Gene IRAK-0_bs (S.moellendorffii)

IRAK-0_bs

Species: S.moellendorffii
Alias: IRAK-0_bs
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_bs.AA Protein None 564 None Fasta, JSON
IRAK-0_bs.NA RNA None 1695 None Fasta, JSON
IRAK-0_bs.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_bs.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF26 IRAK-0_bs.AA DUF26 94-139 25 7.5e-08 25.79 Pfam 12-55 (55) Show / Hide 
Range on Protein: 94-139
Range on HMM: 12-55/55
Sequence Identity: 25% (12 aa)

DQTNCASCIQQTYNEF-RQVAPLAVGGVLWTNDTSNRCRLRFENYN-F
. ..|..|...  ... .|  | ..||. |    . .| ||...|. |
SPSDCRDCLATAVRQMLPQCCPNRQGGRIW----YDWCYLRYSDYPNF
Kinase IRAK-0_bs.AA TKL 259-525 20 1.2e-67 231.07 In-house 1-364 (364) Show / Hide 
Range on Protein: 259-525
Range on HMM: 1-364/364
Sequence Identity: 20% (78 aa)

LGQGGFGTVYKATLNN---------GSQVAVKKLSLQSNQGK---------------------------REFVNEITIITGIQHRNLVRLKGYCVEADE-
.|.||||.|||.....         |  |||||.. .... .                            ....|| ..  ..| |.|...||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFLNKGS-LDRALFSSESNAFLDWQSRFQIAIGIARGLAYLHEESH-----VQVIHRDIKASNILLDDKLQ------------
              .|.|.  .|| |.. .          |. |...|..||||..||| .        ..||||.| .|||.|....            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKISDFGISKLFDLDKGFGFTSTK----------------VAGTLGYMAPEYTS----------------RGRLTAKADVFSYGILVLEIASGRKCVD
  .||.|||.|. .. ...   |.|.                . ||...||||                    .  . |.||.|.||.  ||.....   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

PAL-PAEEELLLQ----LSWKLVMANRMSECIDKRLGG----DYAVDEVSRLLRVAMLCTQEHEEARPTMSDVVAML
|   . ... ..|    . ...|  ...   |. .           |   .. . .. | ..  |.||......  |
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_bs.AA IRAK 253-457 35 9.8e-63 214.74 In-house 1-225 (317) Show / Hide 
Range on Protein: 253-457
Range on HMM: 1-225/317
Sequence Identity: 35% (80 aa)

FSKRNKLGQGGFGTVYKATLNNGS-QVAVKKL----SLQSNQGKREFVN---EITIITGIQHRNLVRLKGYCVEADERLLVYEFLNKGSLDRALFSSE-S
|.| |..|.||||.||.. ..|    .|||||    ... |. ...|     |. . . ..| |.| | ||| | ..  |||...  |||   |     .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

NAF--LDWQSRFQIAIGIARGLAYLHEES-HVQVIHRDIKASNILLDDKLQPKISDFGISKLF----DLDKGFG--FTSTKVAGTLGYMAPEYTS--RGR
..   | |. |. |..|.|.|. .||. .  . .||.||| .|||||. ..|||.|||         .. |.    .   .| ||. ||.||.     |.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTAKADVFSYGILVLEIASGRKCVD
|| | ||.| || .||...|.. |.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_bs.AA Pkinase 253-453 29 1.5e-48 172.39 Pfam 1-209 (293) Show / Hide 
Range on Protein: 253-453
Range on HMM: 1-209/293
Sequence Identity: 29% (64 aa)

FSKRNKLGQGGFGTVYKATLNNGSQ-VAVKKLSLQSNQG--KREFVN--EITIITGIQHRNLVRLKGYCVEADERLLVYEFLNKG----SLDRALFSSES
. .  |.|.|.||.|||..  . .. ||||.......    ... ..  || |   ..| | |||.... . |.  .| |....|    .| . .  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NAF-LDWQSRFQIAIGIARGLAYLHEESHVQVIHRDIKASNILLDDKLQP----KISDFGISKLFDLDKGFGFTSTKVAGTLGYMAPEYTS-RGRLTAKA
..| ....    ..  |.|||.|.|..    .||||.| .|||.|.. ..    ||.|||..|.||     .   | ..||..|||||    .   . |.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVFSYGILVLEIASGR
|..|.|... | ..||
DMWSCGCILYEMLCGR
Kinase IRAK-0_bs.AA TKL-Unique 257-452 33 2.6e-45 156.87 In-house 3-224 (290) Show / Hide 
Range on Protein: 257-452
Range on HMM: 3-224/290
Sequence Identity: 33% (74 aa)

NKLGQGGFGTVYKATLNNGSQVAVKKLSL---QSNQGKREFVNEITIITGIQ-HRNLVRLKGYCV----EADERLLVYEFLNKGSLDRALF----SS---
||.|.||.|.|||..  .|..||.|....   .||. ..|| ||....  .. | |.|.. |||.     . .. .| |... |||.  |      .   
NKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

ESNAFLDWQSRFQIAIGIARGLAYLHEESHVQVIHRDIKASNILLDDK-----LQPKISDFGISKLFD-LDKGFGFTS-----TKVAGTLGYMAPEYTSR
..|  |..| | ..|| ||.|. ||| ..   .||||.| ||.|.| .     .. ||.|||.||. .  .|..  ..     . . |.. .|||| ...
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--GRLTAKADVFSYGILVLEIASG
     . |.||.|.|| . |||..
NFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_bs.AA Dicty4 253-450 32 5.8e-45 148.0 In-house 1-211 (277) Show / Hide 
Range on Protein: 253-450
Range on HMM: 1-211/277
Sequence Identity: 32% (69 aa)

FSKRNKLGQGGFGTVYKATLNNGSQVAVKKL-SLQSN-QGKR--EFVNEITIITGIQHRNLVRLKGYCV----EADERLLVYEFLNKGSLDRALFS----
  . ...|.|.||.|||.|   |..|||||| ... |   ..  || .|..|   |.| |.. ..|.|     .  . . | |.. ||.| . | .    
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

SESNAFLDWQSRFQ---IAIGIARGLAYLHEESHVQVIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGF-TSTKVAGTLGYMAPEYTSRGRLTAK
  ..  |||  . .   .|. .|||...||. . . .||||.|..|.| |. .. |..|||.|...  .. ... ..| ..|| ..||||     . . |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT-ACGTPCWMAPEVMMHQPYNEK

ADVFSYGILVLEIA
|||.|.||.  ||.
ADVYSFGIVLWEIL
Kinase IRAK-0_bs.AA MLK 253-453 25 3.7e-43 147.57 In-house 1-233 (291) Show / Hide 
Range on Protein: 253-453
Range on HMM: 1-233/291
Sequence Identity: 25% (61 aa)

FSKRNKLGQGGFGTVYKATLNNGS----QVAVKKLSL------QSNQGKREFVNEITIITGIQHRN----LVRLKGYCVEADE-RLLVYEFLNKGSLDRA
.    ..| |.|| |.|..  |       ||||.         ..   ...|  |. .   ..|.|     ....| | .     ..| |.. .||| . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFSSESNAF-----------LDWQSRFQIAIGIARGLAYLHEESHVQVIHRDIKASNILLDD------KLQPKISDFGISKLFDLDKGFGFTSTKVAGTL
| . .|. .            | .. ...|  .|||..|||..  ...||||.| .|||.|.      ... ||.|||.|  .|. .    . .. |||.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS--RDWHQMC-TNMMSNAGTY

GYMAPEYT---SRGRLTAKADVFSYGILVLEIASGR
 .|||| .     .. . |.||.|.|..  |. ...
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_bs.AA TK 253-451 16 1.3e-40 133.39 In-house 1-389 (486) Show / Hide 
Range on Protein: 253-451
Range on HMM: 1-389/486
Sequence Identity: 16% (64 aa)

FSKRNKLGQGGFG---TVYKATLNNGS--------------------------QVAVKKLSLQSNQGKRE-----------------FVNEITIITG--I
    .|||.| ||   .|||.......                          .|||| | . ... ..|                 ...|. .      
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLVRLKGYCVEADE------------RLLVYEFLNKGS----LDRALFSSES---------------------------------------------
.| |.||| |.|.. ..             ..| |. ..|.    |.  | ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------NAFLDWQSRFQIAIGIARGLAYLHEE--SHV--QVIHRDIKASNILLDDKLQ-----------PKISDFGIS
                            ...|. . .  ..  ||.|..|||.   .    ...|||. | |.|......            ||.||| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------KLFDLDKGFGFTSTKVAGTLG-------------------------YMAPEYTS---------RGRLTAKADVFSYGILVLEIAS
         |....   ....  || .                         .||||             |. | | ||.|.|.|. || .
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_bs.AA STE 253-453 22 2.4e-39 136.64 In-house 1-265 (359) Show / Hide 
Range on Protein: 253-453
Range on HMM: 1-265/359
Sequence Identity: 22% (62 aa)

FSKRNKLGQGGFGTVYKATLNN----------------GSQVAVKKLSLQSNQG-----------------KREFVNEITIITGIQ--HRNLVRLKGYCV
. .  |.|.|.|||||||  ..                |  .|.|...|....                  . .. .|| |    .  | | |.  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EA-------DERLLVYEFLNKGSLDRALF---SSESN--------AFLDWQSRFQIAIGIARG-LAYLHEESHVQVIHRDIKASNILLDDKLQPKISDFG
         ||  .. |... ||||  .    .   .         ... .    |.  | .| |.|||.     .||||||..||||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

ISKLFDLDKG-------------FGFTSTKVAGTLGYMAPEYTSRGR------LTAKADVFSYGILVLEIASGR
... .. .                .  .. ..||  .||||  ....       ..|.|. | |....| | |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_bs.AA Dicty4-Unclassified 256-452 34 5.8e-38 127.58 In-house 4-204 (263) Show / Hide 
Range on Protein: 256-452
Range on HMM: 4-204/263
Sequence Identity: 34% (72 aa)

RNKLGQGGFGTVYKATLNNGSQVAVKKLSLQSNQGK----REFVNEITIITGIQHRNLVRLKGYCVEA----DERLLVYEFLNKGSLDRALF--SSESNA
   .|.| |  |.|     |  |||||.   . .       .|  |. |   ||| |||...|||.           | ||. || |        || . 
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

FLDWQS--RFQIAIGIARGLAYLHEESHVQVIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGFTSTKVAGTLGYMAPEYTSRGRLTAKADVFSYG
 .   .     .|. ||.|...||    . .||||||.||||.|     || |||||   |    | |. | .|||    .||       . |.||.||.
PIKLDDTLIIKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIADFGISRVID----FNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYA

ILVLEIASG
..  | | |
MMLYELATG
Kinase IRAK-0_bs.AA S_TKc 253-529 23 1.6e-37 131.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 253-529
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

FSKRNKLGQGGFGTVYKATLNN-GSQVAVKKLSLQSNQGKREFVNEITIITGIQHRNLVRLKGYCVEADERLLVYEFLNK--GSLDRALFSSESNA----
. . .|.|.|.||.|||.. .. | .||.|...       . . .|| |    .| |.|.|...... |.  .| |...   |.| . . .  ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FLDWQSRFQIAIGIARGLAYLHEESHVQVIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGFTSTKVAGTLGYMAPEYTSRGRLTA-KADVFSYGI
|   . || ..  |...|.|.|  || ..||||.| .|||||.  . ||.|||.....          | . ||. |||||       .  |.|. | |.
FPE-HARF-YMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LVLEIASGRKCVDPALPAEEELLLQLSWKLVMANRMSECIDKRLGGDYAVDEVSRLLRVAMLCTQEHEEARPTMSDVVA-----MLLGYL
.. | ..|.   .     ........                           . ..   . | |   | |||  .. .     ..  ..
ILYEMLCGYPPFP-----QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_bs.AA LRRK 253-453 24 8e-37 127.8 In-house 1-279 (351) Show / Hide 
Range on Protein: 253-453
Range on HMM: 1-279/351
Sequence Identity: 24% (71 aa)

FSKRNKLGQGGFG-TVYKATLNN---------------------------GSQVAVKKLSLQ---------SNQG-------------------------
. . ...|.|||| .||.|....                           .. ||.||. .          .. .                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

KREFVNEITIITGIQHRNLVRLKGYCVEADERLLVYEFLNKGSLDRALFSSESNAF------LDWQSRFQIAIGIARGLAYLHEESHV-QVIHRDIKASN
 ||| .|..|. . .| |.| |||.| .   . .| |..  |.|.. |.......|      ..|. . .||. ||.|..|||  ||   .|||| |  |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH--SHNPPIIHRDLKSPN

ILL---D---------DKLQPKISDFGISKLFDLDKGFGFT-STKVAGTLGYMAPEYTSRG---RLTAKADVFSYGILVLEIASGR
|||   .         .    ||.||||| .|   . |. .   .. |. |.||||    .     | |.|..|.|..  |. ...
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMF---QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAK-0_bs.AA TyrKc 253-525 26 1.8e-36 128.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 253-525
Range on HMM: 1-280/280
Sequence Identity: 26% (79 aa)

FSKRNKLGQGGFGTVYKATLNNGSQVAVKKLSLQSNQGKREFVNEITIITGI--QHRNLVRLKGYCVEA-------DERLLVYEFLNKGSLDRALFSSES
 ..  ||| | ||.|||.|..   |||||.|   .   ...| .|. | . .  .| |.||| |.|..        .  ..| |.  .|.|.  | ... 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NAFLDWQSRFQIAIGIARGLAYLHEESHVQVIHRDIKASNILLDDKLQPKISDFGISKLFDLD------KGFGFT----STKVAGTLGYMAPEYTSRGRL
.  | ..   .... ||.| .|||.    ..||||. | |.|...... |||||| |.  . |      |    .    ..|    .  ||||    |. 
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TAKADVFSYGILVLEIASGRKCVDPALPAEEE----LLLQLSWKLVMANRMSECIDK-----RLGGDYAVDEVSRLLRVAMLCTQEHEEARPTMSDVVAM
| | ||.|.|..  || .     . . | ...    .  |   ..|.. .. .. .             |   . . ..   | .|  | |||.|...  
TTKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase IRAK-0_bs.AA Pkinase_Tyr 253-402 30 8.5e-35 118.47 Pfam 1-160 (270) Show / Hide 
Range on Protein: 253-402
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

FSKRNKLGQGGFGTVYKATLN-----NGSQVAVKKLSLQSNQG---KREFVNEITIITGI-QHRNLVRLKGYCV-EADE--RLLVYEFLNKGSLDRALFS
 ..  |||.| ||.|||.|..     .. .||||.|  .. .    ...| .|. | . . .| |.||| | |. . .    ..| |.  .|.|.  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S-ESNAFLDWQSRFQIAIGIARGLAYLHEESHVQVIHRDIKASNILLDDKLQPKISDFGISKL
  |..  |. .   |... ||.|..||..      ||||. | |.|...... ||.||| ...
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-0_bs.AA TK-Unique 253-451 23 5.1e-34 114.73 In-house 1-234 (294) Show / Hide 
Range on Protein: 253-451
Range on HMM: 1-234/294
Sequence Identity: 23% (56 aa)

FSKRNKLGQGGFGTVYKATLNNGS-------QVAVKKLSLQSNQG-KREFVNEITIITGIQ-HRNLVRLKGYCVEAD-ERLLVYEFLNKGSLDRALFSSE
.   ...|.| ||.|..... ...       .||||.|   ...  |..| .|| .   .  | |.|.. |.|.. |   ....|.. .|.|.  | .. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

SN-----------------------AFLDWQSRFQIAIGIARGLAYLHE--ESHVQVIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGFTSTKVA
 .                       .... .. ...|..||.|..||..  .   ...|||. |.|.|| .... ||.|||...  . ..    . ..  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

GTLGYMAPEYTS--RGRL-TAKADVFSYGILVLEIAS
  . .||||. .  .|   | | || |.|.|  ||..
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_bs.AA TK 502-525 29 0.000399 8.88 In-house 463-486 (486) Show / Hide 
Range on Protein: 502-525
Range on HMM: 463-486/486
Sequence Identity: 29% (7 aa)

RVAMLCTQEHEEARPTMSDVVAML
.. . | ..  | |||.|... .|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_bs.AA TK-Unique 507-525 31 0.001795 7.98 In-house 276-294 (294) Show / Hide 
Range on Protein: 507-525
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CTQEHEEARPTMSDVVAML
|.|. .| ||. .... .|
CWQWEPEERPSFRQIKHRL
Kinase IRAK-0_bs.AA Pkinase_Tyr 423-454 45 0.00375 11.3 Pfam 181-213 (270) Show / Hide 
Range on Protein: 423-454
Range on HMM: 181-213/270
Sequence Identity: 45% (15 aa)

MAPEYTSRGRLTAKADVFSYGILVLEIAS-GRK
||||  . |. | | || |.|.|  || . |..
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAK-0_bs.AA LRRK 505-527 30 0.17657 0.98 In-house 329-351 (351) Show / Hide 
Range on Protein: 505-527
Range on HMM: 329-351/351
Sequence Identity: 30% (7 aa)

MLCTQEHEEARPTMSDVVAMLLG
..| |.. . ||..|..|  |  
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-0_bs.AA Pkinase_Tyr 513-525 46 1.229388 2.78 Pfam 258-270 (270) Show / Hide 
Range on Protein: 513-525
Range on HMM: 258-270/270
Sequence Identity: 46% (6 aa)

EARPTMSDVVAML
| |||.|... .|
EDRPTFSEIHEQL