Gene WNK_e (S.moellendorffii)
WNK_e
Species: S.moellendorffii
Alias: WNK_e
External Links:
Annotation:
Sequence
Protein domains of WNK_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | WNK_e.AA | WNK | 32-289 | 48 | 3.2e-137 | 445.87 | In-house | 2-261 (261) | Show / Hide |
Range on Protein: 32-289 Range on HMM: 2-261/261 Sequence Identity: 48% (127 aa) RYNEVLGRGAFKTVYKAFDEVDGIEVAWNQVNVQDVLGRPEDLERLYSEVHLLRGLKHKNVIKFFTSWVDP---RTKNVNFITEIFTSGTLRQYRKKHKN ...| .|||.|||||...| ..||||. . | . . . |. |. .| .|.| |...|...| . . .. .|| |||||. | | |. KFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSK--NERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKK-CIVLVTELMTSGTLKTYLKRFKK VDMKAVKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNQGEVKIGDLGLA-TILRQAHAAHSVIGTPEFMAPELYEEDYNELVDIYAFGMCVLEL . | . | ||||.|| .||. | |||||||||||||..| |.||||||||| | .. . | ||||||||||||.||| | | ||.||||||.|| MKPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSF-AKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEM VTFDYPYSECTNAAQIYKKVSSGIKPAALDKVKDPEVRSFIQKCLATAS-KRLPARELLKDPFL .| .||||||.||||||.||..||||....|...|||. .| ||. . | ...||.. |. ATSEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF |
|||||||||
| S_TKc | WNK_e.AA | S_TKc | 31-289 | 26 | 1.8e-62 | 214.8 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 31-289
Range on HMM: 1-231/231
Sequence Identity: 26% (73 aa)
GRYNEVLGRGAFKTVYKAFDEVDGIEVAWNQVNVQDVLGRPEDLERLYSEVHLLRGLKHKNVIKFFTSWVDPRTKNVNFITEIFTS--GTLRQYRKKHKN
. ...|.||| .|||. . .| .|| ... |....|. .|. .|.|..|.. ...| ... ...| |.|..| ||..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR
------VDMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLATILRQAHAAHSVIGTPEFMAPELYEEDYNE-LVDIYAFGM
. .. ...||...| |.||| ||||||| .||... ..||.| |||..| ....|||..||||. |. .|....|
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC
CVLELVTFDYPYSECTNAAQIYKKVSSGIKPAALDKVKDPEVRSFIQKCLA-TASKRLPARELLK-------DPFL
.. |... |.. . ....||. .||...||.||| .||. | |.|. .|..
ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Pkinase | WNK_e.AA | Pkinase | 31-289 | 24 | 9.2e-55 | 193.05 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 31-289 Range on HMM: 1-293/293 Sequence Identity: 24% (72 aa) GRYNEVLGRGAFKTVYKAFDEVDGIEVAWNQVNVQDVLGRPEDLERLYSEVHLLRGLKHKNVIKFFTSWVDPRTKNVNFITEIFTSG----TLRQYRK-- . ...|.|.| .|||. . .|..|| ...... . |. ||..... |.|.|..... .. | ... ...| | | | . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW KHKNV--DMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEV----KIGDLGLATI--LRQAHAAHSVIGTPEFMAPEL--YEEDYNELV .|... ... .|....|||||| |.||. ||||||| .||... |.|.. ||.| ||| . . .... |||..||||. ..| | RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV DIYAFGMCVLELVTFDYPYSEC-----TNAAQIYKKVSSGIKPAALDKVKD-------------------PEVRSFIQKCLAT-ASKRLPARELLKDPFL |....| . |... |.... . |..... ... . .. . .| ..|| .||. .||. |...|..|.. DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | WNK_e.AA | CAMK | 36-289 | 16 | 8.6e-48 | 151.66 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 36-289
Range on HMM: 1-425/425
Sequence Identity: 16% (69 aa)
VLGRGAFKTVYKAFDEVDG------------IEVAWNQVNVQDVLG------------------------RPEDLERLYSEVHLLRG-------LKHKNV
.||||.| .|..... .. .|| .. . . . ||.|......|..... |.|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
IKFFTSWVDPR-----------------TKNVNFIT---EIFTSG----TLRQYRKKHKN---------------VDMKAVKNWARQILRGLLYLHSHDP
||.. . ||. .|.. ... | . | | .| ..|.. .. . .. . |||. .. |.|||.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-
PIIHRDLKCDNIFVNGNQ----------------GEVKIGDLGLATILRQAH------------------------AAHSVIGTPEFMA-PELYE-----
|.|||||..|| .. | . .|| | |.|..... . . . ||||.|| ||. .
