Gene IRAK-0_ad (S.moellendorffii)

IRAK-0_ad

Species: S.moellendorffii
Alias: IRAK-0_ad
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_ad.AA Protein None 694 None Fasta, JSON
IRAK-0_ad.NA RNA None 2085 None Fasta, JSON
IRAK-0_ad.kin_dom Protein Kinase Domain None 149 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_ad.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_ad.AA TKL 95-241 24 2.2e-42 147.1 In-house 1-206 (364) Show / Hide 
Range on Protein: 95-241
Range on HMM: 1-206/364
Sequence Identity: 24% (52 aa)

LGQGGFGPVHKGVLRN---------GQVVAVKSLDSASLQGE---------------------------KEFQNEMAVIGSIRCSHIVGLMGYCAERKK-
.|.|||| |.||..|.         |..|||| . | . . .                           ... .|. .. ..|. .|| .|||| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEYMANRSLQEALFHDGYPVELDWKMRYKVILDIAQALAFLHF------RCEPPIIHGDIKPSNVLLDDKLC------------
              .|.||. . || . |          |  | . .||||.....||       .  ||||| |.|..|.|.|...             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--ARLADFGLARVKTE
  . ..||||.|....
WCCKICDFGLSRFMSQ
Kinase IRAK-0_ad.AA IRAK 89-237 37 1.6e-37 130.54 In-house 1-161 (317) Show / Hide 
Range on Protein: 89-237
Range on HMM: 1-161/317
Sequence Identity: 37% (60 aa)

FSIENKLGQGGFGPVHKGVLRNGQ-VVAVK----SLDSASLQGEKEFQN---EMAVIGSIRCSHIVGLMGYCAERKKRLLVYEYMANRSLQEALFHDGYP
|. .|..|.|||| | .|...|   ..|||      |.   . ...||    |. |  ..|  .|| | |||.|| .  |||.||.| ||.  |   .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VE---LDWKMRYKVILDIAQALAFLHFRC-EPPIIHGDIKPSNVLLDDKLCARLADFGLAR
.    | | .| .. . .| .. |||      ||||||||..|.|||. . . ..||||.|
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHR
Kinase IRAK-0_ad.AA TKL-Unique 91-240 33 4.7e-31 106.81 In-house 1-168 (290) Show / Hide 
Range on Protein: 91-240
Range on HMM: 1-168/290
Sequence Identity: 33% (57 aa)

IENKLGQGGFGPVHKGVLRNGQVVAVKSLD-SASLQGE--KEFQNEMAVIGSIR-CSHIVGLMGYCA----ERKKRLLVYEYMANRSLQEALF-------
. ||.|.||.|.| ||. | |  ||.|..   ...  |  .|| ||  ..  ..    || .||||.      ... .| ||.   || . |        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--HDGYPVELDWKMRYKVILDIAQALAFLHFRCEPPIIHGDIKPSNVLLDDK-----LCARLADFGLARVKT
   . ..  |....|.| ..||||.. .||. |||||||.|.|.||.|.| .     . ....||||.....
NNNNNCK--LNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNS
Kinase IRAK-0_ad.AA LRRK 89-246 21 2.1e-29 101.16 In-house 1-239 (351) Show / Hide 
Range on Protein: 89-246
Range on HMM: 1-239/351
Sequence Identity: 21% (53 aa)

FSIENKLGQGGFG-PVHKGVLRN---------------------------GQVVAVKSLDSA----------------------------------SLQG
. ||...|.|||| .|... .|.                           .| ||.|...                                    ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EKEFQNEMAVIGSIRCSHIVGLMGYCAERKKRLLVYEYMANRSLQEALF---HDGY---PVELDWKMRYKVILDIAQALAFLHFRCEPPIIHGDIKPSNV
  ||..|.... . . ..|| |.|.|   . . .| ||. . .|.. |.   .||    . ...| ...|. |.|| ....|| .. ||||| | |. |.
FREFRHEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNI

LL---D---------DKLCARLADFGLAR----VKTEAAPDV
||   .         .  || .||||. |    .....|...
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGC
Kinase IRAK-0_ad.AA Pkinase_Tyr 89-237 27 2.7e-28 96.43 Pfam 1-159 (270) Show / Hide 
Range on Protein: 89-237
Range on HMM: 1-159/270
Sequence Identity: 27% (44 aa)

FSIENKLGQGGFGPVHKGVLR-----NGQVVAVKSL-DSASLQG--EKEFQNEMAVIGSI-RCSHIVGLMGYCA-ERKK--RLLVYEYMANRSLQEALFH
 ..  |||.| || |.||...     ... ||||.| ..|. .    ..| .|...  .. .. .|| |.| |  ...    ..| |||.. .| . |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D-GYPVELDWKMRYKVILDIAQALAFLHFRCEPPIIHGDIKPSNVLLDDKLCARLADFGLAR
    .  |. |.  .  ..||.....|. .    .|| |.   |.|........ .||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase IRAK-0_ad.AA TK 89-242 14 4.3e-25 80.43 In-house 1-306 (486) Show / Hide 
Range on Protein: 89-242
Range on HMM: 1-306/486
Sequence Identity: 14% (46 aa)

FSIENKLGQGGFG---PVHKGVLRNG--------------------------QVVAVKSLDSASLQGEKEFQN-----------------EMAVIGS--I
  ...|||.| ||    |.|| .|..                          . |||| | . . . ..||.                  ||..  .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RCSHIVGLMGYCAERKK------------RLLVYEYMANRS----LQEALF-HDGYPVE-----------------------------------------
.. .|| | |.| . .              ..| |||.. .    |.. |  ....  .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWKMRYKVILDIAQALAFLHFR---CEPPIIHGDIKPSNVLLDDKLC-----------ARLADFGLAR
                               |. . .    ..||.....|| .    .. ..|.|.   |.|.....            ...|||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKT--EA
...   |
QGSGVLA
Kinase IRAK-0_ad.AA CAMK 94-587 8 1.4e-24 75.51 In-house 1-331 (425) Show / Hide 
Range on Protein: 94-587
Range on HMM: 1-331/425
Sequence Identity: 8% (53 aa)

KLGQGGFGPVHKGVLR-NG------------QVVAVKSLDSASLQ----------------------------GEKEFQNEMAVIGS-------IRCSHI
.||.|.|| |.... . ..            | ||.| .|   |.                             .|....|...  .       ..  .|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGLMG-------------------YCAE-RKKRLLVY---EYMANR----SLQEALFHDGYP------------VELDWKMRYKVILDIAQALAFLHFRC
. |                     .. . .|.  .|    ||. .      | . .   |..              .. .   ...  |..|....| . 
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

EPPIIHGDIKPSNVLLDDK-----------------LCARLADFGLARVKTE-----------------AAPDVRSEDVLLNGEAAQDHDRVKVERFVQG
   |.| |.|| |.||||.                     ..|||.|.....                 .   .                          
---IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQ---W--------------------------

SSSSLRSLSCGTMVVDQTVETSAGGMRVEEEEVGFSFHNESAAAAAAADNTPPPPSSPRVDGACWKVESRRSLGADRNEDGTSQVVSKWWWKQQDERDET
                                                                                                    
----------------------------------------------------------------------------------------------------

NAIVKDYTVDWLSCQVKSGRSRSRDWGDASVGNSFQGKNSKKQHRSRDVSGNLTKSREWWREEYLEDLCNKSRELKGGKKMSSQSRSRDLSSCSFDFSGD
                                                                                                    
----------------------------------------------------------------------------------------------------

LSSKYQHQPQGGGGGGREWWSGDLLHWIHRRGDSGTIDFSGELNSFSRELRSRERTLSRERWSGELGSRGAVSSTTS--------MRGTVCYAA-PEYGG
                                                                          ||.        . || .|.| ||   
--------------------------------------------------------------------------TTPTEGQKMKTFCGTPEYMAAPEVLN

AGI--------------LSEKSDVYSFGVLVLVIVAGR
                  ..|.|. | ||.  . . |.
GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGY
Kinase IRAK-0_ad.AA Pkinase 89-238 23 2.1e-24 87.35 Pfam 1-161 (293) Show / Hide 
Range on Protein: 89-238
Range on HMM: 1-161/293
Sequence Identity: 23% (38 aa)

FSIENKLGQGGFGPVHKGVLRNGQV-VAVKSLDSASLQGEKEFQN-----EMAVIGSIRCSHIVGLMGYCAERKKRLLVYEYMANR----SLQEALF-HD
. |. |.|.|.|| | |.. .. .  |||| ..    . ... |.     | ..  .... .|| | ... ....  .| ||. .     .| . .  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GYPVELDWKMRYKVILDIAQALAFLHFRCEPPIIHGDIKPSNVLLDDKLCA----RLADFGLARV
. .. ....   .... |...|...| .    ||| |.||.|.|.|..       ...|||||..
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ
Kinase IRAK-0_ad.AA LISK 94-238 30 6.1e-23 71.2 In-house 1-154 (296) Show / Hide 
Range on Protein: 94-238
Range on HMM: 1-154/296
Sequence Identity: 30% (48 aa)

