Gene ULK-f4 (S.moellendorffii)
ULK-f4
Species: S.moellendorffii
Alias: ULK-f4
External Links:
Annotation:
Sequence
Protein domains of ULK-f4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | ULK-f4.AA | Fused | 2-144 | 67 | 2.3e-100 | 339.76 | In-house | 109-251 (251) | Show / Hide |
Range on Protein: 2-144 Range on HMM: 109-251/251 Sequence Identity: 67% (96 aa) ALHYLHSHRIIHRDMKPQNILIGAGGIVKLCDFGFARAMSCNTMVLRSIKGTPLYMAPELVREQPYNHTADLWSLGVILYELYVGQPPFYTNSVYTLIRH || ||||||| |||||||||| . .. .|||||||||.|| ||.|| |||||||||||||| |||| |.||.|||| ||||| ||||||..||.. |.. ALYYLHSHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCANSIFHLVSM IVKDPVKYPDTISSNFKSFLKGLLNKVSESRLTWPALLDHPFV |..|.||.| ||.| ...|| ||| | |..||.|| |||| IKHDDVKWPSTITSCCRNFLQGLLTKDPRHRISWPQLLCHPFV |
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| Kinase | ULK-f4.AA | AGC | 2-144 | 24 | 3.5e-70 | 179.74 | In-house | 165-395 (395) | Show / Hide |
Range on Protein: 2-144 Range on HMM: 165-395/395 Sequence Identity: 24% (58 aa) ALHYLHS-HRIIHRD-MKPQNILIGAGGIVKLCDFGFARA--MSC------------------------------------------------NTMVLRS ||.|||| . ||||| .|| |||. . | .||.|||.. ... .. . ALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWT IKG--TPLYMAPELVREQPYNHTADLWS--LGVILYELYVGQPPFYTNS----------VYTLIRHIV------KDPVKYP----------DTISSNFKS . | || ||||| . |....| || ||...||. .|.|||| .. . . | ...||.| . .|.. |. FCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKD FLKGLLNKVSESRLT----------WPALLDHPFV ..|.||.| | ||. . .||. LIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | ULK-f4.AA | ULK | 2-144 | 31 | 3.1e-62 | 213.07 | In-house | 142-329 (329) | Show / Hide |
Range on Protein: 2-144 Range on HMM: 142-329/329 Sequence Identity: 31% (59 aa) ALHYLHSHRIIHRDMKPQNILIGAG------------GIVKLCDFGFARAMSCN---TMVLRSIK------GTPLYMAPELVR----EQPYN-HTADLWS .. .||.|.|||||.||||||| | |..|..|||||. .... .. . . ||||||||... ..||. ...|.|| GFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWS LGVILYELYVGQPPFYTNSVYTLI-----RH----------IVKDPVKYP-----DTISSNFKSFLKGLLNKVSESRLTWPALLDHPFV ||.|.||. .|.||||.. .... . | | | ..| ..||...|......| . . | .|. |..||.. LGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | ULK-f4.AA | ULK | 2-144 | 29 | 1.5e-58 | 200.79 | In-house | 138-324 (324) | Show / Hide |
Range on Protein: 2-144 Range on HMM: 138-324/324 Sequence Identity: 29% (56 aa) ALHYLHSHRIIHRDMKPQNILIGAG------------GIVKLCDFGFARAMSCNT---MVLRSIK------GTPLYMAPELVR----EQPYN-HTADLWS .. .||.| |||||.||||||| | |..|..|||||. .|. ... ... ||||||||... ..||. . .|.|| GFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWS LGVILYELYVGQPPFYTNSVYTLI----RH----------IVKDPVKYPD-----TISSNFKSFLKGLLNKVSESRLTWPALLDHPFV ||.|.||. |..||... .... .. | . |...|. ||...|......| . . | .|. ...||.. LGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Pkinase | ULK-f4.AA | Pkinase | 1-144 | 33 | 4.8e-55 | 193.98 | Pfam | 119-293 (293) | Show / Hide |
Range on Protein: 1-144
Range on HMM: 119-293/293
Sequence Identity: 33% (60 aa)
RALHYLHSHRIIHRDMKPQNILIGAGGIV----KLCDFGFARAM-SCNTMVLRSIKGTPLYMAPELVR-EQPYNHTADLWSLGVILYELYVGQPPFYTN-
|.| |.||..|||||.||.|||| | . |.||||.|. . | . .. ||| |||||..| |.| . .| ||.|.||||.. |.|||.
RGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC
-----SVYTLIRHIVKDPVKYPDTIS---------------------SNFKSFLKGLLNKVSESRLTWPALLDHPFV
. . .|. | . |.... . ...|.|.|..|.| ..|.|.. .| ||..
WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | ULK-f4.AA | RSK | 2-144 | 31 | 1.6e-49 | 170.85 | In-house | 116-278 (278) | Show / Hide |
Range on Protein: 2-144 Range on HMM: 116-278/278 Sequence Identity: 31% (51 aa) ALHYLHSHRIIHRDMKPQNILIGA---GGIVKLCDFGFARAMSCN-TMVLRSIKGTPLYMAPELVR---EQP-YNHTADLWSLGVILYELYVGQPPFYT- |. .||.. ||||| || ||| | .||.||||.. ..|. . . . .| |||||... | ... .|.|||||..||. .|.|||. AVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGP --NSVYTLIRHIVKDP--VKYP--DTISSNFKSFLKGLLNKVSESRLT-----WPALLDHPFV |. ... | | .. | ...| ..|......| . . ||. ...||. NDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | ULK-f4.AA | CAMK | 2-144 | 24 | 9.1e-48 | 151.58 | In-house | 191-425 (425) | Show / Hide |
Range on Protein: 2-144
Range on HMM: 191-425/425
Sequence Identity: 24% (58 aa)
ALHYLHSHRIIHRDMKPQNILI-GAG----------------GIVKLCDFGFARAMSCN-----------------------TMVLRSIKGTPLYMA-PE
|.||.||| |.||| || |||. . . .|..|||||. . . . .. ||| ||| ||
AVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE
LVR--------------EQPYNHTADLWSLGVILYELYVGQPPFYTN-------------SVYTLIRHIVKDPVKYPDT----------------ISSN-
... ...|. .| ||.||||| . .| |||| . | | . | | .|. || .
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF
-------FKSFLKGLLNKVSESRLTWPALLDHPFV
|......|.. | |.| |.||..
HHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | ULK-f4.AA | Ciliate-E2 | 2-144 | 28 | 9.3e-47 | 158.52 | In-house | 172-365 (365) | Show / Hide |
Range on Protein: 2-144
Range on HMM: 172-365/365
Sequence Identity: 28% (59 aa)
ALHYLHSHR-IIHRDMKPQNILIGAGGIVKLCDFGFAR-AMSCNT------------------------------MVLRSIKGTPLYMAPELVREQP---
||.|||| ||||| ||.|||. .|..|||... . .| .. ..| ||| ||||| .. ..
ALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDN
------YNHTADLWSLGVILYELYVGQPPFYTNSVYTLIRHIVKDPVKYP------------------DTISSNFKSFLKG----LLNKVSESRLT-WPA
|.. .|.|||||||||. |.||| .. | . ....| . .| . | ..| .|.| | |.| |
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ
LLDHPFV
.|.||.
ILNHPWF
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| Kinase | ULK-f4.AA | STE | 1-144 | 28 | 2.4e-42 | 147.03 | In-house | 162-359 (359) | Show / Hide |
Range on Protein: 1-144 Range on HMM: 162-359/359 Sequence Identity: 28% (58 aa) RA-LHYLHSHRIIHRDMKPQNILIGAGGIVKLCDFGFARAMSCN--------------TMVLR--SIKGTPLYMAPELVRE------QPYNHTADLWSLG .. |.|||||.||||| ||.|||. |||||||.. .. . ||. . .. ||| .|||| .. ..|. .| |||| KGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLG VILYELYVGQPPFYT-NSVYTLIRHIVK---------------DPVKYPDTIS-------------------SNFKSFLKGLLNKVSESRLTWPALLD-- . |. |.||. . . . . . . . .| . ||..| ..|| |.. |.| . | | || CTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSE HPFV |||. HPFI |
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| Kinase | ULK-f4.AA | AktR | 2-144 | 35 | 4.1e-42 | 146.22 | In-house | 113-268 (268) | Show / Hide |
Range on Protein: 2-144 Range on HMM: 113-268/268 Sequence Identity: 35% (56 aa) ALHYLHSH-RIIHRDMKPQNILIGAGGIVKLCDFGFAR--AMSCNTMVLRSIKGTPLYMAPELVRE-QPYNHTADLWSLGVILYELYVGQPPFYTNSVYT || |||.| || ||.||.|||.. | ||. ||| .. | .. . .|. ||| ||||| ... ...| ..|.|..|. .||. .|.|||| .. . ALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQ LIRHIVKDP-VKYPDT--ISSNFKSFLK-GLLNKVSESRLT-----WPALLDHPFV .. | . . .| |.. .||..|.... .||.| . ||. | . .||. MFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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| Kinase | ULK-f4.AA | Aur | 52-144 | 33 | 1e-37 | 96.69 | In-house | 163-257 (257) | Show / Hide |
Range on Protein: 52-144 Range on HMM: 163-257/257 Sequence Identity: 33% (32 aa) GTPLYMAPELVREQPYNHTADLWSLGVILYELYVGQPPFYT-NSVYTLIRHIV-KDPVKYPDTISSNFKSFLKGLLNKVSESRLTWPALLDHPFV || ||.|| |..|...|. |.|.|||..||| .|.|||. .. . .. | | ...|. || | . ...| . ...|.| . ||.. GTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPPFESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI |
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| Kinase | ULK-f4.AA | Aur | 2-35 | 60 | 5.7e-20 | 48.91 | In-house | 113-147 (257) | Show / Hide |
Range on Protein: 2-35 Range on HMM: 113-147/257 Sequence Identity: 60% (21 aa) ALHYLHSHRIIHRDMKPQNILIG-AGGIVKLCDFG ||.|.|| ||||| || |||.. | .|.|||| ALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFG |
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| Kinase | ULK-f4.AA | S_TKc | 1-144 | 22 | 8e-15 | 40.5 | SMART | 17-231 (231) | Show / Hide |
Range on Protein: 1-144 Range on HMM: 17-231/231 Sequence Identity: 22% (55 aa) RALH----------------------------------------------------------------------------------------YLHSHRII .. | |.|||.|| KCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGII HRDMKPQNILIGAGGIVKLCDFGFARAMSCNTMVLRSIKGTPLYMAPELVREQPYNH-TADLWSLGVILYELYVGQPPFYTNSVYTLIRHIVKDPVKYPD ||| ||.|||. .|.||||.|| . ... ||| |||||.. .|.. .| ||.|.||||...|.|||. .......|. HRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------- TISSNFKSFLKGLLNKVSESRLTWPALLD-------HPFV |. .|.|....|.| | |.| .| ||.. --SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | ULK-f4.AA | Pkinase_Tyr | 1-105 | 31 | 2e-11 | 39.32 | Pfam | 122-231 (270) | Show / Hide |
Range on Protein: 1-105 Range on HMM: 122-231/270 Sequence Identity: 31% (35 aa) RALHYLHSHRIIHRDMKPQNILIGAGGIVKLCDFGFARAM-SCNTMVLRSIKGTPL---YMAPELVREQPYNHTADLWSLGVILYELYV-GQPP-FYTNS ... ||.|...|||| |.|.. ...|| |||| ||.. . . .|. .|..| |||| .. ... | || || ..|.. |. | .. | KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMS VYTLIRHIVKD . ....| .| NEEVYEYIYED |
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| Kinase | ULK-f4.AA | TyrKc | 1-144 | 15 | 0.000147 | -148.91 | SMART | 17-280 (280) | Show / Hide |
Range on Protein: 1-144
Range on HMM: 17-280/280
Sequence Identity: 15% (42 aa)
RA----------------------------L------------------------------------------------------------------HYL
.. | ||
KGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYL
HSHRIIHRDMKPQNILIGAGGIVKLCDFGFARAMSCN--------TMVLRSIKGTP--L---YMAPELVREQPYNHTADLWSLGVILYELY-VGQPPFYT
||...|||| |.|.|....|| .||| .|. . . .. ||. | |||| .. ... | || || ..|.. ||.| .
HSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPG
-----NSVYTLIRHIVKD--PVKYPD-------TISSNFKSFLKGLLNKVSESRLTWPALLDHPFV
| . .|... . . . |. . .. . | . |.| | .. | .
MIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Arm | ULK-f4.AA | Arm | 285-295 | 45 | 40.914665 | 0.57 | Pfam | 31-41 (41) | Show / Hide |
Range on Protein: 285-295 Range on HMM: 31-41/41 Sequence Identity: 45% (5 aa) QALRVLWNLLG .|...|||| NACWALWNLCA |
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| Arm | ULK-f4.AA | Arm | 872-915 | 15 | 1.088247 | 5.95 | Pfam | 1-41 (41) | Show / Hide |
Range on Protein: 872-915 Range on HMM: 1-41/41 Sequence Identity: 15% (7 aa) SRLLAIDIVKEGLLSPLLMAKMLDPSSPKDVVLDVLMTVSNLAR . ....| . ||. ..|. .. .|. ... ...||.. NPEQKQAVIQCGCVPPLV--QLLH-HPDEEVQENACWALWNLCA |
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| HEAT | ULK-f4.AA | HEAT | 929-959 | 32 | 0.010017 | 13.3 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 929-959 Range on HMM: 1-31/31 Sequence Identity: 32% (10 aa) IWDSFKTYLVHGDSNVRARCCSALGNMCRHT | . . . | . |..||. .|..||..|.| ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| Arm | ULK-f4.AA | Arm | 939-957 | 42 | 0.054476 | 10.39 | Pfam | 23-41 (41) | Show / Hide |
Range on Protein: 939-957 Range on HMM: 23-41/41 Sequence Identity: 42% (8 aa) HGDSNVRARCCSALGNMCR |.|..|. .| ||.|.|. HPDEEVQENACWALWNLCA |
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| Arm | ULK-f4.AA | Arm | 1001-1040 | 26 | 9e-07 | 26.71 | Pfam | 1-41 (41) | Show / Hide |
Range on Protein: 1001-1040 Range on HMM: 1-41/41 Sequence Identity: 26% (11 aa) NDQLYEQLRRA--IPHLTNLLLGNEEDKTKANAAGALSNLVR |.. ...... .|.| .|| ... ... ||..||.||.. NPEQKQAVIQCGCVPPLVQLLH-HPDEEVQENACWALWNLCA |
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| HEAT | ULK-f4.AA | HEAT | 971-1001 | 29 | 0.007328 | 13.77 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 971-1001 Range on HMM: 1-31/31 Sequence Identity: 29% (9 aa) LIKLLIDRCADPDRHTRKFACFAVGNAAYHN .. .|. . ||| . |. || ..|. . | ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | ULK-f4.AA | HEAT | 1011-1042 | 21 | 0.346714 | 7.97 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1011-1042 Range on HMM: 1-31/31 Sequence Identity: 21% (7 aa) AIPHLTNLLLGNEEDKTKANAAGALSNLVRNS .||| ..| .... ...|. .|..|.... ILPHLLKCLN-DPDWEVREAACWCLGQLCEHC |
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| Arm | ULK-f4.AA | Arm | 1042-1062 | 19 | 7.288405 | 3.13 | Pfam | 1-21 (41) | Show / Hide |
Range on Protein: 1042-1062 Range on HMM: 1-21/41 Sequence Identity: 19% (4 aa) SSKLCEDIISQGAMKALIQVI ... . .| .|....|.| . NPEQKQAVIQCGCVPPLVQLL |
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| Arm | ULK-f4.AA | Arm | 1096-1126 | 16 | 58.060499 | 0.05 | Pfam | 1-31 (41) | Show / Hide |
Range on Protein: 1096-1126 Range on HMM: 1-31/41 Sequence Identity: 16% (5 aa) HAPCRQYLRSLELFRVLLQLKNSTDSTIIKY .....|... . ..|.|| ...|. . .. NPEQKQAVIQCGCVPPLVQLLHHPDEEVQEN |
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