....| |||||.|..    . ..  .. .||||.||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTC-DDELWIVMEYCG
Kinase PEK-S1_h.AA NEK 106-193 34 6.7e-20 67.08 In-house 1-88 (286) Show / Hide 
Range on Protein: 106-193
Range on HMM: 1-88/286
Sequence Identity: 34% (33 aa)

YEVLACVGQGASGKVYKCRSKEDEQI-----YAIKVIKVRTATKSRDQD--VALVFKEGEMLQRCEHPNIVEYFDMWKEEGEPGKSKVYIVMEFC
||..  .|||. |||||.|.|.|...     |..| |..   .    |.       .|   |..  |||||.|.| . ||.   ... .||||.|
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQN----NEVRILKQLKHPNIVKYYDSFIEEQ---NNCLCIVMEYC
Kinase PEK-S1_h.AA GCN2 186-266 33 3.5e-19 63.48 In-house 282-370 (511) Show / Hide 
Range on Protein: 186-266
Range on HMM: 282-370/511
Sequence Identity: 33% (30 aa)

VYIVMEFCG-RSLQSVLLGGESPPADA-----FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKN--KESMLETENIK
.||.||.|. ..| . .  .   ....     |||.| .....|..  .|||. | |||.. .|..| ||||||.|  .||  ..   |
LYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQK
Kinase PEK-S1_h.AA NEK1 106-193 35 6.8e-19 62.3 In-house 1-82 (276) Show / Hide 
Range on Protein: 106-193
Range on HMM: 1-82/276
Sequence Identity: 35% (31 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVEYFDMWKEEGEPGKSKVYIVMEFC
|...  .|.|. ||... ..||| | |.|| |.|   .|. ...   . .|.  |.. .|||||.|..   |.|       |||||.|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINV---MKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGC---GILYIVMEYC
Kinase PEK-S1_h.AA PEK 106-182 32 2.5e-16 52.67 In-house 1-90 (655) Show / Hide 
Range on Protein: 106-182
Range on HMM: 1-90/655
Sequence Identity: 32% (29 aa)

YEVLACVGQGAS-GKVYKCRSKEDEQIYAIKVIKVRTATKS------------RDQDVALVFKEGEMLQRCEHPNIVEYFDMWKEEGEPG
.|...|.|.|.  | |||...| |.. |||| ||.  ....             .   . |..|   | |..||||| |. .| |. | .
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEK
Kinase PEK-S1_h.AA NEK 214-254 38 4.9e-14 46.18 In-house 122-171 (286) Show / Hide 
Range on Protein: 214-254
Range on HMM: 122-171/286
Sequence Identity: 38% (19 aa)

QLLQAVAHVHDN-----VGVHRDIAPHNIFVTDDGR----IKLGDFGLAK
|.. |. ..||.       .|||| | ||| |....    .|.||||..|
QMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISK
Kinase PEK-S1_h.AA NEK1 212-254 36 4.8e-11 34.72 In-house 110-169 (276) Show / Hide 
Range on Protein: 212-254
Range on HMM: 110-169/276
Sequence Identity: 36% (22 aa)

FRQLLQAVAHVHDNVGVHRDIAPHNIFVT--DDG---------------RIKLGDFGLAK
| |.  |. |.||    |||| . ||| |  ..|                .|||||| |.
FCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIAR
Kinase PEK-S1_h.AA TyrKc 106-354 18 7.8e-11 -47.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 106-354
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

YEVLACVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRC--EHPNIVEYFDMWKEEGEPGK---SKVYIVMEFC-GRSLQS
 . .   | || |.|||.. |   .  |.|..|  .        ..   .| ... .   .|||||  .    ..|.        ..||||.. . .|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKD

VLLGGESPPADAFRQLLQAVAHV-------HDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKNKESM----LETENIKK-----GRAV----YYSP---Q
 |   .       ..||.    .       |..  .|||.|  |. |......| .||||... ..      ... ..|     |...     ..|   .
YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

RRSNSTYTDMLALGVILFELHWRCPPDQERE----SVLIDVRDGVLPADWAYQHPS--------IAPKVLELV----AARRDQRPSARDILCDP
 .  .| .|  . || ..|.  .. .  . .       ..|.  |   .   | |.          ... ..     ..  ..||. ..|  . 
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PEK-S1_h.AA GCN2 106-172 27 7e-10 30.35 In-house 1-67 (511) Show / Hide 
Range on Protein: 106-172
Range on HMM: 1-67/511
Sequence Identity: 27% (19 aa)

YEVLACVGQGASGKVYK-CRSKEDEQIYAIKVIKVRTATKSRDQDVAL--VFKEGEMLQRCEHPNIVEYF
 |...|.|.|. |.|.|  |.. |...|||| .... . ..   .  .   ..| . | |. |...| |.
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRK---LPCKHKIMREVKLLCRLHHQHVVRYY
Kinase PEK-S1_h.AA STE20 213-253 46 1e-06 20.89 In-house 124-164 (288) Show / Hide 
Range on Protein: 213-253
Range on HMM: 124-164/288
Sequence Identity: 46% (19 aa)

RQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLA
|..||. .. | |  .||||   || .|.||..|| |||..
REVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVC
Kinase PEK-S1_h.AA Pkinase_Tyr 228-254 48 7e-06 20.52 Pfam 133-159 (270) Show / Hide 
Range on Protein: 228-254
Range on HMM: 133-159/270
Sequence Identity: 48% (13 aa)

VHRDIAPHNIFVTDDGRIKLGDFGLAK
.|||.|  |. ||... .| .|||||.
IHRDLAARNCLVTENNVVKICDFGLAR
Kinase PEK-S1_h.AA Pkinase_Tyr 106-193 26 0.000169 15.86 Pfam 1-89 (270) Show / Hide 
Range on Protein: 106-193
Range on HMM: 1-89/270
Sequence Identity: 26% (25 aa)

YEVLACVGQGASGKVYKCRSK----EDEQIYAIKVIKVRTATKSRDQD--VALVFKEGEMLQRC-EHPNIVEYFDMWKEEGEPGKSKVYIVMEFC
 . .   |.|| |.|||.. |    ....  |.|..|     .. ...   .  ..| ...     ||||| .     ..|||.  ..|||||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYM
Kinase PEK-S1_h.AA GCN2 285-314 34 0.018447 3.93 In-house 434-465 (511) Show / Hide 
Range on Protein: 285-314
Range on HMM: 434-465/511
Sequence Identity: 34% (11 aa)

DMLAL-GVILFELHWR-CPPDQERESVLIDVR
|| .| |.|.||.  .  ..  || ..| . |
DMYSLGGIIFFEMWYPPFCTQMERVQILKQLR
Kinase PEK-S1_h.AA NEK 342-356 46 0.046358 3.52 In-house 272-286 (286) Show / Hide 
Range on Protein: 342-356
Range on HMM: 272-286/286
Sequence Identity: 46% (7 aa)

DQRPSARDILCDPAW
.||||...|| .|  
EQRPSCNQILEMPFI