Gene IRAK-0_bm (S.moellendorffii)

IRAK-0_bm

Species: S.moellendorffii
Alias: IRAK-0_bm
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_bm.AA Protein None 272 None Fasta, JSON
IRAK-0_bm.NA RNA None 819 None Fasta, JSON
IRAK-0_bm.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_bm.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_bm.AA TKL 45-240 20 2.6e-38 133.58 In-house 1-290 (364) Show / Hide 
Range on Protein: 45-240
Range on HMM: 1-290/364
Sequence Identity: 20% (62 aa)

LGQGASGVVYRGRSSG---------GYNVAVKQLINVEF------------------------KYLVHQAGFAKEIEILSRARHKNVAGLLGFCNSRDD-
.|.|..|.||.|.  |         |. ||||..   .                         ..   .  . .|| ..|| || |.  ..|.|.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KFLVSEYVPGPN-LTAFLSGQRRKEFDWDKRKIVILGVAKGLAYLHSSG------MEIIHGSLKPSNILIDDDFT-------------
             ..| ||.|| . |  ..         |..|   .|..|.|..||||..      . |||  ||..|||.|...|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKLTDHGLYRLLQQTSS-------------------QARDVR-NAVYDPPEASTGTLMSSKG----------------DSYGFGVFLIQMITGQPPWF
 .|..| || | ..|...                   .   .. .  . .||.  |..  ..                 | | ||. |  ..|...|..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
Kinase IRAK-0_bm.AA IRAK 39-238 31 4.7e-31 107.35 In-house 1-223 (317) Show / Hide 
Range on Protein: 39-238
Range on HMM: 1-223/317
Sequence Identity: 31% (71 aa)

FDETNILGQGASGVVYRGRSSGGY-NVAVKQLI-NVEFKYLVHQAGFAK---EIEILSRARHKNVAGLLGFCNSRDDKFLVSEYVPGPNLTAFLSGQRRK
|.. | .|.|. |.||||. ..    .||| |. ... .   |   |     |.....| ||.|.  |.|.|  |..  || .| |.  | . |..|   
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

EF----DWDKRKIVILGVAKGLAYLHSSG--MEIIHGSLKPSNILIDDDFTPKLTDHGLYR------LLQQTSS---QARDVRN-AVYDPPEAST---GT
       | .|. . .| |.|. .||. .    ||||  |..||| |..||||..| || |       . ....    .  ||  . | |||. .   | 
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LMSSKGDSYGFGVFLIQMITGQPP
| . | | | ||. |   .||...
L-TKKTDVYSFGIVLLEVLTGCRA
Kinase IRAK-0_bm.AA Pkinase 39-239 29 4.2e-29 103.98 Pfam 1-212 (293) Show / Hide 
Range on Protein: 39-239
Range on HMM: 1-212/293
Sequence Identity: 29% (63 aa)

FDETNILGQGASGVVYRGRSSGGYN-VAVKQLINVEFKYLVHQAGFA-KEIEILSRARHKNVAGLLGFCNSRDDKFLVSEYVPGP----NLTAFLSGQRR
.    ..|.|..|.||...  |    ||||..  .. |  ..|. .   ||.|. | .|.|.  |.... ..|.  .| ||..|      | ...|..|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KEF--DWDKRKIVILGVAKGLAYLHSSGMEIIHGSLKPSNILIDDDFTP----KLTDHGLYRLL-QQTSSQARDVR-NAVYDPPEAST-GTLMSSKGDSY
. |  ...  | ... ...||.|.||  | |||  |||.|||||.. ..    |..| || ...    .| . ..     | .||    |.  ..| | .
GCFYFSEWECKFYMYQILRGLEYCHS--MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

GFGVFLIQMITGQPPW
..|. |..|..|.||.
SCGCILYEMLCGRPPF
Kinase IRAK-0_bm.AA TKL-Unique 42-236 25 8.8e-23 77.29 In-house 2-225 (290) Show / Hide 
Range on Protein: 42-236
Range on HMM: 2-225/290
Sequence Identity: 25% (57 aa)

TNILGQGASGVVYRGRSSG-GYNVAVKQLI-NVEFKYLVHQAGFAKEIEILSRAR-HKNVAGLLGFCN----SRDDKFLVSEYVPGPNLTAFLSG-----
 | .|.|..|.||.|   . || ||.||.  | ..   . |  | .|. .... . |.|.  . |.|     .  . ..|.||.|| .|   |.      
WNKIGEGGYGQVYKGK--WRGYPVAIKQFHPNEDSSNEMMQE-FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---QRRKEFDWDKRKIVILGVAKGLAYLHSSGMEIIHGSLKPSNILIDDD-----FTPKLTDHGLYRLLQ--QTSSQARD--------VRNAVYDPPEAS
    . ..... .|   .. .|.|. |||...  |||. ||.||.|.| .     .  |. | || ...    ...  .         . .. . .||  
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

TG--TLMSSKGDSYGFGVFLIQMITGQ
..  .. | | | | ||. |. ..|..
RMNFCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAK-0_bm.AA TK 39-238 13 1.5e-22 71.7 In-house 1-395 (486) Show / Hide 
Range on Protein: 39-238
Range on HMM: 1-395/486
Sequence Identity: 13% (54 aa)

FDETNILGQGASG---VVYRG--------------------------RSSGGYNVAVKQLINV-EFKYLVHQA-------------GFAKEIEILS--RA
    . ||.|. |   .||.|                           . |   ||||.|    .     ...              .| |.....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHKNVAGLLGFCNSRDDK------------FLVSEYVPGPN----LTAFLSGQRRK--------------------------------------------
.|.|.  |.| |   . |             .| ||.|. .    |  .|   |.|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------EFDWDKRKIVILGVAKGLAYLHSSGM----EIIHGSLKPSNILIDDDFT-----------PKLTDHG---
                               ..   .    . .|.|..|||| .      ..|. |   |.|.... .            |..| |   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LYRLLQQ----TSSQARDVRNAVYD------------------------PPEASTGTL---------MSSKGDSYGFGVFLIQMIT-G-QPP
     | | ...    .... ....  . .                        .||. ..            ..| | . |||..  . | | .|.
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPY
Kinase IRAK-0_bm.AA Ciliate-E2 39-239 18 2.8e-22 73.27 In-house 1-296 (365) Show / Hide 
Range on Protein: 39-239
Range on HMM: 1-296/365
Sequence Identity: 18% (55 aa)

FDETNILGQGASGVVYRG--RSSGGYN----------------------VAVKQLINVEFKYLVHQAGFAKEIE----------ILSRARHKNVAGLLGF
..  ...|||. |.||..  .. .                         .|.|.... . ...       .||.          ||..  |.|.  .  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CN--SRDDKFLVSEYVPGPNLTAFLS---GQRRKE------FDWDKRKIVILGVAK---------------GLAYLHSSGMEIIHGSLKPSNILIDDDFT
    ...  .|| ||. | .|  ..     .| .|      |.. ..| ..  ...               .| |||| .  |||  .||.|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

PKLTDHGLYRLLQ---------QTSSQARDVR------------------------NAVYDPPEASTGTL---------MSSKGDSYGFGVFLIQMITGQ
.|..| || . ..         | .    . .                        .. | .||   |            . | | . .|| | .|..|.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPW
||.
PPF
Kinase IRAK-0_bm.AA MLK 39-238 26 3.2e-21 70.47 In-house 1-235 (291) Show / Hide 
Range on Protein: 39-238
Range on HMM: 1-235/291
Sequence Identity: 26% (63 aa)

FDETNILGQGASGVVYRGRSSGGY----NVAVKQ-LINVEFKYLVH---QAGFAKEIEILSRARHKN----VAGLLGFCNSR-DDKFLVSEYVPGPNLTA
...  ..| |..|.|..||  .       ||||.  .. .    .    |  | .|...|.. .|.|    .  ..| |..   . ..|.||..|  |  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

FLSGQRRKEF------------DWDKRKIVILGVAKGLAYLHSSG-MEIIHGSLKPSNILIDD------DFTPKLTDHGLYRLLQQT-SSQARDVRNAVY
.| |.| |..            | |      | .|.|..||||   . |||  ||..|||||.      . | | .| |. | ..|. .       .. .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

DPPEA---STGTLMSSKGDSYGFGVFLIQMITGQPP
  ||.   . ..  | | | . .|| | .|.|.. |
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_bm.AA STE 39-183 21 9.1e-20 66.56 In-house 1-190 (359) Show / Hide 
Range on Protein: 39-183
Range on HMM: 1-190/359
Sequence Identity: 21% (42 aa)

FDETNILGQGASGVVYRGRSS-GG-YN--------------VAVKQLINVEF--------------KYLVHQAGFAKEIEILSRAR--HKNVAGLLGFCN
..   ..|.||.|.||...    . ..              .|.||.   .               |    .  . |||.|... .  |.|.   .| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-------SRDDKFLVSEYVPGPNLTAFLS---GQRR---------KEFDWDKRKIVILGVAKG-LAYLHSSGMEIIHGSLKPSNILIDDDFTPKLTD
       ..|. ... ||..|  |. ..    |  .         . |. .  ....  . || |.|||| .  |||  .||.|||.      ||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCD
Kinase IRAK-0_bm.AA Ciliate-E2-Unclassified 39-238 18 3.1e-19 63.39 In-house 1-269 (352) Show / Hide 
Range on Protein: 39-238
Range on HMM: 1-269/352
Sequence Identity: 18% (50 aa)

FDETNILGQGASGVVYRGRSSGGYNVAVKQLINVEFKYLVHQAGF----------AKEIE-------------ILSRARHKNVAGLLGFCNSRDDKFLVS
.    ..|||. |.||. . .  . ..... ...  .| ..|  .           ....             ||.   | ..  ..   ....  ..| 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYVPGPNLTAFLSG---------------QRRKEFDWDKRK-----IVILGVAKGLAYLHSSGMEIIHGSLKPSNILIDDD---FTPKLTDHGLYRLLQ-
||..| .|  ...                ..||.|.  . |       .  . .|| |||...  |||  .||.|||.|..   . .|..| |. . .| 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------QTSSQARDVRNAVYD----PPEASTGTLMS----SKGDSYGFGVFLIQMITGQPP
               .   .   . .  |     .||   |   .     | | ...|| | .|..|..|
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase IRAK-0_bm.AA Dicty4 39-196 28 4.5e-19 60.4 In-house 1-170 (277) Show / Hide 
Range on Protein: 39-196
Range on HMM: 1-170/277
Sequence Identity: 28% (50 aa)

FDETNILGQGASGVVYRGRSSGGYNVAVKQL--INVEF-KYLVHQAGFAKEIEILSRARHKNVAGLLGFCN----SRDDKFLVSEYVPGPNLTAFLSG--
 . ....|.|. | ||.|.   |  |||| |   |. |  ..     |.||..|..  || |.  ..| |.       .   |.||.|  ||   |    
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNE--FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

---QRRKEFDWDKRKI---VILGVAKGLAYLHSSGMEIIHGSLKPSNILIDDDFTPKLTDHGLYRLLQQTSSQ
   | ... ||  .|      . .|.|...||..   |||  ||..|.|.|.... | .| || .. .  ...
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDH
Kinase IRAK-0_bm.AA TK-Unique 39-186 25 2.2e-18 60.08 In-house 1-179 (294) Show / Hide 
Range on Protein: 39-186
Range on HMM: 1-179/294
Sequence Identity: 25% (46 aa)

FDETNILGQGASGVVYRGRSSGGY-------NVAVKQLINVEFKYLVHQAGFAKEIEILSRAR-HKNVAGLLGFCNSRD-DKFLVSEYVPGPNLTAFLSG
.   ...|.|| | |.||  .|.        .||||.|   .   .. .. | |||....    |.|.  .|| | . | . ... ||.|. ||  .|  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK--DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

QRRKEFDW---------------DKRK--IV-------ILGVAKGLAYLHSSGMEIIHGSLKPSNILIDDDFTPKLTDHGL
 |.. ..                ..|.  |        . ..|.|..||.|  ..|.|. |  .|.|. .|.. |..| |.
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGM
Kinase IRAK-0_bm.AA S_TKc 39-269 23 9.4e-15 39.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 39-269
Range on HMM: 1-231/231
Sequence Identity: 23% (61 aa)

FDETNILGQGASGVVYRGRSSG-GYNVAVKQLINVEFKYLVHQAGFAKEIEILSRARHKNVAGLLGFCNSRDDKFLVSEYVPG--PNLTAFLSGQRRKE-
..  ...|.|| |.||..|  . |  ||.|..             . .||.||.. .|.|.  |.... . |. ..| ||..|   .|  ..  ..|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDWDKRKIVILGVAKGLAYLHSSGMEIIHGSLKPSNILIDDDFTPKLTDHGLYRLLQQTSSQARDVRNAVYDPPEASTGTLMSS-KGDSYGFGVFLI
   |.    . ..  ....|.|.|| |  |||  |||.|||.|.  . |..| || |.|         .    | .||       .  | | . .|. |.
RFPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

QMITGQPPWF----LLETVRSAGVMLRDWVWKFFFHFHF----------------TRFF
 |..|.||.     ... ..     ..| . | .                       .|
EMLCGYPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase IRAK-0_bm.AA Pkinase_Tyr 39-156 25 2.3e-12 42.53 Pfam 1-129 (270) Show / Hide 
Range on Protein: 39-156
Range on HMM: 1-129/270
Sequence Identity: 25% (34 aa)

FDETNILGQGASGVVYRGRSS-----GGYNVAVKQLINVEFKYLVH--QAGFAKEIEILSRA-RHKNVAGLLGFCNSRDDK---FLVSEYVPGPNLTAFL
      ||.|| |.||.|.       ... |||| | . |     .  .. | .|..|..   .|.|.  |.| | ....    ..| ||.|. .|  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-K-EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

SGQ--RRKEFDWDKRKIVILGVAKGLAYLHS
  .   .. ..        . .|||..||.|
RKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase IRAK-0_bm.AA TyrKc 39-269 21 5.2e-12 -28.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 39-269
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FDETNILGQGASGVVYRGRSSGGYNVAVKQLINVEFKYLVHQAGFAKEIEILSRA--RHKNVAGLLGFCNSR-------DDKFLVSEYVPGPNLTAFLSG
     .|| || |.||.|. .  ..|||| | .        .. | .|..|...   .|.|.  |.| | .        .  ..| ||.|. .|  .|  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QRRKEFDWDKRKIVILGVAKGLAYLHSSGMEIIHGSLKPSNILIDDDFTPKLTDHGLYRLL----------QQTSS----QARDVRNAVYDPPEASTGTL
 |.| . ...     . .|.| .||||    .||  |   |.|.....| | .| || | .          .  ..    .....      .||.     
HRPK-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

MSSKGDSYGFGVFLIQMIT-GQPPWF-----------LLETVRSAGVMLRDWV--------------------WKF------FFHFHFTRFF
 ..| | . ||| .  . | ||.|.            ..| |.. . | .                       |..       |     ..|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase IRAK-0_bm.AA STE 217-240 41 0.080585 2.36 In-house 246-269 (359) Show / Hide 
Range on Protein: 217-240
Range on HMM: 246-269/359
Sequence Identity: 41% (10 aa)

SSKGDSYGFGVFLIQMITGQPPWF
. | | . .|  .| |.||.|||.
DTKCDIWSLGCTIIEMATGKPPWH