Gene IRAK-0_bn (S.moellendorffii)

IRAK-0_bn

Species: S.moellendorffii
Alias: IRAK-0_bn
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_bn.AA Protein None 433 None Fasta, JSON
IRAK-0_bn.NA RNA None 1302 None Fasta, JSON
IRAK-0_bn.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_bn.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_bn.AA IRAK 64-76 38 0.187294 1.12 In-house 1-13 (317) Show / Hide 
Range on Protein: 64-76
Range on HMM: 1-13/317
Sequence Identity: 38% (5 aa)

FSKSRSIGSGAIA
|.|.. ||.|...
FHKDNRIGEGGFG
Kinase IRAK-0_bn.AA IRAK 160-427 27 2.8e-62 213.24 In-house 1-317 (317) Show / Hide 
Range on Protein: 160-427
Range on HMM: 1-317/317
Sequence Identity: 27% (89 aa)

FSKECEVGCGGFGRVYRGNLEDGR-TVAIK----QASAKSKQGQREFRN---EIQLLSRLHHRHLVRLLGFCQSGKNQVLVYEFMENGNLHDRLLGKY-S
|.|.   | |||| |||| .     ..|.|     |. . ..  ..|.    |.....|..| ..| |.|.|  . .  |||..| || |.||| .   .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

GQL--LDCYQRLAIAVAVAQGLDYLHSYA---VIIHRDLKPSNILLDGNLTAKISDFGISKVS----PEFDTHV----STKPAGTAGYLDPEYFL--RRQ
. .  |   ||. |.   | |. .||.      |||.| |..||||| ..|.||.|||    .      ... .      .  ||. |. ||.     .|
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTTASDVYSFGVVLLELITGQKAIDQKRPE---EFNLIEWVKPRLRN-----------------------GGIRSVIDSRIAENFPEEQYLALATIALRC
||. .||||||.||||..||..| .  |||     .|.| ..   .                          .   ||.| ..  |..  ....  |..|
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHR-MPPCPPNMEKEMCQCACCC

AAFDKSERPSIKVSLEAY
..  . .|....  ..  
GHHRANRRCDMAWVMQQL
Kinase IRAK-0_bn.AA TKL 166-419 21 3.1e-60 206.43 In-house 1-356 (364) Show / Hide 
Range on Protein: 166-419
Range on HMM: 1-356/364
Sequence Identity: 21% (78 aa)

VGCGGFGRVYRGNLED---------GRTVAIKQASAKSKQGQ---------------------------REFRNEIQLLSRLHHRHLVRLLGFCQSGKN-
.| |||| ||.|..           |..||.|. . .. .                              ....|| ..|||.| ..|...|.|..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------QVLVYEFMENGNLHDRLLGKYSGQLLDCYQR-LAIAVAVAQGLDYLHSYAV-------IIHRDLKPSNILLDGNLT------------
              .|.|....|.|...|.           .. . .|  .|.|..||||          |||||||..|||.| |.|            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKISDFGISKVS----PEFDTHVSTK--------------PAGTAGYLDPEYFLRR----------------QLTTASDVYSFGVVLLELITGQKAID
  .||.|||.|..        ||  ...              . || ... || .                   . ....||||||.|| |..|...  .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

QKRPEEFNLI---EWVKPRLRNGGIRSVIDSRIA----ENFPEEQYLA-LATIALRCAAFDKSERPS
.  ...  .    |.      . | |  |...         |... .  .. .. .| . | ..|||
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKM-CPCPDCPPSMKKLMQDCWDHDPEKRPS
Kinase IRAK-0_bn.AA S_TKc 160-428 23 2.6e-47 164.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 160-428
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

FSKECEVGCGGFGRVYRGNLED-GRTVAIKQASAKSKQGQREFRNEIQLLSRLHHRHLVRLLGFCQSGKNQVLVYEFMEN--GNLHDRLLGKYSG---QL
. .  ..| |.||.||..   . || ||||. .       . .|.|||.|.. || ..|.|....|. ..  .| |....  |.|.|..  . ..   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDCYQRLAIAVAVAQGLDYLHSYAVIIHRDLKPSNILLDGNLTAKISDFGISKVSPEFDTHVSTKPAGTAGYLDPEYFLRRQLTT-ASDVYSFGVVLLEL
..  .   ..  ....|.|.||   ||||||||.|||||   . ||.|||....         |   ||  |. || .   . .. ..|..|.|..| |.
FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ITGQKAIDQKRPEEFNLIEWVKPRLRNGGIRSVIDSRIAENFPEEQYLALATIALRCAAFDKSERPSIKVSLE--------AYI
..|.   .    ... ... ..                           .  .  .|  .| ..||..   |.         ..
LCGYPPFP----QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_bn.AA MLK 160-356 28 2.4e-46 158.77 In-house 1-233 (291) Show / Hide 
Range on Protein: 160-356
Range on HMM: 1-233/291
Sequence Identity: 28% (68 aa)

FSKECEVGCGGFGRVYRGNLEDGR----TVAIKQAS----AKSKQG--QREFRNEIQLLSRLHHRH----LVRLLGFCQS-GKNQVLVYEFMENGNLHDR
.  .  .| |.|| |..|.    .    .||.|..     .||. .  |..|. |. .|..| |.      ....| |.. ... ..| |..|.| |.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LLGKYSGQL-----------LDCYQRLAIAVAVAQGLDYLHSYAV--IIHRDLKPSNILLD------GNLTAKISDFGISKVSPEFDTH-V-STKPAGTA
| |. |.              |  . . .|. .|.|..|||| |.  |||||||..|||.|      ...|.||.|||.|.   .. ..    .. |||.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR---DWHQMCTNMMSNAGTY

GYLDPEYFLR---RQLTTASDVYSFGVVLLELITGQ
 .  || . .    . . ..||.|.|||| |..|..
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_bn.AA Pkinase 160-356 29 5.2e-46 163.78 Pfam 1-209 (293) Show / Hide 
Range on Protein: 160-356
Range on HMM: 1-209/293
Sequence Identity: 29% (63 aa)

FSKECEVGCGGFGRVYRG-NLEDGRTVAIKQASAKSKQG--QREFRN--EIQLLSRLHHRHLVRLLGFCQSGKNQVLVYEFMENG----NLHDRLLGKYS
. ..  .| |.||.||.. .  .|..||.|. . ...    ... |.  |||.. ||.| . |||.........  .| |..|.|     |.|.. ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GQL-LDCYQRLAIAVAVAQGLDYLHSYAVIIHRDLKPSNILLDGNLTA----KISDFGISKV-SPEFDTHVSTKPAGTAGYLDPEYFL-RRQLTTASDVY
| . ..  .   ..  ...||.|.||   ||||||||.|||.| | .     ||.|||..|. . .   .  | ..|| .|. ||  . ..  ....|..
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVVLLELITGQ
|.|..| |...|.
SCGCILYEMLCGR
Kinase IRAK-0_bn.AA RIPK 166-358 29 2.5e-42 142.06 In-house 1-227 (290) Show / Hide 
Range on Protein: 166-358
Range on HMM: 1-227/290
Sequence Identity: 29% (68 aa)

VGCGGFGRVYRGNLEDGRTVAIKQASA-KS------KQGQREFRNEIQLLSRLHHRHLVRLLGFCQSG-----KN-QVLVYEFMENGNLHDRLLGKYSG-
|| |||| |..    . .....| ..  |       .| . .   | . . .| ..| |...||||        . . .| |.||||.| . |  | .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---QLLDCYQRLAIAVAVAQGLDYLHSYA-VIIHRDLKPSNILLDGNLTAKISDFGISK---VSPEFD---------THVSTKPAGTAGYLDPEYFL--R
    ...   |  . . .. |  ||||   .||||||||.|||.|.|. .||.||| ..    |  ..            | .. ||  |..|| |.   
HHPDPWPLRCR--MIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDN

RQL----TTASDVYSFGVVLLELITGQKA
.      |...|||||..|. |. |. ..
KKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-0_bn.AA TK 160-354 17 5.7e-42 138.0 In-house 1-389 (486) Show / Hide 
Range on Protein: 160-354
Range on HMM: 1-389/486
Sequence Identity: 17% (68 aa)

FSKECEVGCGGFG---RVYRGNLEDGR--------------------------TVAIKQASAKSKQGQREFRN-----------------EIQLLS--RL
   . . | | ||   .||.| .....                          .||.|.  ... . |.||.                  |.....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHRHLVRLLGFCQSGKN------------QVLVYEFMENGN----LHDRLL--GKYSGQLLDCY------------------------------------
|| ..|||.| |  |..              .| |.|..|.    |.| |    ..  . .||.                                    
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------------QRLAIAVAVAQGLDYLHSYAV-----IIHRDLKPSNILLDGNLT-----------AKISDFGISK
                                   |.| ... .|.|. ||||  .     ..||||   |.|.. |..           .||.||| |.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----VSPEFD---THVSTKPAGTAG-------------------------YLDPEYFLRRQ---------LTTASDVYSFGVVLLELIT
      . . .     ..... ||..                         .. || .. |.          ||.|||.||||.. |. |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_bn.AA TKL-Unique 165-356 33 9.8e-40 137.83 In-house 4-225 (290) Show / Hide 
Range on Protein: 165-356
Range on HMM: 4-225/290
Sequence Identity: 33% (75 aa)

EVGCGGFGRVYRGNLEDGRTVAIKQASA---KSKQGQREFRNEIQLLSRLH-HRHLVRLLGFCQ----SGKNQVLVYEFMENGNLHDRLL-------GKY
 .| ||.|.||.|    |  ||||| .    .|..  .||.||. ....|| |  .|.. |.|     . .|  .| |... |.|.| |           
KIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

SGQLLDCYQRLAIAVAVAQGLDYLHSYAV-IIHRDLKPSNILLDGN-----LTAKISDFGISKVSP-EFDTHVSTK-------PAGTAGYLDPEYFLR--
.   |.  ||. .|  .|||..|||..   |||||||.||.|.| |     . .||.|||.||..  . .. ....       . |.. .. || . .  
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF

RQLTTASDVYSFGVVLLELITGQ
 | .. |||||||.|| |..|..
CQYSEKSDVYSFGIVLWEIATRK
Kinase IRAK-0_bn.AA LRRK 160-356 26 2.4e-37 129.66 In-house 1-279 (351) Show / Hide 
Range on Protein: 160-356
Range on HMM: 1-279/351
Sequence Identity: 26% (76 aa)

FSKECEVGCGGFG-RVYRGNLED---------------------------GRTVAIKQASAK----------------------------------SKQG
. .| ..| |||| .|||.....                           . .||||.                                      .   
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QREFRNEIQLLSRLHHRHLVRLLGFCQSGKNQVLVYEFMENGNLHDRLLGKYSGQL------LDCYQRLAIAVAVAQGLDYLHSYA-VIIHRDLKPSNIL
 ||||.|. ..|.|.| ..| |.||| .     .| |.. .|.|...|  | . ..      ..   .| ||. .| |..||||    |||||||. |||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

L---D---------GNLTAKISDFGISKVSPEFDTH-VSTKPAGTAGYLDPEYFL---RRQLTTASDVYSFGVVLLELITGQ
|   .          . .|||.||||| .    ... |  .  |. |.. ||      . . |. .|.||||..| ||.|.|
LWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAK-0_bn.AA Ciliate-E2 160-356 19 4.5e-37 124.79 In-house 1-293 (365) Show / Hide 
Range on Protein: 160-356
Range on HMM: 1-293/365
Sequence Identity: 19% (59 aa)

FSKECEVGCGGFGRVYRGNL-EDGR--------------------TVAIKQASAKSKQGQREFRNEIQLLSRLH----------------HRHLVRLLGF
. .    | |.|| ||...  ....                    .. |.    ..|.. ... .||... ...                | .....  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CQ--SGKNQVLVYEFMENGNLHDRLL--GKYSGQL------LDCYQRLAIAVAVAQ---------------GLDYLHSYAVIIHRDLKPSNILLDGNLTA
 |  . .|  || |. . |.| |..    | ...       ....... |   ..|               .| ||||   |||||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KISDFGISKVSPEF-----------------DTHVSTK-------------PAGTAGYLDPEYFLRRQ---------LTTASDVYSFGVVLLELITGQ
||.|||.||   ..                 ||....               .||.||. || . . .          ....|..|.||.| |...|.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK
Kinase IRAK-0_bn.AA Dicty4 160-356 32 6.2e-37 120.83 In-house 1-214 (277) Show / Hide 
Range on Protein: 160-356
Range on HMM: 1-214/277
Sequence Identity: 32% (70 aa)

FSKECEVGCGGFGRVYRGNLEDGRTVAIKQA-SAKSK---QGQREFRNEIQLLSRLHHRHLVRLLGFCQ----SGKNQVLVYEFMENGNLHDRLLGKYSG
  .| . | |.|| ||.|.   |  ||.| . . . .       |||.|. ... . | ... ..| |          . | |.|  |||.  |. | | 
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

QL----LD--CYQR-LAIAVAVAQGLDYLHS-YAVIIHRDLKPSNILLDGNLTAKISDFGISK-VSPEFDTHV-STKPAGTAGYLDPEYFLRRQLTTASD
|     ||   . | . .|  .|.|. .||.   ||||||||..|.| | |...|..|||.|.   .. |     . ..||...  ||    .  . ..|
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKAD

VYSFGVVLLELITGQ
||||| || |. |.|
VYSFGIVLWEILTRQ
Kinase IRAK-0_bn.AA Ciliate-E2-Unclassified 160-356 22 1.1e-35 121.26 In-house 1-267 (352) Show / Hide 
Range on Protein: 160-356
Range on HMM: 1-267/352
Sequence Identity: 22% (61 aa)

FSKECEVGCGGFGRVYRG-NLEDGRTVAIKQASAKSKQGQREF------------RNEIQ-------------LLSRLHHRHLVRLLGFCQSGKNQVLVY
. .    | |||| ||.  . ...   |.|... . .. |.               |...             .|. . | ..|...   |. .|  .|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFMENGNLHDRLL--------------GKYSGQLLDCYQRL-----AIAVAVAQGLDYLHSYAVIIHRDLKPSNILLDGNL---TAKISDFGISK---VS
|..|.|.|.. .                ..... ....| .      ..  . |||.|||.   |||||.||.|||.| |      ||.||||||    .
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

PEFDTHV------------STKPAGTAGYL----DPEYFLRRQLT----TASDVYSFGVVLLELITGQ
...| .             ..  .|| .|.     ||.. . .       ..|..|.||.| |...|.
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY
Kinase IRAK-0_bn.AA Pkinase_Tyr 160-306 31 4.8e-35 119.31 Pfam 1-159 (270) Show / Hide 
Range on Protein: 160-306
Range on HMM: 1-159/270
Sequence Identity: 31% (50 aa)

FSKECEVGCGGFGRVYRGNLE-----DGRTVAIKQASAKSKQGQ---REFRNEIQLLSRL-HHRHLVRLLGFCQ-SGKN--QVLVYEFMENGNLHDRLLG
 ..  . | | ||.||.| .      .. .||.|    .. . |   ..| .|..... | || ..|||.| |   |.     .| |.|..|.|.| |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K-YSGQLLDCYQRLAIAVAVAQGLDYLHSYAVIIHRDLKPSNILLDGNLTAKISDFGISK
.  ..| |.  . | ... .|.|..||.|   .|||||   |.|.. |...||.||| ..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase IRAK-0_bn.AA TyrKc 160-427 26 3.3e-32 114.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 160-427
Range on HMM: 1-280/280
Sequence Identity: 26% (79 aa)

FSKECEVGCGGFGRVYRGNLEDGRTVAIKQASAKSKQGQREFRNEIQLLSRL--HHRHLVRLLGFCQSG-------KNQVLVYEFMENGNLHDRLLGKYS
 ... . |.| ||.||.| .   ..||.|   . .   ...|..|......|  || ..|||.| | ..       .   .| |.|..|.|.|.|  .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

GQLLDCYQRLAIAVAVAQGLDYLHSYAVIIHRDLKPSNILLDGNLTAKISDFGISKVSPEF-------DTHV-----STKPAGTAGYLDPEYFLRRQLTT
   |   . | ... .|.| .||||   .|||||   |.|.. |.|.|||||| |.   .        |. .     ..|       . || .  .  ||
K--LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

ASDVYSFGVVLLELITGQKAIDQKRPEE----FNLIEWVKPRLRNGGIRSVIDSRIAENF-----PEEQYLALATIALRCAAFDKSERPSIKVSLEAY
.|||.||||.. |. |     .|  |..     . .| |  ....|. .   ..   .       |.|    . .| ..| ..| ..||. .   |  
KSDVWSFGVCMWEIFTY---GQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDY-P-MSFVCCPDE----MYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_bn.AA Pkinase_Tyr 328-357 45 0.000231 15.4 Pfam 183-213 (270) Show / Hide 
Range on Protein: 328-357
Range on HMM: 183-213/270
Sequence Identity: 45% (14 aa)

PEYFLRRQLTTASDVYSFGVVLLELIT-GQK
|| .  .  ||.|||.||||.. |..| |..
PECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAK-0_bn.AA APH 172-275 22 0.004851 11.25 Pfam 11-112 (248) Show / Hide 
Range on Protein: 172-275
Range on HMM: 11-112/248
Sequence Identity: 22% (25 aa)

GRVYRGNLEDGR-TVAIKQASAKSKQGQREFRNEIQLLSRLHHRHL---V-RLLGFCQSGKNQVLVYEFMENGNLHDRLLGKYSGQL-LDCYQRLAIAVA
.|.|.   .| | ..  .....   . ..|...|...| .|. ...   | |.|..|. .  . .....||    .|           |.| || |.. |
NRTYYRTTDD-RPRYVLRRYPPP--WWAEELHREHRWLRHLAAHGIPVPVPRVLWGCTDDEFHGWPWYLMEWLPGEDLWRW-----HALHCAQRPALLEA

VAQGLDYLHS
.|. |  ||.
LARFLARLHQ
Kinase IRAK-0_bn.AA APH 277-294 27 0.367409 4.84 Pfam 170-191 (248) Show / Hide 
Range on Protein: 277-294
Range on HMM: 170-191/248
Sequence Identity: 27% (6 aa)

AVIIHRDLKPSNILLD----GN
....|.|..| |...|    |.
PCWCHGDFHPGNVMWDPRPDGG