Gene MEKK2-p1_b (S.moellendorffii)

MEKK2-p1_b

Species: S.moellendorffii
Alias: MEKK2-p1_b
External Links:
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: MEKK2-plant1

Sequence

Name Sequence Type Origin Length Description Download
MEKK2-p1_b.AA Protein None 277 None Fasta, JSON
MEKK2-p1_b.NA RNA None 834 None Fasta, JSON
MEKK2-p1_b.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of MEKK2-p1_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MEKK2-p1_b.AA STE11 13-277 46 1e-147 497.04 In-house 1-303 (303) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-303/303
Sequence Identity: 46% (140 aa)

WRKGELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNF--AKGKAQLSA--HIRELEEEVKLLQNLSHPNIVRYLGTAR---EEEALNIFLEFVPGGSI
|.|||.|| ||.|.||..||.| |||.||||. |  .|   .. . ....   .....||.||...|.|.|||||.|. .   ... .|||.|..||||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SSLLG-KFGS--FTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGH-IKVADFGASKKVLELATISEA--------KSMKGTPY--------
||.|  |.|   |.|.||| ||.|.| || |||...| ||||||||||.| .|. .| ||||..|.. . .| ..         |||.||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVVRQTG---HNWQADIWSVGCTVIEMATGKPPWSDQFQ-EVAALFHIGTT-KSHPPIPEHLS------PDAKSFLLKCLQREPRLRPTAAELLKV
||||||..|.|   .  .|||||.||||||||||||||... . . ||.|.||.. |.|||||||.|      .... ||..|....|  ||||..||. 
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

CAL
  .
PFI
Kinase MEKK2-p1_b.AA STE11-Unclassified 13-273 43 5.6e-137 461.36 In-house 1-304 (308) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-304/308
Sequence Identity: 43% (134 aa)

WRKGELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASN----FAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTA--REEEALNIFLEFVPGGSIS
| |||.|| |..|.|| .||.. ||..||||. |  .|     .. .      |  ...|.|.|..|.|.|||.|.|.   ..|  .|||.| .|||||.
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKE-----MIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIW

SLLGKFGSFTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGHIKVADFGASK-------------KVLELA--TISEAK--------SMKGT
|.| |.| | |.||. ||.|.| ||.|||...| ||||||||||.| .| .| .|||..|             |. .    .|....        ||.||
SMLNKYGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGT

PY---WMAPEVVR---QTGHNWQADIWSVGCTVIEMATGKPPWSDQFQ--EVAALFHIGTTKSHPPIPEHLS-----------PDAKSFLLKCLQREPRL
||   ||||||..   ||||   .||||.|||||||||||.|||.  .  ...|...|. ... |.||||||           ...| || ||.|. |  
PYQPFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKK

RPTAAELLK
|||| .||.
RPTANQLLQ
Kinase MEKK2-p1_b.AA MEKK15 13-277 48 3.6e-104 352.37 In-house 1-264 (264) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-264/264
Sequence Identity: 48% (131 aa)

WRKGELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTAREEEALNIFLEFVPGGSISSLLGKF
|.||...| |||| || |.  . | ||||||| .  ..  | | |     | | |||.||. | | ||| |||.. |.  .|||..|||||||||.. .|
WKKGNILGKGAYGTVYCGL-TNTGQLIAVKQVELDEIDKEKAKQQY----RKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRF

GSFTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGHIKVADFGASKKVLELATISEAK-----SMKGTPYWMAPEVVRQTGHNWQADIWSVG
|.  | |   ||.|.| | .|||.| ..||||||.|...   | ||. |||  |. | .. |. ..     ||.||||||||||.  ||.  ..||||.|
GPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKR-LCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIG

CTVIEMATGKPPWSDQFQEVAALFHIGTT-KSHPPIPEHLSPDAKSFLLKCLQREPRLRPTAAELLKVCAL
||| ||||.|||| |  . .||.| ||.     |..|.. | ||. |   || |.   |||| .|||   .
CTVFEMATRKPPWAD-MDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MEKK2-p1_b.AA STE 13-277 30 3.9e-103 348.93 In-house 1-359 (359) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-359/359
Sequence Identity: 30% (112 aa)

WRKGELIGVGAYGRVYMGMNLD---------------SGELIAVKQVLIAASNFAKGK---AQLSA-------HIRELEEEVKLLQNLS--HPNIVRYLG
|.. | || ||.| || .|| .               .||..|.||. .  .|  . .   .            . ....|.|......  |||||.|.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG

TAREE-------EALNIFLEFVPGGSISSLLG-KFGSFT-------------EPVIRMYTRQLLLG-LEYLHQNKIMHRDIKGANILVDNQGHIKVADFG
.   |       . |.|..|...|||.....  |.| .              |..|. ..||.| | |.|||...|.|||||.||||.     .| .|||
CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFG

ASKKVLE-LA------------TIS-EAKSMKGTPYWMAPEVVRQ------TGHNWQADIWSVGCTVIEMATGKPPWSDQFQEVAALFHIGTT-------
 .... . .|            |.. . ... ||| ||||||..|       |.. ..||||.|||.||||||||||.| ..   |.|.| .        
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHD-MHPMRAMFMIPFNYHMQQQF

-------KSHPPIPE-------------------HLSPDAKSFLLKCLQREPRLRPTAAELLK--VCAL
       . .||.|.                   ..||. | |. ||||..|. |||| .|||     .
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEKK2-p1_b.AA MEKK2 13-277 45 2.5e-94 319.67 In-house 1-262 (262) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-262/262
Sequence Identity: 45% (122 aa)

WRKGELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTAREEE--ALNIFLEFVPGGSISSLLG
||.| |.| ||.||||.    | |  .||||| .  .|     .. .  .. || |..||.|| |. || | |  |...   | ||.|..||||.   | 
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDN-----PETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLK

KFGSFTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGHIKVADFGASKKVLELAT-ISEAKSMKGTPYWMAPEVVRQTGHNWQADIWSVGCT
 .|. || | | ||||.| |..|||.. |.|||||||||| |  | .|..||||||..  .   |   ||. ||||||.|||.   |   .||.||.|||
AYGALTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCT

VIEMATGKPPWSDQFQEVAALFHIGTTKSHPPIPEHLSPDAKSFLLKCLQREPRLRPTAAELLKVCAL
|.|| | |||| . .  .||.| | | .  | .|.|.| .|. || .| ..    || |.|||.    
VVEMLTEKPPWAE-YEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MEKK2-p1_b.AA S_TKc 13-274 29 6.3e-92 312.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-274
Range on HMM: 1-231/231
Sequence Identity: 29% (83 aa)

WRKGELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTAREEEALNIFLEFVPG--GSISSLLG
......|| ||.|.|| . . ..|.. |.|..                  . .. |...|..  |||||..... .. . | ...|...|  |.  ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK

KFGS------FTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGHIKVADFGASKKVLELATISEAKSMKGTPYWMAPEVVRQTGHNW-QADI
| |.      |.| ..| |..|....|||.|...|.|||.| .|||.|.  |||..||| ....         ... |||..|||||.   |..   .|.
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSVGCTVIEMATGKPPWSDQFQEVAALFHIGTTKSHPPIPEHLSPDAKSFLLKCLQREPRLRPTAAELLK----------V
||.||...||..|.||..    .....|..             ||.||.|. ||||..|. |||| |.|.          .
WSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEKK2-p1_b.AA Pkinase 13-273 28 2.8e-86 297.75 Pfam 1-289 (293) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-289/293
Sequence Identity: 28% (86 aa)

WRKGELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTAREEEALNIFLEFVPGG----SISSL
...|. || |..|.|| ... ..|.. |||..     .  | .. . .       |......|.||||||.... ...  . . .|...||    . ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LG--KFGSF--TEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGHI----KVADFGASKKVLELATISEAKSMKGTPYWMAPEVVR-QTGHNW
.   . |.|  .| ....| .|.| ||||.|...|.|||.| .|||.||.|||    |..||| .|..  .   | ...  |||..|||||.| ....  
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

QADIWSVGCTVIEMATGKPPWSDQ-----FQEVAALFHIGTTKSHPPIPEHLS-------------------PDAKSFLLKCLQREPRLRPTAAELLK
 .|.||.||...||..|.||....       . . .. |. .. | ..|.  |                   ...|.|. .||.. |  ||||...|.
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ
Kinase MEKK2-p1_b.AA Dicty2 16-273 39 1.6e-84 287.15 In-house 4-260 (264) Show / Hide 
Range on Protein: 16-273
Range on HMM: 4-260/264
Sequence Identity: 39% (105 aa)

G-ELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTAREEEALNIFLEFVPGGSISSLLGKFGS
| | || || | || | .  .|.  | ||. |        . |..     .  |..||..|.|.|||.|..    |  |.|.||.. .|| |  . ||| 
GDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQS----IMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKKFGC

FTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGH---IKVADFGASKKVLELATISEAKSMKGTPYWMAPEVVRQTG--HNWQADIWSVGCT
| |. .  | .| | ||.|||.... |||||.||||.   |    || ||||   ..  .  .  . .  ||||||||||    |  .    ||||.|||
FPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHID-YSDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDIWSLGCT

VIEMATGKPPWSDQFQEVAALFHIGTTKSHPPIPEHLSPDAKSFLLKCLQREPRLRPTAAELLK
.||. || || .|  .  .|.| .     |||.|.  ||. | ||. | ...| .|.|| .||.
IIELLTGNPPYWD-LNPMHAMFRM-VQDDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLH
Kinase MEKK2-p1_b.AA ASK 18-277 42 1.7e-83 277.61 In-house 1-254 (254) Show / Hide 
Range on Protein: 18-277
Range on HMM: 1-254/254
Sequence Identity: 42% (112 aa)

LIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTAREEEALNIFLEFVPGGSISSLL-GKFGSFT
 .| |.|| || | ...    ||.| .    |.          . . | ||..| ..| | |||.|||.. |.. . ||.| |||||.|.||  |.| . 
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR----------YVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMK

--EPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDN-QGHIKVADFGASKKVLELATISEAKSMKGTPYWMAPEVVRQT--GHNWQADIWSVGCTVI
  |  .. ||.|.| ||.|||.|.|.|||||| |.||    | .|..||| .|..  .  ..|  . .||  .|||||. |   |.   |||||.|||..
DNENTMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTE--TFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMV

EMATGKPPWSDQFQEVAALFHIGTTKSHPPIPEHLSPDAKSFLLKCLQREPRLRPTAAELLKVCAL
||||||||. .  .  ||.|..|  | ||.||| || ..| |.|.| . .|. |..|..||.   |
EMATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MEKK2-p1_b.AA STE20 13-273 34 9.2e-79 267.97 In-house 1-284 (288) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-284/288
Sequence Identity: 34% (100 aa)

WRKGELIGVGAYGRVYMGMNLDSGEL----IAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTAREE----EALNIFLEFVPGGS
. . | || |.|| || . . ..||.    .|.|.. .   .      |   ...... |.  .... |||||.|.|.   .    . | |  |.  |||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNE----Q--DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS

ISSLLG---KFG------SFTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGHIKVADFGASKKVLEL---ATISEAKSMKGTPYWMAPEVV
.. ..    | |      ...|. |   .|..| ||.|||.|.|.|||||..|||.. .| .| |||| . .. ..   .  .. ... ||||||||||.
LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVI

RQ-----TGHNWQADIWSVGCTVIEMATGKPPWSDQFQEVAALFHIGTTKSHPP---I--PEHLSPDAKSFLLKCLQREPRLRPTAAELLK
..      |..  .||||.| | ||||.|.|| .| .. . |.|.| . .  ||      |.. ||. . |. ||||..|  |||| .|||
QCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFD-MHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLK
Kinase MEKK2-p1_b.AA MEKK1 13-277 37 2.5e-73 249.94 In-house 1-266 (266) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-266/266
Sequence Identity: 37% (103 aa)

WRKGELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTAREEEALNIFLEFVPGGSISSLLGKF
| ||  ||.||.   ||      | | ||||.     |           . |. .|....  . ||.|.| .|   ..   |.| |  ||||.. || ..
WTKGQQIGTGAFSSCYMAQDVKTGTLMAVKQITYCRNN----SSDQEDVMEEIRKEIRMMAHFNHPHIIRMMGATCHDSHYNVFIEWMPGGSVAHLLKDY

GSFTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQG-HIKVADFGASKKVLELATISEAKSMK----GTPYWMAPEVVRQTGHNWQADIWSVG
| | . |.  |. |...|| ||| |.| |||.|||| |.|  | |  .||||.  .    . |  .   .    ||   ||||| |        ||||||
GAFKNSVVINYIHQVCRGLSYLHDNQIIHRDVKGANLLMDSTGHHLRIADFGTAARM--NSDITRTDEFQGQFLGTIAFMAPEVLRGQQYGRSCDIWSVG

