Gene IRAK-0_ba (S.moellendorffii)

IRAK-0_ba

Species: S.moellendorffii
Alias: IRAK-0_ba
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_ba.AA Protein None 489 None Fasta, JSON
IRAK-0_ba.NA RNA None 1470 None Fasta, JSON
IRAK-0_ba.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_ba.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_ba.AA TKL 184-449 21 7.2e-72 245.08 In-house 1-364 (364) Show / Hide 
Range on Protein: 184-449
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

LGEGGYGIVYRG-CLG--------DGTPVAVKSLLNNSGQ---------------------------AEKEFRVEVEAIGRVRHKNLVRLLGYCVEINY-
.|.||.|.||.| . |        .|..|||| .  .. .                           .......|.  . | || |.|...||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RMLVYEYVDNGNLEQWLHGPASILNSPTWEVRMKIALGTAKALAYLHEAL-----EPKVVHRDIKASNILLDAHWN------------
             ..|.||...|.|.  ||          |..|...||..|....|||         |...|||.| .|||.| .|.            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKISDFGLAKLLGSDNSHVKTR------------------VMGTFGYVAPEYAN----------------TGLLNERSDVYSFGVLLMEMITGRDPVD
  .||.||||.. .  ...  .|                   . ||... |||  .                 .  .|..||||||..| |..|.. | .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-YSRPSAEVNLVDWVKLMVASRRSEEVADSRLDA-------KPSTRALKRALLVALRCVDPDAIKRPKMGYIVHML
 |  .. ...  . ...| . . ..     . .         | . ....    . .| |.|. ||| .  |.. |
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_ba.AA IRAK 178-381 36 2.1e-58 200.34 In-house 1-225 (317) Show / Hide 
Range on Protein: 178-381
Range on HMM: 1-225/317
Sequence Identity: 36% (83 aa)

FSPDNVLGEGGYGIVYRG-CLGDGTPVAVKSLLNNS----GQAEKEFRV---EVEAIGRVRHKNLVRLLGYCVEINYRMLVYEYVDNGNLEQWLHGPA-S
|..||..||||.| |||| . . . ..||| | ..     .. ...|.    |...  | ||.|.| |.||| |     |||.|  || ||  |.. . .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

ILNSP---TWEVRMKIALGTAKALAYLHEALEPK--VVHRDIKASNILLDAHWNAKISDFGLAKLL----GSDNSHV---KT-RVMGTFGYVAPEYAN--
  ..|   .|  | .|..|||... .||.. .|.  . |.||| .|||||.| ..||.||||.       ..  . .   .| .| ||  | .||. .  
--CPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDP

TGLLNERSDVYSFGVLLMEMITGRDPVD
.| |  ..||||||. |.| .||. .|.
QGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_ba.AA TKL-Unique 180-376 34 2.4e-48 166.96 In-house 1-224 (290) Show / Hide 
Range on Protein: 180-376
Range on HMM: 1-224/290
Sequence Identity: 34% (77 aa)

PDNVLGEGGYGIVYRGCLGDGTPVAVKSLL-NNSGQAE--KEFRVEVEAIGRVR-HKNLVRLLGYCV----EINYRMLVYEYVDNGNLEQWLH--GPAS-
. |..|||||| ||.|  . |.|||.|..  |..   |  .||. ||  . . . |.|.|.. |||.     .... .| ||.. |.|   ||   . . 
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---ILNSPTWEVRMKIALGTAKALAYLHEALEPKVVHRDIKASNILLDAH-----WNAKISDFGLAKLLGSDNSHVKTRV--------MGTFGYVAPEYA
     . .....|.|.|.  |... |||  .||.. |||.| ||.|.| .     ||.||.||||.|.. ..|   ...         .|.| ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

NT--GLLNERSDVYSFGVLLMEMITG
.    . .| |||||||. | |..|.
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_ba.AA TK 178-449 17 1.3e-47 157.26 In-house 1-486 (486) Show / Hide 
Range on Protein: 178-449
Range on HMM: 1-486/486
Sequence Identity: 17% (84 aa)

FSPDNVLGEGGYG---IVYRGCL--------------------------GDGTPVAVKSLLNNSGQAEKEFRV--------------EVEAIGRVR----
    ..|||| .|    ||.| .                          |  |||||| |   ......||.               |.|..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLVRLLGYCVEI------------NYRMLVYEYVDNGN----LEQWLHGPASILNS-----------------------------------------
 |.|.|||.|.|..                |.| ||...|.    | ..|.      .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PTWEVRMKIALGTAKALAYLHEA---LEPKVVHRDIKASNILLDAHWN-----------AKISDFG---
                               .| . .. ...  |....|||.    .....||||. | |.|.. . .           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLGSDNSHVKTRVMGTFG-------------------------YVAPEYAN---------TGLLNERSDVYSFGVLLMEMIT-GRDPVDYSR
     ||. ..||   ....  || .                         . |||  |         .|   . |||.|||||. |. | |. |     
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PS------AEVNLVDWVKLMVA--------------SRRSE-EVADS----RLDAKPSTRALKRALLVALRCVDPDAIKRPKMGYIVHML
..        .|     .|                  |.   . . .    |  . |.  . .   .. ..| ..|. .|| .  ....|
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_ba.AA LISK 183-379 26 5.2e-43 137.47 In-house 1-238 (296) Show / Hide 
Range on Protein: 183-379
Range on HMM: 1-238/296
Sequence Identity: 26% (64 aa)

VLGEGGYGIVYRGCLG-DGTPVAVKSLLN-----NSGQAEKEFRVEVEAIGRVRHKNLVRLLGYCVE-INYRMLVYEYVDNGNLEQWLHGPASILNSPTW
..|.|..| ||.|..  .|...|.| . .     |   ..| .  ||. . . ||.| |.  | |..     ..| ||.. |.|.| |. ...    ..|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EVRMKIALGTAKALAYLHEALEPKVVHRDIKASNILLDAH----WNAKISDFGLAKLLGSDN-----------------------------SHVKTR---
..|.||||. |....|||.    ...||| |. |.|..      |..|. |||.|...  .|                             .    .   
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

-VMGTFGYVAPEYANTGLLNERSDVYSFGVLLMEMITGRDP
 . ||   .|||  .    .|..||.|||..| |.||....
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase IRAK-0_ba.AA Dicty4 178-379 32 9e-41 133.81 In-house 1-216 (277) Show / Hide 
Range on Protein: 178-379
Range on HMM: 1-216/277
Sequence Identity: 32% (70 aa)

FSPDNVLGEGGYGIVYRGCLGDGTPVAVKSL-LNNSG--QAE-KEFRVEVEAIGRVRHKNLVRLLGYCV----EINYRMLVYEYVDNGNLEQWLHG----
   .. .|.|..| ||.|    |. |||| | ..| .  ... .||| ||.  .  || |.. ..|.|     .    . | ||.  |||.  ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--PASILNSPTWEVRMKIALGTAKALAYLHEALEPKVVHRDIKASNILLDAHWNAKISDFGLAKLLGSDNSHVK--TRVMGTFGYVAPEYANTGLLNERS
  .   | .|. .  |..|. .|. ...||.   | ..|||.|..|.| |..|..|..||||...   . .|    . . || ...|||       || .
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCC-NPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVLLMEMITGRDP
|||||| .| |. |. .|
DVYSFGIVLWEILTRQEP
Kinase IRAK-0_ba.AA LRRK 178-381 25 1.8e-39 137.27 In-house 1-284 (351) Show / Hide 
Range on Protein: 178-381
Range on HMM: 1-284/351
Sequence Identity: 25% (74 aa)

FSPDNVLGEGGYG-IVYRGCLGD---------------------------GTPVAVKSLLN-----------NSG-----------------------QA
.   . .|.||.| .|||. . .                           ...||.|...            ...                        |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EKEFRVEVEAIGRVRHKNLVRLLGYCVEINYRMLVYEYVDNGNLEQWLHGPA-SIL----NSPTWEVRMKIALGTAKALAYLHEALEPKVVHRDIKASNI
  ||| ||  . . .| |.| |.|.|  |. ...| ||...|.| . || .. . .     . .| .. ||||  ||...||| .  |...||| |  ||
FREFRHEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNI

LL---D---------AHWNAKISDFGLAKLLGSDNSHVKTRVMGTFGYVAPEYANTG---LLNERSDVYSFGVLLMEMITGR-DPVD
||   .         || .|||.|||.  .  .. . |  .. |..|..|||  . .     .| .|.||||..| | .|.. .| |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_ba.AA Pkinase_Tyr 178-379 29 5.2e-39 132.73 Pfam 1-214 (270) Show / Hide 
Range on Protein: 178-379
Range on HMM: 1-214/270
Sequence Identity: 29% (65 aa)

FSPDNVLGEGGYGIVYRGCLG-----DGTPVAVKSLLNNSGQAE---KEFRVEVEAIGRV-RHKNLVRLLGYCV-E---INYRMLVYEYVDNGNLEQWLH
 . . .|||| .| ||.| .      ...|||||.| ... . .   ..|  |..      .|.|.|||.| |. .   . . ..| ||. .|.|   |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLR

GPASILNSPTWEVRMKIALGTAKALAYLHEALEPKVVHRDIKASNILLDAHWNAKISDFGLAKLL-GSDNS-HVKTRVMGTFGYVAPEYANTGLLNERSD
 . .  ...| .   ....  ||...||..    . .|||. | |.|..    .||.|||||...   |.  ....  .      |||  |.|  .. ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESK---NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VYSFGVLLMEMIT-GRDP
|.|||||. |..| |. |
VWSFGVLMWEIFTYGEQP
Kinase IRAK-0_ba.AA MLK 178-379 25 1e-37 128.46 In-house 1-235 (291) Show / Hide 
Range on Protein: 178-379
Range on HMM: 1-235/291
Sequence Identity: 25% (60 aa)

FSPDNVLGEGGYGIVYRGCLGDGTP-----VAVKSLL------NNSGQAEKEFRVEVEAIGRVRHKN----LVRLLGYCVEINY-RMLVYEYVDNGNLEQ
.    ..|.|..| |..|    ..      ||||           ..   ..|. |..   ...|.|     ....| | . ..   .| ||...| |  
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WLHG-PASILNS---------PTWEVRMKIALGTAKALAYLHEALEPKVVHRDIKASNILLDA------HWNAKISDFGLAKLLGSDNSHVKTRVMGTFG
 ||| .  .  .          . .. |..||  |....|||. . ....|||.| .|||.|.      | ..||.|||... . .     ..  .||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YVAPEY---ANTGLLNERSDVYSFGVLLMEMITGRDP
. |||    .  .  .| .||.|.||.| ||.|.. |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_ba.AA Pkinase 178-377 26 1.4e-37 133.98 Pfam 1-209 (293) Show / Hide 
Range on Protein: 178-377
Range on HMM: 1-209/293
Sequence Identity: 26% (59 aa)

FSPDNVLGEGGYGIVYRGC-LGDGTPVAVKSLLNNSGQAEKEFRV-----EVEAIGRVRHKNLVRLLGYCVEINYRMLVYEYVDNG----NLEQWLH-GP
.    ..|.|..| ||...  |.|  ||||  .. ... ... .      |..   |..|.| |||.... . ..  .| ||...|     |  ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK-IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

ASILNSPTWEVRMKIALGTAKALAYLHEALEPKVVHRDIKASNILLDAHWNA----KISDFGLAKLL-GSDNSHVKTRVMGTFGYVAPEYANTGLLN---
   .   ....  .... ....|.|.|.    ...|||.| .|||.| . .     ||.||||||..    ||  .|.. || .|.|||      ..   
HGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEV-----IRGGQ

---ERSDVYSFGVLLMEMITGR
    ..|..|.|..| ||..||
YYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_ba.AA S_TKc 178-449 22 2.4e-37 131.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 178-449
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FSPDNVLGEGGYGIVYRGCLGD-GTPVAVKSLLNNSGQAEKEFRVEVEAIGRVRHKNLVRLLGYCVEINYRMLVYEYVDN--GNLEQWLHGPASILN---
.   ...|.|..| ||..   . |  ||.| .        . .| |..   . .|.|.|.|...... ..  .| ||.|.  |.| . ..   .  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

SPTWEVRMKIALGTAKALAYLHEALEPKVVHRDIKASNILLDAHWNAKISDFGLAKLLGSDNSHVKTRVMGTFGYVAPEYANTGLLNE-RSDVYSFGVLL
 |  ..| ...  ...||.|.|.    ...|||.| .|||||   . ||.|||||..|        | . ||  |.|||       .  ..|..|.|..|
FPE-HAR-FYMYQICCALEYCHSH---GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

MEMITGRDPVDYSRPSAEVNLVDWVKLMVASRRSEEVADSRLDAKPSTRALKRALLVALRCVDPDAIKRPKMGYIVH---------ML
 ||..|. | .        ..    |...                      . |.    .| . |  |||    . .          .
YEMLCGYPPFP--------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_ba.AA TyrKc 178-449 23 5.6e-37 130.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 178-449
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

FSPDNVLGEGGYGIVYRGCLGDGTPVAVKSLLNNSGQAEKEFRVEVEAIGRV--RHKNLVRLLGYCVEI-------NYRMLVYEYVDNGNLEQWLHGPAS
 . . .|||| .|.||.| .   ..||||.| ...   ...|. | .   ..  .|.|.|||.|.|..           |.| ||...|.| . |. .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

ILNSPTWEVRMKIALGTAKALAYLHEALEPKVVHRDIKASNILLDAHWNAKISDFGLAKLLGSD-------NSHVK-----TRVMGTFGYVAPEYANTGL
     ...   ....  |.  .|||.    ...|||. | |.|...   .|||||||.. ...|          .|     .. |      |||  |.| 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

LNERSDVYSFGVLLMEMITGRDPVDYSRPSAE-----VNLVDWVKLMVASRRSEEVAD----SRLDAKPSTRALKRALLVALRCVDPDAIKRPKMGYIVH
 .. |||.||||.. |. |  ..     |  .     ..  . ...  . .| .  ..    |      . .. .    . ..| . |. .|| .  |..
FTTKSDVWSFGVCMWEIFTYGQQ-----PYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

ML
 .
CF
Kinase IRAK-0_ba.AA Dicty4-Unclassified 181-379 32 1.3e-35 119.43 In-house 4-207 (263) Show / Hide 
Range on Protein: 181-379
Range on HMM: 4-207/263
Sequence Identity: 32% (69 aa)

DNVLGEGGYGIVYRGCLGDGTPVAVKSLLNNSGQAE----KEFRVEVEAIGRVRHKNLVRLLGYCVEI----NYRMLVYEYVDNGNLEQWLH-GPASILN
|  .|.|    |..|    |  |||| .  |. ..     ..|. |||  | . | |||.. |||.         . | |    |||    |  |.    
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

SPTWEV--RMKIALGTAKALAYLHEALEPKVVHRDIKASNILLDAHWNAKISDFGLAKLLGSDNSHVKTRVMGTFGYVAPEYANTGLLNERSDVYSFGVL
.   .    .|.|.  |. ...||      ..|||||.||||.| | |.|| |||..     |.    | . ||    .||       | .|||||....
PIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

LMEMITGRDP
| |..||  |
LYELATGDEP
Kinase IRAK-0_ba.AA STE 178-379 20 6.5e-34 117.18 In-house 1-267 (359) Show / Hide 
Range on Protein: 178-379
Range on HMM: 1-267/359
Sequence Identity: 20% (56 aa)

FSPDNVLGEGGYGIVYRGCLGD----------------GTPVAVKSLLNNSG-----------------QAEKEFRVEVEAIGRVR--HKNLVRLLGYCV
.    ..|.|..| ||...  .                |. .|.| .  ..                  . ....  |..   . .  |.| |. .|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EI-------NYRMLVYEYVDNGNLEQWLH---GPASILNSPTW------EVRM-KIALGTAKA-LAYLHEALEPKVVHRDIKASNILLDAHWNAKISDFG
         ..  .. ||.|.| |.. ..   |.   ||..        |    .|.  . |. |.|||.     ..|||||..||||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLLGSD--------------NSHVKT-RVMGTFGYVAPEYANT------GLLNERSDVYSFGVLLMEMITGRDP
... | ..              ..  |.  . ||  . |||  .       .  ....|..|.| ...||.||. |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase IRAK-0_ba.AA MLK 430-449 40 0.006621 6.07 In-house 272-291 (291) Show / Hide 
Range on Protein: 430-449
Range on HMM: 272-291/291
Sequence Identity: 40% (8 aa)

RCVDPDAIKRPKMGYIVHML
.| ..|. |||.. .||  |
QCWNQDPHKRPSFRQIVQHL