Gene IRAK-0_as (S.moellendorffii)

IRAK-0_as

Species: S.moellendorffii
Alias: IRAK-0_as
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_as.AA Protein None 445 None Fasta, JSON
IRAK-0_as.NA RNA None 1338 None Fasta, JSON
IRAK-0_as.kin_dom Protein Kinase Domain None 170 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_as.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF26 IRAK-0_as.AA DUF26 74-132 25 0.000326 14.81 Pfam 1-55 (55) Show / Hide 
Range on Protein: 74-132
Range on HMM: 1-55/55
Sequence Identity: 25% (16 aa)

VYANTGCYNRPD--QQSCTVCINIAYSRA-QTSAPLTIGATVWLNETVHQYACSLTFEVYN-F
||.   |  |||   ..|  |.. | ... ... |  .|...|. .      | | ...|. |
VYGMAQC--RPDLSPSDCRDCLATAVRQMLPQCCPNRQGGRIWYDW------CYLRYSDYPNF
Kinase IRAK-0_as.AA TKL 236-399 23 5.1e-52 179.14 In-house 1-243 (364) Show / Hide 
Range on Protein: 236-399
Range on HMM: 1-243/364
Sequence Identity: 23% (59 aa)

LGQGGFGVVYKANLKD---------GTQVAVKKLSLHSKQGK---------------------------QEFVNELNIITGIRHRNLAKLHGYCVEANE-
.|.||||.|||....          |. |||||.. |. . .                           .....|....  .|| |. .. ||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFLENGN-LDSALFQSSLALNWQSRFQITLGIARGLAYLHEESH-----FQIIHRDIKASNVLLDAKLQ--------------
              .|.|. ..|. |.  .        |. |... |.||||..||| .        .|||||.| .|.|.| ...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

PKISDFGLSKLFDLDGEYGVSK------------------VAGTFGYMAPE
.||.|||||. .. .|.   ..                  . ||...||||
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPE
Kinase IRAK-0_as.AA IRAK 230-409 35 4.4e-51 176.02 In-house 1-204 (317) Show / Hide 
Range on Protein: 230-409
Range on HMM: 1-204/317
Sequence Identity: 35% (72 aa)

FSEENQLGQGGFGVVYKANLKDGT-QVAVKKL----SLHSKQGKQEFVN---ELNIITGIRHRNLAKLHGYCVEANERLLVYEFLENGNLD---SALF-Q
|...| .|.||||.||.. .|  |  .|||||    ..  .. .|.|     || . . .|| |.  | ||| |  .  |||... || |    ...  |
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

SSL-ALNWQSRFQITLGIARGLAYLHEES-HFQIIHRDIKASNVLLDAKLQPKISDFGLSKL-----FDLDGEY---GVSKVAGTFGYMAPEYAV--HRR
 .. .| |. |. | .|.|.|. .||. .    |||.||| .|.|||. ..|||.||||          ....|    .|.| ||  ||.||.     ..
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSPK
|..|
LTKK
Kinase IRAK-0_as.AA Pkinase 230-399 28 1.8e-40 144.19 Pfam 1-181 (293) Show / Hide 
Range on Protein: 230-399
Range on HMM: 1-181/293
Sequence Identity: 28% (53 aa)

FSEENQLGQGGFGVVYKANLKDGTQ-VAVKKLSLHSKQGKQE--FVN--ELNIITGIRHRNLAKLHGYCVEANERLLVYEFLENG----NLDSALF-QSS
.  . ..|.|.||.|||.  |.  . ||||.......  ...   ..  |. |   ..| |  .|.... . ..  .| |..|.|     | . .  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

LAL--NWQSRFQITLGIARGLAYLHEESHFQIIHRDIKASNVLLDAKLQP----KISDFGLSKLFDLDGEYGVSKVAGTFGYMAPE
 ..   ..    . . |.|||.|.|..    |||||.| .|.|.| . ..    ||.||||.|.||    .. . ..|| .|||||
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPE
Kinase IRAK-0_as.AA TKL-Unique 234-399 32 3.9e-39 135.7 In-house 3-196 (290) Show / Hide 
Range on Protein: 234-399
Range on HMM: 3-196/290
Sequence Identity: 32% (63 aa)

NQLGQGGFGVVYKANLKDGTQVAVKKLSL---HSKQGKQEFVNELNIITGIR-HRNLAKLHGYCV----EANERLLVYEFLENGNLDSALF---------
| .|.||.|.|||.  . |..||.|....    |.. .||| ||.|..  .. | |. .. |||.     .... .| |... |.|.. |          
NKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

QSSLALNWQSRFQITLGIARGLAYLHEESHFQIIHRDIKASNVLLDAK-----LQPKISDFGLSKLFD--LDGEYGVS------KVAGTFGYMAPE
 ... ||.| | .. . ||.|. ||| ..   |||||.| ||.|.| .     .. ||.||||||. .  ... .. .       . |.| .||||
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE
Kinase IRAK-0_as.AA TK 230-409 14 6e-38 124.27 In-house 1-374 (486) Show / Hide 
Range on Protein: 230-409
Range on HMM: 1-374/486
Sequence Identity: 14% (56 aa)

FSEENQLGQGGFG---VVYKANLKDG--------------------------TQVAVKKLSLHSKQGKQEFVN--------------ELNIITGIR----
   ...||.| ||   .|||. ....                          |.|||| | ... . ..||                |....   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLAKLHGYCVEA------------NERLLVYEFLENGN----LDSALFQSSLA--------------------------------------------
 | |. .|.|.|..                ..| |. ..|.    |.. | ...                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LNWQSRFQITLGIARGLAYLHEE--SHF--QIIHRDIKASNVLLDAKLQ-----------PKISDFG--
                               |. . .  . . ||.|..|||.   . |  ...|||. | |.|.. ...            ||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSKLFDLDGEYGVSKVAGTFG-------------------------YMAPEYAV---------HRRLSPK
      |..  . |..| ...  || .                         .||||            ... ..|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTK
Kinase IRAK-0_as.AA Pkinase_Tyr 230-388 29 3e-36 123.38 Pfam 1-170 (270) Show / Hide 
Range on Protein: 230-388
Range on HMM: 1-170/270
Sequence Identity: 29% (51 aa)

FSEENQLGQGGFGVVYKANLK-----DGTQVAVKKL--SLHSKQ-GKQEFVNELNIITGI-RHRNLAKLHGYCV-EANE--RLLVYEFLENGNLDSALFQ
 .   .||.| ||.|||. .|     ....||||.|  . ...|  ...| .|..| . . .| |. .|.| |. .      ..| |. ..|.|.. | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S---SLALNWQSRFQITLGIARGLAYLHEESHFQIIHRDIKASNVLLDAKLQPKISDFGLSKLFDLDGEYGVSK
      .|. .   |. . ||.|..||..     .||||. | |.|.. ... ||.||||...   |..| . |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRK
Kinase IRAK-0_as.AA LRRK 230-399 24 1.3e-33 116.22 In-house 1-249 (351) Show / Hide 
Range on Protein: 230-399
Range on HMM: 1-249/351
Sequence Identity: 24% (61 aa)

FSEENQLGQGGFG-VVYKANLKD---------------------------GTQVAVKKLSLH----------------------------------SKQG
. .|.|.|.|||| .||.|....                           .. ||.||. ..                                  .   
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

KQEFVNELNIITGIRHRNLAKLHGYCVEANERLLVYEFLENGNLDSALF---QSSL-----ALNWQSRFQITLGIARGLAYLHEESHFQ--IIHRDIKAS
 .|| .|. |. . .| |. .| |.|   . . .| |.. .|.|.. |.   |...      ..|. . .| | ||.|..|||    .   ||||| |  
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS---HNPPIIHRDLKSP

NVLL---D---------AKLQPKISDFGLSKLFDLDGEYGVSKVAGTFGYMAPE
|.||   .         |    ||.|||.| .|  ... ..... |..|.||||
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPE
Kinase IRAK-0_as.AA STE 230-399 21 4.1e-33 114.31 In-house 1-232 (359) Show / Hide 
Range on Protein: 230-399
Range on HMM: 1-232/359
Sequence Identity: 21% (51 aa)

FSEENQLGQGGFGVVYKANLKD----------------GTQVAVKKLSLHSKQG-----------------KQEFVNELNIITGIR--HRNLAKLHGYCV
.    ..|.|.||.||||  ..                |. .|.|...| ...                  .|.. .|..|    .  | |  | .|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EA-------NERLLVYEFLENGNLDSALFQSSLALN-------------WQSRFQITLGIARG-LAYLHEESHFQIIHRDIKASNVLLDAKLQPKISDFG
         .|  .. |....| ||. . .    ..              .    |.  | .| |.|||.     |||||||..|.||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LSKLFDLDG-------------EYG-VS-KVAGTFGYMAPE
... .. ..               .  .  ..||  .||||
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase IRAK-0_as.AA Dicty4 230-399 33 1.6e-31 102.49 In-house 1-187 (277) Show / Hide 
Range on Protein: 230-399
Range on HMM: 1-187/277
Sequence Identity: 33% (63 aa)

FSEENQLGQGGFGVVYKANLKDGTQVAVKKLSLHSKQGK-----QEFVNELNIITGIRHRNLAKLHGYCV----EANERLLVYEFLENGNLDSALFQ---
   |. .|.|.|| |||.. . |..|||||| .| .|.      .|| .| .|   ||| |. .. |.|     .  . . | |..  ||| | |     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNH-NQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

---SSLALNWQSRFQ---ITLGIARGLAYLHEESHFQIIHRDIKASNVLLDAKLQPKISDFGLSKLFDLDGEYGV--SKVAGTFGYMAPE
   .|  | |  . .   . . .|||...||. .   |||||.|..| | |. .. |..|||||...  . . .   . ..|| ..||||
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE
Kinase IRAK-0_as.AA Ciliate-E2 230-399 22 1.2e-30 102.42 In-house 1-257 (365) Show / Hide 
Range on Protein: 230-399
Range on HMM: 1-257/365
Sequence Identity: 22% (59 aa)

