Gene IRAK-0_bh (S.moellendorffii)

IRAK-0_bh

Species: S.moellendorffii
Alias: IRAK-0_bh
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_bh.AA Protein None 653 None Fasta, JSON
IRAK-0_bh.NA RNA None 1962 None Fasta, JSON
IRAK-0_bh.kin_dom Protein Kinase Domain None 216 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_bh.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_bh.AA TKL 328-609 22 5.4e-62 212.28 In-house 1-364 (364) Show / Hide 
Range on Protein: 328-609
Range on HMM: 1-364/364
Sequence Identity: 22% (86 aa)

LGRGGFAKVYYGVLPD---------GREIAAKVYFQENE------------------------RLRRRRDAFLNEVEILSRVHHKNLVSLIGYCVESLS-
.|.|||..|| |..           |...| |.. ..|.                         ... |. . .|. ..|| .| |.|...||| .. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LIVVFEYMSGGTVQGKLHAGTQACLTWETRLTIALDAAQGVEYLHTCCI-----PQVMHRDLKSSNILLSDKMM--------------
            |  | ||..||.    ||        |. |. .|||.|.|..|||..       |.. ||||||.|||. ...               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVGDFGISKFLSPDDD-------------------ISNSVKGTPGYVDPEY-----------GSFSLCHSCLYCIHRYFATN----RFSEKSDVYSFGV
.|..|||.|.|.|.. .                    .... |||..  ||            |               .        .|||.||||||.
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI--------------DE-FCKGFEYSEKCDVYSFGI

VLLELICGRGP---LDLELMDQGLTLIVWFRSLVQSGKTREVVDLRLEN----TYNLESMQRVVDTANSCIESDPSNRPDMSTIVGEL
|| |..... |   .. . |. .   . .. ..| . . |  .. . .|      .   .... . .  | ..||..|| ...|. .|
VLWEILTRCRPYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_bh.AA TKL-Unique 324-534 32 1.2e-39 137.5 In-house 1-222 (290) Show / Hide 
Range on Protein: 324-534
Range on HMM: 1-222/290
Sequence Identity: 32% (77 aa)

FSKELGRGGFAKVYYGVLPDGREIAAKVYFQENERLR-RRRDAFLNEVEILSRVH-HKNLVSLIGYCV----ESLSLIVVFEYMSGGTVQGKLHA-----
|.. .|.||...|| |. . | ..| |. .  || .. . .. | ||| .... | |.|.| ..|||.        .. | ||..||.    ||      
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---GTQACLTWETRLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSDK-----MMAKVGDFGISKFLSPDDDISNSVK---------GTPGYVDPEY
        |... |...|.|.||| .|||.|  | ..||||||||.|.. .     . .|. |||.|||.| ... .|. .         |.. .. || 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

GSFSLCHSCLYCIHRYFATNRFSEKSDVYSFGVVLLELI
    |. .           . .||||||||||.|| |..
----LRMNF----------CQYSEKSDVYSFGIVLWEIA
Pkinase IRAK-0_bh.AA Pkinase 322-537 23 1.5e-38 137.4 Pfam 1-209 (293) Show / Hide 
Range on Protein: 322-537
Range on HMM: 1-209/293
Sequence Identity: 23% (53 aa)

QNFSKELGRGGFAKVYYGVLPDGRE-IAAKVYFQENERLRRRRDAFL-NEVEILSRVHHKNLVSLIGYCVESLSLIVVFEYMSGG----TVQGKLHAGTQ
  . . .|.|.|..|| ..  . ..  | |.   ..|.   .. ... .|..|. |..|.| | |.... .. .. .|.||. ||         ...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

ACL--TWETRLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSDKMMA----KVGDFGISKFL-SPDDDISNSVKGTPGYVDPEYGSFSLCHSCLYCI
 |.  ....   ...  ..|.||.| .    ..|||||..|||.....      |..|||..|..    .   ... |||.|. ||              
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-------------

HRYFATNRFSEKSDVYSFGVVLLELICGR
      .  . |.|..|.|..| |..|||
--IRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_bh.AA Dicty4 323-494 31 3.2e-37 121.81 In-house 2-187 (277) Show / Hide 
Range on Protein: 323-494
Range on HMM: 2-187/277
Sequence Identity: 31% (59 aa)

NFSKELGRGGFAKVYYGVLPDGREIAAKVYFQENERL-RRRRDAFLNEVEILSRVHHKNLVSLIGYCV----ESLSLIVVFEYMSGGTVQGKLHA-----
|. ...|.|.|..|| |    | | | |. .  |. .   .  .|..||.|..   | |.. . |.|     .. ..  | |||. |..   ||.     
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

GTQACLTWETRLT---IALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSDKMMAKVGDFGISKFLSPDDDISN---SVKGTPGYVDPE
     | |....    .|.|||.|. .|| ||.| . ||||||.|.| .. . .||.|||.|.   .. | .    ...|||... ||
QQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE
S_TKc IRAK-0_bh.AA S_TKc 322-615 21 2.6e-34 121.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 322-615
Range on HMM: 1-231/231
Sequence Identity: 21% (66 aa)

QNFSKELGRGGFAKVYYGVLPD-GREIAAKVYFQENERLRRRRDAFLNEVEILSRVHHKNLVSLIGYCVESLSLIVVFEYMSG--GTVQGKLHAGTQ---
  . ...|.|.|.||| ..  . ||. | |.            . ...|..||.. ||.|.| |......  .| .|.||..|  |..   ..       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-ACLTWETRLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSDKMMAKVGDFGISKFLSPDDDISNSVKGTPGYVDPEYGSFSLCHSCLYCIHRYFAT
   ..  .   ..   ....||.|   |   .||||| .||||..    |..|||....|       ... ||| |. ||                    
RFPFPE-HARFYMYQICCALEYCHSHGI---IHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL------------------

NRFSE-KSDVYSFGVVLLELICGRGPLDLELMDQGLTLIVWFRSLVQSGKTREVVDLRLENTYNLESMQRVVDTANSCIESDPSNRPDMSTIVG---ELK
  ..  |.|..|.|..| |..||. | .        .. . |. ..                      . . |  . | . ||..||    .     . |
-GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

EALWL
   |.
CHPWF
Kinase IRAK-0_bh.AA LISK 327-469 33 1.3e-31 99.82 In-house 1-150 (296) Show / Hide 
Range on Protein: 327-469
Range on HMM: 1-150/296
Sequence Identity: 33% (52 aa)

ELGRGGFAKVYYGVLP-DGREIAAKVYFQ--ENERLRRRRDAFLNEVEILSRVHHKNLVSLIGYCVE-SLSLIVVFEYMSGGTVQGKLHAGTQ--ACLTW
|.|.|.|.||| | .  .|...| |   .  .   ..  .  .| ||... .  |.| |  .| |.. . .|  | ||..||...  |..  .    |.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

ETRLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSDK----MMAKVGDFG
. |. |||| |.| .|||  .|   .|||||| |.|....      .||.|||
PQRVKIALDIACGMSYLHSMNI---IHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase IRAK-0_bh.AA IRAK 324-469 30 2.3e-31 108.46 In-house 1-158 (317) Show / Hide 
Range on Protein: 324-469
Range on HMM: 1-158/317
Sequence Identity: 30% (49 aa)

FSKE--LGRGGFAKVYYGVLPDGRE--IAAK----VYFQENERLRRRRDAFLNEVEILSRVHHKNLVSLIGYCVESLSLIVVFEYMSGGTVQGKLHAGTQ
|.|.  .| |||. || |.. .. .   | |    .   . . ...| .. .||.....| .|.|.|.| ||| |.  .  |..||..|. .  |.. ..
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

AC----LTWETRLTIALDAAQGVEYLHTCC-IPQVMHRDLKSSNILLSDKMMAKVGDFG
.|    |.| .|. |.. .| |...||.      . |.| ||.|||| . ...| .|||
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFG
Kinase IRAK-0_bh.AA MLK 322-539 24 5.6e-31 104.77 In-house 1-235 (291) Show / Hide 
Range on Protein: 322-539
Range on HMM: 1-235/291
Sequence Identity: 24% (62 aa)

QNFSKELGRGGFAKVYYGVLPDGRE-----IAAKVYFQENERLRRR----RDAFLNEVEILSRVHHKN----LVSLIGYCVESLS-LIVVFEYMSGGTVQ
 .|.. .| |.| ||. |.   ...     .| | .... .    .    ...|  |...|... |.|     . . | | .. . . .| ||..||   
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

GKLHAGTQ------------ACLTWETRLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSD------KMMAKVGDFGISKFLSPDDDISNSVKGTPG
  ||...             .  . .  ...||. |.|..|||    ... ||||||.|||...      .. .|. |||.|....  ..   | .||. 
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA

YVDPEYGSFSLCHSCLYCIHRYFATNRFSEKSDVYSFGVVLLELICGRGP
.  ||  .              |  ...|||.||.|.|||| |.. .. |
WMAPEVIQQ-------------FRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_bh.AA LRRK 322-494 26 1.9e-29 101.32 In-house 1-249 (351) Show / Hide 
Range on Protein: 322-494
Range on HMM: 1-249/351
Sequence Identity: 26% (66 aa)

QNFSKELGRGGFA-KVYYGVLPD---------------------------GREIAAKVYFQE-------------------------------NERLRRR
. . ...|||||. .|| . . .                           . ..|.|..  .                                | . | 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

RDAFLNEVEILSRVHHKNLVSLIGYCVESLSLIVVFEYMSGGTVQGKLH--AGTQ-----ACLTWETRLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNI
   | .|| |.|. .| |.|||.|.| . | ..   ||.. |. .  ||  . ..     | ..| ..| |||. | |.|||| .  | . |||||| ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVM--EYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHN-PPIIHRDLKSPNI

LL-SDK-----------MMAKVGDFGISK-FLSPDDD-ISNSVKGTPGYVDPE
|| | .           . ||..|||||  | ...   . . . |.||.. ||
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPE
Kinase IRAK-0_bh.AA Pkinase_Tyr 323-478 28 2.6e-29 99.89 Pfam 2-165 (270) Show / Hide 
Range on Protein: 323-478
Range on HMM: 2-165/270
Sequence Identity: 28% (49 aa)

NFSKELGRGGFAKVYYGVLP-----DGREIAAKVYFQENERLRRR---RDAFLNEVEILSRV-HHKNLVSLIGYCV-ESLS--LIVVFEYMSGGTVQGKL
 | |.||.| | .|| |..      .. . | |.    .|    .   |..|..|..|..   ||.|.|.|.| |. .. .  ...|.||| .|     |
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML---KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HAG--TQACLTWETRLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSDKMMAKVGDFGISKFLSPDD
..    .  || .. | .... |.| |||.        ||||   |.|..... .|..||| .. . .||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase IRAK-0_bh.AA TK 322-479 15 1.3e-28 92.47 In-house 1-310 (486) Show / Hide 
Range on Protein: 322-479
Range on HMM: 1-310/486
Sequence Identity: 15% (49 aa)

QNFSKELGRGGFA---KVYYGVLPDGR--------------------------EIAAKVYFQENERLRRRRDA-----------FLNEVEILSRVH----
  . |.||.| |    .|| | . ...                          . | |.   ...   ... .           ||.|.|...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLVSLIGYCVES------------LSLIVVFEYMSGGT----VQGKLH--AGTQAC-----------------------------------------
 |.|.|.|.|.|...              ...| |||..|      .  |.   ..  .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTWETRLTIALDAAQGVEYLHTC---CIPQVMHRDLKSSNILLSDKMM-----------AKVGDFGISK
                               || ...| .....|.| |||| .    |... ||||   |.|.....            .|..||| |.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

F----LSPDDD
     |. |..
QGSGVLARDIY
Kinase IRAK-0_bh.AA Dicty4-Unclassified 323-471 32 5.4e-28 92.93 In-house 2-156 (263) Show / Hide 
Range on Protein: 323-471
Range on HMM: 2-156/263
Sequence Identity: 32% (52 aa)

NFSKELGRGGFAKVYYGVLPDGREIAAKVYFQENERLR-RRRDAFLNEVEILSRVHHKNLVSLIGYCVES----LSLIVVFEYMSGGTVQGKLH---AGT
   ...|.| |.||. |.   |...| |       . |    . |. |||||  . | ||| . |||.        ...| | |  |.     |   .  
QIDQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

QACLTWET--RLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSDKMMAKVGDFGIS
|  .  .    . .|.| |||  .|||  .    |||.||||||.     .|..|||||
QQPIKLDDTLIIKYAFDIAQGMQHLHTRNF---IHRDIKSSNILMDKHFNIKIADFGIS
Kinase IRAK-0_bh.AA TyrKc 322-609 22 1.3e-27 98.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 322-609
Range on HMM: 1-280/280
Sequence Identity: 22% (72 aa)

QNFSKELGRGGFAKVYYGVLPDGREIAAKVYFQENERLRRRRDAFLNEVEILSRV--HHKNLVSLIGYCVES-------LSLIVVFEYMSGGTVQGKLHA
  . |.||.| | .|| |..   .. | |.   .       | .|..| .|....  ||.|.| |.|.|...         | .|.|||..|  .  |..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

GTQACLTWETRLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSDKMMAKVGDFGISKFLSPDDDISNSVKGTPGYVDPEYGSFS---LCHS------
     |.... | .....|.| ||||     .. ||||   |.|....  .|..||| |...  ||            .  .| . .    ...      
HRPK-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---------ESKDYYRKKEHKGGKTMLPIRW

----CLYCIHRYFATNRFSEKSDVYSFGVVLLELICGRGPLDLELMDQGLTLIVWFRSLVQSGKTREVVDLRLENTYNLESM------QRVVDTANSCIE
    |.        ...|..||||.||||.. |.    ..   .   |        . .|..|. ..  .  .      . |      . . .   .| .
MAPECI-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY------P-MSFVCCPDEMYQIMKQCWH

SDPSNRPDMSTIVGEL
 ||..|| .|.|. ..
EDPEDRPTFSEIHECF
Kinase IRAK-0_bh.AA UTK 323-475 24 2.2e-23 76.85 In-house 2-179 (296) Show / Hide 
Range on Protein: 323-475
Range on HMM: 2-179/296
Sequence Identity: 24% (45 aa)

NFSKELGRGGFAKVYYGVLPDGREIAAKVYFQENERL-----RRRRD---AFLNEVE---ILSRVH-HKNLVSLIGYCVESLSLIVVFEYMSGGTVQG--
 ....||.| |  |. . . . .|.. ...    ..      .. ..    |..|     .....| | |.. |.|.|. .  ...| |||..|  .   
QLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYL

-KLHAGTQACLTWET---RLTIALDAAQGVEYLHTCCIPQVMHRDLKSSNILLSDK-------MMAKVGDFG---ISKFLS
 . .  . || .| |   ||  |.| | |..|||.|   .. ||||   |.|. .        | .|..|||    |. ..
RRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC---GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVN
Kinase IRAK-0_bh.AA TK 513-609 20 7.2e-10 28.47 In-house 367-486 (486) Show / Hide 
Range on Protein: 513-609
Range on HMM: 367-486/486
Sequence Identity: 20% (27 aa)

ATNRFSEKSDVYSFGVVLLELIC-GRGPLD-----------------LELMDQGLTLIVWFRSLVQSGKTREVVD-----LRLEN-TYNLESM-------
....|..||||.||||.. |.   |..|                   .|.  .|..|         ||      .     .|..   .  ..|       
KYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL-CR------SG----L-NEVGYRMRMPQPPHCPDWMRYRMHPP

----QRVVDTANSCIESDPSNRPDMSTIVGEL
    . . |   .| . ||. ||..|... .|
HCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_bh.AA LISK 518-537 50 6.7e-08 21.54 In-house 217-236 (296) Show / Hide 
Range on Protein: 518-537
Range on HMM: 217-236/296
Sequence Identity: 50% (10 aa)

SEKSDVYSFGVVLLELICGR
.|..||.|||.||.|.|...
DESCDVFSFGIVLCEIITRV
Kinase IRAK-0_bh.AA IRAK 516-537 54 7.1e-07 20.58 In-house 200-221 (317) Show / Hide 
Range on Protein: 516-537
Range on HMM: 200-221/317
Sequence Identity: 54% (12 aa)

RFSEKSDVYSFGVVLLELICGR
. . |.||||||.||||.. |.
QLTKKTDVYSFGIVLLEVLTGC
Kinase IRAK-0_bh.AA UTK 512-533 52 9.9e-07 19.06 In-house 211-233 (296) Show / Hide 
Range on Protein: 512-533
Range on HMM: 211-233/296
Sequence Identity: 52% (12 aa)

FATN-RFSEKSDVYSFGVVLLEL
.. . ||..||||.|||||. |.
LTHHTRFTTKSDVWSFGVVCWEI
Kinase IRAK-0_bh.AA LRRK 517-541 46 6e-06 17.1 In-house 259-284 (351) Show / Hide 
Range on Protein: 517-541
Range on HMM: 259-284/351
Sequence Identity: 46% (12 aa)

FSEKSDVYSFGVVLLELICGR-GPLD
..||.|.||||..| ||. ..  | |
YTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_bh.AA Pkinase_Tyr 512-539 41 1.9e-05 19.05 Pfam 186-214 (270) Show / Hide 
Range on Protein: 512-539
Range on HMM: 186-214/270
Sequence Identity: 41% (12 aa)

FATNRFSEKSDVYSFGVVLLELIC-GRGP
.....|..||||.||||.. |..  |. |
INYGKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAK-0_bh.AA MLK 591-609 42 2.3e-05 14.72 In-house 273-291 (291) Show / Hide 
Range on Protein: 591-609
Range on HMM: 273-291/291
Sequence Identity: 42% (8 aa)

CIESDPSNRPDMSTIVGEL
| ..||..||... || .|
CWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_bh.AA Dicty4 515-533 57 4.3e-05 13.11 In-house 192-210 (277) Show / Hide 
Range on Protein: 515-533
Range on HMM: 192-210/277
Sequence Identity: 57% (11 aa)

NRFSEKSDVYSFGVVLLEL
... ||.|||||| || |.
QPYNEKADVYSFGIVLWEI
Kinase IRAK-0_bh.AA LRRK 589-611 39 6e-05 13.42 In-house 329-351 (351) Show / Hide 
Range on Protein: 589-611
Range on HMM: 329-351/351
Sequence Identity: 39% (9 aa)

NSCIESDPSNRPDMSTIVGELKE
..| . || .|| .|.||  |..
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-0_bh.AA Dicty4-Unclassified 517-539 47 0.000615 9.33 In-house 185-207 (263) Show / Hide 
Range on Protein: 517-539
Range on HMM: 185-207/263
Sequence Identity: 47% (11 aa)

FSEKSDVYSFGVVLLELICGRGP
.  ||||||....| ||. |  |
YNQKSDVYSYAMMLYELATGDEP
Kinase IRAK-0_bh.AA TKL-Unique 589-609 38 0.001197 8.95 In-house 270-290 (290) Show / Hide 
Range on Protein: 589-609
Range on HMM: 270-290/290
Sequence Identity: 38% (8 aa)

NSCIESDPSNRPDMSTIVGEL
. |  .|||.||  ..|. .|
QQCWHHDPSQRPSFDEIIHRL
Kinase IRAK-0_bh.AA UTK 589-609 33 0.002046 7.55 In-house 276-296 (296) Show / Hide 
Range on Protein: 589-609
Range on HMM: 276-296/296
Sequence Identity: 33% (7 aa)

NSCIESDPSNRPDMSTIVGEL
..| ..||..|||. ..| ..
HRCWHYDPQERPDFEDLVQQM
Kinase IRAK-0_bh.AA Pkinase_Tyr 590-609 40 0.004041 11.19 Pfam 251-270 (270) Show / Hide 
Range on Protein: 590-609
Range on HMM: 251-270/270
Sequence Identity: 40% (8 aa)

SCIESDPSNRPDMSTIVGEL
.| . ||..|| .| |. .|
QCWHYDPEDRPTFSEIHEQL
Kinase IRAK-0_bh.AA Dicty4 591-611 30 0.040547 3.06 In-house 255-277 (277) Show / Hide 
Range on Protein: 591-611
Range on HMM: 255-277/277
Sequence Identity: 30% (7 aa)

CIESDPSNRPDMSTIVGE--LKE
| . ||..|| .. |. .  | .
CWDHDPQHRPSFEEIIQRRILEH
Kinase IRAK-0_bh.AA Dicty4-Unclassified 591-609 42 0.042728 2.93 In-house 245-263 (263) Show / Hide 
Range on Protein: 591-609
Range on HMM: 245-263/263
Sequence Identity: 42% (8 aa)

CIESDPSNRPDMSTIVGEL
|   ||  || |  |.  |
CWHNDPNKRPTMNQIIQYL
Kinase IRAK-0_bh.AA LISK 591-609 47 0.20144 0.15 In-house 278-296 (296) Show / Hide 
Range on Protein: 591-609
Range on HMM: 278-296/296
Sequence Identity: 47% (9 aa)

CIESDPSNRPDMSTIVGEL
|.. ||.|||  ..||  |
CCKYDPKNRPSFKEIVQWL