Gene IRAK-0_bb (S.moellendorffii)

IRAK-0_bb

Species: S.moellendorffii
Alias: IRAK-0_bb
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_bb.AA Protein None 226 None Fasta, JSON
IRAK-0_bb.NA RNA None 681 None Fasta, JSON
IRAK-0_bb.kin_dom Protein Kinase Domain None 181 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_bb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_bb.AA TKL 51-225 19 1e-47 164.81 In-house 1-236 (364) Show / Hide 
Range on Protein: 51-225
Range on HMM: 1-236/364
Sequence Identity: 19% (52 aa)

LGKGAFGKVYKGVLSD---------GTLVAIKQLNKMGD----------------------------NTGDFVNEATLISTVQHRNLVKLYGCCTEGNN-
.|.|.||.||||..           |. ||.|..... |                            .   ...|. ..|  .| |.|...|.|..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------WILVFEFMENNNLHQALLSKYFNLVLPSSSMYSVGPSGRNIHLSWPTRFNICIGVARGLAYLHEESS-----PRIIHRDIKATNVLLD
              .| |.... .|.  |.                          |. |.......|||..||| .       | |||||.|  |.|.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVD

QALV--------------AKIADFGLARLFEDHQSHISTR------------------VAGT
. .               .||.||||.| .. ...   |                   . ||
ENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT
Kinase IRAK-0_bb.AA Pkinase_Tyr 49-210 31 1.2e-43 148.45 Pfam 5-160 (270) Show / Hide 
Range on Protein: 49-210
Range on HMM: 5-160/270
Sequence Identity: 31% (55 aa)

RLLGKGAFGKVYKGVLS-----DGTLVAIKQL--NKMGDN--TGDFVNEATLISTV-QHRNLVKLYGCCT-EGNN--WILVFEFMENNNLHQALLSKYFN
. ||.||||.||||..      ... ||.| |  . | ..    || .|| . ..  .| |.|.|||.|| .|    ...|.|.|.. .|.  | ..   
KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--

LVLPSSSMYSVGPSGRNIHLSWPTRFNICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQALVAKIADFGLARL
                . .|. ..  ..|. .|.|..||..     .||||. | |.|..  .|.||.||||||.
--------------EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-0_bb.AA TK 45-217 19 3.8e-39 128.35 In-house 1-312 (486) Show / Hide 
Range on Protein: 45-217
Range on HMM: 1-312/486
Sequence Identity: 19% (60 aa)

FDPARLLGKGAFG---KVYKGVLSDG--------------------------TLVAIKQLNK-MGDNTGDFVN--------------EATLISTVQ----
    . ||.|.||   .|||| . ..                          | ||.|.| .  ...  .|                ||  ..  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVKLYGCCTEGNN------------WILVFEFMENNN----LHQALL--SKYFNLVLPSSSM----------------------YSVGPSGRNIH-
 | |.|.|||.||.| .            |..| |.|.. .    |.. |   ...|.  .....                       .|..|   . . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

--------------------------------LSWPTRFNICIGVARGLAYLHEE----SSPRIIHRDIKATNVLLDQALV-----------AKIADFGL
                                |. ...  .|  .|.|..|||.       ....|||. | |.|... .|           .|||||||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

AR-----LFEDHQSH
.|     |  |..|.
SRQGSGVLARDIYSD
Pkinase IRAK-0_bb.AA Pkinase 45-222 24 1.2e-36 130.62 Pfam 1-172 (293) Show / Hide 
Range on Protein: 45-222
Range on HMM: 1-172/293
Sequence Identity: 24% (48 aa)

FDPARLLGKGAFGKVYKGVLSDG-TLVAIKQLNKMGDNTGDFVN-----EATLISTVQHRNLVKLYGCCTEGNNWILVFEFMENN----NLHQALLSKYF
.   | .|.|.||.|||..  .   .||.|...| ... .  ..     |. .   ..| | |.||........  .|.|..|.      |.  .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

NLVLPSSSMYSVGPSGRNIHL--SWPTRFNICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQALVA----KIADFGLARLF-EDHQSHISTRV
                |.  .  |. .  ...  ..|||.|.|..   .|||||.|  |.|.|.  .     ||.|||||..| . ..|  .|..
---------------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC
Kinase IRAK-0_bb.AA LISK 50-215 28 2.2e-34 109.01 In-house 1-159 (296) Show / Hide 
Range on Protein: 50-215
Range on HMM: 1-159/296
Sequence Identity: 28% (51 aa)

LLGKGAFGKVYKGVLS-DGTLVAIKQLNK------MGDNTGDFVNEATLISTVQHRNLVKLYGCCTE-GNNWILVFEFMENNNLHQALLSKYFNLVLPSS
 .|||.||||||| .  .|. .|||.. .        ...  .  |  ..   .|.| |. .| | .      .| |...  .||| | .. .       
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDK-------