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC
----------EDYNELVDIYAFGMCVLELVTFDYPYSECT------------NAAQIYKKVSSGIKPAALDKVKD----------------------PEV
. |.. .|. . | ... .|. . . | ....|. .| ..... .|.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC
RSFIQKCLAT-ASKRLPARELLKDPFL
...|.|.| . .||. . . |..|..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
|
|||||||||
| Kinase | WNK_e.AA | STE | 32-289 | 21 | 6.6e-47 | 162.16 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 32-289
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)
RYN-EVLGRGAFKTVYKAFDEV---------------DGIEVAWNQVNVQDVL-------------GRPEDLERLYSEVHLLRGLK--HKNVIKFFTSWV
. |..|.||| ||||| . | .| |.|... .|..... |. ... .. |.|..|.. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
DPRTK-----NVNFITEIFTSGTLRQYRKKHKNVDM--------------KAVKNWARQILRG-LLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLG
. .. ... . | |.|.. |. . . . . .. .||||.| | ||||| |||||.|..||.. ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG
LATILRQAHA-----------------AHSVIGTPEFMAPELYEED-------YNELVDIYAFGMCVLELVTFDYPYSECTNAAQIYKKVSS--------
....| . .| ...||| .|||| . . |.. .||. .| ...|..| .|... .. .. . .
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE
------GIKPAALDKVKD------------------PEVRSFIQKCLATASK-RLPARELLK--DPFL
| | |.... || . ||.||| . | | .||| ||.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
|
|||||||||
| Kinase | WNK_e.AA | Ciliate-E2 | 31-289 | 17 | 4e-45 | 152.83 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 31-289 Range on HMM: 1-365/365 Sequence Identity: 17% (67 aa) GRYNEVLGRGAFKTVYKAFDEVDGIEVA---------------WNQVNVQDVLGR-PEDLERLYSEVHLLR----------------GLKHKNVIKFFTS ....|.|.| .|||. . .. ..| .... . . ..| . .| |..| |.|.|.||.. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC WVDPRTKNVNFITEIFTSGTLRQYRKKH-----------KNVDMKAVKNWARQILR---------------GLLYLHSHDPPIIHRDLKCDNIFVNGNQG . . ..|. ...| . |.|..| |.. |. ..| .|. .|||. .| |||| . |||||.| .||.. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF----- EVKIGDLGLATILRQA--------------------------------HAAHSVIGTPEFMAPELYE----------EDYNELVDIYAFGMCVLELVTFD .|| |.||.... . . .....|||..|||| .. ..|.. .||...|.. |... -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK YPYSECTNAAQIYKKVSSGIKPAALDKVKDPEVR----------------------------SFIQK----CLATA-SKRLP-ARELLKDPFL .|. ... |. ... .|.| .| .||. . ..|. |.. PPF---------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | WNK_e.AA | NRBP | 34-290 | 36 | 3e-43 | 149.88 | In-house | 2-261 (261) | Show / Hide |
Range on Protein: 34-290 Range on HMM: 2-261/261 Sequence Identity: 36% (98 aa) NEVLGRGAFKTVYKAFDEVDGIEVAWNQVNVQDVLGRPEDLERLYSEVHLLRGLKHKNVIKFFTSWVDPRTKN--VNFITEIFTSGTLRQY----RKKHK .| | ...| | |. .|.|| || |. . . |.. | |.|.|..|| |.| . . | |||| || ..|. .|.|| RDVPG---IDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHK NVDMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLATILRQAHAAHSVIGTPEFMAPELYEEDYNEL---VDIYAFGMCVL |...|| | |. ||| | |||| |||||| | || ||. | | .||| .| .. ... |.||| . ..| ||||.|||| | NMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHN-GLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCAL ELVTFDYPYSECTNAAQIYKKVSSGIKPAALDKVKDPEVRSFIQKCLATASKRLP-ARELLKDPFLQ |. .. | |.|. | |. . | ..|| | ||.|||. .| | ||||| . | EMAVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF |
|||||||||
| Kinase | WNK_e.AA | TKL | 37-285 | 20 | 9.4e-42 | 145.03 | In-house | 1-362 (364) | Show / Hide |
Range on Protein: 37-285
Range on HMM: 1-362/364
Sequence Identity: 20% (74 aa)
LGRGAFKTVYKA-FDEVD-------GIEVAWNQVNVQDVLGRPE-----------------------DLERLYSEVHLLRGLKHKNVIKFFTSWVDPR--
.|.|.| .|||. . . | .|| . ..... . . ... |. ... |.| |...| . .|.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
---------TKNVNFITEIFTSGTLRQYRKKHKNVDMKAVKNWARQILRGLLYLHSHD------PPIIHRDLKCDNIFVNGN-------------QGEVK
... ...| |.|. | . .||..| ||. ||||.. ||||||||| .||.|. | .. .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
IGDLGLATIL--------------------RQAHAAHSVIGTPEFMAPELYE-----------------EDYNELVDIYAFGMCVLELVTFDYPYSECTN
|.|.||.. . ... . ....||| .||||. . ..|.| .|.|.||.. |..| ||.. .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
AAQI---------YKKVSSGIKPAAL-----------DKVKDPEVRSFIQKCLAT-ASKRLPARELLK
.| .. .. | .| . .|.... .|.| .. ..||. . |.||
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK
|
|||||||||
| Kinase | WNK_e.AA | NEK | 32-289 | 25 | 9.4e-40 | 137.8 | In-house | 2-286 (286) | Show / Hide |
Range on Protein: 32-289 Range on HMM: 2-286/286 Sequence Identity: 25% (74 aa) RYNEVLGRGAFKTVYKAFDEVDGIE-----VAWNQVNVQDVLGRPEDLERLY-SEVHLLRGLKHKNVIKFFTSWVDPRTKNVNFITEIFT-SGTLRQY-- .. ...|.|.| .|||. . || . ..| ..|.. ... . .. .||..|. ||| |..|.. |... . . | |.| | EIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMS--EKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK -RKKHK----NVDMKAVKNWARQILRGLLYLHSH-DP--PIIHRDLKCDNIFVNGNQGE---VKIGDLGLATILR-QAHAAHS-VIGTPEFMAPELY-EE ||.| . . . . .| |.. .| |.|.. | |.|||.|. ||| . | . |||||.|.. .| . .|.. ..||| .|.||. .. SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK DYNELVDIYAFGMCVLELVTF--DYPYSECT--NAAQIYKKVSSGIKPAALDKV--KDPEVRSFIQKCLAT-ASKRLPARELLKDPFL ||. .|| ..| .. |..|. | | . | . |.|. |.... . . .. ...|...| ..| ....|..||. PYNNKSDIWSLGCVLYEMCTLKPKHPF-EAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
|||||||||
| Kinase | WNK_e.AA | Ciliate-E2-Unclassified | 32-289 | 19 | 3.5e-37 | 126.54 | In-house | 2-352 (352) | Show / Hide |
Range on Protein: 32-289 Range on HMM: 2-352/352 Sequence Identity: 19% (70 aa) RYNEVLGRGAFKTVYKAFDEVDGIEV-----AWNQVNVQDVLGRPEDLERLYSEVHLLRG----------------LKHKNVIKFFTSWVDPRTKNVNFI . ....|.|.| .|||. .. .. .. . . .. . . . .| | . .. .. . | |.. .. ... ..|. .. KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV TEIFTSGTLRQYRKKHKN-----------------VDMKAVK-----NWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNQG--EVKIGDLGLATILR .| . |.|.|| || |. .. ...| ....||| || |||. |||||.|..||... |.. ..|| |.|.. . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ QA----------------HAAHSVIGTPEFM----APELYEE-DYN----ELVDIYAFGMCVLELVTFDYPYS--ECTN-------------AAQIYKKV | . .....|||..| |||.... |. . .||...|.. |... ||.. |. |.|.. QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI SSGIK--PAALD----KVKDPEVRSFIQ----KCLATASK-RLPARELLKDPFL .. | . | .||. ||. |.| . |. . ..|. |.. KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
| Kinase | WNK_e.AA | ULK | 34-271 | 22 | 9.6e-34 | 115.21 | In-house | 4-310 (329) | Show / Hide |
Range on Protein: 34-271 Range on HMM: 4-310/329 Sequence Identity: 22% (71 aa) NEVLGRGAFKTVYKAFDEVD----GIEVAWNQVNVQDVLGRPED------LERLYSEVHLLRGLK----HKN----VIKFFT-SWVDPRTKNVNFITEIF |..|| |.| .|||.... . .. || .. | . . .. | .|. ... || ||| ..|.. .. . .|. .|.| NHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-NNIYIIMEYC TSGTLRQYRKKHKNVDMKA----------VKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNQGE-----------VKIGDLGLATILRQA----H |.|.|| ||.|. .. ... .||| |. .||.| |||||.| .|| .. .|. .||.| |.| . NGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ AAHSVI------GTPEFMAPELYEED-----YNEL-VDIYAFGMCVLELVTFDYPYSECTNAAQI----YKKVSSG------IKPAALD-------KVKD ... ||| .|||.. .. |.. .||. .|. |... .|.... . |. .| . . || |. .. MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS PEVRSFIQKCL ||....|...| PECKDLIRRML |
|||||||||
| Kinase | WNK_e.AA | STE11 | 134-289 | 28 | 1.5e-32 | 114.43 | In-house | 118-303 (303) | Show / Hide |
Range on Protein: 134-289 Range on HMM: 118-303/303 Sequence Identity: 28% (54 aa) VKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLATILRQAH--AAH---------SVIGTPE--------FMAPELYE-ED---Y ... .|||.|| ||||| |||||.| .||... . . .|..| | |. | . . ... |. ||| .|||| . | | IRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGY NELVDIYAFGMCVLELVTFDYPYSECTN--AAQIYKKVSS-GIKPAALDKVKD-----PEVRSFIQKCLATASK-RLPARELLKDPFL .|| ..| .|.| .| |...... .|...| ... . | ... .| | |...|. | | |..||..||. GRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI |
|||||||||
| Kinase | WNK_e.AA | TyrKc | 31-287 | 21 | 1.3e-16 | 46.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 31-287 Range on HMM: 1-280/280 Sequence Identity: 21% (63 aa) GRYNEVLGRGAFKTVYKAFDEVDGIEVAWNQVNVQDVLGRPEDLERLYSEVHLLRGL--KHKNVIKFFTSWVDP-----RTKNVNFITEIFTSGTLRQYR . ...||.||| .|||. |.|| .. .| ...| ... | .|.|..... ... . . ..| | |..| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL KKHKN-VDMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLATILRQA---HAAHSVIGT-----PEF------MAPELYEE .||.. . || ... || .| ||||. ..||||| . |. |. |. |||.| ||. . ...... . . |||| . RKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY D-YNELVDIYAFGMCVLELVTF-DYPYSEC----TNAAQIYKKVSSGIKPAALDKV-------KDPEVRSFIQKCLAT-ASKRLPARELLKDP ... |...|| | |. |. . ||.. ........| .| . . . .|. . ...| . ...| .|. .. GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | WNK_e.AA | Pkinase_Tyr | 123-182 | 39 | 3.1e-07 | 25.12 | Pfam | 99-158 (270) | Show / Hide |
Range on Protein: 123-182 Range on HMM: 99-158/270 Sequence Identity: 39% (25 aa) RKK---HKNVDMKAVKNWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA ||. ....|| ....|| .|. ||.|. .||||| . |. |. | |||.| ||| RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA |
|||||||||
| Kinase | WNK_e.AA | STE11 | 35-96 | 26 | 9.5e-05 | 13.43 | In-house | 5-76 (303) | Show / Hide |
Range on Protein: 35-96 Range on HMM: 5-76/303 Sequence Identity: 26% (19 aa) EVLGRGAFKTVYKAFDEVDGIEVAWNQVNVQDVL----GRPEDLER------LYSEVHLLRGLKHKNVIKFF |..|.||| ||||... | ..| |. .|. . . .. . .|. |...|.||| .... EIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYY |
|||||||||
| Kinase | WNK_e.AA | Pkinase_Tyr | 71-95 | 21 | 1.81126 | 2.21 | Pfam | 42-69 (270) | Show / Hide |
Range on Protein: 71-95 Range on HMM: 42-69/270 Sequence Identity: 21% (6 aa) PED--LERLYSEVHLLRGL-KHKNVIKF .|. .| . .|. ... | .|.|.... HEQNCREDFMREAKIMKQLGHHPNIVRL |
|||||||||
| FRWNK_Wnk1 | WNK_e.AA | FRWNK_Wnk1 | 361-397 | 40 | 3e-05 | 16.34 | In-house | 43-79 (92) | Show / Hide |
Range on Protein: 361-397 Range on HMM: 43-79/92 Sequence Identity: 40% (15 aa) IHFAFDLEADTAFSVASEMVTELDLSDQDVATIAEMI | | |||| |.. || ||| . ..|. ..| .| IEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSI |
|||||||||