Gene IRAK-0_b-1 (S.moellendorffii)

IRAK-0_b-1

Species: S.moellendorffii
Alias: IRAK-0_b-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_b-1.AA Protein None 328 None Fasta, JSON
IRAK-0_b-1.NA RNA None 987 None Fasta, JSON
IRAK-0_b-1.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_b-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_b-1.AA TKL 51-317 20 2.4e-64 220.11 In-house 1-364 (364) Show / Hide 
Range on Protein: 51-317
Range on HMM: 1-364/364
Sequence Identity: 20% (80 aa)

LGTGSFGTVFQGVLDD---------DTPVAIKKANSTTGP---------------------------RIQQFLNEVTILSQVNHRNLVKLLGCCLETDV-
.| |.||.|..|..           ...||.|| .|.                                ... .|. ..|. .| |.|...|.|.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PLLVFEFVPNGTLFEHLQHRRSSILSWERRLQIAIETAEAISYLHSSAA-----QPIYHRDVKSTNILLDEKFT--------------
            . .| |..|.|.|...|.        |..|...|...| ...||||.        || ||| || |||.||..|              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVADFGISKLVSLEA--THVSTT----------------VHGTPGYIDPQY----------------QQNYQLTDKSDVYSFGVVLLELITGQKPVDFS
.|..|||.|. .| .   .. .||                . |||..  |                  ..... . |.||||||.|| |..|...     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

RNSSDKNLTAFS-LAYIQSS-------RIEDIIDKGLELGDE---------RAKISSIQEVANLAIRCLEFDRENRPAMRSVAEEL
          .. . |..          .. ..|||| .                .  .....|. .| . | |.|| .  . ..|
---------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_b-1.AA IRAK 45-246 34 2.3e-58 200.2 In-house 1-225 (317) Show / Hide 
Range on Protein: 45-246
Range on HMM: 1-225/317
Sequence Identity: 34% (78 aa)

FKAELMLGTGSFGTVFQGVLDDDT-PVAIK----KANSTTGPRIQQFLN---EVTILSQVNHRNLVKLLGCCLETDVPLLVFEFVPNGTLFEHLQHRR-S
| ... .| | ||.|..|...  | ..|.|     |.....   |.|.    |. ...   | |.| |.| |.|.. . ||... |||.|.  |. .  .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

SI---LSWERRLQIAIETAEAISYLHSSA-AQPIYHRDVKSTNILLDEKFTAKVADFGISKLV----SLEATHV----STTVHGTPGYIDPQYQQ--NYQ
     ||| .|. |.. || .| .||.   . || |.|.|| |||||. ||.| .|||         ..|.. .      .| ||  |  | .      |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTDKSDVYSFGVVLLELITGQKPVD
|| |.||||||.||||..||...|.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_b-1.AA S_TKc 45-324 23 9.3e-42 145.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-324
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

FKAELMLGTGSFGTVFQGVLDD-DTPVAIKKANSTTGPRIQQFLNEVTILSQVNHRNLVKLLGCCLETDVPLLVFEFVPN--GTLFEHLQHRRS----SI
..    .| |.||.|....  . .  ||||. .       .....|. ||.. .| |.|||.... . |   .|.|....  |.||.....|..    . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLEATHVSTTVHGTPGYIDPQYQQNYQLTD-KSDVYSFGVVLL
..  .   .. ....|. |.||   . | |||.|  ||||||  . |..|||.....        ||. ||| |. |      . .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELITGQKPVDFSRNSSDKNLTAFSLAYIQSSRIEDIIDKGLELGDERAKISSIQEVANLAIRCLEFDRENRPAMRSVAE--ELMKIKHIL
|...|. | .                      .. ...| .            .|. ..  .||..| |.||    . .  .. |.   .
EMLCGYPPFP---------------------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_b-1.AA TKL-Unique 50-244 29 1.1e-41 144.82 In-house 4-233 (290) Show / Hide 
Range on Protein: 50-244
Range on HMM: 4-233/290
Sequence Identity: 29% (68 aa)

MLGTGSFGTVFQGVLDDDTPVAIKKAN--STTGPRIQQ-FLNEVTILSQVN-HRNLVKLLGCCL-ETDVPL---LVFEFVPNGTLFEHLQH--------R
 .|.|..|.|..|.    .|||||. .  .   ... | | |||....  . | |.|.. | |  ..  |    .| |..| |.| ..|.         .
KIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

RSSILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEK-----FTAKVADFGISKLVSLEATHVST--------TVHGTPGYIDPQYQQN-
... |....|...||  | .  |||.. .  |.||| ||.|.|.|..     . .|..|||.||. | . .  ..        |. |.. .. |.   . 
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-YQLTDKSDVYSFGVVLLELITGQK------P
 .| . ||||||||.|| |..|..       |
FCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase IRAK-0_b-1.AA Dicty4 45-244 30 7.6e-40 130.67 In-house 1-216 (277) Show / Hide 
Range on Protein: 45-244
Range on HMM: 1-216/277
Sequence Identity: 30% (67 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKA--NSTT--GPRIQQFLNEVTILSQVNHRNLVKLLGCCL----ETDVPLLVFEFVPNGTLFEHLQH----
 . |  .|.||||.|. |     . ||.||.  . ..    ... |..||.|...  | |.....| |.    .   .. | |..| |.|.. |      
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-RRSSILSWERRLQ---IAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLEATHVS--TTVHGTPGYIDPQYQQNYQLTDKS
   |  |.|.....   .|. .|  . .||..    | ||| || |.| |. ...||.|||.|..   . .|    .|. |||..  |   ..   . |.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVVLLELITGQKP
|||||| || |. |.| |
DVYSFGIVLWEILTRQEP
Kinase IRAK-0_b-1.AA Pkinase 51-323 20 5.6e-39 138.91 Pfam 7-293 (293) Show / Hide 
Range on Protein: 51-323
Range on HMM: 7-293/293
Sequence Identity: 20% (64 aa)

LGTGSFGTVFQGVLDDD-TPVAIKKANSTTGPRIQQ---FLN--EVTILSQVNHRNLVKLLGCCLETDVPLLVFEFVPNG----TLFEHLQHRRSSIL--
.| ||||.|....  ..   ||.|. .   . . ..    ..  |. |.  .|| | |.|.... . | . .|.|....|     ||.... .|.  .  
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

SWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTA----KVADFGISKLVSLEATHVSTTVHGTPGYIDPQYQQ-NYQLTDKSDVYSFGV
|..    .. ...... |.||     | |||.|. |||.|.. .     |..|||..|....   .  ||. |||.|. |   . .   . |.|..|.|.
SEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC

VLLELITGQKPVDFSRNSSDKNLTAFSLAYIQSS------RIEDIIDKGLELGDERAKISSI--------------------QEVANLAIRCLEFDRENR
.| |...|.                      ...      .   .|.. ..   ..    ..                    .|   .  .||..| . |
ILYEMLCGR-------------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PAMRSVAEELMKIKHI
|     ||.... . .
PT----AEQILQHPWF
Kinase IRAK-0_b-1.AA Pkinase_Tyr 45-194 26 9.8e-38 128.43 Pfam 1-161 (270) Show / Hide 
Range on Protein: 45-194
Range on HMM: 1-161/270
Sequence Identity: 26% (44 aa)

FKAELMLGTGSFGTVFQGVLD-----DDTPVAIKKANSTTGPR---IQQFLNEVTILSQV-NHRNLVKLLGCCL-ETDV--PLLVFEFVPNGTLFEHLQH
 .   .|| |.||.|..|...     ...|||.|. . .. ..   .. |..|. |..|  .| |.|.|.|.|. . .   ...|.|..|.| | ..|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R--RSSILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLV
.      |. .. ||.... |.. .||.|   ... |||.   |.|..|....|..||| ....
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase IRAK-0_b-1.AA TK 45-244 16 2.7e-37 122.06 In-house 1-394 (486) Show / Hide 
Range on Protein: 45-244
Range on HMM: 1-394/486
Sequence Identity: 16% (65 aa)

FKAELMLGTGSFG---TVFQGVLDDD--------------------------TPVAIKKANSTTGPRIQQ--------------FLNEVTILSQVN----
 . .  || | ||   .|..| . ..                          ||||.|   ....   ..              ||.|. .... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVKLLGCCLETDV------------PLLVFEFVPNGT----LFEHLQHRRS---------------------------------------------
 | |.|.|.|.|.. .             ...| |..|.|     | ..|. .|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------SILSWERRLQIAIETAEAISYLHSS----AAQPIYHRDVKSTNILLDEKFT-----------AKVADFGIS
                             ..|. ...| ..   |.. .||||       | . |||.   |.|..|. .           .|.|||| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