SMYSVGPSGRNIHLSWPTRFNICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQA----LVAKIADFGLARLFEDHQ
         . |.|.|| | .|  ..|.|..|||.     ||||| |..|.|...       .|..|||.||.... .
---------HKIPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCEN
Kinase IRAK-0_bb.AA Src 45-213 33 1.5e-33 111.32 In-house 1-151 (255) Show / Hide 
Range on Protein: 45-213
Range on HMM: 1-151/255
Sequence Identity: 33% (57 aa)

FDPARLLGKGAFGKVYKGVLSDGTLVAIKQLNKMGDNTGDFVNEATLISTVQHRNLVKLYGCCTEGNNWILVFEFMENNNLHQALLSKYFNLVLPSSSMY
.   | ||.| || |..|.  . | ||.| | .    . .|  || .  ...| .||.||  |...     | |.|....| .. | |            
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSL-LDYLKK------------

SVGPSGRNIHLSWPTRFNICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQALVAKIADFGLARLFE--D
    .|.  ||. |.   .   ||.| ||| .    ..||||  | ||| .. .|.|.||||||||..  |
----DGEGRHLHLPQLIDMAAQVAEGMAYLESM---NYIHRDLAARNVLVGENNVCKVADFGLARLIKEDD
Kinase IRAK-0_bb.AA MLK 45-214 24 3e-31 105.71 In-house 1-186 (291) Show / Hide 
Range on Protein: 45-214
Range on HMM: 1-186/291
Sequence Identity: 24% (49 aa)

FDPARLLGKGAFGKVYKGVLSDGTL-----VAIKQLN-------KMGDNTGDFVNEATLISTVQHRN----LVKLYGCCTE-GNNWILVFEFMENNNLHQ
..  . .|.|.||||.||.   ...     ||.|. .       ...    ||  |. . . ..|.|     ...||.|.. ...  .| |..|.  |. 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

AL---LSKYF--NLVLPSSSMYSVGPSGRNIHLSWPTRFNICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQ------ALVAKIADFGLARLFEDH
 |    || .  |          ...  . .  .    .|..  .|||..|||..  . |||||.|  |.|.|.       ...||.|||..| . ..
VLHGARSKWMDAN---------HNQK--NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQM
Kinase IRAK-0_bb.AA Dicty4 45-217 30 5.5e-30 97.33 In-house 1-170 (277) Show / Hide 
Range on Protein: 45-217
Range on HMM: 1-170/277
Sequence Identity: 30% (57 aa)

FDPARLLGKGAFGKVYKGVLSDGTLVAIKQL--NKMG--DNT-GDFVNEATLISTVQHRNLVKLYGCCT----EGNNWILVFEFMENNNLHQALLSKYFN
 .   ..|||.||.||||    |. ||.| |  .. .   |.  .| .|... .  .| |.....| ||    .      | |.|   ||.  |..|   
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDK---

LVLPSSSMYSVGPSGRNIHLSWPTRFN---ICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQALVAKIADFGLARLFEDHQSH
   ||           .| |.||..     ... .|||...||. . |.|||||.|. | | |. ...|..||||....  | .|
---PSEQQ-------QSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDH
Kinase IRAK-0_bb.AA UTK 45-210 27 1.3e-29 98.45 In-house 1-177 (296) Show / Hide 
Range on Protein: 45-210
Range on HMM: 1-177/296
Sequence Identity: 27% (54 aa)

FDPARLLGKGAFGKVYKGVLSDGT------LVAIKQLNKMGD----NTG--DFVNEAT---LISTVQ-HRNLVKLYGCCTEGNNWILVFEFMENNNLHQA
  . |.||.|||| |.|. . . .      .||.|.... .|     ..  || .||.   . . .. |.|...|.| || .  |..| |.||| .| . 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LLSKYFNLVLPSSSMYSVGPSGRNIHLSWPT---RFNICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQA-------LVAKIADFG---LARL
| .   ..                ..  | |   |   .  .|||..|||.    ...|||. | |.|...        .|.||||||   ..|.
LRRHRPTPP---------------ACPHWLTLHQRLCMAWDIARGMQYLHSC---GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRR
Kinase IRAK-0_bb.AA STE 45-225 22 7.8e-28 95.42 In-house 1-226 (359) Show / Hide 
Range on Protein: 45-225
Range on HMM: 1-226/359
Sequence Identity: 22% (55 aa)

FDPARLLGKGAFGKVYKGVLSD----------------GTLVAIKQLNKMGDNTG------------------DFVNEATLISTVQ--HRNLVKLYGCCT
..  . .||||||.|||..  .                |...||||.|.  .|.                   .. .|  . .  .  | | || |||. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------NNWILVFEFMENNNLHQALLSKY-FNLVLPSSSMYSVGPSGRNIHLSWPTRFNICIGVARG-LAYLHEESSPRIIHRDIKATNVLLDQALV
 .       ..  .. |.|..  | . . .||  .  |....       . . ... .    ||  . .| |.|||.     |||||||. |.||     
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ------H-QHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----

AKIADFGLARLFEDHQSHI---------------STRVAGT
.|..|||..  ..|. ..|               .. ..||
VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGT
Kinase IRAK-0_bb.AA IRAK 155-209 51 2e-25 87.18 In-house 106-161 (317) Show / Hide 
Range on Protein: 155-209
Range on HMM: 106-161/317
Sequence Identity: 51% (29 aa)

LSWPTRFNICIGVARGLAYLHEESSP-RIIHRDIKATNVLLDQALVAKIADFGLAR
|||..|. ||.| |.|. .||. ..   |||.|||  |.|||| ...||.||||.|
LSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHR
Kinase IRAK-0_bb.AA TKL-Unique 47-129 28 2.9e-16 54.02 In-house 1-91 (290) Show / Hide 
Range on Protein: 47-129
Range on HMM: 1-91/290
Sequence Identity: 28% (26 aa)

PARLLGKGAFGKVYKGVLSDGTLVAIKQLNK----MGDNTGDFVNEATLISTVQ-HRNLVKLYGCCT----EGNNWILVFEFMENNNLHQAL
.  ..| |..|.||||.   |. |||||...      . . .| || ..... . | |.|...| |.      .|...| |... ..|.  |
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVL
Kinase IRAK-0_bb.AA TKL-Unique 151-210 38 3.8e-16 53.58 In-house 103-166 (290) Show / Hide 
Range on Protein: 151-210
Range on HMM: 103-166/290
Sequence Identity: 38% (25 aa)

RNIHLSWPTRFNICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQA-----LVAKIADFGLARL
.|. |..  | .. | .|.|. ||| .. | |||||.| .|.|.|..     . .||.||||...
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKF
Kinase IRAK-0_bb.AA IRAK 45-122 31 1.1e-14 48.54 In-house 1-87 (317) Show / Hide 
Range on Protein: 45-122
Range on HMM: 1-87/317
Sequence Identity: 31% (27 aa)

FDPARLLGKGAFGKVYKGVLSDGT-LVAIKQLNKMGDNTGDFVNEATLI--------STVQHRNLVKLYGCCTEGNNWILVFEFMEN
|......|.|.|| ||.|...  |  .|.| | .| | . . . .  .         .. .| |.| ||| |||. .  ||...| |
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPN
Kinase IRAK-0_bb.AA TyrKc 45-226 17 2.7e-14 8.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 45-226
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

FDPARLLGKGAFGKVYKGVLSDGTLVAIKQLNKMGDNTGDFVNEATLISTV--QHRNLVKLYGCCTEG-------NNWILVFEFMENNNLHQAL-LSKYF
    . || ||||.||||...  . ||.| |..      || .|| . . .  .| |.|.|||.||..           .|.|.|.. .|.. |  ..  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

NLVLPSSSMYSVGPSGRNIHLSWPTRFNICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQALVAKIADFGLARLFEDH-------QSHI-----STR-
                    |....  ..|. .|.| .|||.    ..||||. | |.|..  ...||.||||.|  .|.       .        ... 
--------------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

----------------------------------------------------------------------------------------------------
                                                                                                    
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

--VAGTM
  .   .
SEIHECF
Kinase IRAK-0_bb.AA S_TKc 45-226 18 2.3e-10 -25.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-226
Range on HMM: 1-231/231
Sequence Identity: 18% (50 aa)

FDPARLLGKGAFGKVYKGVLSD-GTLVAIKQLNKMGDNTGDFVNEATLISTVQHRNLVKLYGCCTEGNNWILVFEFMEN--NNLHQALLSKYFN-----L
..  |..||||||||||..  . | .||||...       .. .|  . .  .| |.||||... . ..  .|.|....   .|.. . ..  .     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

VLPSSSMYSVGPSGRNIHLSWPTRFNICIGVARGLAYLHEESSPRIIHRDIKATNVLLDQALVAKIADFGLAR---------------------------
       |                   .  ....|.|.|.    .|||||.|  |.|||.  . ||.||||||                           
PE-HARFY-------------------MYQICCALEYCHSH---GIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWW

--------------LFEDHQSH-------------------------ISTRVAGT----------M
              .|. ..                           ..   | .          .
SCGCILYEMLCGYPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF