Gene IRAK-0_a-1 (S.moellendorffii)

IRAK-0_a-1

Species: S.moellendorffii
Alias: IRAK-0_a-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_a-1.AA Protein None 417 None Fasta, JSON
IRAK-0_a-1.NA RNA None 1254 None Fasta, JSON
IRAK-0_a-1.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_a-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_a-1.AA TKL 162-415 22 4.8e-66 225.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 162-415
Range on HMM: 1-364/364
Sequence Identity: 22% (85 aa)

IGSGGFGTVFEGSLSD---------GSRIAVKRLDDSN-QGE---------------------------KQFKAEVRAICNIHHRNLVSLRGYCSQKPH-
|||||||.|. | .           |  .|||..   | . .                           .... |.. . ...| |.|.. ||| . |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HFLVYDYVHNGSLDRWLFDSSKAKSLDWNRRFLIVQDIARGLAYLHE----ECSST--VLHLDIKPQNVLLDESFT------------
            ...|..|...|||   |          |..|. ...|||||..|||      |  .  ..| |.|..|.|.|| .|            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKISDFGLSRMLGGDG----------------RTDNAVTAIKGTPGYMAPEWLTQA----------------KVTKALDVYSFGIVVLEIITGLSAVD
  .||.||||||.. ..|                .....   . |||..|||| | ..                . ... ||||||||  ||.|.    .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-ERMSRQNVS----STLKVVIDQGMDRTKR------------SQI-ENLIQIGLWCTKVEQSQRPSMVEVVKVL
 . .. . ..      ...|.| |.  .              ... . ....  .| . . ..|||. |..| |
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_a-1.AA IRAK 157-361 37 1.9e-54 187.22 In-house 2-228 (317) Show / Hide 
Range on Protein: 157-361
Range on HMM: 2-228/317
Sequence Identity: 37% (86 aa)

NFSKRIGSGGFGTVFEGSLSDGS-RIAVKRLDDS-----NQGEKQFKA---EVRAICNIHHRNLVSLRGYCSQKPHHFLVYDYVHNGSL-DR-WLFDSSK
. . |||.||||.|. | ..      |||.|        |. ...| .   |... | ..| |.|.| |||.. . | |||.|  |||| || |  | . 
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

A-KSLDWNRRFLIVQDIARGLAYLHEECSS-TVLHLDIKPQNVLLDESFTAKISDFGLSRML---GGDGRTDN---AVTAIKGTPGYMAPEWLT--QAKV
. | | | .|. | . .|.|. .||.  .   . | |||. |.|||. ||.||.|||| |     ..  ..      .  ..||  ||.|| ..  | . 
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

TKALDVYSFGIVVLEIITGL-SAVDER
|| .||||||||.||..||.  ..|.|
TKKTDVYSFGIVLLEVLTGCRAVYDDR
Pkinase IRAK-0_a-1.AA Pkinase 156-354 25 5.9e-46 163.58 Pfam 1-208 (293) Show / Hide 
Range on Protein: 156-354
Range on HMM: 1-208/293
Sequence Identity: 25% (54 aa)

RNFSKRIGSGGFGTVFEGSLSDGSR-IAVKRLDDSNQGEKQFKA-----EVRAICNIHHRNLVSLRGYCSQKPHHFLVYDYVHNG----SLDRWLFDSSK
  . ..||||.||.|...   . ..  |||... ... ... ..     |..   ...| | | |....  |.|  .| .|. .|    .| ...   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

AKSL--DWNRRFLIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTA----KISDFGLSRMLGGDGRTDNAVTAIKGTPGYMAPEWLT-QAKVTKA
 ...  ...    ..  |.|||.|.|..    ..| |.||.|.|.|.  .     ||.||||.. .      .   | . |||.|||||..  . . ...
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

LDVYSFGIVVLEIITG
 |..|.|... | ..|
VDMWSCGCILYEMLCG
Kinase IRAK-0_a-1.AA TKL-Unique 158-354 30 6.1e-45 155.63 In-house 1-224 (290) Show / Hide 
Range on Protein: 158-354
Range on HMM: 1-224/290
Sequence Identity: 30% (70 aa)

FSKRIGSGGFGTVFEGSLSDGSRIAVKRLD---DSNQGEKQ-FKAEVRAICNIH-HRNLVSLRGYCS----QKPHHFLVYDYVHNGSLDRWLFD----S-
|.. ||.||.|.|. |    |. .|.|..    ||.  ..| |. ||. . ..| | |.| . |||     . |. ..| .|.  |||.  | .    . 
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--SKAKSLDWNRRFLIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDES-----FTAKISDFGLSRMLGGDGRTDNAVTAI--------KGTPGYMAPE
  .. . |....|  ...|||.|. ||| .    ..|.|.|..|.|.|.      . .||.|||||. .  . .... .. .        .|.. .||||
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFN--SKINKMTNNEHKGTRNQTRCGSFRWMAPE

WLTQ--AKVTKALDVYSFGIVVLEIITG
 |..  .. ..  ||||||||. ||.|.
VLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_a-1.AA Dicty4 157-354 35 1.5e-41 136.45 In-house 2-213 (277) Show / Hide 
Range on Protein: 157-354
Range on HMM: 2-213/277
Sequence Identity: 35% (77 aa)

NFSKRIGSGGFGTVFEGSLSDGSRIAVKRLDDSNQG--E---KQFKAEVRAICNIHHRNLVSLRGYCS----QKPHHFLVYDYVHNGSLDRWLFD----S
|. .|||.|.||.|. |.   |.  ||| |   ||.  |   . |..||   |.| | |.. . |.|     ...    |  |.. |.| . | |     
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

SKAKSLDWNRRFL---IVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSR-MLGGDGRTDNAVTAIKGTPGYMAPEWLTQAKVTKAL
 . ..||| ..     .  |.|||...||. | . ..|.|.|. | | |.....|..|||||. |  .   .||. || .|||..|||| .     . . 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVMMHQPYNEKA

DVYSFGIVVLEIITG
||||||||  || |.
DVYSFGIVLWEILTR
S_TKc IRAK-0_a-1.AA S_TKc 156-415 22 5.9e-38 133.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 156-415
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

RNFSKRIGSGGFGTVFEGSLSD-GSRIAVKRLDDSNQGEKQFKAEVRAICNIHHRNLVSLRGYCSQKPHHFLVYDYVHN--GSLDRWLFDSSKAKS---L
  . . ||.|.||.|. .   . | . |.|...      .... |..   . || |.| | ...    | ..| .|. .  |.| . . .  . .    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DWNRRFLIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSRMLGGDGRTDNAVTAIKGTPGYMAPEWLTQAKVTK-ALDVYSFGIVV
.  .   ... |...|.|.|.     ..| |.||.|.||||  . ||.||||.| |          | . ||| ||||| |   . .| . |..|.|...
PE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEIITGLSAVDERMSRQNVSSTLKVVIDQGMDRTKRSQIENLIQIGLWCTKVEQSQRPSMVEVVK---------VL
 | ..|    .      ..  ..|..             . ....   | ... ..||.  |. .          .
YEMLCGYPPFP------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_a-1.AA MLK 156-354 28 2.7e-36 123.45 In-house 1-232 (291) Show / Hide 
Range on Protein: 156-354
Range on HMM: 1-232/291
Sequence Identity: 28% (67 aa)

RNFSKRIGSGGFGTVFEGSLSDGSR-----IAVKRLD-------DSNQGEKQFKAEVRAICNIHHRN----LVSLRGYCSQKPHH-FLVYDYVHNGSLDR
 .|.. ||||.|| |. |    . .     .|||| .       |.    ..|. |.|    . |.|     . ..| |.| |.| ..|  |. .||| .
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WLFDSSKAKS-----------LDWNRRFLIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDE------SFTAKISDFGLSRMLGGDGRTDN-A-VTAIK
 | . ..  .            |    . .  ..|||..|||..   .. | |.|..|.|.||        |.||.|||.||..     ... .  .  .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW-----HQMCTNMMSNA

GTPGYMAPEWLTQ---AKVTKALDVYSFGIVVLEIITG
||. .|||| ..|    |.... ||.|.|.|  |..|.
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK-0_a-1.AA LISK 161-357 28 5.3e-35 111.01 In-house 1-238 (296) Show / Hide 
Range on Protein: 161-357
Range on HMM: 1-238/296
Sequence Identity: 28% (69 aa)

RIGSGGFGTVFEGSLS-DGSRIAVKRLD------DSNQGEKQFKAEVRAICNIHHRNLVSLRGYCSQ-KPHHFLVYDYVHNGSLDRWLFDSS-KAKSLDW
 ||.|.|| |. |..  .|. .|.| .       . .  .| .. ||  . |. |.| |   | | . . . ..|  |.  | | . |.|.. . . | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

NRRFLIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDES----FTAKISDFGLSRMLGGDG-------------------------------RTDNAVT
  |  |  |||.|..|||. .   ..| | | .|.|..|.    ...|. |||. ||.  .                                .. .   
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

AIKGTPGYMAPEWLTQAKVTKALDVYSFGIVVLEIITGLSA
.| |||  |||| |.. . . . ||.|||||..||||.  |
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase IRAK-0_a-1.AA TK 156-415 14 1.8e-33 108.99 In-house 1-486 (486) Show / Hide 
Range on Protein: 156-415
Range on HMM: 1-486/486
Sequence Identity: 14% (73 aa)

RNFSKRIGSGGFG---TVFEGSLSDGS--------------------------RIAVKRLDD-SNQGEKQFKA--------------EVRAICNIH----
  . | .|.| ||   .|..| . ...                          . ||| | . ... ...|..              |.....  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVSLRGYCSQK------------PHHFLVYDYVHNGS----LDRWLFDSSKAKS------------------------------------------
 | |.|.| |.|.|.            ..  .|  |...|.    |. .| .... ..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWNRRFLIVQDIARGLAYLHEE-CSST---VLHLDIKPQNVLLDESFT-----------AKISDFGLS
                               |.  ..  . ..||.|..|||.  |.     . | |.   |.|..|. .           .||.|||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

R-----MLGGDGRTDNAVTAI-KGTPG-------------------------YMAPEWLTQAK---------VTKALDVYSFGIVVLEIITGLSAVDER-
|     .   ... |. ...  .||..                         .|||| |.  .          | . ||.|||... || |   .     
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

MSRQNV-----SSTLKVVIDQG--------------MDRTKRSQIE--------------NLIQI-GLWCTKVEQSQRPSMVEVVKVL
|| |.|        .   . .|              | . .  .                 ....  . | . . ..||.. .... |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_a-1.AA DRK 157-353 35 1.1e-32 108.06 In-house 2-197 (258) Show / Hide 
Range on Protein: 157-353
Range on HMM: 2-197/258
Sequence Identity: 35% (71 aa)

NFSKRIGSGGFGTVFEGSLSDGSRIAVKRLDDSNQG-E---KQFKAEVRAICNIHHRNLVSLRGYCSQKPHHFLVYDYVHNGSLDRWLFDSSKAKSLDWN
    ||| |..| || |.   |. .|||.|   |   |   . |. |.  .|.  | | .   | |   |    .  |   ||| . | | |   ..|| 
KIGNRIGRGNYGEVFRGTWR-GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDES--IEMDWP

RRFLIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSRMLGGDGRTDNAVTAIKGTPGYMAPEWLTQAKVTKALDVYSFGIVVLEII
..  .  |.|.|. |||  |   ..| | |  | | ||..  |..|||||           | |.. |||.  ||| |     |   |||||.||  |..
LMKQMMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV

T
|
T
Kinase IRAK-0_a-1.AA RIPK 162-354 27 5.1e-32 106.38 In-house 1-224 (290) Show / Hide 
Range on Protein: 162-354
Range on HMM: 1-224/290
Sequence Identity: 27% (62 aa)

IGSGGFGTVFEGS-LSDGSRIAVKR-----LDDS--NQGEKQFKAEVRAICNIHHRNLVSLRGYCSQK-----PH-HFLVYDYVHNGSLDRWLFDSS--K
.|.||||.||     . | ..|.|       .     | ... | |. .  .. ... |.. | | ..     .    .|  |  ||||   |   .   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

AKSLDWNRRFLIVQDIARGLAYLHEECSST--VLHLDIKPQNVLLDESFTAKISDFGLSRMLGGDGRTD--------NAVTAIK--GTPGYMAPEWLT--
 . . |  |. ... |..|  |||   | .  ..|.| ||.|.|.|  | .||.||||.  ...  ...           .  .  ||  ||.|| .   
HHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

QAKV----TKALDVYSFGIVVLEIITG
..|     |.. |||||.||. |. |.
NKKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK-0_a-1.AA STE 156-354 21 3.8e-31 107.28 In-house 1-264 (359) Show / Hide 
Range on Protein: 156-354
Range on HMM: 1-264/359
Sequence Identity: 21% (59 aa)

RNFSKRIGSGGFGTVFEGSLSD----------------GSRIAVKRLDDSNQG------------------EKQFKAEVRAICNIH--HRNLVSLRGYCS
  . ..||.|.||||. .   .                | ..|.|... .|.                   ..|.. |..   . .  | | |   |.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QK-------PHHFLVYDYVHNGSLDRWLF-DSSKAKSLD----------WNRRFLIVQDIARG-LAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFG
..        . ...  |. .||||  .    .. |.|.           .    |...| .| |.|||.     . | ||||.|.||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LSRMLGGDGR------------TDNAVT-AIKGTPGYMAPEWLTQ------AKVTKALDVYSFGIVVLEIITG
..  |  ...            |    .  . ||| .|||| ..|       . .   |..|.|....| .||
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase IRAK-0_a-1.AA Pkinase_Tyr 157-353 28 2e-30 103.68 Pfam 2-209 (270) Show / Hide 
Range on Protein: 157-353
Range on HMM: 2-209/270
Sequence Identity: 28% (61 aa)

NFSKRIGSGGFGTVFEGSLS-----DGSRIAVKRL-DDSNQGE---KQFKAEVRAICNI-HHRNLVSLRGYCS-QKPH--HFLVYDYVHNGSLDRWLFDS
 | | .|.| ||.|..| .      ..   ||| | ... . .   . | .|..  ... || |.|.| | |. |. .  ...|  |. .|.|.  | . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

-SKAKSLDWNRRFLIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSRMLGGDGRT----DNAVTAIKGTPGYMAPEWLTQAKVTKA
 .  ..|.  .   . ..||.|..||..       | |.   |.|..|....||.||||.| .  |.      ...   || .    ||| .   | | .
REDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTK

LDVYSFGIVVLEIIT
 ||.|||..  ||.|
SDVWSFGVLMWEIFT
Kinase IRAK-0_a-1.AA TyrKc 156-415 26 9.5e-25 89.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 156-415
Range on HMM: 1-280/280
Sequence Identity: 26% (78 aa)

RNFSKRIGSGGFGTVFEGSLSDGSRIAVKRLDDSNQGEKQFKAEVRAICNI--HHRNLVSLRGYCSQK-------PHHFLVYDYVHNGSLDRWLFDSSKA
  . | .|.| ||.|..| ..     ||| | ..   .. |  | |  |..  || |.| | |.|.|.       . ...|  |. .|.|.  | .. . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KSLDWNRRFLIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSRMLGGD---GRTDNAVTAIK---GTPG-----YMAPEWLTQAKV
  | .     .  .||.| .|||.     . | |.   |.|..| .|.||||||||| .. |   |     .   |   |. .      |||| .   | 
--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TKALDVYSFGIVVLEIITGLSAVDERMSRQN-VS--STLKVVIDQGMDRTKRSQIEN------------LIQIGLWCTKVEQSQRPSMVEVVKVL
| . ||.|||..  || |     .  .   . .    . . || . ...  . | .|            . || ..| . . ..||.. |... .
TTKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_a-1.AA DRK 403-417 46 0.000655 9.17 In-house 244-258 (258) Show / Hide 
Range on Protein: 403-417
Range on HMM: 244-258/258
Sequence Identity: 46% (7 aa)

SQRPSMVEVVKVLEI
..|||| |... || 
QHRPSMQECLERLEA
Kinase IRAK-0_a-1.AA LISK 388-415 28 0.001266 7.42 In-house 269-296 (296) Show / Hide 
Range on Protein: 388-415
Range on HMM: 269-296/296
Sequence Identity: 28% (8 aa)

ENLIQIGLWCTKVEQSQRPSMVEVVKVL
. .... ..|.|.. . |||  |.|..|
PPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAK-0_a-1.AA Dicty4 403-417 35 0.011667 4.89 In-house 261-277 (277) Show / Hide 
Range on Protein: 403-417
Range on HMM: 261-277/277
Sequence Identity: 35% (6 aa)

SQRPSMVEVVKV--LEI
..|||. |...   || 
QHRPSFEEIIQRRILEH
Kinase IRAK-0_a-1.AA MLK 403-415 38 0.160763 1.2 In-house 279-291 (291) Show / Hide 
Range on Protein: 403-415
Range on HMM: 279-291/291
Sequence Identity: 38% (5 aa)

SQRPSMVEVVKVL
..|||. ..|. |
HKRPSFRQIVQHL
Kinase IRAK-0_a-1.AA Pkinase_Tyr 403-415 30 5.301997 0.63 Pfam 258-270 (270) Show / Hide 
Range on Protein: 403-415
Range on HMM: 258-270/270
Sequence Identity: 30% (4 aa)

SQRPSMVEVVKVL
..||.. |..  |
EDRPTFSEIHEQL