Gene FRAY_b (S.moellendorffii)

FRAY_b

Species: S.moellendorffii
Alias: FRAY_b
External Links:
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: FRAY

Sequence

Name Sequence Type Origin Length Description Download
FRAY_b.AA Protein None 418 None Fasta, JSON
FRAY_b.NA RNA None 1257 None Fasta, JSON
FRAY_b.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of FRAY_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase FRAY_b.AA FRAY 19-287 54 7.70000000001e-166 519.38 In-house 1-277 (277) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-277/277
Sequence Identity: 54% (156 aa)

YQLLEEVGQGVSATVYRAMCISFKEIVAIKSLDLEKCS-SNLDEIRKEAKTMSLINHPNVVRAYCSFVVEHSLWVVMPYMAGGSCLHIMKAAYPDGF---
|.| | .|.| .|.|..|.|| ..| .|||  .||||    .||..|| . |.. .|||||  . ||||  .||.|| |  .|||| |||  .|.|.   
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIMKFKMPQGEPHK

----EEAVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFDTGD--RQRSRNTFVGTPCWCLPCECRMAPEVMEQIHGYDFK
    .|.||||.||..||.|.|.|..| ||||.|  ||||...|.| . |||||| | ..||  |. .| ||||||||       |||||||| ||||||
QGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTFVGTPCW-------MAPEVMEQVHGYDFK

ADIWSFGITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERDRR-----FSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
||||||||||.||| | ||. ||||||||. |||| || |. . |.      ...|||.||  || ||| ||||| .||||.||
ADIWSFGITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase FRAY_b.AA STE20 19-287 40 5e-124 418.34 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-288/288
Sequence Identity: 40% (122 aa)

YQLLEEVGQGVSATVYRAMCISFKEI----VAIKSLDLEKCS---SNLDEIRKEAKTMSLINHPNVVRAYCSFVVE----HSLWVVMPYMAGGSCLHIMK
|.|||..||| . .||.| ... .|.    |||| ..||||.     ...| ||   |.  .|||.|. |.|....    ..||.||.|..|||.. |||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

AAYPDG-------FEEAVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFD--TGDRQRS--RNTFVGTPCWCLPCECRMAP
. ...|       ..|. ||......|..|.|||... ||||.|  |||....| .|| ||||.| | .  . |  ..  ||||||||.|       |||
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYW-------MAP

EVMEQ----IHGYDFKADIWSFGITALELAHGHAPFSKYPPMKVLLMTL--QNAPPGLDYERD-RRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
||...     .|||.|.||||.||||.|.| |. |.....||....|..  || || |  .   ...|..|..... ||.||| |||||..||||.|.
EVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDD-KPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase FRAY_b.AA YSK 19-287 42 3.3e-107 323.88 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-257/257
Sequence Identity: 42% (116 aa)

YQLLEEVGQGVSATVYRAMCISFKEIVAIKSLDLEKCSSNLDEIRKEAKTMSLINHPNVVRAYCSFVVEHSLWVVMPYMAGGSCLHIMKAAYPDGFEEAV
.  .| .| |    || .     ...|||| .|||. .   . | .|    |    |.. . | |.    .||..| | .|||||  ||. |  .|.|  
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFDTGDRQRSRNTFVGTPCWCLPCECRMAPEVMEQ-IHGYDFKADIWSFGIT
||..|.  ||.|.|||    ||||.|  |.|.  .| .||.||||.. . ||  .   |||||||| |       |||||  | . .||||||||| |||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIK---RNTFVGTPYW-------MAPEVICQEVSYYDFKADIWSLGIT

ALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERDRRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
|.|.| |. | ..| ||.|.     | || |    .| .||.||| ...||.||| .||.|. ||||.| 
AYEMAKGEPPYCDYHPMRVMFLIPKNNPPKL---EGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase FRAY_b.AA STE 19-287 32 1.5e-106 360.27 In-house 1-359 (359) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-359/359
Sequence Identity: 32% (120 aa)

YQLLEEVGQGVSATVYRAMCI------SFKEI---------VAIKSLDLEKCS----------------SNLDEIRKEAKTMSLIN--HPNVVRAYCSFV
....|..|.| . |||.||..      . .|.         .||| ..||.|.                .....| || |.|.  |  |||.|. |....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VE-------HSLWVVMPYMAGGSCLHIMKAAYPDGFE------------EAVIATVLKDTLKA-LEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSA
.|       ..||..| ||.|||.  |.|  |  |..            | .||......||. |.|||.|. ||||.|  |||.     .|| ||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

CLFDTGD-------------RQRSRNTFVGTPCWCLPCECRMAPEVMEQ-----IHGYDFKADIWSFGITALELAHGHAPFSKYPPMKVLLMTLQN----
.| |...             .|  ||||||||         |||||..|      .|||.|.||||.|.|..|.| |. |.....||....|...|    
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--------WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

-----------APPGLDYERD---------------RRFSKSFKEMIAMCLVKDPTKRPTAEKLLK--HSFF
            || |  . .               ...|..||. |. ||.||| |||||..|||  |.|.
QQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase FRAY_b.AA MST 19-287 40 1.2e-85 272.2 In-house 1-254 (254) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-254/254
Sequence Identity: 40% (111 aa)

YQLLEEVGQGVSATVYRAMCISFKEIVAIKSLDLEKCSSNLDEIRKEAKTMSLINHPNVVRAYCSFV--VEHSLWVVMPYMAGGSCLHIMKAAYPDGFEE
. ..|  |||    ||.| ... ..||||| .  .   . |.|| ||  .|.  . ...|. | |.    .  .| || | ..|| . |||.     . |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVN---EDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRT-LNE

AVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFDTGDRQRSRNTFVGTPCWCLPCECRMAPEVMEQIHGYDFKADIWSFGI
. ||..|.|||. |.|||.   |||| |  |||..  |. || |||||..|.||   .. |||..|||.|       ||||| ..| .|| |||||| ||
QQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDT---MAKRNTVIGTPYW-------MAPEVIQEI-KYDCKADIWSLGI

TALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERD-RRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
||.|.| |. |.|   || .. |  |. ||..   .|  ..|  |   .. ||.|.| .|.||| ||.|.|.
TAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTF---KDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase FRAY_b.AA S_TKc 19-287 31 2.4e-83 284.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-231/231
Sequence Identity: 31% (90 aa)

YQLLEEVGQGVSATVYRAMCISFKEIVAIKSLDLEKCSSNLDEIRKEAKTMSLINHPNVVRAYCSFVVEHSLWVVMPYMAG--GSCLHIMKAAYPDG---
|..|...|.|  ..||..  .. ..||||| ..        . ||.| . ..  .|||.|. | .|.  ..|..|| |. |  |. ....|   . |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FEEAVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFDTGDRQRSRNTFVGTPCWCLPCECRMAPEVMEQIHGYDF-KADI
 | | ... ... ...||||.|.|| ||||.|  |||.|.   ||..|||... |          .||.||| .       |||||.    ||.. |.|.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWY-------MAPEVL----GYGKCKCDW

WSFGITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERDRRFSKSFKEMIAMCLVKDPTKRPTAEKLLK-------HSFF
||.|..  |.. |  ||.    |....  .               |...|..|  ||.|||.||||| ..|.       | .|
WSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FRAY_b.AA PAKA 19-287 35 6e-72 245.35 In-house 1-260 (260) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-260/260
Sequence Identity: 35% (97 aa)

YQLLEEVGQGVSATVYRAMCISFKEI--VAIKSLDLEKCSSNLDEIRKEAKTMSLINHPNVVRAYCSFVVEHSLWVVMPYMAGGSCLHIMKAAY--PDG-
|. .|..||| | .||.|  |. ..   |||| ..... ..  . |  | ..|   .|.|.|. . |..|.. ||||| ||.||.   . ..     .. 
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPK-KELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNY

FEEAVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFDTGDRQRSRNTFVGTPCWCLPCECRMAPEVMEQIHGYDFKADIWS
..|. || |.. .|..||..|... ||||.|  |||....| .|. |||  | | .    |..||| |||| |       |||||  . . || | ||||
MDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQ---EQQKRNTMVGTPYW-------MAPEVIRR-KQYDEKVDIWS

FGITALELAHGHAPFSKYPPMKVLLMTLQN-APPGLDYERDRRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
 || |.|.. |  |. ..|| . .    .| .|. .| .   ..|..|..  . || .|. .|..|..||.| |.
LGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPD---KWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase FRAY_b.AA KHS 19-287 40 1.4e-66 222.9 In-house 1-258 (258) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-258/258
Sequence Identity: 40% (111 aa)

YQLLEEVGQGVSATVYRAMCISFKEIVAIKSLDLEKCSSNLDEIRKEAKTMSLINHPNVVRAYCSFVVEHSLWVVMPYMAGGSCLHIMKAAYPDGFEEAV
|.||  || |    ||.|  |  .|..|.| . .|  . ..  | .|   |    |||.|  . |.. .  ||..| |  |||   | ..  |   .|  
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKME-PGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGP--LSELQ

IATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFDTGDRQRSRNTFVGTPCWCLPCECRMAPEV--MEQIHGYDFKADIWSFGI
|| | ..||..|.||| .| .|||.|  |||. ..| .|| |||||| .  |  . .|   |.||| |       |||||  .|.  ||.   |||. ||
IAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKS---FIGTPYW-------MAPEVAAVERKGGYNQLCDIWAVGI

TALELAHGHAPFSKYPPMKVL-LMTLQN-APPGLDYERDRRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
||.|||    |.    ||..| |||  |  || |  .  ...|..| . . |.|.|.| |||||||||.| |.
TAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL--KDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase FRAY_b.AA Pkinase 19-287 29 1.1e-63 222.72 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

YQLLEEVGQGVSATVYRAMCISFKEIVAIKSLDLEKCSSNLDEIRK---EAKTMSLINHPNVVRAYCSFVVEHSLWVVMPYMAGG----SCLHIMKAAYP
|.... .|.| ...||... ..  .|||.| ..... .|. |...    |.. |  .||||.|| |..|  . ....||.|. ||    .  ..... . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DGF--EEAVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAI----KLGDFGVSACLFDTGDRQRSRNTFVGTPCWCLPCECRMAPEVMEQIHGY
 .|  .| ..  ... .|..|||.|..| ||||.|  |||||.|| |    |..|||.....     ...  .||.||| .       |||||     .|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWY-------MAPEVIRGGQYY

DFKADIWSFGITALELAHGHAPFS------KYPPMKVLLMTLQNAPPGLDYERDRRFS-----------------KSFKEMIAMCLVKDPTKRPTAEKLL
. |.|.||.|..  |.. |. ||.      .   .....     .|.  |.. ... |                 ...|. |  || |||.|||||| .|
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

KHSFF
.| .|
QHPWF
Kinase FRAY_b.AA SLK 19-287 35 7e-61 204.09 In-house 1-259 (259) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-259/259
Sequence Identity: 35% (97 aa)

YQLLEEVGQGVSATVYRAMCISFKEIVAIKSLDLEKCSSNLDEIRKEAKTMSLINHPNVVRAYCSFVVEHSLWVVMPYMAGGSCLHIMKAAYPDGFEEAV
.... |.| |    ||.|     | . | |......   .|..   |   .| ..|||.|. | .. ... ||... . .||    ||      . .|  
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKD-EEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIM-VELEHPLTEDQ

IATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFDTGDRQRSRNTFVGTPCWCLPCECRMAPEVM----EQIHGYDFKADIWSF
|. | | .. ||..||..  ||||.|  |||.  .| ..| |||||| .  | ..   | ||.||| |       |||||.     . . ||.||||||.
IQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQK---RDTFIGTPYW-------MAPEVVMCETFKDQPYDYKADIWSL

GITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERDRRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
||| .|.|..  | .   ||.|||   .  || |  |.  ..||.||...  |||||| .|.|...|..| ..
GITLIEMAQMEPPHHEMNPMRVLLKIQKSEPPTL--EQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase FRAY_b.AA MSN 19-287 34 3e-60 197.56 In-house 1-265 (265) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-265/265
Sequence Identity: 34% (97 aa)

YQLLEEVGQGVSATVYRAMCISFKEIVAIKSLDLEKCSSNLDEIRKEAKTMS-LINHPNVVRAYCSFV------VEHSLWVVMPYMAGGSCLHIMKAAYP
..| | ||.|    ||. .     ...||| .|...   . .||..|   .    .| |..  |  |.       .| ||.|| . . ||   ..| .  
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVRE--DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKG

DGFEEAVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFDTGDRQRSRNTFVGTPCWCLP--CECRMAPEVMEQIHGYDFKA
.   |  || . .. |. | .|| |  ||||.|  |.|.  |  .|| |||||| |  |  |   ||||.||| |  |   .|   |.       ||...
QSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGR---RNTFIGTPYWMAPEVIACDENPDAT-----YDYRS

DIWSFGITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERDRRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
|.|| ||||.|.| |. |  .  ||. |.. . |.|| |     ...|| |.. .  ||.|.  .||..|..|||.| 
DLWSVGITAIEMAEGQPPLCDMHPMRALFLIPRNPPPKLK---SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase FRAY_b.AA STLK 19-158 27 8.7e-35 117.19 In-house 1-143 (313) Show / Hide 
Range on Protein: 19-158
Range on HMM: 1-143/313
Sequence Identity: 27% (40 aa)

YQLLEEVGQG---VSATVYRAMCISFKEIVAIKSLDLEKCSS-NLDEIRKEAKTMSLINHPNVVRAYCSFVVEHSLWVVMPYMAGGSCLHIMKAAYPDGF
| .|.. |..      ..| .  .  .. |..|   .. |.   .  . ||  . .| .|||..  . .|... ..||.|. |. |||  . .  ...|.
YECLRYMGNCFDNMMYVHYARHKP-TGDYVTVKKFNMDQCMEEMYCLFQKECHNSRLMQHPNIFEYWTCFICKNWIWVIMHFMCYGSCKDLLCTYCHWGM

EEAVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKL
 | .|| .... .||| |.|. . |||.||   |||.. |  .|
NEKAIAMIHRGVVKALDYIHQMHYIHRSVKAKHILISTDGKVHL
Kinase FRAY_b.AA Pkinase_Tyr 19-164 25 8.1e-21 71.12 Pfam 1-158 (270) Show / Hide 
Range on Protein: 19-164
Range on HMM: 1-158/270
Sequence Identity: 25% (41 aa)

YQLLEEVGQGVSATVYRAMCI----SFKEIVAIKSLDLEKCSSN---LDEIRKEAKTMSLI-NHPNVVRAYCSFV-VEHS--LWVVMPYMAGGSCLHIMK
 ..... |.|   .||.. .     . |  ||.|.|  |....    ...  .|||.|. . .|||.|| |   .  . .  ...||.||..|. |.  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AA--YPDGFEEAVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVS
.    .. .    .     .  |..|||.... ||||.   |.|...|. .| .||| .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase FRAY_b.AA STLK 195-238 51 6.6e-18 58.28 In-house 178-222 (313) Show / Hide 
Range on Protein: 195-238
Range on HMM: 178-222/313
Sequence Identity: 51% (23 aa)

APEVMEQ-IHGYDFKADIWSFGITALELAHGHAPFSKYPPMKVLL
|||| .| .|||| |.||.| |||..|.| |. ||.. .|.. |.
APEVLNQNLHGYDAKSDIYSVGITCCEMANGCMPFKDMHPTQMLH
Kinase FRAY_b.AA TyrKc 19-287 21 7.1e-17 50.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

YQLLEEVGQGVSATVYRAMCISFKEIVAIKSLDLEKCSSNLDEIRKEAKTMSLI--NHPNVVRAYCSFVVE-------HSLWVVMPYMAGGSCLHIMKAA
 .|... | |   .||... .   . ||.|.|  ..    . ....||. |. .  .|||.|| |   . .       . |..|| ||..|....  .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

YPDGFEEAVIATVLKDTLKALEYLHRHGHIHRDVKVWNILIDSNGAIKLGDFGVSACLFDT------GDRQRSRNTFVGTPCWCLPCE---CR-------
 |. .  .       .  .  ||||... ||||    |.|...|. .| .||| |  . |       .|  |..             |   ..       
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKK-------------EHKGGKTMLPIRW

MAPEVMEQIHGYDFKADIWSFGITALELAHGHAPFSKY-----PPMKVLLMTLQNA----PPGLDYERDRR----FSKSFKEMIAMCLVKDPTKRPTAEK
||||.. . . . .| |.||||..  |.    ..          . . ..  ...     .|  ||          ..   ... .|   || .||| . 
MAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

LLKHSFF
.  |..|
I--HECF
Kinase FRAY_b.AA STLK 254-287 47 5.4e-12 37.64 In-house 280-313 (313) Show / Hide 
Range on Protein: 254-287
Range on HMM: 280-313/313
Sequence Identity: 47% (16 aa)

RRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
||||. | | .. || ..| .|. | .|. ||||
RRFSTHFHEFMEQCLQYNPEQRWSASHLMSHSFF
Kinase FRAY_b.AA Pkinase_Tyr 194-217 41 0.02351 8.6 Pfam 181-203 (270) Show / Hide 
Range on Protein: 194-217
Range on HMM: 181-203/270
Sequence Identity: 41% (10 aa)

MAPEVMEQIHGYDFKADIWSFGIT
||||..     .  | |.||||..
MAPECINYGK-FTTKSDVWSFGVL