Gene IRAK-0_x (S.moellendorffii)

IRAK-0_x

Species: S.moellendorffii
Alias: IRAK-0_x
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_x.AA Protein None 456 None Fasta, JSON
IRAK-0_x.NA RNA None 1371 None Fasta, JSON
IRAK-0_x.kin_dom Protein Kinase Domain None 204 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_x.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_x.AA TKL 170-433 22 5.2e-65 222.29 In-house 1-364 (364) Show / Hide 
Range on Protein: 170-433
Range on HMM: 1-364/364
Sequence Identity: 22% (86 aa)

LGKGAFGAVYKGVLEN---------GQAVAIKRAIISN----NRSS-----------------------ELFEKELHLLTRTHHSCLVNLVGYCMEEK--
.|.|.|| ||||.. .         |. ||.|.  . |    ...|                       . .|.|. .. |..|  .| ..|||....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------LLVFEFMSRGSLYDNIFCGSRPDAGLQWICRIKIAAQAARGLEYLHKYAC-----PAIIHRDVKSANILLDDDWN------------
              .| |....|||....           |  |...| ..|||..|||         |.||||| ||.|||.|..|.            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AHVSDFGLSLFGPLGSATHLS----------------NMTIVGTPGYLDPEYGLSM----------------KLTSKSDVYSFGVVLLELLSGAKPMD
  . ..||||| |    .    .                .||..|||... ||    .                . . |.||||||.|| |.|.. .   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

PFR-PARHIVAWAVELMEDDALHAVLDSALDVPAA------------SGPLYRAVELALECTKVSGKERPSMTEVAKSL
|.. .    . ..  . ... .  | |  |  |              .  . .  .|. .| .   ..|||..|. | |
PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_x.AA IRAK 164-367 35 7.5e-55 188.55 In-house 1-225 (317) Show / Hide 
Range on Protein: 164-367
Range on HMM: 1-225/317
Sequence Identity: 35% (80 aa)

YSDEMVLGKGAFGAVYKGVLENGQ-AVAIK----RAIISNNRSSELFEK---ELHLLTRTHHSCLVNLVGYCMEEKL--LVFEFMSRGSLYDNIFCGSRP
.. . ..|.|.|| ||.|.. |    .|.|     | .| | . . |     || ...| .|  .| | ||| |.    ||...|. ||| |   |    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

DAG--LQWICRIKIAAQAARGLEYLHKYA-CPAIIHRDVKSANILLDDDWNAHVSDFGLSLFG-PLG--SATHL---SNMTIVGTPGYLDPEYGL--SMK
..   | |. |..|.  .|.|...||    | .|||.|.||||||||.. ..  .||||  || | .   .. .      ...||  |. ||.    . .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTSKSDVYSFGVVLLELLSGAKPMD
|| |.||||||.||||.|.| ....
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_x.AA TKL-Unique 166-362 33 6.6e-42 145.55 In-house 1-224 (290) Show / Hide 
Range on Protein: 166-362
Range on HMM: 1-224/290
Sequence Identity: 33% (76 aa)

DEMVLGKGAFGAVYKGVLENGQAVAIKRAII---SNNRSSELFEKELHLLTRTH-HSCLVNLVGYCM----EEK--LLVFEFMSRGSLYDNIF---CGS-
.  ..| |..|.||||.  .|  ||||.  .   |.|.... ||.|. .. . | |  .| ..||||     ..   .| |....|||||..      . 
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--RPDAGLQWICRIKIAAQAARGLEYLHKYACPAIIHRDVKSANILLDDD-----WNAHVSDFGLSLFGPLGSATHLSNM------TIVGTPGYLDPEYG
  ..   | .  |.|.| ..|.|..||| .  | ||||| || |.|.| .     ||. ..||||| |    ... ...       | .|.. .. ||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-

LSM---KLTSKSDVYSFGVVLLELLSG
|.|   . . ||||||||.|| |....
LRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_x.AA LRRK 164-367 26 3e-39 136.48 In-house 1-284 (351) Show / Hide 
Range on Protein: 164-367
Range on HMM: 1-284/351
Sequence Identity: 26% (77 aa)

YSDEMVLGKGAFG-AVYKGVLEN---------------------------GQAVAIKRAII-----------SNN-----------------------RS
   |  .|.|.||  ||.. ...                           .| ||||  ..           |||                       |.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

SELFEKELHLLTRTHHSCLVNLVGYCMEEKLLVFEFMSRGSLYDNIFCGSRPD-----AGLQWICRIKIAAQAARGLEYLHKYACPAIIHRDVKSANILL
  .| .|.... . .|...|.|.|.|..   .| |... |.||. ..  ..       | . |  ..||| | |.|.||||. . | ||||| || ||||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNILL

---D---------DDWNAHVSDFGLSL-FGPLGSA-THLSNMTIVGTPGYLDPEYGLSM---KLTSKSDVYSFGVVLLELLSGA-KPMD
   .         .. .|...|||.|  | ..... .    .. ||.||.. ||    .     | |.|.||||..| |||..   |.|
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVA----KGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_x.AA Pkinase 164-362 26 1.6e-37 133.71 Pfam 1-208 (293) Show / Hide 
Range on Protein: 164-362
Range on HMM: 1-208/293
Sequence Identity: 26% (58 aa)

YSDEMVLGKGAFGAVYKGVLENGQA-VAIKRAIISNNRSSELFEK----ELHLLTRTHHSCLVNLVGYCMEEKLLV--FEFMSRG----SLYDNIFCGSR
|  . ..|.|.|| |||..  . .  ||.|.   ....|... ..    |.... | .| . | | ....... .   .|..  |    .|.| |    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

PDAGL--QWICRIKIAAQAARGLEYLHKYACPAIIHRDVKSANILLDDDWNA----HVSDFGLSLFGPLGSATHLSNMTIVGTPGYLDPEYGL-SMKLTS
 . ..  ..   .... | .|||||.|.     |||||.|..|||.|.. .     ...||||. .          ..|..|||.|. ||  . . . ..
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDVYSFGVVLLELLSG
|.|..|.|..| |.|.|
KVDMWSCGCILYEMLCG
Kinase IRAK-0_x.AA MLK 164-365 28 1e-33 114.39 In-house 1-235 (291) Show / Hide 
Range on Protein: 164-365
Range on HMM: 1-235/291
Sequence Identity: 28% (68 aa)

YSDEMVLGKGAFGAVYKGVLENGQ----AVAIKRAII------SNNRSSELFEKELHLLTRTHHSC----LVNLVGYCMEE-K--LLVFEFMSRGSLYDN
   . ..|.|.||.|.||.  |       ||.||. .      .   ... ||.|  .| .  |       . ..| | .. .  ..| |... ||||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IFCG-SRPD---------AGLQWICRIKIAAQAARGLEYLHKYACPAIIHRDVKSANILLDD------DWNAHVSDFGLSLFGPLGSATHLSNMTI-VGT
.  . | ..         .       ...| | |||..|||. | ..||||| || |||.|.      . .. ..|||.| .    . .. .||.   ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRD---WHQMC-TNMMSNAGT

PGYLDPEY---GLSMKLTSKSDVYSFGVVLLELLSGAKP
. .  ||      . | . |.||.|.|||| |.|..  |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_x.AA Dicty4 164-360 34 5.4e-33 107.51 In-house 1-211 (277) Show / Hide 
Range on Protein: 164-360
Range on HMM: 1-211/277
Sequence Identity: 34% (75 aa)

YSDEMVLGKGAFGAVYKGVLENGQAVAIKRAIISNNR--SSEL--FEKELHLLTRTHHSCLVNLVGYCM------EEKLLVFEFMSRGSLYDNIFC---G
.  |  .|||.|| ||||    |..||.| .   |    ...|  | || |..    |  .. . |.|       .. . | |.|..|.||  .      
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

SRPDAGLQWICRIK---IAAQAARGLEYLHKYAC--PAIIHRDVKSANILLDDDWNAHVSDFGLSLFGPLGSATHLSNMTIVGTPGYLDPEYGLSMKLTS
  .   |.|. ...   .|  ||||. .||   |  | ||||| ||.|.| |..|.. |.|||||     ..      || .|||..  ||   .   ..
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH---CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

KSDVYSFGVVLLELL
|.|||||| || |.|
KADVYSFGIVLWEIL
Kinase IRAK-0_x.AA TK 164-365 16 9.5e-33 106.53 In-house 1-394 (486) Show / Hide 
Range on Protein: 164-365
Range on HMM: 1-394/486
Sequence Identity: 16% (65 aa)

YSDEMVLGKGAFG---AVYKGVLENG--------------------------QAVAIKRAIISNNRSSELFEK--------------ELHLLTRTH----
   . .||.|.||    |||| ....                          . ||.|     .. |.| |.               |.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HSCLVNLVGYCMEEK--------------LLVFEFMSRGS--------LYDN------------------------------IFCGSRPDAG-------
 |  .|.|.|.|....              ..| |.|. |.        | ..                              |   |. ...       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY-SHESNSPCPEEQD

--------------------------------LQWICRIKIAAQAARGLEYLHKYAC---PAIIHRDVKSANILLDDDWN-----------AHVSDFGLS
                                |   ... ...|.|.|.||||.  |   . ..|||.   |.|.... .           . ..|||||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LFGPLGSATHLSNMTIVGTPG-------------------------YLDPEYGL---------SMKLTSKSDVYSFGVVLLELLSGA-KP
      |   ..| .    ..  ||..                         .. ||  .           | |.||||.||||.. |... . .|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAK-0_x.AA S_TKc 164-437 24 2.9e-32 114.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 164-437
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

YSDEMVLGKGAFGAVYKGVLEN-GQAVAIKRAIISNNRSSELFEKELHLLTRTHHSCLVNLVGYCM-EEKLLVFEFMSR--GSLYDNIFCGSRPDAG--L
|    ..|||||| |||..  . |. ||||.         | ...|. .| . ||  .|.| ...  ..  .|.|...   |.|.| |    |.  .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QWICRIKIAAQAARGLEYLHKYACPAIIHRDVKSANILLDDDWNAHVSDFGLSLFGPLGSATHLSNMTIVGTPGYLDPEYGLSMKLTS-KSDVYSFGVVL
      ....| ...|||.|.     |||||.| .|||||.  .  ..||||. .           .|..||| |. ||     . .  |.|..|.|..|
PE-HARFYMYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LELLSGAKPMDPFRPARHIVAWAVELMEDDALHAVLDSALDVPAASGPLYRAVELALECTKVSGKERPSMTEVAK-----SLEEIL
 |.|.|  | .      .. .    ..                        | ..   | ..  ..||.  |. .      . . .
YEMLCGYPPFP------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_x.AA DRK 171-360 34 5.8e-31 102.12 In-house 8-196 (258) Show / Hide 
Range on Protein: 171-360
Range on HMM: 8-196/258
Sequence Identity: 34% (68 aa)

GKGAFGAVYKGVLENGQAVAIKRAIISNNRSSEL---FEKELHLLTRTHHSCLVNLVGYCME--EKLLVFEFMSRGSLYDNIFCGSRPDAGLQWICRIKI
|.| .| |. |    |  ||.|..   |    ..   | .|  |. .  |   .   | | .  . . . |.|.||||| ||     .   ..|  ....
GRGNYGEVFRGTWR-GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLY-NILHD--ESIEMDWPLMKQM

AAQAARGLEYLHKYACPAIIHRDVKSANILLDDDWNAHVSDFGLSL-FGPLGSATHLSNMTIVGTPGYLDPEYGLSMKLTSKSDVYSFGVVLLELL
.  .|.|. |||    | ||||| || | | |. |   |.|||||  |    .  |   || .|||.   ||   .   | | |||||..|| |..
MFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQ--HKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase IRAK-0_x.AA STE 164-362 22 6.1e-30 102.95 In-house 1-264 (359) Show / Hide 
Range on Protein: 164-362
Range on HMM: 1-264/359
Sequence Identity: 22% (61 aa)

YSDEMVLGKGAFGAVYKGVLEN----------------GQAVAIKRAIISNN-----------------RSSELFEKELHLLTRTH--HSCLVNLVGYCM
. .  ..|||||| |||..  .                |. .|||.  ..|.                    . ..||. .. . .  |   |.  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------EEKLLVFEFMSRGSLYDNIF-CGSRPD---------AGLQWICRIKIAAQAARG-LEYLHKYACPAIIHRDVKSANILLDDDWNAHVSDFG
         .|  .. |.|. ||| | |  ......           ..    ..|. |  .| |.|||.     |||||.|.|||||     .  .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LSL-FGPLGS------------ATHLSNMTIVGTPGYLDPEYGLSMK------LTSKSDVYSFGVVLLELLSG
..  . . ..             .   . |.|||| .  ||  . ..       . |.|..|.| ...|.. |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase IRAK-0_x.AA LISK 169-365 28 1.5e-29 93.04 In-house 1-238 (296) Show / Hide 
Range on Protein: 169-365
Range on HMM: 1-238/296
Sequence Identity: 28% (68 aa)

VLGKGAFGAVYKGVLE-NGQAVAIKRAII----SNNRSSE-LFEKELHLLTRTHHSCLVNLVGYCME-EKLL--VFEFMSRGSLYDNIFCGSRPDAGLQW
..|||.|| |||| .   || .|||  ..    .|... .  ...|. .. .  |   |. .| | . .. |  | |... | | . ..  .  .  | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

ICRIKIAAQAARGLEYLHKYACPAIIHRDVKSANILLD----DDWNAHVSDFGLS-LFGPLG------------------------------SATHLSNM
  |.|||   |.|..|||      ||||| || |.|..    ..|.. | |||.  ..                                  ...  . |
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TIVGTPGYLDPEYGLSMKLTSKSDVYSFGVVLLELLSGAKP
||.|||    ||  | .. . ..||.|||.||.|.  . |.
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase IRAK-0_x.AA Pkinase_Tyr 169-310 29 6.3e-24 81.66 Pfam 6-158 (270) Show / Hide 
Range on Protein: 169-310
Range on HMM: 6-158/270
Sequence Identity: 29% (46 aa)

VLGKGAFGAVYKGVLE-----NGQAVAIKRA-IISNNRS--SELFEKELHLLTRT-HHSCLVNLVGYCM--EEK---LLVFEFMSRGSLYDNIFCGSR--
.||.|||| ||||..      ... ||.|     .  .   .| | .|. ...   ||  .|.|.| |.  .|    ..|.|.|  |.|.|  .  ..  
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD--YLRKHRE

PDAGLQWICRIKIAAQAARGLEYLHKYACPAIIHRDVKSANILLDDDWNAHVSDFGLS
..  |     .....| |.|.|||.      .||||.   |.|....  . ..||||.
DKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLA
Kinase IRAK-0_x.AA TyrKc 164-433 23 1.1e-18 69.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 164-433
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

YSDEMVLGKGAFGAVYKGVLENGQAVAIKRAIISNNRSSELFEKELHLLTRT--HHSCLVNLVGYCM---------EEKLLVFEFMSRGSLYDNI-FCGS
 . . .|| |||| ||||..   . ||.|    .     | | .|. ....   || ..|.|.|.|.         |  ..|.|.|. |.| | .  .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RPDAGLQWICRIKIAAQAARGLEYLHKYACPAIIHRDVKSANILLDDDWNAHVSDFGLSLFGPLG-------SATH-----LSN--MTIVGTPGYLDPEY
.    |..   .... |.|.| ||||.     .||||    |.|....  . .|||||| ..  .       .  .      ..  . |  ..    || 
K----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA----PEC

GLSMKLTSKSDVYSFGVVLLELLS-GAKPMDP----FRPARHIVAWAVELMEDDALHAVLDSALDVPAA---SGPLYRAVELALECTKVSGKERPSMTEV
    | |.||||.||||.. |... |..|       . ........  . .  .  . ..      |       |      . ..| .   ..||...|.
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY------P-MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI

AKSL
 . .
HECF
Kinase IRAK-0_x.AA Pkinase_Tyr 341-365 50 1.1e-05 19.86 Pfam 189-214 (270) Show / Hide 
Range on Protein: 341-365
Range on HMM: 189-214/270
Sequence Identity: 50% (13 aa)

MKLTSKSDVYSFGVVLLELLS-GAKP
.| |.||||.||||.. |... |..|
GKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAK-0_x.AA LISK 409-433 36 0.000695 8.28 In-house 272-296 (296) Show / Hide 
Range on Protein: 409-433
Range on HMM: 272-296/296
Sequence Identity: 36% (9 aa)

VELALECTKVSGKERPSMTEVAKSL
..|...|.|.  |.||| .|. . |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAK-0_x.AA IRAK 411-433 26 0.002183 8.06 In-house 295-317 (317) Show / Hide 
Range on Protein: 411-433
Range on HMM: 295-317/317
Sequence Identity: 26% (6 aa)

LALECTKVSGKERPSMTEVAKSL
.|..|.    ..|..|..| ..|
CACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_x.AA Dicty4 421-435 35 0.009257 5.23 In-house 261-277 (277) Show / Hide 
Range on Protein: 421-435
Range on HMM: 261-277/277
Sequence Identity: 35% (6 aa)

KERPSMTEVAKS--LEE
. |||. |. .   ||.
QHRPSFEEIIQRRILEH
Kinase IRAK-0_x.AA TK 410-433 20 0.01624 3.39 In-house 463-486 (486) Show / Hide 
Range on Protein: 410-433
Range on HMM: 463-486/486
Sequence Identity: 20% (5 aa)

ELALECTKVSGKERPSMTEVAKSL
.| ..| .   ..||..... . |
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_x.AA LRRK 421-435 33 0.063654 2.57 In-house 337-351 (351) Show / Hide 
Range on Protein: 421-435
Range on HMM: 337-351/351
Sequence Identity: 33% (5 aa)

KERPSMTEVAKSLEE
|.||..... | |..
KKRPHFSQIVKRLSQ
Kinase IRAK-0_x.AA MLK 421-433 30 0.141028 1.4 In-house 279-291 (291) Show / Hide 
Range on Protein: 421-433
Range on HMM: 279-291/291
Sequence Identity: 30% (4 aa)

KERPSMTEVAKSL
..|||. .. . |
HKRPSFRQIVQHL
Kinase IRAK-0_x.AA DRK 423-435 53 0.171709 0.86 In-house 246-258 (258) Show / Hide 
Range on Protein: 423-435
Range on HMM: 246-258/258
Sequence Identity: 53% (7 aa)

RPSMTEVAKSLEE
|||| |. . || 
RPSMQECLERLEA