Gene IRAK-0_ae-1 (S.moellendorffii)

IRAK-0_ae-1

Species: S.moellendorffii
Alias: IRAK-0_ae-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_ae-1.AA Protein None 339 None Fasta, JSON
IRAK-0_ae-1.NA RNA None 1020 None Fasta, JSON
IRAK-0_ae-1.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_ae-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_ae-1.AA TKL 21-291 21 4.6e-66 225.79 In-house 1-364 (364) Show / Hide 
Range on Protein: 21-291
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

IGSGGFGTVYKGLFDD---------GSVLAIKRANH---------------------------TSKQSSRHFYNEVAVLSQVNHRNLLRLMGCCVDSDV-
|||||||.|||| .           | . |.|. .                            ....   .. .|. ..|. .| |....||.| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PILVYEYIPNGNLFEHLHKRPGVLSWSNRLTIAIETAEALAYLHSAAY-----PPIYHRDVKSANILLDNAFT--------------T
            . .|.||.|.|.|...||       |. |. .|...| ...||||        ||| ||| ||.|||.|. .|               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVADFGLSRLVPVD-----------------VTHVSTMVQG-TPGYVDPEY----------------HQTYQLTDKSDVYSFGVVLLEMVTGRKPVDFAR
|..|||||| .  .                 ...  || |. ||..  ||                  . .. . |.||||||.|| |..|...      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------

ASKDVNLSAYS-VP-----------LIRKGLIEEIVDPKLE-----VRVSGNAADLELLESIRAVANVAMACLAFTRDERPTMKRVLEEL
         |.  |           .. .. ...   | .      ..     .        . ... .. | .   ..||.....|..|
--------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH---K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_ae-1.AA IRAK 15-215 37 3.3e-57 196.36 In-house 1-225 (317) Show / Hide 
Range on Protein: 15-215
Range on HMM: 1-225/317
Sequence Identity: 37% (84 aa)

FDKEHKIGSGGFGTVYKGLFDDGS-VLAIK----RANHTSKQSSRHFYN---EVAVLSQVNHRNLLRLMGCCVDSDVPILVYEYIPNGNLFEHLHKRPG-
|.|...||.||||.||.| ..    . |.|     |. . ... . |     |. |..   | |.. | | | ... . |||.|.||| |.  |. . | 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-V---LSWSNRLTIAIETAEALAYLHSAA-YPPIYHRDVKSANILLDNAFTTKVADFGLSRLV---PVDVTHVS-----TMVQGTPGYVDPEYHQ--TYQ
     |||  |. |.. || .. .||..    || |.|.||||||||  || | .|||| |     ..   ...       |.||  |  ||.    . |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTDKSDVYSFGVVLLEMVTGRKPVD
|| |.||||||.|||| .||...|.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_ae-1.AA TKL-Unique 19-210 33 1.4e-46 161.08 In-house 3-224 (290) Show / Hide 
Range on Protein: 19-210
Range on HMM: 3-224/290
Sequence Identity: 33% (75 aa)

HKIGSGGFGTVYKGLFDDGSVLAIKRANH---TSKQSSRHFYNEVAVLSQVN-HRNLLRLMGCCVDSDVPIL----VYEYIPNGNLFEHLH---------
 |||.||.|.|||| .   .| |||. .     |..... |.||| ...  . | |....|| |.|  |..     | ||.| |.| ..||         
NKIGEGGYGQVYKGKWRGYPV-AIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

KRPGVLSWSNRLTIAIETAEALAYLHSAAYPPIYHRDVKSANILLDNA-----FTTKVADFGLSRLVPVDVTHVSTMV--------QGTPGYVDPEYHQT
..   |....|...||  | .. |||.   | |.||| || |.|.||.     .  |..|||||..   . .  ...         .|.. .. ||    
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--YQLTDKSDVYSFGVVLLEMVTG
  .| . ||||||||.|| |..|.
NFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_ae-1.AA Pkinase 15-211 30 1.8e-46 165.41 Pfam 1-209 (293) Show / Hide 
Range on Protein: 15-211
Range on HMM: 1-209/293
Sequence Identity: 30% (65 aa)

FDKEHKIGSGGFGTVYKGLFDDGSV-LAIKRANHTSKQSSRHFYN----EVAVLSQVNHRNLLRLMGCCVDSDVPILVYEYIPNG----NLFEHLH-KRP
. .. |||||.||.|||.   . .   |.|. .  .. |. . ..    |....  .|| | .|| ... |.| . .| || ..|     ||.... .| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GVL--SWSNRLTIAIETAEALAYLHSAAYPPIYHRDVKSANILLDNAFTT----KVADFGLSRLVPVDVTHVSTMVQGTPGYVDPEYHQ-TYQLTDKSDV
|..  |.     .. .....|.|.||     | |||.|..|||.||  ..    |..||||....     .  | . |||.|. || ..     . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGVVLLEMVTGR
.|.|..| ||..||
WSCGCILYEMLCGR
Kinase IRAK-0_ae-1.AA S_TKc 15-292 25 1.2e-44 155.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-292
Range on HMM: 1-231/231
Sequence Identity: 25% (75 aa)

FDKEHKIGSGGFGTVYKGLFDD-GSVLAIKRANHTSKQSSRHFYNEVAVLSQVNHRNLLRLMGCCVDSDVPILVYEYIPN--GNLFEHLHKRPGV-----
...  |||.|.||.|||.   . | . |||. .       .|...|...|.. .| |. .| ....| |   .| ||...  |.||....||..      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSWSNRLTIAIETAEALAYLHSAAYPPIYHRDVKSANILLDNAFTTKVADFGLSRLVPVDVTHVSTMVQGTPGYVDPEYHQTYQLTD-KSDVYSFGVVLL
..      .. ....||.|.||     | |||.| .|||||.  . |..||||.|..        | . ||| |. ||     . .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMVTGRKPVDFARASKDVNLSAYSVPLIRKGLIEEIVDPKLEVRVSGNAADLELLESIRAVANVAMACLAFTRDERPTMKRVLE--------ELV
||..|. | .              . .. | .                        |  |     . || .  ..|||   .|.        . .
EMLCGYPPFP-------------QMQMMFKKIG-----------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_ae-1.AA MLK 15-213 29 4.8e-41 140.14 In-house 1-235 (291) Show / Hide 
Range on Protein: 15-213
Range on HMM: 1-235/291
Sequence Identity: 29% (71 aa)

FDKEHKIGSGGFGTVYKGLFDDGS----VLAIKRAN---HTSKQS----SRHFYNEVAVLSQVNHRN----LLRLMGCCVDSDV-PILVYEYIPNGNLFE
.. ...||||.|| |.|| .        ..|.||..     .|..    ...|  |.  |. ..|.|      ...|.| ..     .| ||...| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLHKRPG-------------VLSWSNRLTIAIETAEALAYLHSAAYPPIYHRDVKSANILLDN------AFTTKVADFGLSRLVPVDVTHV-STMVQ--G
 || ...             | . .  ...|   |....|||| | .|| ||| || |||.|.        | |..|||.||    |...  ..|    |
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSNAG

TPGYVDPEY---HQTYQLTDKSDVYSFGVVLLEMVTGRKP
|. .  ||     .  . . |.||.|.|||| ||.|.. |
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_ae-1.AA TK 15-213 16 4.5e-38 124.71 In-house 1-394 (486) Show / Hide 
Range on Protein: 15-213
Range on HMM: 1-394/486
Sequence Identity: 16% (65 aa)

FDKEHKIGSGGFG---TVYKGLFDDGS--------------------------VLAIKRANHTSKQSSRHFYN--------------EVAVLSQVN----
   ..|.|.| ||   .||||.  ...                            |.|    .. .|.. |                |...... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLLRLMGCCVDSDV------------PILVYEYIPNGN----LFEHLHKRPGV--------------------------------------------
 | |..|| |.|....             ...| || |.|.    | ..|.|...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSWSNRLTIAIETAEALAYLHSAAY---PPIYHRDVKSANILLDNAFT-----------TKVADFG---
                               |.   .| ..   |....||||  .   . . |||.   |.|...  .            |.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRLVPVDVTHVSTMVQGTPG-------------------------YVDPEYHQ---------TYQLTDKSDVYSFGVVLLEMVT-GRKP
     |.| .. |   ...  .||..                         .  ||  .         .   | ||||.||||.. |..| |..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAK-0_ae-1.AA LRRK 15-215 28 5.6e-38 131.95 In-house 1-284 (351) Show / Hide 
Range on Protein: 15-215
Range on HMM: 1-284/351
Sequence Identity: 28% (81 aa)

FDKEHKIGSGGFG-TVYKGLFDD---------------------------GSVLAIKRANHT----------------------------------SKQS
. .| .||.|||| .||.. . .                           ..  |||  | .                                  .  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

SRHFYNEVAVLSQVNHRNLLRLMGCCVDSDVPILVYEYIPNGNLFEHLH--KRPG------VLSWSNRLTIAIETAEALAYLHSAAYPPIYHRDVKSANI
 | | .||...|  || |.. |.| | .   ...| ||.|.|.| ..||  |. |      ..||. .| ||.. |....||||.  ||| ||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHN-PPIIHRDLKSPNI

LL---D---------NAFTTKVADFGLSRLVPVDVTH--VSTMVQGTPGYVDPEYHQ---TYQLTDKSDVYSFGVVLLEMVTGR-KPVD
||   .         .. . |.||||.||.    ...  ....| |.||.. ||  .   . . |.|.|.||||..| | .|..  | |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCV-GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_ae-1.AA Ciliate-E2 15-257 20 6.2e-37 124.32 In-house 1-336 (365) Show / Hide 
Range on Protein: 15-257
Range on HMM: 1-336/365
Sequence Identity: 20% (75 aa)

FDKEHKIGSGGFGTVYKG-------LF-----------------DDGSVLAIKRANHTSKQSSR---HFY----------NEVAVLSQVNHRNLLRLMGC
...  |||.|.||.|||.       .|                 ....  |.|. ..  ...     | .          ||  .|.|.|| |....  |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CV--DSDVPILVYEYIPNGNLFEHLHKRP----------GVLSWSNRLTIAIETAE---------------ALAYLHSAAYPPIYHRDVKSANILLDNAF
    | .   || ||.  |.||... ...          . ...  ...|  . ..               || ||||     | ||| |  |||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

TTKVADFGLSRLVPVD-----------------VTHVSTM-------------VQGTPGYVDPEYHQ--TYQ-------LTDKSDVYSFGVVLLEMVTGR
  |..|||||. .  |                  |....              . |||||. || ..   |.        . |.|..|.||.| ||..|.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

KPVDFARASKDVNLSAYSVPLIRKGLIEEIVDPKLEVR--------------------VSGNAADL
 |                        ...| . |.. .                    .| .. ||
PPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDL
Kinase IRAK-0_ae-1.AA Dicty4-Unclassified 18-213 32 1.4e-35 119.35 In-house 4-207 (263) Show / Hide 
Range on Protein: 18-213
Range on HMM: 4-207/263
Sequence Identity: 32% (69 aa)

EHKIGSGGFGTVYKGLFDDGSVLAIKRANHTSKQSSR-----HFYNEVAVLSQVNHRNLLRLMGCCVDS----DVPILVYEYIPNGNLFEHLH----KRP
   || | |  |.||    |   |.|  |   | . |      |  ||..|  . | ||... | |.         . | | .. |||||  |     . 
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNEN-KFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQ

GVLSWSN--RLTIAIETAEALAYLHSAAYPPIYHRDVKSANILLDNAFTTKVADFGLSRLVPVDVTHVSTMVQGTPGYVDPEYHQTYQLTDKSDVYSFGV
  ..      . .|.. |  ...||.     . |||.||.|||.|  |  |.||||.||   .| .   | . |||    ||       . ||||||...
QPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMDKHFNIKIADFGISRV--IDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAM

VLLEMVTGRKP
.| |..||  |
MLYELATGDEP
Kinase IRAK-0_ae-1.AA LISK 20-163 32 1.5e-32 102.92 In-house 1-155 (296) Show / Hide 
Range on Protein: 20-163
Range on HMM: 1-155/296
Sequence Identity: 32% (52 aa)

KIGSGGFGTVYKG-LFDDGSVLAIKRANH-----TSKQSSRHFYNEVAVLSQVNHRNLLRLMGCCVD-SDVPILVYEYIPNGNLFEHLHKRPG---VLSW
.||.|.|| |||| .. .|.| |||           .   . .  ||...    |.| .. || |.  ..   .| |||  |.|.. |....    .|.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

SNRLTIAIETAEALAYLHSAAYPPIYHRDVKSANILLDNA----FTTKVADFGLSRLV
. |. ||   |....||||     | ||| || |.|...     .. ||.|||. |..
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMM
Kinase IRAK-0_ae-1.AA Pkinase_Tyr 15-163 27 3.1e-32 109.79 Pfam 1-161 (270) Show / Hide 
Range on Protein: 15-163
Range on HMM: 1-161/270
Sequence Identity: 27% (45 aa)

FDKEHKIGSGGFGTVYKGLFD-----DGSVLAIKRANHTSKQS---SRHFYNEVAVLSQV-NHRNLLRLMGCCV-DSDV--PILVYEYIPNGNLFEHLHK
  . .|.|.| ||.||||  .     ..   |.|  .... ..   .. | .|.....|  .| |..||.|.|. ...   ...| || |.|.| ..|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---PGVLSWSNRLTIAIETAEALAYLHSAAYPPIYHRDVKSANILLDNAFTTKVADFGLSRLV
.   .. |. .  | .... |....||.|     . |||.   |.|... .. |..||||.|..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase IRAK-0_ae-1.AA Dicty4 56-213 34 3.5e-31 101.37 In-house 45-216 (277) Show / Hide 
Range on Protein: 56-213
Range on HMM: 45-216/277
Sequence Identity: 34% (59 aa)

FYNEVAVLSQVNHRNLLRLMGCCV----DSDVPILVYEYIPNGNLFEHLHK------RPGVLSWSNRLT---IAIETAEALAYLHSAAYPPIYHRDVKSA
| .||. ...  | |.. .|| |      .  .  | || | |||.. ||.          |.|. ..    .|. .|  ...||.   | | ||| ||.
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCN-PVIIHRDLKSH

NILLDNAFTTKVADFGLSRLVPVDVTHVS-TM-VQGTPGYVDPEYHQTYQLTDKSDVYSFGVVLLEMVTGRKP
|.| |  .. ||.|||||..   . .|   .| . |||... ||  .    . |.|||||| || |..|.  |
NLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEP
Kinase IRAK-0_ae-1.AA TyrKc 15-291 23 2.4e-24 88.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-291
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FDKEHKIGSGGFGTVYKGLFDDGSVLAIKRANHTSKQSSRHFYNEVAVLSQV--NHRNLLRLMGCCVDS-------DVPILVYEYIPNGNLFEHLHKRPG
  ...|.|.| ||.||||  .     |.|  .. .    . |..|  .....  .| |..|| |.|...       . . .| || |.|.| ..|.|. .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

VLSWSNRLTIAIETAEALAYLHSAAYPPIYHRDVKSANILLDNAFTTKVADFGLSRLVPVD----VTHVSTMVQGTPGYVD--------PEYHQTYQLTD
 |...  | ...  |.  .||||    .. |||    |.|... .| |..|||||| .  |    . .   ..... |  .        ||  ...  | 
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KSDVYSFGVVLLEMVTGRKPVDFA-----RASKDVNLSAYSVPLIRKGLIEEIVDPKLEVRVSGNAADLELLESIRAVANVAMACLAFTRDERPTMKRVL
||||.||||.. |. |  ..            ..|      . ....|   .. .  .   .|         .   .. ..   | ..  ..|||.. . 
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV------IEYVKQGYRMPQPPNDY-P-MS-------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

EEL
|..
ECF
Kinase IRAK-0_ae-1.AA LISK 192-213 45 2.1e-07 19.89 In-house 217-238 (296) Show / Hide 
Range on Protein: 192-213
Range on HMM: 217-238/296
Sequence Identity: 45% (10 aa)

TDKSDVYSFGVVLLEMVTGRKP
....||.|||.||.|..|..|.
DESCDVFSFGIVLCEIITRVKA
Kinase IRAK-0_ae-1.AA Dicty4 15-32 55 3.4e-05 13.45 In-house 1-18 (277) Show / Hide 
Range on Protein: 15-32
Range on HMM: 1-18/277
Sequence Identity: 55% (10 aa)

FDKEHKIGSGGFGTVYKG
 ..| .||.|.||.||||
INIEQRIGKGSFGEVYKG
Kinase IRAK-0_ae-1.AA Pkinase_Tyr 192-213 56 0.000128 16.27 Pfam 192-214 (270) Show / Hide 
Range on Protein: 192-213
Range on HMM: 192-214/270
Sequence Identity: 56% (13 aa)

TDKSDVYSFGVVLLEMVT-GRKP
| ||||.||||.. |..| |..|
TTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAK-0_ae-1.AA TK 265-291 22 0.000763 7.92 In-house 460-486 (486) Show / Hide 
Range on Protein: 265-291
Range on HMM: 460-486/486
Sequence Identity: 22% (6 aa)

AVANVAMACLAFTRDERPTMKRVLEEL
... . . | ..  ..|||.. ..|.|
EYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_ae-1.AA IRAK 269-291 26 0.069746 2.66 In-house 295-317 (317) Show / Hide 
Range on Protein: 269-291
Range on HMM: 295-317/317
Sequence Identity: 26% (6 aa)

VAMACLAFTRDERPTMKRVLEEL
.|  |..    .|..|. |...|
CACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_ae-1.AA Pkinase_Tyr 266-291 23 0.170012 5.69 Pfam 245-270 (270) Show / Hide 
Range on Protein: 266-291
Range on HMM: 245-270/270
Sequence Identity: 23% (6 aa)

VANVAMACLAFTRDERPTMKRVLEEL
. .. . | ..  ..|||.. ..|.|
IYDLMKQCWHYDPEDRPTFSEIHEQL