KLGQGGFGPVHKGVLR-NGQVVAVKSLDS-----ASLQGEKEFQNEMAVIGSIRCSHIVGLMGYCAE-RKKRLLVYEYMANRSLQEALFHDGY-PVELDW
..|.|.|| | || .|  |||.|.| . .          .| .. |.... ..|  .||  || | .  ..  .| ||.    |.. |.  .   . | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

KMRYKVILDIAQALAFLHFRCEPPIIHGDIKPSNVLLDDK----LCARLADFGLARV
. | |  ||||.....||...   ||| | |  |.|....      ....|||.||.
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARM
Kinase IRAK-0_ad.AA RIPK 95-236 33 6.5e-23 74.9 In-house 1-156 (290) Show / Hide 
Range on Protein: 95-236
Range on HMM: 1-156/290
Sequence Identity: 33% (52 aa)

LGQGGFGPVHKGVLRN-GQVVAVKSLDSAS------LQGEKEFQNEMAVIGSIRCSHIVGLMGYCAERKK------RLLVYEYMANRSLQEALFHDG--Y
.| |||| | | . |  | .||.|   .         | ...   | .   ..||.||| . | | . ..        .| |||.| || . |       
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

PVELDWKMRYKVILDIAQALAFLHFRCEPPIIHGDIKPSNVLLDDKLCARLADFGLA
.  . |. |   |  |. .  .||    ||||| | ||.|.|.|  . . .||||||
HHPDPWPLRCRMIHEISCGMCYLH-SMNPPIIHRDLKPENILVDNNFHVKIADFGLA
Kinase IRAK-0_ad.AA Dicty4 89-239 32 2e-22 71.73 In-house 1-164 (277) Show / Hide 
Range on Protein: 89-239
Range on HMM: 1-164/277
Sequence Identity: 32% (55 aa)

FSIENKLGQGGFGPVHKGVLRNGQVVAVKSL----DSASLQGEKEFQNEMAVIGSIRCSHIVGLMGYCA----ERKKRLLVYEYMANRSLQEALFHD---
  ||...|.|.|| |.||  | |. |||| |    . ...   .|| .| .  ..||  .|. .||.|     .  | . | |||   .| . | ||   
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNL-YSLLHDKPS

--GYPVELDWKMRYK---VILDIAQALAFLHFRCEPPIIHGDIKPSNVLLDDKLCARLADFGLARVK
     ..|||  . .     .|.|. .. ||  | | ||| |.|..| | |. . .  .||||....
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYM
Kinase IRAK-0_ad.AA S_TKc 89-661 10 3.1e-22 81.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 89-661
Range on HMM: 1-231/231
Sequence Identity: 10% (62 aa)

FSIENKLGQGGFGPVHKGVLRN-GQVVAVKSLDSASLQGEKEFQNEMAVIGSIRCSHIVGLMGYCAERKKRLLVYEYMAN--RSLQEALFHDGYPVE---
. | .|.|.|.|| |.|.. .. |..||.| ..       . ...|...  . .. .|| | ... . ..  .| ||. .   .| . . . |..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWKMRYKVILDIAQALAFLHFRCEPPIIHGDIKPSNVLLDDKLCARLADFGLARVKTEAAPDVRSEDVLLNGEAAQDHDRVKVERFVQGSSSSLRSLSC
..  .  ...  |..||...| .    ||| |.||.|.|||.  .  ..||||||.                                            
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

GTMVVDQTVETSAGGMRVEEEEVGFSFHNESAAAAAAADNTPPPPSSPRVDGACWKVESRRSLGADRNEDGTSQVVSKWWWKQQDERDETNAIVKDYTVD
                                                                                                    
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WLSCQVKSGRSRSRDWGDASVGNSFQGKNSKKQHRSRDVSGNLTKSREWWREEYLEDLCNKSRELKGGKKMSSQSRSRDLSSCSFDFSGDLSSKYQHQPQ
                                                                                                    
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GGGGGGREWWSGDLLHWIHRRGDSGTIDFSGELNSFSRELRSRERTLSRERWSGELGSRGAVSSTTSMRGTVCYAAPEYGGAGILSEKSDVYSFGVLVLV
                                                                 |.. ||  | |||    |   .|.|..|.|...  
-----------------------------------------------------------------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYE

IVAGRRPLQVVSPSVEFERANLTSWARHLVHNGDVLELVDPSLRGEFSREQAALCIMVALQCIQRLPASRPSMAEVVR----------V
 ..|. | .   . . |..                                   ..    .| |. |. ||.  |. .          .
MLCGYPPFP--QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_ad.AA MLK 89-237 24 7.9e-19 62.04 In-house 1-181 (291) Show / Hide 
Range on Protein: 89-237
Range on HMM: 1-181/291
Sequence Identity: 24% (44 aa)

FSIENKLGQGGFGPVHKGVLRNGQ----VVAVKSLD----SASLQG--EKEFQNEMAVIGSIRCSH----IVGLMGYCAER-KKRLLVYEYMANRSLQEA
. .. ..| |.|| |.||. ||      .||||  .    ..|  .   ..|. |      ..       |. ..| |..  .. ..| ||... || . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFHDGYP------------VELDWKMRYKVILDIAQALAFLHFRCEPPIIHGDIKPSNVLLDD------KLCARLADFGLAR
| |.. .            .  |     .  |..|.....||    .|||| |.|..|.|.|.      .. .. .|||..|
L-HGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase IRAK-0_ad.AA TyrKc 89-662 8 2.7e-15 24.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 89-662
Range on HMM: 1-280/280
Sequence Identity: 8% (56 aa)

FSIENKLGQGGFGPVHKGVLRNGQVVAVKSLDSASLQGEKEFQNEMAVIGSI--RCSHIVGLMGYCAER-------KKRLLVYEYMANRSLQEAL-FHDG
 . . ||| | || |.||...  . ||||.| . .   ...| .|. .  ..  .  .|| | |.| .        .  ..| |||.. .|.. |  | .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

YPVELDWKMRYKVILDIAQALAFLHFRCEPPIIHGDIKPSNVLLDDKLCARLADFGLARVKTEA------APDVR-----SED-----------VLLNG-
    | .|   .  ..||.  ..|| .   ..|| |.   |.|........ .||||.|  ..           |     ...           ..  | 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

-------------------EAAQDHDR-----VKVERFVQGSSSSLRSLSCGT---MVVDQTVETSAGGMRVEEEEVGFSFHNESAAAAAAADNTPPPPS
                     .| .       .. .. ..   .  |         |                                           
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------------

SPRVDGACWKVESRRSLGADRNEDGTSQVVSKWWWKQQDERDETNAIVKDYTVDWLSCQVKSGRSRSRDWGDASVGNSFQGKNSKKQHRSRDVSGNLTKS
                                                                                                    
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REWWREEYLEDLCNKSRELKGGKKMSSQSRSRDLSSCSFDFSGDLSSKYQHQPQGGGGGGREWWSGDLLHWIHRRGDSGTIDFSGELNSFSRELRSRERT
                                                                                                    
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LSRERWSGELGSRGAVSSTTSMRGTVCYAAPEYGGAGILSEKSDVYSFGVLVLVIVAGRRPLQVVSPSVEFERANLTSWARHLVHNGDVLELVDPSLRGE
                                                                                                    
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FSREQAALCIMVALQCIQRLPASRPSMAEVVRVV
|  .  .   .. .|| .. |..||...|...  
F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_ad.AA IRAK 544-589 39 1.1e-08 27.07 In-house 176-223 (317) Show / Hide 
Range on Protein: 544-589
Range on HMM: 176-223/317
Sequence Identity: 39% (19 aa)

VSSTTSMRGTVCYAAPEYGG--AGILSEKSDVYSFGVLVLVIVAGRRP
.  |   |||  | .||.     |.|. |.||||||. .| ...|.|.
CMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRA
Kinase IRAK-0_ad.AA TKL 547-589 30 4e-06 18.08 In-house 230-288 (364) Show / Hide 
Range on Protein: 547-589
Range on HMM: 230-288/364
Sequence Identity: 30% (18 aa)

TTSMRGTVCYAAPEY----------------GGAGILSEKSDVYSFGVLVLVIVAGRRP
| . .|| .. |||                  . .  |||.||||||..   |....||
TMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase IRAK-0_ad.AA RIPK 544-589 27 2e-05 14.39 In-house 174-227 (290) Show / Hide 
Range on Protein: 544-589
Range on HMM: 174-227/290
Sequence Identity: 27% (15 aa)

VSSTTSMR--GTVCYAAPEYGG----AG--ILSEKSDVYSFGVLVLVIVAGRRP
|.|..|    ||  | .||       .   . ..|.|||||....  . ... |
VYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-0_ad.AA MLK 548-579 40 0.000127 12.11 In-house 191-225 (291) Show / Hide 
Range on Protein: 548-579
Range on HMM: 191-225/291
Sequence Identity: 40% (14 aa)

TSMRGTVCYAAPEY---GGAGILSEKSDVYSFGVL
.|..||. . |||      ..  |||.||.|.||.
MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVV
Kinase IRAK-0_ad.AA TK 640-662 21 0.000563 8.37 In-house 464-486 (486) Show / Hide 
Range on Protein: 640-662
Range on HMM: 464-486/486
Sequence Identity: 21% (5 aa)

VALQCIQRLPASRPSMAEVVRVV
. .|| .. |. ||.......  
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_ad.AA TK 565-580 62 0.001092 7.39 In-house 369-384 (486) Show / Hide 
Range on Protein: 565-580
Range on HMM: 369-384/486
Sequence Identity: 62% (10 aa)

GILSEKSDVYSFGVLV
|. ..||||.|||||.
GKFTTKSDVWSFGVLM
Kinase IRAK-0_ad.AA LRRK 540-579 27 0.003929 6.91 In-house 225-271 (351) Show / Hide 
Range on Protein: 540-579
Range on HMM: 225-271/351
Sequence Identity: 27% (13 aa)

SR--GAVSS--TTSMRGTVCYAAPEYGGAG---ILSEKSDVYSFGVL
||   .. .  .  . |.  . |||  ...     .||.|.||||..
SRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMI
Kinase IRAK-0_ad.AA LISK 568-589 31 0.004504 5.6 In-house 217-238 (296) Show / Hide 
Range on Protein: 568-589
Range on HMM: 217-238/296
Sequence Identity: 31% (7 aa)

SEKSDVYSFGVLVLVIVAGRRP
.|..||.|||.... |......
DESCDVFSFGIVLCEIITRVKA
Kinase IRAK-0_ad.AA Dicty4 547-577 45 0.008302 5.39 In-house 174-204 (277) Show / Hide 
Range on Protein: 547-577
Range on HMM: 174-204/277
Sequence Identity: 45% (14 aa)

TTSMRGTVCYAAPEYGGAGILSEKSDVYSFG
.... ||.|. |||        ||.||||||
QMTACGTPCWMAPEVMMHQPYNEKADVYSFG
Kinase IRAK-0_ad.AA Pkinase_Tyr 565-579 66 0.014312 9.33 Pfam 189-203 (270) Show / Hide 
Range on Protein: 565-579
Range on HMM: 189-203/270
Sequence Identity: 66% (10 aa)

GILSEKSDVYSFGVL
|. ..||||.|||||
GKFTTKSDVWSFGVL
Kinase IRAK-0_ad.AA TKL-Unique 568-578 90 0.016198 4.91 In-house 206-216 (290) Show / Hide 
Range on Protein: 568-578
Range on HMM: 206-216/290
Sequence Identity: 90% (10 aa)

SEKSDVYSFGV
||||||||||.
SEKSDVYSFGI
Kinase IRAK-0_ad.AA Pkinase_Tyr 642-662 28 0.026391 8.43 Pfam 250-270 (270) Show / Hide 
Range on Protein: 642-662
Range on HMM: 250-270/270
Sequence Identity: 28% (6 aa)

LQCIQRLPASRPSMAEVVRVV
.|| .  |. ||...|...  
KQCWHYDPEDRPTFSEIHEQL
Kinase IRAK-0_ad.AA IRAK 639-662 25 0.063347 2.81 In-house 294-317 (317) Show / Hide 
Range on Protein: 639-662
Range on HMM: 294-317/317
Sequence Identity: 25% (6 aa)

MVALQCIQRLPASRPSMAEVVRVV
..|..|  .  . |..||.|.   
QCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_ad.AA MLK 643-662 35 0.126998 1.56 In-house 272-291 (291) Show / Hide 
Range on Protein: 643-662
Range on HMM: 272-291/291
Sequence Identity: 35% (7 aa)

QCIQRLPASRPSMAEVVRVV
|| .  |..|||....|   
QCWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_ad.AA Pkinase 545-591 30 0.322083 5.39 Pfam 167-213 (293) Show / Hide 
Range on Protein: 545-591
Range on HMM: 167-213/293
Sequence Identity: 30% (16 aa)

SSTTSMRGTVCYAAPEYGGAGIL-----SEKSDVYSFGVLVLVIVAGRRPLQ
| .|.  ||  |.|||     |.     . |.|..|.|...   . || | .
S-MTTFCGTPWYMAPEV----IRGGQYYGPKVDMWSCGCILYEMLCGRPPFP