FSEENQLGQGGFGVVYKANL-KDGTQVA--------------------VKKLSLHSKQGKQEFVNELNIITGIR----------------HRNLAKLHGY
.   ...|||.||.|||..  |.. |.|                     . .   .|...... .|..|.  |.                | |. |.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CV--EANERLLVYEFLENGNLDS-----ALFQ------SSLALNWQSRFQITLGIAR---------------GLAYLHEESHFQIIHRDIKASNVLLDAK
      |   || |... |.| .      ...        . .... . .|.  |..               .| |||.. .  ||||||| .|.|.   
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF---

LQPKISDFGLSKLFDLD----------GEYGVSK---------------------VAGTFGYMAPE
  .||.|||||| .| |          ..|   |                     ..|| ||||||
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE
Kinase IRAK-0_as.AA MLK 230-399 25 2.7e-30 102.38 In-house 1-203 (291) Show / Hide 
Range on Protein: 230-399
Range on HMM: 1-203/291
Sequence Identity: 25% (52 aa)

FSEENQLGQGGFGVVYKANLKDGTQ-----VAVKKLS---LHSKQG----KQEFVNELNIITGIRHRN----LAKLHGYCVEA-NERLLVYEFLENGNLD
. ..  .| |.||.|.|.. . ..      ||||.       .|.     ...|  | ..   ..|.|      .. | | .  .. ..| |..|.| | 
IQFHEWIGSGSFGKVWKGRWR-NKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

SALFQ-------------SSLALNWQSRFQITLGIARGLAYLHEESHFQIIHRDIKASNVLLDA------KLQPKISDFGLSKLFDLDGEYGVSKVAGTF
. |               ..     .. ... | .|||..|||..   .|||||.| .|.|.|.      ... ||.|||.|. .   .     . |||.
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

GYMAPE
 .||||
AWMAPE
Kinase IRAK-0_as.AA UTK 234-377 28 3.9e-29 96.83 In-house 5-177 (296) Show / Hide 
Range on Protein: 234-377
Range on HMM: 5-177/296
Sequence Identity: 28% (50 aa)

NQLGQGGFGVVYKANLKDGT------QVAVKKLSLHSKQGKQ-----EFVNELN---IITGIR-HRNLAKLHGYCVEANERLLVYEFLENGNLDS-----
.||||| ||.|.|| ... .      .||||... |..  ..     .| .| .   .    . |.|...| |.|.     ..|.|. |||.|.|     
RQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRH

--ALFQSSLALNWQSRFQITLGIARGLAYLHEESHFQIIHRDIKASNVLLDAK-------LQPKISDFG---LSKL
  ....  ..|.  .| .  . ||||..|||.    ...|||. | |.|...        .. ||.|||   .|..
RPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC---GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRR
Kinase IRAK-0_as.AA TyrKc 230-444 21 2.9e-17 56.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 230-444
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FSEENQLGQGGFGVVYKANLKDGTQVAVKKLSLHSKQGKQEFVNELNIITGI--RHRNLAKLHGYCVEA-------NERLLVYEFLENGNLDSALFQSSL
 . . .|| | ||.|||. .|  .|||||.|  ..   ...| .|..| . .  .| |. .|.|.|..           ..| |. ..|.|.. |  .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

ALNWQSRFQITLGIARGLAYLHEESHFQIIHRDIKASNVLLDAKLQPKISDFGLSKLFDLD-------GEYGV-----SKVAGTFGYMAPEYAVHRRLSP
 |...   .. . ||.| .|||.    ..||||. | |.|...... ||||||||.  . |         | .     .|       ||||   ... ..
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

K-------------AELTHRQKP------RALRHSRKCVRTTEYMILIRG---------------------------------IPIPL
|               .     |         .. ...|.. ..|                                      |   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_as.AA S_TKc 230-445 24 1.9e-15 49.64 SMART 1-220 (231) Show / Hide 
Range on Protein: 230-445
Range on HMM: 1-220/231
Sequence Identity: 24% (62 aa)

FSEENQLGQGGFGVVYKANLKD-GTQVAVKKLSLHSKQGKQEFVNELNIITGIRHRNLAKLHGYCVEANERLLVYEFLEN--GNLDSALFQSSL------
.   ...|.|.||.|||.  |. | .||.|...       . . .|..|    .| |. ||...... ..  .| |....  |.| . . .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ALNWQSRFQITLGIARGLAYLHEESHFQIIHRDIKASNVLLDAKLQPKISDFGLSKLFDLDGEYGVSKVAGTFGYMAPEYAVHRRLSP-KA---------
    . || ..  |...|.|.|  || .|||||.| .|.|||   . ||.||||....        . . ||  |||||       .. |.         
FPE-HARF-YMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

-ELTHRQKPRALRHS---RKCVRTTEYMILIRGIPIP----------LQ
 |.  .. |    .    .|.. . |   .||..             ||
YEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQