Gene PEK-S1_l (S.moellendorffii)

PEK-S1_l

Species: S.moellendorffii
Alias: PEK-S1_l
External Links:
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
PEK-S1_l.AA Protein None 250 None Fasta, JSON
PEK-S1_l.NA RNA None 753 None Fasta, JSON
PEK-S1_l.kin_dom Protein Kinase Domain None 246 None Fasta, JSON

Protein domain

Protein domains of PEK-S1_l.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase PEK-S1_l.AA Pkinase 1-144 31 9e-35 124.03 Pfam 6-160 (293) Show / Hide 
Range on Protein: 1-144
Range on HMM: 6-160/293
Sequence Identity: 31% (50 aa)

CVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFCGR-----SLQ-------
..|.|..|.||||. | ...|.|.|.||.|.. .. ||  ..   | ....|. |||||...|.. .     |...|.|||.|.      .|        
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWR

SVLL-GGESPPADAFRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRI----KLGDFGLAK
.  . . |    . ..|.|..... |..  .|||. | ||.. ..| |    |..||||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase PEK-S1_l.AA CAMK 1-152 18 2.9e-33 104.01 In-house 1-278 (425) Show / Hide 
Range on Protein: 1-152
Range on HMM: 1-278/425
Sequence Identity: 18% (51 aa)

CVGQGASGKVYKCRSKEDE------------QIYAIKVIKVRTATKS-----------------------RDQDVALVFKEGEMLQRCE-------HPNI
  |.|. |||..|. |..             | .|||.|. . ....                       |..| . |..| |.....        ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYFDMWKEEG------EPG---------KSKVYIVM---EFCGR-----SLQSVLLG----------------GESPPADA---FRQLLQAVAHVHDNV
.| ....  .       . .         ....|.||   |.|        | . .                  |  . ..|   |||...||.. |.. 
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

GVHRDIAPHNIFVTDD-----------------GRIKLGDFGLAKNKES--------------------------MLET
 ||||. | || ..|.                 . ||. |||.|. ...                          ...|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT
Kinase PEK-S1_l.AA STE 1-145 24 1.1e-28 98.4 In-house 6-196 (359) Show / Hide 
Range on Protein: 1-145
Range on HMM: 6-196/359
Sequence Identity: 24% (48 aa)

CVGQGASGKVYKCRSKE---------------DEQIYAIKVIKVRTATKSRDQ-------------DVALVFKEGEMLQRCE--HPNIVKYFDMWKEEGE
..|.||.|.|||.. ..                 .|.|||...... ...  .             ..  . || .....|   |||||||...   ||.
KIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGH

P--GKSKVYIVMEFCG-RSLQSVLL---GG---------------ESPPADAFRQLLQA-VAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKN
.   .....|.||...  || ...    |                ||  |   ||.|..  .. |..  .|||| | ||..     .|| |||....
NHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQ
Kinase PEK-S1_l.AA WEE 2-145 26 2.5e-28 92.2 In-house 7-181 (297) Show / Hide 
Range on Protein: 2-145
Range on HMM: 7-181/297
Sequence Identity: 26% (48 aa)

VGQGASGKVYKCRSKEDEQIYAIKVI-KVRTATKSRDQDVALVFKEGEMLQ---RCE-HPNIVKYFDMWKEEGEPGKSKVYIVMEFCGRS------LQSV
.|.| .|.|||||...| .|||||.. . .  ...|.. .  | .  . |     |. ||.||.|.  |.|     ... ||.||.| ..      ... 
IGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREV-YAHMVLGQIMDCDHHPHIVRYYSAWEE-----DDHMYIQMEYCNGGSNLLQFWIQQ

LLG-----GESPPADAFRQLLQAVAHVHDN-VGVHRDIAPHNIFVTDDG--------------------RIKLGDFGLAKN
 .       |.   . .....|...|.|.|   || || | |||.. ..                    ..|.||||....
CHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTD
Kinase PEK-S1_l.AA PEK 102-246 24 2.9e-28 95.0 In-house 433-655 (655) Show / Hide 
Range on Protein: 102-246
Range on HMM: 433-655/655
Sequence Identity: 24% (54 aa)

FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGR-----IKLGDFGLAKNKE--------------SMLETENIKK-------------------------
|||.| .....| .  .|||. |.|||...||.     .| ||||||.| |              | .. .....                         
FRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYH

------------------GRAVYYSPQRRSNS-----TYT---DMLALGVILFELHWRCPPDQ-ERESVLIDVRD------GVLP-ADWAYQHPSIAPKV
                  |.. | ||.  |..      |.   || .||.|.||.. .    . ||  .| |.||      | .|  ...  .|  |  .
IQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFI

LELVAARRDQRPSARDILCDPAW
. ..    .||||| .||  .  
QWMLSHDPQQRPSAQQILQHEFF
Kinase PEK-S1_l.AA CAMKL 3-152 26 1.6e-27 84.79 In-house 8-192 (297) Show / Hide 
Range on Protein: 3-152
Range on HMM: 8-192/297
Sequence Identity: 26% (49 aa)

GQGASGKVYKCRS-KEDEQIYAIKVIKVRTAT------------KSRDQDVALVFKEGEMLQRCE---HPNIVKYFDMWKEEGE--PGKSKVYIVMEFCG
|.|. |||  ..  .  .. .|||.|. . ..            |. ..|.  ...| . ...     ||||.| ....  .       .|.|.||| |.
GKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH-ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCS

RS---LQSVL--LGGES---PPADA---FRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDG--RIKLGDFGLA-------KNKESMLET
     |.  .   |.     |. .|   |||.. ||.. |..  ||||| | || ....|   ||. |||..       .... .|.|
GGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKT
Kinase PEK-S1_l.AA S_TKc 1-246 24 4.3e-27 97.24 SMART 6-231 (231) Show / Hide 
Range on Protein: 1-246
Range on HMM: 6-231/231
Sequence Identity: 24% (65 aa)

CVGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFCGR---SLQSVLLGGESP
 .|.|| ||||||| |.. .|.|||.||              . .| ..|..  ||||||..|.. .      ...|.|||.|.    .| ...    ..
KIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRH

P---------ADAFRQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKNKESMLETENIKKGRAVYYSPQRRSNST-YTDMLALGVILFELH
.         .  ..|...|... |..  .|||. | ||....  .||..|||||.         .   |   | .|   . ..   |. ..|.||.|. 
GLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEML

WRCPPDQERESVLIDVRDGVLPADWAYQHPSIAPK--VLELVAARRDQRPSARDILC-------DPAW
 ..|| .  . .....              |   |  .  .     ..||.| ..|        .|  
CGYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PEK-S1_l.AA CMGC 2-144 18 5.5e-27 84.95 In-house 7-252 (513) Show / Hide 
Range on Protein: 2-144
Range on HMM: 7-252/513
Sequence Identity: 18% (47 aa)

VGQGASGKVYKCRS--------------KEDEQIYAIKVIKVRTATKSR-----DQDVAL--VFKEGEMLQRCE-----------------HPNIVKYFD
.|.|. |.|||||               .|...|.||| || .   .         |.     . | ..|..                   |.|||| .|
IGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYD

MWKEEGEPGKS------------KVYIVMEFCGRSLQSVLLGGES--------PPADAF-----------------------RQLLQAVA--HVHDNV--
. . ... |.             ..|.|.|... .|  ..             |  .                         .|.|....  . | .   
IFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGN

GVHRDIAPHNIFVTDD--------------------GRIKLGDFGLAK
 .|||. | || ....                    ||.|..|||||.
IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLAR
Kinase PEK-S1_l.AA TKL 2-195 16 1.1e-25 89.44 In-house 1-291 (364) Show / Hide 
Range on Protein: 2-195
Range on HMM: 1-291/364
Sequence Identity: 16% (50 aa)

VGQGASGKVYKCRSKEDE--------QIYAIKVIKVRTATK--------------------SRDQDVALVFKEGEMLQRCE--HPNIVKYFDMWKEEGE-
.|.|..|.||| . .           .  |.|..|..   .                    ....  .  |.| |...     |||||..    ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------PGKSKVYIVMEFC-GRSLQSVLLGGESPPADAFR---QLLQAVAHVHDNV--------GVHRDIAPHNIFVTDDGR--------------IKL
        .... .||||.| | || ..|.     .   .|   .  ..... | .          .|||. ..||.| ....              .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

GDFGLAKNKESMLE-------------------TENIKKGRAVYYSPQRRSNS----------------TYT---DMLALGVILFELHWRCPPDQE
.||||..... . .                   | . . |   . .|    ..                .|.   |. . |..|.|.  ||.| ..
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD
Kinase PEK-S1_l.AA STE20 1-84 31 4.3e-21 74.06 In-house 6-91 (288) Show / Hide 
Range on Protein: 1-84
Range on HMM: 6-91/288
Sequence Identity: 31% (28 aa)

CVGQGASGKVYKCRSKEDEQI----YAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFCG
..|||..|||||.. |.  ..    .|||.......   . ... ...||  ....| |||||||..    . ..  .. .||||.||
KIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTC-DDELWIVMEYCG
Kinase PEK-S1_l.AA NEK 2-83 35 7e-17 56.31 In-house 7-88 (286) Show / Hide 
Range on Protein: 2-83
Range on HMM: 7-88/286
Sequence Identity: 35% (32 aa)

VGQGASGKVYKCRSKEDEQI-----YAIKVIKVRTATKSRDQD--VALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFC
.|||. |||||.|.|.|...     |..| |..   .    |.       .|   |..  |||||||.| . ||.   ... .||||.|
IGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQN----NEVRILKQLKHPNIVKYYDSFIEEQ---NNCLCIVMEYC
Kinase PEK-S1_l.AA NEK1 2-83 37 1.4e-15 50.71 In-house 7-82 (276) Show / Hide 
Range on Protein: 2-83
Range on HMM: 7-82/276
Sequence Identity: 37% (31 aa)

VGQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPGKSKVYIVMEFC
.|.|. ||... ..||| | |.|| |.|   .|. ...   . .|.  |.. .|||||||..   |.|       |||||.|
IGEGSFGKAWLVKHKEDGQHYVIKEINV---MKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGC---GILYIVMEYC
Kinase PEK-S1_l.AA NEK 104-144 38 4.9e-14 46.18 In-house 122-171 (286) Show / Hide 
Range on Protein: 104-144
Range on HMM: 122-171/286
Sequence Identity: 38% (19 aa)

QLLQAVAHVHDN-----VGVHRDIAPHNIFVTDDGR----IKLGDFGLAK
|.. |. ..||.       .|||| | ||| |....    .|.||||..|
QMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISK
Kinase PEK-S1_l.AA PEK 1-72 32 9.6e-13 39.97 In-house 6-90 (655) Show / Hide 
Range on Protein: 1-72
Range on HMM: 6-90/655
Sequence Identity: 32% (28 aa)

CVGQGAS-GKVYKCRSKEDEQIYAIKVIKVRTATKS------------RDQDVALVFKEGEMLQRCEHPNIVKYFDMWKEEGEPG
|.|.|.  | |||...| |.. |||| ||.  ....             .   . |..|   | |..||||| |. .| |. | .
CLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEK
Kinase PEK-S1_l.AA NEK1 102-144 36 4.8e-11 34.72 In-house 110-169 (276) Show / Hide 
Range on Protein: 102-144
Range on HMM: 110-169/276
Sequence Identity: 36% (22 aa)

FRQLLQAVAHVHDNVGVHRDIAPHNIFVT--DDG---------------RIKLGDFGLAK
| |.  |. |.||    |||| . ||| |  ..|                .|||||| |.
FCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIAR
Kinase PEK-S1_l.AA TyrKc 3-244 18 1.2e-10 -50.69 SMART 8-280 (280) Show / Hide 
Range on Protein: 3-244
Range on HMM: 8-280/280
Sequence Identity: 18% (53 aa)

GQGASGKVYKCRSKEDEQIYAIKVIKVRTATKSRDQDVALVFKEGEMLQRC--EHPNIVKYFDMWKEEGEPGK---SKVYIVMEFC-GRSLQSVLLGGES
| || |.|||.. |   .  |.|..|  .        ..   .| ... .   .|||||. .    ..|.        ..||||.. . .|.. |   . 
GEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHRP

PPADAFRQLLQAVAHV-------HDNVGVHRDIAPHNIFVTDDGRIKLGDFGLAKNKESM----LETENIKK-----GRAV----YYSP---QRRSNSTY
      ..||.    .       |..  .|||.|  |. |......| .||||... ..      ... ..|     |...     ..|   . .  .| 
K--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

TDMLALGVILFELHWRCPPDQERE----SVLIDVRDGVLPADWAYQHPS--------IAPKVLELV----AARRDQRPSARDILCDP
.|  . || ..|.  .. .  . .       ..|.  |   .   | |.          ... ..     ..  ..||. ..|  . 
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PEK-S1_l.AA STE20 103-143 46 1e-06 20.89 In-house 124-164 (288) Show / Hide 
Range on Protein: 103-143
Range on HMM: 124-164/288
Sequence Identity: 46% (19 aa)

RQLLQAVAHVHDNVGVHRDIAPHNIFVTDDGRIKLGDFGLA
|..||. .. | |  .||||   || .|.||..|| |||..
REVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVC
Kinase PEK-S1_l.AA Pkinase_Tyr 118-144 48 7e-06 20.52 Pfam 133-159 (270) Show / Hide 
Range on Protein: 118-144
Range on HMM: 133-159/270
Sequence Identity: 48% (13 aa)

VHRDIAPHNIFVTDDGRIKLGDFGLAK
.|||.|  |. ||... .| .|||||.
IHRDLAARNCLVTENNVVKICDFGLAR
Kinase PEK-S1_l.AA Pkinase_Tyr 3-83 28 0.000206 15.57 Pfam 8-89 (270) Show / Hide 
Range on Protein: 3-83
Range on HMM: 8-89/270
Sequence Identity: 28% (25 aa)

GQGASGKVYKCRSK----EDEQIYAIKVIKVRTATKSRDQD--VALVFKEGEMLQRC-EHPNIVKYFDMWKEEGEPGKSKVYIVMEFC
|.|| |.|||.. |    ....  |.|..|     .. ...   .  ..| ...     |||||..     ..|||.  ..|||||..
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYM
Kinase PEK-S1_l.AA NEK 232-246 46 0.046358 3.52 In-house 272-286 (286) Show / Hide 
Range on Protein: 232-246
Range on HMM: 272-286/286
Sequence Identity: 46% (7 aa)

DQRPSARDILCDPAW
.||||...|| .|  
EQRPSCNQILEMPFI