--------KLVSLEATHVSTTVHGTPG-------------------------YIDPQYQQ---------NYQLTDKSDVYSFGVVLLELIT-GQKP
        . .  .   .... .||..                         .  |   .         .   | ||||.||||.. |. | ||.|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAK-0_b-1.AA LRRK 45-246 28 3.4e-37 129.14 In-house 1-284 (351) Show / Hide 
Range on Protein: 45-246
Range on HMM: 1-284/351
Sequence Identity: 28% (83 aa)

FKAELMLGTGSFG-TVFQGVLDD---------------------------DTPVAIKKANST-----------TG-----------------------PR
.| | ..| |.|| .|... . .                           ...||||| | .           ..                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IQQFLNEVTILSQVNHRNLVKLLGCCLETDVPL-LVFEFVPNGTLFEHLQHRR-SSI------LSWERRLQIAIETAEAISYLHSSAAQ-PIYHRDVKST
 . | .||.|.|  || |.|.|.| |..   || .| |..|.|.| ..|.... ...      .||  .|.||.. |... ||||  .  || ||| || 
FREFRHEVWIMSHLNHPNIVSLKGFCIH---PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRDLKSP

NILL---D---------EKFTAKVADFGISKLVSLEATHVSTTVHGTPGYIDP---QYQ--QNYQLTDKSDVYSFGVVLLELITGQ-KPVD
||||   .         .  .||.|||||| . .   . |  .. |.||.  |   .|    .|  |.|.|.||||..| ||.|.|  | |
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEY--TEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_b-1.AA Dicty4-Unclassified 45-244 33 5.6e-37 124.17 In-house 1-207 (263) Show / Hide 
Range on Protein: 45-244
Range on HMM: 1-207/263
Sequence Identity: 33% (71 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKANSTT-GPR---IQQFLNEVTILSQVNHRNLVKLLGCCLET----DVPLLVFEFVPNGTLFEHLQ---HR
 .    .| | |  |  |.      ||.|| |.     |   || |. || ||  . | ||||. | |.           | || . |.|||        
IQIDQFIGKGHFSKVHKGNWKGKD-VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

RSSILSWER--RLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLEATHVSTTVHGTPGYIDPQYQQNYQLTDKSDVYSF
.   .. .    . .|.. |  . .||.     . |||.|| |||.|  | .|.||||||  ..   .   ||. |||    |        . ||||||.
QQQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNM--TTIAGTPKWESPECLMHESYNQKSDVYSY

GVVLLELITGQKP
...| ||.||  |
AMMLYELATGDEP
Kinase IRAK-0_b-1.AA Ciliate-E2 45-323 17 1.3e-36 123.16 In-house 1-365 (365) Show / Hide 
Range on Protein: 45-323
Range on HMM: 1-365/365
Sequence Identity: 17% (68 aa)

FKAELMLGTGSFGTVFQGVLDDD---------------------TPVAIKKANSTTGPRIQQFLNEVTILSQVN----------------HRNLVKLLGC
.|   ..|.|.||.|...  . .                     . . |.  ..     |.|...|  |. ..|                | |..|.  |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CL--ETDVPLLVFEFVPNGTLFEHLQHRRSSI---------LSWERRLQIAIETAE---------------AISYLHSSAAQPIYHRDVKSTNILLDEKF
     ..   ||.|..  |.||....... .          .... ...|  . ..               |. ||||     | ||| |  |||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

TAKVADFGISKLVSLE------------------------------ATHVSTTVHGTPGYIDPQYQQ--NYQ-------LTDKSDVYSFGVVLLELITGQ
  |..|||.|| .. .                                ..  |. |||||  |.  .  .|.        . |.|..|.||.| |...|.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

KPVDFSRNSSDKNLTAFSLAYIQSSRIEDIIDKGLELGDER-------------AKISSIQEVANLAIR----CLEFDRENRPAMRSVAEELMKIKHI
 |                        .. |... ...  .               . .  ||. .|  .    .|. | |.|.     .|.... . .
PPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
Kinase IRAK-0_b-1.AA MLK 45-192 28 5.3e-34 115.4 In-house 1-181 (291) Show / Hide 
Range on Protein: 45-192
Range on HMM: 1-181/291
Sequence Identity: 28% (52 aa)

FKAELMLGTGSFGTVFQGVLDDDT----PVAIKKAN------STTGPRIQQFLNEVTILSQVNHRN----LVKLLGCCLETDV-PLLVFEFVPNGTLFEH
.. .  .| |||| |. |.    .     ||.|...      | |.  ...|  |. .|. ..|.|     ....|.||..    ..| |....| |.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LQHRRS------------SILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDE------KFTAKVADFGISK
|  .||             . . .  ...|   |....|||| | .|| ||| || |||.||      . |.|..|||.|.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase IRAK-0_b-1.AA DRK 45-244 33 3.3e-32 106.42 In-house 1-201 (258) Show / Hide 
Range on Protein: 45-244
Range on HMM: 1-201/258
Sequence Identity: 33% (68 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKANSTTGP---RIQQFLNEVTILSQVNHRNLVKLLGCCLETDVPLLVFEFVPNGTLFEHLQHRRSSILSWE
 |     | |..| || |     | ||.|..          .. |  |.....|  | | .  .| |..   .. . |. | | |   | |  |  ..| 
IKIGNRIGRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNIL-HDESIEMDWP

RRLQIAIETAEAISYLHSSAAQP-IYHRDVKSTNILLDEKFTAKVADFGISK-LVSLEATHVSTTVHGTPGYIDPQYQQNYQLTDKSDVYSFGVVLLELI
...|...  |  . |||..   | | ||| || | | || .  |||||| |      .      |  |||. . |    |   | | |||||..|| |..
LMKQMMFDCAKGMIYLHCC--NPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV

TGQKP
| | |
TRQDP
Kinase IRAK-0_b-1.AA TyrKc 45-317 22 8.3e-30 106.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 45-317
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKANSTTGPRIQQFLNEVTILSQV--NHRNLVKLLGCCLET-------DVPLLVFEFVPNGTLFEHLQHRRS
 . . .|| | ||.|..|...  ..||.|. .. .   .. |..|  |....  .| |.|.|.|.|..        . ...|.|..|.| | ..|. .| 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLE--------ATHVSTTVHGT---------PGYIDPQYQQ
  |...  |....  |.  .||||    .. |||    |.|..|..|.|..||| |. .  .          ..... .|          |  |     .
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

NYQLTDKSDVYSFGVVLLELIT-GQKPVDF---SRNSSDKNLTAFSLAYIQSSRIED---IIDKGLELGDERAKISSIQEVANLAIRCLEFDRENRPAMR
 .  | ||||.||||.. |. | ||.|          |.. . ..  .     . ..   .                 .|. ..  .| ..| |.|| ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS----------F-VCCPDEMYQIMKQCWHEDPEDRPTFS

SVAEEL
 . |..
EIHECF
Kinase IRAK-0_b-1.AA MLK 217-244 41 5.9e-07 20.31 In-house 207-235 (291) Show / Hide 
Range on Protein: 217-244
Range on HMM: 207-235/291
Sequence Identity: 41% (12 aa)

Q-QNYQLTDKSDVYSFGVVLLELITGQKP
| .. . . |.||.|.|||| |..|.. |
QFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_b-1.AA Pkinase_Tyr 223-244 56 0.00022 15.47 Pfam 192-214 (270) Show / Hide 
Range on Protein: 223-244
Range on HMM: 192-214/270
Sequence Identity: 56% (13 aa)

TDKSDVYSFGVVLLELIT-GQKP
| ||||.||||.. |..| |..|
TTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAK-0_b-1.AA IRAK 290-317 25 0.003766 7.21 In-house 290-317 (317) Show / Hide 
Range on Protein: 290-317
Range on HMM: 290-317/317
Sequence Identity: 25% (7 aa)

QEVANLAIRCLEFDRENRPAMRSVAEEL
.| . .|..|..    .|..|. | ..|
KEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_b-1.AA TK 290-317 32 0.003963 5.48 In-house 459-486 (486) Show / Hide 
Range on Protein: 290-317
Range on HMM: 459-486/486
Sequence Identity: 32% (9 aa)

QEVANLAIRCLEFDRENRPAMRSVAEEL
.|.. |  .| ..| | || .. . |.|
EEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_b-1.AA Pkinase_Tyr 290-317 32 0.024323 8.55 Pfam 243-270 (270) Show / Hide 
Range on Protein: 290-317
Range on HMM: 243-270/270
Sequence Identity: 32% (9 aa)

QEVANLAIRCLEFDRENRPAMRSVAEEL
.|. .|  .| ..| |.|| .. . |.|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase IRAK-0_b-1.AA MLK 298-317 30 0.33693 0.07 In-house 272-291 (291) Show / Hide 
Range on Protein: 298-317
Range on HMM: 272-291/291
Sequence Identity: 30% (6 aa)

RCLEFDRENRPAMRSVAEEL
.| . | ..|| .|.. ..|
QCWNQDPHKRPSFRQIVQHL