Gene FRAY_a-2 (S.moellendorffii)

FRAY_a-2

Species: S.moellendorffii
Alias: FRAY_a-2
External Links:
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: FRAY

Sequence

Name Sequence Type Origin Length Description Download
FRAY_a-2.AA Protein None 354 None Fasta, JSON
FRAY_a-2.NA RNA None 1065 None Fasta, JSON
FRAY_a-2.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of FRAY_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase FRAY_a-2.AA FRAY 17-278 54 1.3e-163 512.38 In-house 1-277 (277) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-277/277
Sequence Identity: 54% (152 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEYVAVKQLDLEKCS-GTLDTIRKEAQTMSLISHSNVVKAHCSFVVSQHLWVVMPYMGGGSCLHIMKATSPDGF---
|.| | ||.| ...|..| |.|. | .|.|  .||||   ..| ..|| | |.. .| |||. | ||||   ||.|| | ..|||| |||   |.|.   
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIMKFKMPQGEPHK

----DEPVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGD--RQWSRKTFVGTPCWMAPEVMEQINGYDFKADVWSFG
    || ||||||...||.|.|.|. | ||||.||||||| |.|.. . |||| |.. . ||  |. .|.|||||||||||||||| .|||||||.||||
QGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTFVGTPCWMAPEVMEQVHGYDFKADIWSFG

ITALELAHGHAPFSKYPPLKVLLMTLQNAAPGLTYERDKR-----FSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
|||.||| | ||. |||| |||. ||||  | |  . |.      ...|||.||  || ||| ||||| .||||.||
ITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase FRAY_a-2.AA STE20 17-278 43 1.4e-131 443.39 In-house 1-288 (288) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-288/288
Sequence Identity: 43% (125 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEY----VAVKQLDLEKCS---GTLDTIRKEAQTMSLISHSNVVKAHCSFVVS----QHLWVVMPYMGGGSCLHIMK
|.|||.|||| .| |..| ..| |||    ||.|...||||.     ...| || . |.   | |.|| ..|....    ..||.||.|.||||.. |||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ATSPDG-------FDEPVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGDRQWS----RKTFVGTPCWMAPEVMEQ--
.. ..|       ..|. ||.|.|..|..|.|||... ||||.||.|||. |.| ||| ||||.| . . | |. .    |.||||||.||||||...  
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-RD-TMQFKRNTFVGTPYWMAPEVIQCME

--INGYDFKADVWSFGITALELAHGHAPFSKYPPLKVLLMTLQNAAPGLTYER--DKRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
   .|||.|.|.||.||||.|.| |. |.....|.....|...|  | .| .    ...|..|..... ||.||| |||||..||||.|.
GPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase FRAY_a-2.AA YSK 17-278 44 1.5e-109 331.03 In-house 1-257 (257) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-257/257
Sequence Identity: 44% (117 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEYVAVKQLDLEKCSGTLDTIRKEAQTMSLISHSNVVKAHCSFVVSQHLWVVMPYMGGGSCLHIMKATSPDGFDEPV
.. .| || |  | |. .  .  .. ||.| .|||. .   . | .| |  |    ... |   |.  .  ||..| | ||||||  ||.    .|||. 
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGDRQWSRKTFVGTPCWMAPEVMEQ-INGYDFKADVWSFGITALELAHG
||.|||  ||.|.||| .  ||||.|| |.|. |.| |||.|||||.   |.  .   | |||||| ||||||  | . .||||||.|| ||||.|.| |
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIK---RNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKG

HAPFSKYPPLKVLLMTLQNAAPGLTYERDKRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
. | ..| |..|.     |  | |.   .. .||.||| ...||.||| .||.|. ||||.| 
EPPYCDYHPMRVMFLIPKNNPPKLE---GRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase FRAY_a-2.AA STE 17-278 30 2.4e-108 366.28 In-house 1-359 (359) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-359/359
Sequence Identity: 30% (113 aa)

YKLLEEIGQGVSGLVFRAFCV------PLGEY---------VAVKQLDLEKCS----------------GTLDTIRKEAQTMSLIS--HSNVVKAHCSFV
....|.||.| .| |..| ..      . ||          .|.||..||.|.                  .. | || ..|.  .  | |.|| .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VS-------QHLWVVMPYMGGGSCLHIMKATSPDGFD------------EPVIATILRDTLKA-LEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAA
.        ..||..| ||.|||.  |.| .   |..            |..||.|.|..||. |.|||... ||||.|..|||.     ||| ||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

FMFDNGD-------------RQWSRKTFVGTPCWMAPEVMEQ-----INGYDFKADVWSFGITALELAHGHAPFSKYPPLKVLLMTLQN-----------
 . |...             .|  |.|||||| ||||||..|      .|||.|.|.||.|.|..|.| |. |.....|.....|...|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----AAPGLTYERD---------------KRFSKSFKEMIAMCLVKDPTKRPTAEKLLK--HSFF
      | |  . .               ...|..||. |. ||.||| |||||..|||  |.|.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase FRAY_a-2.AA S_TKc 17-278 31 3.4e-91 310.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEYVAVKQLDLEKCSGTLDTIRKEAQTMSLISHSNVVKAHCSFVVSQHLWVVMPYMGG--GSCLHIMKATSPDG---
|..|..||.|  | |...  .  |..||.|...        ..||.| | ..   | |.|| . .|.  .||..|| |..|  |. ....|   . |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FDEPVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGDRQWSRKTFVGTPCWMAPEVMEQINGYDF-KADVWSFGITA
 |.| ... ... ...||||.|..| ||||.|  |||. |   .|..|||.|...          .||.||| .|||||.    ||.. |.|.||.|.. 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

LELAHGHAPFSKYPPLKVLLMTLQNAAPGLTYERDKRFSKSFKEMIAMCLVKDPTKRPTAEKLLK-------HSFF
 |.. |  ||.    .....  .               |...|..|  ||.|||.||||| ..|.       | .|
YEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FRAY_a-2.AA MST 17-278 40 6.4e-84 266.62 In-house 1-254 (254) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-254/254
Sequence Identity: 40% (107 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEYVAVKQLDLEKCSGTLDTIRKEAQTMSLISHSNVVKAHCSFV--VSQHLWVVMPYMGGGSCLHIMKATSPDGFDE
. ..| .|||  | |..| .   |..||.|..  .   . |. | ||  .|.     ..||   |.     .|.| || | |.|| . |||.|    . |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVN---EDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRT-LNE

PVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFD-NGDRQWSRKTFVGTPCWMAPEVMEQINGYDFKADVWSFGITALELA
  ||.||.|||. |.|||.   |||| ||||||. . |. || ||||..  .| .. |.    |..|||.|||||| ..| .|| ||| || ||||.|.|
QQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRN----TVIGTPYWMAPEVIQEI-KYDCKADIWSLGITAIEMA

HGHAPFSKYPPLKVLLMTLQNAAPGLTYERDKRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
 |. |.|   |  .. |  |.  |...     ..|  |   .. ||.|.| .|.||| ||.|.|.
EGMPPYSDIHPMRAMFMIPQKPPPTFK--DPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase FRAY_a-2.AA PAKA 17-278 36 9.1e-76 258.03 In-house 1-260 (260) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-260/260
Sequence Identity: 36% (97 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEY--VAVKQLDLEKCSGTLDTIRKEAQTMSLISHSNVVKAHCSFVVSQHLWVVMPYMGGGSCLHIMKATS--PDG-
|| .|.|||| || |..|  .  ..   ||.||.....  .  ..|  |  .|    | |.|.   |..|.  ||||| ||.||.   . ...    .. 
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKN-QPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNY

FDEPVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGDRQWSRKTFVGTPCWMAPEVMEQINGYDFKADVWSFGITALE
.||  || ..| .|..||..|... ||||.|  |||.  .| ||. ||| .| . .    | .|.| |||| ||||||  . . || | |.|| || |.|
MDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQ---EQQKRNTMVGTPYWMAPEVIRR-KQYDEKVDIWSLGIMAIE

LAHGHAPFSKYPPLKVLLMTLQNAAPGLTYERDKRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
.. |  |. ..|||. .    .| .| .      ..|..|..  . || .|. .|..|..||.| |.
MIEGEPPYLNEPPLRAMYLIATNGKPDI--KDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase FRAY_a-2.AA KHS 17-278 40 2.4e-72 242.59 In-house 1-258 (258) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-258/258
Sequence Identity: 40% (107 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEYVAVKQLDLEKCSGTLDTIRKEAQTMSLISHSNVVKAHCSFVVSQHLWVVMPYMGGGSCLHIMKATSPDGFDEPV
| ||  .| |  | |..|  .  .| .||| . .|  .  . .| .|   |   .|.|.|  . |..  ..||..| | ||||   | ..| |    |  
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKME-PGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGP--LSELQ

IATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGDRQWSRKTFVGTPCWMAPEV--MEQINGYDFKADVWSFGITALELAH
|| . |.||..|.||| .| .|||.|  |||. ..| ||| ||||.| .     .   || |.||| ||||||  .|.  ||.   |.|. ||||.||| 
IAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAK---RKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAE

GHAPFSKYPPLKVL-LMTLQNAAPGLTYERDKRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
   |.    |...| |||  |  |    .. ...|..| . . |.|.|.| |||||||||.| |.
LQPPMFDLHPMRALFLMTKSNFQPPKLKDK-HKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase FRAY_a-2.AA Pkinase 17-278 30 1e-68 239.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEYVAVKQLDLEKCSGTLD-TIRK--EAQTMSLISHSNVVKAHCSFVVSQHLWVVMPYMGGG----SCLHIMKATSP
|.... ||.| .| |...  .  |. ||||...... .   | | |.  |.| |  ..| |.|. ...|  ..|...||.|..||    .  ..... . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DGF--DEPVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAV----KLGDFGVAAFMFDNGDRQWSRKTFVGTPCWMAPEVMEQINGYDFKADVW
 .|  .| ..  ... .|..|||.|..| ||||.|  ||||..|| .    |..|||.|...     ..   .||.||| .|||||    ..|. |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGITALELAHGHAPFSKY----PPLKVLLMTLQNAAPGLTYERDKRFS-------------------KSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
|.|..  |.. |. ||.      . .  . |  ..  | | .....  |                   ...|. |  || |||.|||||| .|.| .|
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase FRAY_a-2.AA MSN 17-278 35 3.2e-62 204.17 In-house 1-265 (265) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-265/265
Sequence Identity: 35% (96 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEYVAVKQLDLEKCSGTLDTIRKEAQTMSLIS-HSNVVKAHCSFV------VSQHLWVVMPYMGGGSCLHIMKATSP
..| | .|.|  | |..   |  |. .|.| .|...     . |..|   .   | | |..  .  |.        . ||.|| . | ||   ..| |. 
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVRE--DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKG

DGFDEPVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGDRQWSRKTFVGTPCWMAPEVM----EQINGYDFKADVWSF
.   |  || | |. |. | .|| .  ||||.|  |.|. .|  ||| ||||.| .     |   | ||.||| ||||||.    .    ||...|.|| 
QSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGR---RNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSV

GITALELAHGHAPFSKYPPLKVLLMTLQNAAPGLTYERDKRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
||||.|.| |. |  .  |.. |.. . |..| |     |..|| |.. .  ||.|.  .||..|..|||.| 
GITAIEMAEGQPPLCDMHPMRALFLIPRNPPPKLK---SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase FRAY_a-2.AA SLK 17-278 34 5.5e-60 201.02 In-house 1-259 (259) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-259/259
Sequence Identity: 34% (91 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEYVAVKQLDLEKCSGTLDTIRKEAQTMSLISHSNVVKAHCSFVVSQHLWVVMPYMGGGSCLHIMKATSPDGFDEPV
.... |.| |  | | .|     . . | | .....     | .  | . .| . | |.||   .. . ..||... . .||    ||      .  |. 
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMV-EIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELE-HPLTEDQ

IATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGDRQWSRKTFVGTPCWMAPEVM----EQINGYDFKADVWSFGITALEL
|. . . .. ||..||..  ||||.||||||.  .| |.| ||||.|    . ..   | ||.||| ||||||.     . . ||.|||.||.||| .|.
IQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQK---RDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEM

AHGHAPFSKYPPLKVLLMTLQNAAPGLTYERDKRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
|..  | .   |..|||   .   | |  |.  ..||.||...  |||||| .|.|...|..| ..
AQMEPPHHEMNPMRVLLKIQKSEPPTL--EQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase FRAY_a-2.AA STLK 17-229 33 1.5e-57 196.6 In-house 1-222 (313) Show / Hide 
Range on Protein: 17-229
Range on HMM: 1-222/313
Sequence Identity: 33% (75 aa)

YKLLEEIGQGVSGL--VFRAFCVPLGEYVAVKQLDLEKCSG-TLDTIRKEAQTMSLISHSNVVKAHCSFVVSQHLWVVMPYMGGGSCLHIMKATSPDGFD
|..|...|..  ..  | .|   |.|.||.||   .. |.   .  . ||  . .| .|.|..  . .|.. . .||.|. |  |||  . .   ..|. 
YECLRYMGNCFDNMMYVHYARHKPTGDYVTVKKFNMDQCMEEMYCLFQKECHNSRLMQHPNIFEYWTCFICKNWIWVIMHFMCYGSCKDLLCTYCHWGMN

EPVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGDRQ-----WS-RKTFVGTPCWMAPEVMEQ-INGYDFKADVWSFG
| .|| |.|. .||| |.|. . |||.|||  |||   | |.|  |  . .|   | |.        ...|.  . | |||| .| . ||| |.| .| |
EKAIAMIHRGVVKALDYIHQMHYIHRSVKAKHILISTDGKVHLSGFRHCMWMIEHGQRHRCVFDFPNFHSFKQLY-WLAPEVLNQNLHGYDAKSDIYSVG

ITALELAHGHAPFSKYPPLKVLL
||..|.| |. ||.. .|.. |.
ITCCEMANGCMPFKDMHPTQMLH
Kinase FRAY_a-2.AA Pkinase_Tyr 17-208 25 2.8e-27 93.0 Pfam 1-203 (270) Show / Hide 
Range on Protein: 17-208
Range on HMM: 1-203/270
Sequence Identity: 25% (53 aa)

YKLLEEIGQGVSGLVFRAFCV----PLGEYVAVKQLDLEKCSGT---LDTIRKEAQTMSLI-SHSNVVKAHCSFV-VSQH--LWVVMPYMGGGSCLHIMK
 ......|.|  | |... .       .  |||| |  |...     ..   .||..|. . .| |.|. .   .  ...  ...||.|| .|. |.  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AT--SPDGFDEPVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDNGDR-QWSRKTFVGTPCWMAPE-VMEQINGYDFKAD
.   ... .. . .  . ..  |..|||.... ||||. | |.|..||. || .||| |  ... .   . . ..      |||||  .. .  .  | |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGK--FTTKSD

VWSFGIT
|||||..
VWSFGVL
Kinase FRAY_a-2.AA TyrKc 17-278 22 2.7e-22 81.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

YKLLEEIGQGVSGLVFRAFCVPLGEYVAVKQLDLEKCSGTLDTIRKEAQTMSLI--SHSNVVKAHCSFVVS-------QHLWVVMPYMGGGSCLHIMKAT
 .|....| |  | |...      . |||| |  ..    .  ...||. |. .  .| |.|. .   . .       . |..|| || .|....  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

SPDGFDEPVIATILRDTLKALEYLHRQGHIHRDVKAGNILIHENGAVKLGDFGVAAFMFDN------GDRQWS----RKTFVGTPCWMAPEVMEQINGYD
 |. .  .    .  .  .  ||||... ||||  | |.|..||. || .||| . .  |       .|   .     . ..    |||||.. . . . 
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

FKADVWSFGITALELAHGHAPFSKYPPL----KVLLMTLQNAAPGLTYERDKR--------FSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
.| ||||||..  |.       . ||      .     ...   |   .. .          ..   ... .|   || .||| . .  |..|
TKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase FRAY_a-2.AA STLK 245-278 44 7.8e-12 37.09 In-house 280-313 (313) Show / Hide 
Range on Protein: 245-278
Range on HMM: 280-313/313
Sequence Identity: 44% (15 aa)

KRFSKSFKEMIAMCLVKDPTKRPTAEKLLKHSFF
.|||. | | .. || ..| .|. | .|. ||||
RRFSTHFHEFMEQCLQYNPEQRWSASHLMSHSFF