CTVIEMATGKPPWSDQFQE--VAALFHIGTTKSHPPIPEHLSPDAKSFLLKCLQREPRLRPTAAELLKVCAL
| .|||.. ||||         . .| |      |||||||||      | ||  .|  ||   ||||  . 
CCIIEMCCTKPPWNNEKHSNHYQLIFKIASANTPPPIPEHLSPGLRDITLRCLEAQPQDRPPVMELLKHPVF
Kinase MEKK2-p1_b.AA MEKK4 13-277 37 5.8e-68 232.1 In-house 1-271 (271) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-271/271
Sequence Identity: 37% (104 aa)

WRKGELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNLSHPNIVRYLGTAREEEALNIFLEFVPGGSISSLLGKF
|  |  || | .| ||  || |..|..|.| . .   .    ||     |..  .| | .  . ||| ||| |   . | . ||.|.   |   ..    
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQRNDH---KA-----IKNIADEIKIFEGIKHPNLVRYYGVEVHREEMYIFMEYCSQGTLERVCHLG

GSFTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGHIKVADFGASKKVLELA-TI-SEAKSMKGTPYWMAPEVVRQTGHN----------WQ
|   | .|| || ||| .  |||| .| |||||.|||  |  . .|  ||| | |  . . |.  |  |  ||. .|||||  .|.             .
GNMQEHMIRQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCSVKLQNHSQTMPGEFQSTMGTAAYMAPEVYTYTEKDETTGSYSGHGRA

ADIWSVGCTVIEMATGKPPWS--DQFQ-EVAALFHIGTTKSHPPIPEHLSPDAKSFLLKCLQREPRLRPTAAELLKVCAL
|||||.||.|.||.||| ||    |.. . .  .  |     |.||. .||. | |.  ||.  |  |.||.|||    .
ADIWSLGCVVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGH-YPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase MEKK2-p1_b.AA Pkinase_Tyr 13-277 24 1.2e-29 101.06 Pfam 1-270 (270) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-270/270
Sequence Identity: 24% (69 aa)

WRKGELIGVGAYGRVYMGMNL----DSGELIAVKQVLIAASNFAKGKAQLSAH---IRELEEEVKLLQNL-SHPNIVRYLGTAR-EEEA--LNIFLEFVP
 ..|. .| ||.|.||.|       . .   ||| .            . . .   .... .|.|.. .| .||||||..|    ..|   . | .|..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP

GGSISSLLGK----FGSFTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGHIKVADFGASKKVLELATIS-EAKSMKGTPY-WMAPEVVRQT
.|.  . | |     ...| . .  . .|   |.|||..... |||.   |.||......|..||| .. . .       ...    |  |||||. .  
HGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYG

GHNWQADIWSVGCTVIEMAT-GKPP-WSDQFQEVAALFHIGTTKSHPPIPEHLSPDAKSFLLKCLQREPRLRPTAAELLKVCAL
  . . |.|| | .  |. | |. | . .       . .|.      |.||. ...  . ...| . .|  ||| .|.  .  |
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase MEKK2-p1_b.AA TyrKc 13-277 23 1.8e-28 101.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

WRKGELIGVGAYGRVYMGMNLDSGELIAVKQVLIAASNFAKGKAQLSAHIRELEEEVKLLQNL--SHPNIVRYLGTAREE-------EALNIFLEFVPGG
 ..|. .| ||.|.|| |.     .  ||| .   |             .... .| ... .|  .|||||| .| ....       | | | .|..|.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

SISSLLGKFGS-FTEPVIRMYTRQLLLGLEYLHQNKIMHRDIKGANILVDNQGHIKVADFGASKKVLEL-------ATISEAK--SMK--GTPYWMAPEV
.  . | | .  .. .    .  |   | ||||.... |||.   |.||......|..||| |... .         ... ..  . |      |||||.
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

VRQTGHNWQADIWSVGCTVIEMAT-GKPPWSD---QFQEVAALFHIGTTKSHPPIPEH--------LSPDAKSFLLKCLQREPRLRPTAAELLKVCAL
 .    . . |.|| | .  |. | |..|...   |. . . ...   .   .|.|..         ...  .  ..| ...|  ||| .|.  .  .
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF