Gene IRAK-0_t-1 (S.moellendorffii)

IRAK-0_t-1

Species: S.moellendorffii
Alias: IRAK-0_t-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_t-1.AA Protein None 842 None Fasta, JSON
IRAK-0_t-1.NA RNA None 2529 None Fasta, JSON
IRAK-0_t-1.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_t-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAK-0_t-1.AA B_lectin 112-200 24 1.7e-12 44.49 Pfam 22-137 (137) Show / Hide 
Range on Protein: 112-200
Range on HMM: 22-137/137
Sequence Identity: 24% (29 aa)

VGENATLQFTV-DGELKLEESG-----DVVWSS--KTANRG---VRWLAISNRATVMLL-DKSR--MNVIWES--SDEPSDTVLLQRAVKP------GDK
...|.||...  || | | ..|     ..|||.   |...|      . . .     |. | ..   ||.|.|   | |.||.|    .        ...
NNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDD-NNDSNNVLWQSNTFDHPTDTWLPGMKLGWDNNVTIYMN

----LVSWNTSE--DSS
    |.|| ...  | |
WIGYLTSWKSNTNYDPS
B_lectin IRAK-0_t-1.AA B_lectin 49-174 15 0.00034 -3.38 SMART 1-126 (126) Show / Hide 
Range on Protein: 49-174
Range on HMM: 1-126/126
Sequence Identity: 15% (22 aa)

AGLWSNYSDIDISQDMS---YQVWMLSYNAETPKSFFLALIAIRNPREFWDLTRPVILWKARQ--TRLVGE---NATLQFTVDGELKLEESGDVVWSSKT
  . |..  .  .. .    .    .  .      . .      .. .        ..| |.   ...| .   ...| .. ||.| ..  . .||||.|
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ------WCNGIWYKNISNK-----QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD-NRPVWSSNT

A-NRGVRWLAISNRATVMLLDKS---RMNVIWESSDEP
. |.|.  .       . . | .     |.||.| | |
TRNNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP IRAK-0_t-1.AA PAN_AP 375-446 16 0.000741 16.33 SMART 1-85 (85) Show / Hide 
Range on Protein: 375-446
Range on HMM: 1-85/85
Sequence Identity: 16% (15 aa)

QLEYRFVRREGADYFSTNYST-----PVPEASVEACQGRCESNCTCTAAFYDD-GSCFLTH--GDVQSLR---------SGKYVALLKV
. .. ||| ... .   .. .      . ..|.| |. .|  ||.|... |.. ..| | .  ..... |         .....   |.
CCDDCFVRMPNMKL---FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYNTKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAK-0_t-1.AA TKL 525-781 21 1.2e-66 227.78 In-house 1-364 (364) Show / Hide 
Range on Protein: 525-781
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGNGGFGSVFKGLLAD---------GTEVAVKKLEGSN---------------------------QRSKDFFAEVG-ILARTHHWNLVKLLGFCAQGPR-
.| |||| |.|| .           |..|||||.   |                           .. ..|. |.  .. |..| |.|...|.| ..|  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------KRLLVYEYMKNGSLERWIFEDDRIPGNISWKVRFNIAIGTARGLSYLHDDCV-----ERIIHLDLKPENVLLDDGFQ------------
           .  .|.||...|||.  .           | .|...|...|||..||| .         ||| |||..|.|.|. ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKIADFGLSKLMNRKESQL-----------------QLTITRGTPGYVAPECIQ----------------EGTVTEKTDVFGFGVLLLEIITGCKNRN
  .||.|||||. |......                  ..   .|||.. |||...                ... .||.||. ||..| ||.|.|.   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

LSGDYLK-DYLLVS---------NRNGSAGAHLSEE------------ENEKERLKNVAALCVRDDPNLRPSMSKVIQMM
    | . .|  .            ... | ..               ..  ...|. .  |   ||. |||...... .
---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_t-1.AA IRAK 522-733 37 1.1e-48 168.12 In-house 4-238 (317) Show / Hide 
Range on Protein: 522-733
Range on HMM: 4-238/317
Sequence Identity: 37% (88 aa)

SNCLGNGGFGSVFKGLLADGTE--VAVKKL---EGSNQRSKD--FFA---EVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKNGSLE-RWIFED-DR
.| .| |||| |..| . ..|.  .|||||   . ... ...  | .   |. ...| .| |.| |.|.|.... .  |||.||.||||| |    | . 
DNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQ-CHCLVYPYMPNGSLEDRLWCQDGQC

IPGNISWKVRFNIAIGTARGLSYLHDDC-VERIIHLDLKPENVLLDDGFQPKIADFGLSKLM----NRKESQL---QLTITRGTPGYVAPECIQ--EGTV
 |   ||  |. |..|||.|. .||..     ||| | |. |.|||. |.|||.||||        ... . .      ..|||  | .|| |    |  
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

TEKTDVFGFGVLLLEIITGC---KNRNLSGDYLKDYL
| ||||. ||. |||..|||   ....    ||||..
TKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLC
Pkinase IRAK-0_t-1.AA Pkinase 519-718 29 1.8e-46 165.37 Pfam 1-208 (293) Show / Hide 
Range on Protein: 519-718
Range on HMM: 1-208/293
Sequence Identity: 29% (63 aa)

GKFSNCLGNGGFGSVFKGLLADGTE-VAVKKLEGSNQRSKDFFA-----EVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKNG----SLERWIF--E
 ..  ..| |.||.|.|.   .  . ||||... ....|.   .     |. |..| .| | |.|....   ...  .| ||. .|    .| ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

DDRIPGNISWKVRFNIAIGTARGLSYLHDDCVERIIHLDLKPENVLLDDGFQP----KIADFGLSKLMNRKESQLQLTITRGTPGYVAPECIQ-EGTVTE
. ..    |...  ...  ..||| |.|.    .||| ||||||.|.|.  ..    ||.||||.|...   ..  .|   |||.|.||| |.     . 
HGCFY--FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KTDVFGFGVLLLEIITG
| |....|..| | ..|
KVDMWSCGCILYEMLCG
Kinase IRAK-0_t-1.AA Dicty4 520-718 34 9.2e-44 143.93 In-house 2-213 (277) Show / Hide 
Range on Protein: 520-718
Range on HMM: 2-213/277
Sequence Identity: 34% (76 aa)

KFSNCLGNGGFGSVFKGLLADGTEVAVKKLEGSNQRS-----KDFFAEVGILARTHHWNLVKLLGFCA---QGPRKRLLVYEYMKNGSLERWIFED----
.. . .| |.||.|.||    |.|||||||   || .     ..| .|| |..   | |.....| |      | | . | |||  |.|.. .  |    
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYS-LLHDKPSE

--DRIPGNISWKVRFN---IAIGTARGLSYLHD-DCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMNRKESQLQ-LTITRGTPGYVAPECIQEGTVT
  ..|.  ..|  .     .|. .|||. .||  ..|  |||.|||. | | |. .. |..|||||..| . |.. . .. . |||...|||. ..   .
QQQSIK--LDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYN

EKTDVFGFGVLLLEIITG
|| ||. || .| || |.
EKADVYSFGIVLWEILTR
Kinase IRAK-0_t-1.AA MLK 519-718 28 8.3e-43 146.34 In-house 1-232 (291) Show / Hide 
Range on Protein: 519-718
Range on HMM: 1-232/291
Sequence Identity: 28% (66 aa)

GKFSNCLGNGGFGSVFKGLLADGTE-----VAVKKLE-------GSNQRSKDFFAEVGILARTHHWN----LVKLLGFCAQGPRKRLLVYEYMKNGSLER
 .|.  .|.|.||.|.||    ...     ||||. .        .   ..||  |. .|..  | |     ....| |.| | . ..| ||. .||| .
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WIFE-DDRIP---------GNISWKVRFNIAIGTARGLSYLHDDCVERIIHLDLKPENVLLDD------GFQPKIADFGLSKLMNRKESQLQLTITRGTP
 . . .. .          ....  . .|.|   |||..||| . .  ||| |||. |.|.|.      . . ||.|||.|. .....     . ..||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTY

GYVAPECI---QEGTVTEKTDVFGFGVLLLEIITG
 . ||| |   ......|| ||. .||.| |..|.
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK-0_t-1.AA TKL-Unique 521-719 30 1.2e-36 126.81 In-house 1-225 (290) Show / Hide 
Range on Protein: 521-719
Range on HMM: 1-225/290
Sequence Identity: 30% (70 aa)

FSNCLGNGGFGSVFKGLLADGTEVAVKKLE----GSNQRSKDFFAEVGILARTH-HWNLVKLLGFCAQ---GPRKRLLVYEYMKNGSLERWIF------E
|.| .| ||.|.|.||  . |..||.|...     ||. ...|  || .. . | | |.|.. |.|.     | .. .| ||.  |||   .        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

DDRIPGNISWKVRFNIAIGTARGLSYLHDDCVERIIHLDLKPENVLLDDG-----FQPKIADFGLSKLMNRK-ESQLQ-L-----TITRGTPGYVAPECI
  .   ......| ..||  |.|. |||      |||.|||. |.|.| .     .. ||.||||||. ..  .. .  .     .   |.. ..||| .
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

QE--GTVTEKTDVFGFGVLLLEIITGC
     . .|| ||. ||. | ||.|..
RMNFCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAK-0_t-1.AA S_TKc 519-781 24 1.6e-36 128.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 519-781
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

GKFSNCLGNGGFGSVFKGLLAD-GTEVAVKKLEGSNQRSKDFFAEVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKN--GSLERWIFEDDRIPGN--
 .. . .| |.||.|.|.   . | .||.|..       ...  |. || . || |.|||....     .  .| ||. .  |.| . | .  | ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ISWKVRFNIAIGTARGLSYLHDDCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMNRKESQLQLTITRGTPGYVAPECIQEGTVTE-KTDVFGFGVLL
..  .   ..  ....| |.|.    .||| ||||||.|||.  . ||.||||....         |   ||| |.||| .     .  | |.  .|..|
FPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEIITGCKNRNLSGDYLKDYLLVSNRNGSAGAHLSEEENEKERLKNVAALCVRDDPNLRPSMSKVIQ---------MM
 | ..|.           .. .. .. |             . .|.    | . ||. ||.  .. |          .
YEMLCGYPPFP-------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_t-1.AA TK 519-781 16 2.5e-36 118.77 In-house 1-486 (486) Show / Hide 
Range on Protein: 519-781
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

GKFSNCLGNGGFG---SVFKGLLADG--------------------------TEVAVKKLE-GSNQRSKDFFA--------------EVGILARTH----
 .. . || | ||    |.||.. ..                          |.|||| |  |... ...||.              |. ...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HWNLVKLLGFCAQGPRK-----------RLLVYEYMKNGS----LERWIFEDDRIPGN-----------------------------------------
 | |.|.|.| | ||  |            ..| |||..|.    |  .  . ..   .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------ISWKVRFNIAIGTARGLSYLHDDCVE---RIIHLDLKPENVLLDDGFQ-----------PKIADFGLSK
                               .. . .  ..   |.|..|||.  .|   ...| ||   |.|.... .            ||||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

L----MNRKESQLQLTITRGTPG----------------------------YVAPECIQ---------EGTVTEKTDVFGFGVLLLEIITGCK---NRNL
     . |.  . .   .....|                            . ||||..         .|. |.|.||. ||||. || | ..     ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

S-------------GDYLKD---------------YLLVSNRNGSA---GAHLSEEENEKERLKNVAALCVRDDPNLRPSMSKVIQMM
|              .||..               . .    . .    .... ... . | .  .   | . ||. ||..| . ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMH-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_t-1.AA DRK 520-717 35 2.1e-35 117.39 In-house 2-197 (258) Show / Hide 
Range on Protein: 520-717
Range on HMM: 2-197/258
Sequence Identity: 35% (71 aa)

KFSNCLGNGGFGSVFKGLLADGTEVAVKKLEGSNQR----SKDFFAEVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKNGSLERWIFEDDRIPGNIS
|  |  | |..| || |    ||.||||.|   |       ..|  |. .. .  | | .  .| |   |   . . |||  ||| . |  |. |   ..
KIGNRIGRGNYGEVFRGTWR-GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPP-DICICMEYMPRGSLYN-ILHDESI--EMD

WKVRFNIAIGTARGLSYLHDDCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMNRKESQLQLTITRGTPGYVAPECIQEGTVTEKTDVFGFGVLLLEI
|  .  ...  |.|. |||  |   ||| |||  | | |. .| |.||||||    . ...       |||. .|||   .   ||| ||. |.. | |.
WPLMKQMMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWEC

IT
.|
VT
Kinase IRAK-0_t-1.AA Pkinase_Tyr 520-720 32 5.2e-35 119.19 Pfam 2-212 (270) Show / Hide 
Range on Protein: 520-720
Range on HMM: 2-212/270
Sequence Identity: 32% (70 aa)

KFSNCLGNGGFGSVFKGLLA-----DGTEVAVKKL-EGSNQR---SKDFFAEVGILART-HHWNLVKLLGFCA-QGPR-KRLLVYEYMKNGSLERWIFED
.|   || | ||.|.|| .      ....||||.| ||. ..   ..||..|. |.    || |.|.|.| |  ||   . ..| |||..|.|       
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL---

DRI----PGNISWKVRFNIAIGTARGLSYLHDDCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMNRKESQ-LQLTITRGTPGYVAPECIQEGTVTEK
 |     ..... |   ....  |.|..||..     .|| ||   |.|...... ||.||||....  ..    . . ..      |||||..|  |.|
-RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

TDVFGFGVLLLEIITGCK
.||  ||||. ||.| ..
SDVWSFGVLMWEIFTYGE
Kinase IRAK-0_t-1.AA LISK 524-718 28 9.7e-35 110.16 In-house 1-235 (296) Show / Hide 
Range on Protein: 524-718
Range on HMM: 1-235/296
Sequence Identity: 28% (68 aa)

CLGNGGFGSVFKG-LLADGTEVAVKKLEG------SNQRSKDFFAEVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKNGSLERWIF-EDD-RIPGNI
 .| |.||.|.|| ....|...|.|...        .   | .  || .. .  | | |.  | | .  ..  .| ||.. | |.. .. .|   ||  .
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIP--L

SWKVRFNIAIGTARGLSYLHDDCVERIIHLDLKPENVLLD----DGFQPKIADFGLSKLMNRKESQ---------------------------------L
.|..| .|| . |.|.||||. .   ||| |||  |.|..    .... |..|||. ..|. .. .                                  
PWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKR

QLTITRGTPGYVAPECIQEGTVTEKTDVFGFGVLLLEIITG
 .||  |||  .|||..     .|. ||| ||..|.||||.
RMTIC-GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITR
Kinase IRAK-0_t-1.AA RIPK 525-718 28 3.9e-33 110.26 In-house 1-224 (290) Show / Hide 
Range on Protein: 525-718
Range on HMM: 1-224/290
Sequence Identity: 28% (65 aa)

LGNGGFGSVFKGLLADGTEVAVKKL-EGSN-------QRSKDFFAEVGILARTHHWNLVKLLGFCAQG----PRK-RLLVYEYMKNGSLERWIFEDDR-I
.| |||| |||   ..  ....||   . .       | ... . |. ....  . . |...||| .     . |   .| |||.||||.       .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

PGNISWKVRFNIAIGTARGLSYLHDDCVER--IIHLDLKPENVLLDDGFQPKIADFGLSKLMNRKESQLQL--------TI----TR-GTPGYVAPECIQ
.  . |..|. .   ...|  |||.       |||.||||||.|.|  |  |||||||..  ..  |...          .     | ||  | .|| . 
HHPDPWPLRCRMIHEISCGMCYLHS---MNPPIIHRDLKPENILVDNNFHVKIADFGLAT--WMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFR

---EGT---VTEKTDVFGFGVLLLEIITG
         ||.| ||  |.... |. |.
TDNKKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK-0_t-1.AA TyrKc 519-781 26 3e-32 114.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 519-781
Range on HMM: 1-280/280
Sequence Identity: 26% (79 aa)

GKFSNCLGNGGFGSVFKGLLADGTEVAVKKLEGSNQRSKDFFAEVGILART--HHWNLVKLLGFCAQGP------RKRLLVYEYMKNGSLERWI-FEDDR
 ..   ||.| || |.|| .   ..||||.|  .    .||  |  |. .   || |.|.|.| | |.          ..| |||..|.|   .    ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

IPGNISWKVRFNIAIGTARGLSYLHDDCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMNRK----ESQLQLTITR--GTPG-----YVAPECIQEGT
    ...|   ....  |.| .|||.    ..|| ||   |.|...... ||.|||||.    .    ||.   . .   |. .       |||||..|.
----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

VTEKTDVFGFGVLLLEIITGCKNRN-------LSGDYLKDYLLVSNRNGSAGAHLSEEEN--------EKERLKNVAALCVRDDPNLRPSMSKVIQMM
 |.|.||. |||.. || | ..          .| . .  |.   .|       .   .|          . . ..   | . ||. ||..| ... .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR-------MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_t-1.AA LRRK 519-718 25 1e-30 105.89 In-house 1-278 (351) Show / Hide 
Range on Protein: 519-718
Range on HMM: 1-278/351
Sequence Identity: 25% (72 aa)

GKFSNCLGNGGFG-SVFKGLLAD---------------------------GTEVAVKKLEGS----------------------------NQRSKDFFA-
 |. . .| |||| .|... . .                           ...||.||..                              .|.. |.   
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

------EVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKNGSLERWIF---EDDR--IPGNISWKVRFNIAIGTARGLSYLHDDCVER--IIHLDLKP
      || |. . .| |.|.|.||| . ..   .| ||. .|.| . ..   .| .  .. .||| ..  ||.  |.|. |||.    .  ||| |||.
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLC---MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS---HNPPIIHRDLKS

ENVLLDDGFQP------------KIADFGLSKLMNRKESQLQ-LTITRGTPGYVAPECIQEG---TVTEKTDVFGFGVLLLEIITG
.|.||    |.            ||||||.|  |  .  .   .    |.||..|||.....   . |||.|.. ||..| |..|.
PNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTR
Kinase IRAK-0_t-1.AA LRRK 750-783 15 0.003638 7.03 In-house 312-351 (351) Show / Hide 
Range on Protein: 750-783
Range on HMM: 312-351/351
Sequence Identity: 15% (6 aa)

EN-EKE-----RLKNVAALCVRDDPNLRPSMSKVIQMMEG
.. ...     ....   .|   ||. ||..|.... .. 
QHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-0_t-1.AA DRK 763-783 38 0.005266 6.06 In-house 238-258 (258) Show / Hide 
Range on Protein: 763-783
Range on HMM: 238-258/258
Sequence Identity: 38% (8 aa)

CVRDDPNLRPSMSKVIQMMEG
|   ||  ||||  ... .| 
CWNEDPQHRPSMQECLERLEA
Kinase IRAK-0_t-1.AA Dicty4 767-783 42 0.006029 5.86 In-house 259-277 (277) Show / Hide 
Range on Protein: 767-783
Range on HMM: 259-277/277
Sequence Identity: 42% (8 aa)

DPNLRPSMSKVIQM--MEG
||. |||.. .||   .| 
DPQHRPSFEEIIQRRILEH
Kinase IRAK-0_t-1.AA MLK 763-781 36 0.102314 1.89 In-house 273-291 (291) Show / Hide 
Range on Protein: 763-781
Range on HMM: 273-291/291
Sequence Identity: 36% (7 aa)

CVRDDPNLRPSMSKVIQMM
|  .||. |||.. ..|  
CWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_t-1.AA TKL-Unique 763-781 36 0.147847 1.48 In-house 272-290 (290) Show / Hide 
Range on Protein: 763-781
Range on HMM: 272-290/290
Sequence Identity: 36% (7 aa)

CVRDDPNLRPSMSKVIQMM
| ..||  ||| . .|   
CWHHDPSQRPSFDEIIHRL
Kinase IRAK-0_t-1.AA Pkinase_Tyr 767-781 33 4.323915 0.93 Pfam 256-270 (270) Show / Hide 
Range on Protein: 767-781
Range on HMM: 256-270/270
Sequence Identity: 33% (5 aa)

DPNLRPSMSKVIQMM
||. ||..| .....
DPEDRPTFSEIHEQL