Gene WNK_d (S.moellendorffii)

WNK_d

Species: S.moellendorffii
Alias: WNK_d
External Links:
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
WNK_d.AA Protein None 996 None Fasta, JSON
WNK_d.NA RNA None 2991 None Fasta, JSON
WNK_d.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of WNK_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase WNK_d.AA WNK 41-298 48 3.2e-137 445.85 In-house 2-261 (261) Show / Hide 
Range on Protein: 41-298
Range on HMM: 2-261/261
Sequence Identity: 48% (127 aa)

RYNEILGKGAFKTVYRAFDEVDGIEVAWNQVKVEDVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDT---KTKNVNFITEIFTSGTLRQYRKKHKH
...| .|.|.||||||..|   ..||||. ..   . ..  .  |.  |. .|| |.| ||...|..|  .   |  ..  .||  |||||. | |  |.
KFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKN--ERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKK-CIVLVTELMTSGTLKTYLKRFKK

VDMRAVKNWAKQILRGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQAHAAHSVIGTPEFMAPELYEEEYNELVDIYSFGMCLLEMV
.  .  . | .|||.|| .||. .| |||||||||||||..|  |.|||||||||  |...  | ||||||||||||.||| | | ||.|.||||.|||.
MKPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMA

TFEYPYSECTNAAQIYKKVTSGKKPAALDRVKDLEVRAFIEKCLATVS-KRLPARELLMDPFL
| |||||||.||||||.|||.| ||........ ||. .||||. .    |  ...|| . |.
TSEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
S_TKc WNK_d.AA S_TKc 40-298 28 6.8e-66 226.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-298
Range on HMM: 1-231/231
Sequence Identity: 28% (80 aa)

GRYNEILGKGAFKTVYRAFDEVDGIEVAWNQVKVEDVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTKTKNVNFITEIFTS--GTLRQYRKKHKH
 .  ...||||| .||.. .  .| .||  ..|           |....|. .||. .|.||.||| ...|   ... ...|      |.|..| ||...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

------VDMRAVKNWAKQILRGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQAHAAHSVIGTPEFMAPELYEEEYNE-LVDIYSFGM
       .   .. ...||...| |.|||.  ||||||| .||...    ..||.| |||..|      ....|||..||||.    |.   .|..|.| 
HGLRFPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC

CLLEMVTFEYPYSECTNAAQIYKKVTSGKKPAALDRVKDLEVRAFIEKCLA-TVSKRLPARELLM-------DPFL
.| ||.. . |..   . ....||.             . |.. ||.|||    .||. | |.|        .|..
ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase WNK_d.AA Pkinase 40-298 26 8e-57 199.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 40-298
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

GRYNEILGKGAFKTVYRAFDEVDGIEVAWNQVKVEDVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTKTKNVNFITEIFTSG----TLRQYRK--
 .  ...|.|.| .||.. .  .|..||  ..|...   . .   |. ||....|.|.|.||..|| .. |   ... ...|    |     |  | .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

KHKHV--DMRAVKNWAKQILRGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEV----KIGDLGLAAI--LRQAHAAHSVIGTPEFMAPEL--YEEEYNELV
.|. .  ... .|....|||||| |.||.   ||||||| .||... |.|..    ||.| |||.   .   . .... |||..||||.    ..|   |
RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIYSFGMCLLEMVTFEYPYSEC-----TNAAQIYKKVTSGKKPAALDRVKD-------------------LEVRAFIEKCLAT-VSKRLPARELLMDPFL
|..|.|  | ||.. . |....      .  |..... ... .   .   .                    | . ||..||.   .||. |...| .|..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase WNK_d.AA CAMK 45-298 17 1.2e-52 167.61 In-house 1-425 (425) Show / Hide 
Range on Protein: 45-298
Range on HMM: 1-425/425
Sequence Identity: 17% (76 aa)

ILGKGAFKTVYRAFDEVDG------------IEVAWNQVKVEDVLQ------------------------SPEDLERLYSEVHLLKS-------LKHKNI
.||.|.| .|.....  ..             .||   .. . .                          .|.|......|....|.       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYNSWVD-----------TKTK-------NVNFIT---EIFTSG----TLRQYRKKHKH---------------VDMRAVKNWAKQILRGLLYLHSHN
||||  . |           | .|       .. ...   |  . |     | .| ..|..               .. | .. . .||. .. |.||||
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPIIHRDLKCDNIFVNGNQ----------------GEVKIGDLGLAAILRQAH------------------------AAHSVIGTPEFMA-PELYEEE--
  |.|||||..|| .. |                 . .|| | |.|..... .                          . . ||||.|| ||. . .  
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------YNELVDIYSFGMCLLEMVTFEYPYSECT------------NAAQIYKKVTSGKKPAALDRVKD----------------------LE
             |.. .|. | |  |  |.. ..|. . .            |  ....|...||     . ...                       |
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

VRAFIEKCLAT-VSKRLPARELLMDPFL
.. .| |.| .  .||. . . | .|..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase WNK_d.AA STE 41-298 22 3.6e-51 176.32 In-house 1-359 (359) Show / Hide 
Range on Protein: 41-298
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

RYN-EILGKGAFKTVYRAFDEV---------------DGIEVAWNQVKVED------------VLQS-PEDLERLYSEVHLLKSLK--HKNIIKLYNSWV
  . |..||||| |||.| .                  |  .|  |...|.            . .. .|.....  |. ..| ..  |.||.| | . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DTKTK-----NVNFITEIFTSGTLRQYRK-KHKHVDM-------------RAVKNWAKQILRG-LLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLG
.  ..     ... . |    |.|..  | |... ..               ..  ..|||.| | |||||.  |||||.|..||..      ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

LAAILRQAHA-----------------AHSVIGTPEFMAPELYEEE-------YNELVDIYSFGMCLLEMVTFEYPYSECTNAAQIYKKVTS--------
....| . .|                   ...||| .||||  . .       |.. .||.|.| ...||.| ..|... ..   .. . ..        
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------GKKPAALDRVKD------------------LEVRAFIEKCLAT-VSKRLPARELLM--DPFL
      |. |   |....                   | . ||.|||    .||  | .||    ||.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase WNK_d.AA Ciliate-E2 40-298 18 1.8e-50 171.5 In-house 1-365 (365) Show / Hide 
Range on Protein: 40-298
Range on HMM: 1-365/365
Sequence Identity: 18% (72 aa)

GRYNEILGKGAFKTVYRAFDEVDGIEVA---------------WNQVKVEDVLQS-PEDLERLYSEVHLLK----------------SLKHKNIIKLYNS
   ....|.|.| .||.. .  .. ..|                ...|   . .  . ..| . .| |...                .|.|.||||.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WVDTKTKNVNFITEIFTSGTLRQYRKKHKH-----------VDMRAVKNWAKQILR---------------GLLYLHSHNPPIIHRDLKCDNIFVNGNQG
. .....|. ...| .  |.|..| |..|.            ... .|.  ||||.               .| |||| |. |||||.| .||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

EVKIGDLGLAAILRQA--------------------------------HAAHSVIGTPEFMAPELYE----------EEYNELVDIYSFGMCLLEMVTFE
 .|| |.||. .. .                                 . .....|||..|||| ..          ..|.. .||.|.|..| ||.. .
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPYSECTNAAQIYKKVTSGKKPAALDRVKDLEVR----------------------------AFIEK----CLATV-SKRLP-ARELLMDPFL
.|.                     ..  |. ...                             .| |    .|    .||.  . ..|  |..
PPF---------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase WNK_d.AA NRBP 47-299 38 1.3e-44 154.51 In-house 3-261 (261) Show / Hide 
Range on Protein: 47-299
Range on HMM: 3-261/261
Sequence Identity: 38% (100 aa)

GKGAFKTVYRAFDEVDGIEVAWNQVKVEDVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTKTKN--VNFITEIFTSGTLRQY----RKKHKHVDM
     ...| | |. .|.|| || |.  .  .   . |..      |  |.|.||.|.   |.||| .   | ||||   || ..|.    .|.||....
DVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNMNE

RAVKNWAKQILRGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQAHAAHSVIGTPEFMAPELYEEEYNEL---VDIYSFGMCLLEMVT
.| | |. |||  | |||| .|||||  | || ||.  | | .|||     || .. ...        |.|||    | ..|   ||||||||| |||  
KAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHN-GLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEMAV

FEYPYSECTNAAQIYKKVTSGKKPAALDRVKDLEVRAFIEKCLATVSKRLP-ARELLMDPFLQ
.|   | |.|.   |  ||      |   ..|   | ||.|||.   .| | |||||  . | 
LEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase WNK_d.AA Ciliate-E2-Unclassified 41-298 20 6e-43 146.81 In-house 2-352 (352) Show / Hide 
Range on Protein: 41-298
Range on HMM: 2-352/352
Sequence Identity: 20% (72 aa)

RYNEILGKGAFKTVYRAFDEVDGIEV-----AWNQVKVEDVLQSPEDLERLYSEVHLLKS----------------LKHKNIIKLYNSWVDTKTKNVNFI
. ....|.|.| .||.. .. .. ..     .  . .. . ..  .| | . .. .. .                 | |.......  .......|. ..
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEIFTSGTLRQYRKKHKH-----------------VDMRAVK-----NWAKQILRGLLYLHSHNPPIIHRDLKCDNIFVNGNQG--EVKIGDLGLAAILR
.| .  |.|.|| || |.                 .. ...|     ....||| || |||. |  |||||.|..||... |..  ..|| |.|..  . 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

QA----------------HAAHSVIGTPEFM----APELYEE-EYN----ELVDIYSFGMCLLEMVTFEYPYS--ECTN-------------AAQIYKKV
|                 . .....|||..|    |||.... .|.    . .||.|.|..| ||.. .||..   |.                |.|.. 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

TSG--KKPAALD----RVKDLEVRAFIE----KCLAT-VSKRLPARELLMDPFL
  .  ..| .         . |.  ||.    |.|    .||. . ..|  |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase WNK_d.AA NEK 41-298 27 3.7e-41 142.8 In-house 2-286 (286) Show / Hide 
Range on Protein: 41-298
Range on HMM: 2-286/286
Sequence Identity: 27% (79 aa)

RYNEILGKGAFKTVYRAFDEVDGIE-----VAWNQVKVEDVLQSPEDLERLY-SEVHLLKSLKHKNIIKLYNSWVDTKTKNVNFITEIFT-SGTLRQY--
.. . .|.|.| .||.. .  || .     ..| .....    |... . .. .||..||.||| ||.| |.|... .    . . |     |.| |   
EIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGN--MSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-RKKHK----HVDMRAVKNWAKQILRGLLYLHSH-NP--PIIHRDLKCDNIFVNGNQGE---VKIGDLGLAAILR-QAHAAHS-VIGTPEFMAPELY-EE
  ||.|    . . . . .|  |.. .| |.|.. .|   |.|||.|. ||| . |  .   |||||.|.. .|   . .|.. ..||| .|.||.  ..
SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

EYNELVDIYSFGMCLLEMVTF--EYPYSECT--NAAQIYKKVTSGKKPAALDRVKDL-----EVRAFIEKCLAT-VSKRLPARELLMDPFL
 ||. .|| |.| .| ||.|.  . |  | .  |  . |.|.. |      ... .      . . .|...|    ..|  ....| .||.
PYNNKSDIWSLGCVLYEMCTLKPKHPF-EAWDMNMPSLYMKIMKG---PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase WNK_d.AA TKL 46-261 21 3.2e-40 139.95 In-house 1-317 (364) Show / Hide 
Range on Protein: 46-261
Range on HMM: 1-317/364
Sequence Identity: 21% (69 aa)

LGKGAFKTVYRA-FDEVD-------GIEVAWNQVKVEDVLQSPE-----------------------DLERLYSEVHLLKSLKHKNIIKLYNSWVDTK--
.|.|.| .||.. .   .       | .||  . |....  . .                         ...  |. ....|.| ||.... .  . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------TKNVNFITEIFTSGTLRQYRKKHKHVDMRAVKNWAKQILRGLLYLHSHN------PPIIHRDLKCDNIFVNGN-------------QGEVK
         ...  ...|    |.|. |        .    .||..| ||. ||||.|      ||||||||| .||.|. |             .. .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IGDLGLAAIL--------------------RQAHAAHSVIGTPEFMAPELYE-----------------EEYNELVDIYSFGMCLLEMVTFEYPYSECTN
|.|.||.  .                    ... . ....||| .||||. .                 .||.| .|.||||..| |..| . ||..  .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

AAQI---------YKKVTSGKKP
  .|         .. .  |..|
MPMIFQDPFEEMFMMVCDKGLRP
Kinase WNK_d.AA ULK 43-247 27 4.1e-39 136.25 In-house 4-256 (324) Show / Hide 
Range on Protein: 43-247
Range on HMM: 4-256/324
Sequence Identity: 27% (72 aa)

NEILGKGAFK-TVYRAFDEVD---GIEVAWNQVKVED---VLQSPED------LERLYSEVHLLKSLK---HKN--IIKLYNSWVDTKT-KNVNFITEIF
|..||||.|  .||..... .   .  ||   .|. |     ... .      .. | .|. ..| ||   |.|  |.|||  |  |.. .|. .|.|  
NHCLGKGSFGVKVYKGRNKKTNTQNQYVA---CKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYD-WFETSNHNNIYIIMEYC

TSGTLRQYRKKHKHVDMRA----------VKNWAKQILRGLLYLHSHNPPIIHRDLKCDNIFVNGNQGE-----------VKIGDLGLAAIL----RQAH
  |.|.|| ||.|.  .            ...  |||. |. .||.||  |||||.| .|| .. .|.            .||.| |.| ..     .. 
NGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

AAHSVI------GTPEFMAPELYEEE-----YNEL-VDIYSFGMCLLEMVTFEYPYSECTN
  ..        ||| .|||.. ...     |..  .||.|.|. . ||.. .||.... .
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-F
Kinase WNK_d.AA STE11 143-298 29 1.1e-34 121.55 In-house 118-303 (303) Show / Hide 
Range on Protein: 143-298
Range on HMM: 118-303/303
Sequence Identity: 29% (56 aa)

VKNWAKQILRGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQAH--AAH---------SVIGTPE--------FMAPELYE-EE---Y
...  ||||.|| |||||.  |||||.| .||... . . .|..| | |  | . .  ...         |. |||         .|||| .  |    |
IRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGY

NELVDIYSFGMCLLEMVTFEYPYSECTN--AAQIYKKVTS-GKKPAALDRVKD-----LEVRAFIEKCLATVSK-RLPARELLMDPFL
   .|| |.| . .||.|   |......  .|...| ... .  |   ...        | |.|. .|.    | |  |..||..||.
GRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase WNK_d.AA TyrKc 40-297 22 2.6e-17 57.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-297
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

GRYNEILGKGAFKTVYRAFDEVDGIEVAWNQVKVEDVLQSPEDLERLYSEVHLLKSL--KHKNIIKLYNSWVDTKT-----KNVNFITEIFTSGTLRQYR
 . ...|| ||| .||..      |.||   .| .        .| ...|  ....|  .|.||..||   .. .      . .  ..|    | |..| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKHKH-VDMRAVKNWAKQILRGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQA---HAAHSVIGT-----PEF------MAPELY-E
.||.. . |.   ... || .|  ||||.  ..||||| . |. |. |.  |||.| ||.  .       ...... .       .      ||||   .
RKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

EEYNELVDIYSFGMCLLEMVTFEYPYSEC-----TNAAQIYKKVTSGKKPAALDRV-------KDLEVRAFIEKCLAT-VSKRLPARELLMDPF
 ....  |..||| |. |. |.  .  .       ........| .|. .   . .          |.   ...| .   ..|   .|.  . |
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase WNK_d.AA Pkinase_Tyr 132-191 39 1.1e-07 26.7 Pfam 99-158 (270) Show / Hide 
Range on Protein: 132-191
Range on HMM: 99-158/270
Sequence Identity: 39% (25 aa)

RKK---HKHVDMRAVKNWAKQILRGLLYLHSHNPPIIHRDLKCDNIFVNGNQGEVKIGDLGLA
||.    ....|    ... || .|. ||.|.|  .||||| . |. |. |   |||.| |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase WNK_d.AA STE11 44-105 30 6e-07 21.47 In-house 5-76 (303) Show / Hide 
Range on Protein: 44-105
Range on HMM: 5-76/303
Sequence Identity: 30% (22 aa)

EILGKGAFKTVYRAFDEVDGIEVAWNQVKVEDVL----QSPEDLER------LYSEVHLLKSLKHKNIIKLY
||.||||| |||....   | ..|  |.....      .  . ..       . .|. |.| |.||||.. |
EIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYY
Kinase WNK_d.AA Pkinase_Tyr 210-258 26 0.008893 10.03 Pfam 181-232 (270) Show / Hide 
Range on Protein: 210-258
Range on HMM: 181-232/270
Sequence Identity: 26% (14 aa)

MAPE-LYEEEYNELVDIYSFGMCLLEMVTFE-YP-YSECTNAAQIYKKV-TSG
|||| . . ....  |..||| .. |..|.   | | ..   ...|...  .|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
Kinase WNK_d.AA Pkinase_Tyr 79-105 33 0.010612 9.77 Pfam 41-70 (270) Show / Hide 
Range on Protein: 79-105
Range on HMM: 41-70/270
Sequence Identity: 33% (10 aa)

SPED--LERLYSEVHLLKSL-KHKNIIKLY
..|.  .| . .|. ..|.| .|.||..||
MHEQNCREDFMREAKIMKQLGHHPNIVRLY
FRWNK_Wnk1 WNK_d.AA FRWNK_Wnk1 367-416 26 0.000621 11.54 In-house 43-92 (92) Show / Hide 
Range on Protein: 367-416
Range on HMM: 43-92/92
Sequence Identity: 26% (13 aa)

IHFPFSIEGDTAMSVASEMVAELDLSDQDVTTIAEMIDAAIVALVPDWRP
| | | .| |..  || |||.   . ..|. ..| .| . . .     . 
IEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER