Gene IRAK-0_b-2 (S.moellendorffii)

IRAK-0_b-2

Species: S.moellendorffii
Alias: IRAK-0_b-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_b-2.AA Protein None 377 None Fasta, JSON
IRAK-0_b-2.NA RNA None 1134 None Fasta, JSON
IRAK-0_b-2.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_b-2.AA TKL 104-370 20 4.4e-64 219.2 In-house 1-364 (364) Show / Hide 
Range on Protein: 104-370
Range on HMM: 1-364/364
Sequence Identity: 20% (79 aa)

LGTGSFGTVFQGVLDD---------DTPVAIKKANSTTGP---------------------------RIQQFLNEVTILSQVNHRNLVKLLGCCLETEV-
.| |.||.|..|..           ...||.|| .|.                                ... .|. ..|. .| |.|...|.|.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PLLVFEFVPNGTLFEHLQHRRSSILSWERRLQIAIETAEAISYLHSSAA-----QPIYHRDVKSTNILLDEKFT--------------
            . .| |..|.|.|...|.        |..|...|...| ...||||.        || ||| || |||.||..|              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVADFGISKLVSLEA--THVSTT----------------VHGTPGYIDPQY----------------QQNYQLTDKSDVYSFGVVLLELITGQKPVDFS
.|..|||.|. .| .   .. .||                . |||..  |                  ..... . |.||||||.|| |..|...     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

RNSSDKNLTAFS-LAYIQSS-------RIEDIIDKGLELGDE---------RAKISSIQEVANLAIRCLEFNRENRPAMRSVAEEL
          .. . |..          .. ..|||| .                .  .....|. .| . . |.|| .  . ..|
---------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_b-2.AA IRAK 98-299 34 3.8e-58 199.5 In-house 1-225 (317) Show / Hide 
Range on Protein: 98-299
Range on HMM: 1-225/317
Sequence Identity: 34% (78 aa)

FKAELMLGTGSFGTVFQGVLDDDT-PVAIK----KANSTTGPRIQQFLN---EVTILSQVNHRNLVKLLGCCLETEVPLLVFEFVPNGTLFEHLQHRR-S
| ... .| | ||.|..|...  | ..|.|     |.....   |.|.    |. ...   | |.| |.| |.|.. . ||... |||.|.  |. .  .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

SI---LSWERRLQIAIETAEAISYLHSSA-AQPIYHRDVKSTNILLDEKFTAKVADFGISKLV----SLEATHV----STTVHGTPGYIDPQYQQ--NYQ
     ||| .|. |.. || .| .||.   . || |.|.|| |||||. ||.| .|||         ..|.. .      .| ||  |  | .      |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTDKSDVYSFGVVLLELITGQKPVD
|| |.||||||.||||..||...|.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_b-2.AA TKL-Unique 103-297 29 9.7e-42 144.99 In-house 4-233 (290) Show / Hide 
Range on Protein: 103-297
Range on HMM: 4-233/290
Sequence Identity: 29% (68 aa)

MLGTGSFGTVFQGVLDDDTPVAIKKAN--STTGPRIQQ-FLNEVTILSQVN-HRNLVKLLGCCL-ETEVPL---LVFEFVPNGTLFEHLQH--------R
 .|.|..|.|..|.    .|||||. .  .   ... | | |||....  . | |.|.. | |  ..  |    .| |..| |.| ..|.         .
KIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

RSSILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEK-----FTAKVADFGISKLVSLEATHVST--------TVHGTPGYIDPQYQQN-
... |....|...||  | .  |||.. .  |.||| ||.|.|.|..     . .|..|||.||. | . .  ..        |. |.. .. |.   . 
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-YQLTDKSDVYSFGVVLLELITGQK------P
 .| . ||||||||.|| |..|..       |
FCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase IRAK-0_b-2.AA S_TKc 98-371 22 6.4e-41 143.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 98-371
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

FKAELMLGTGSFGTVFQGVLDD-DTPVAIKKANSTTGPRIQQFLNEVTILSQVNHRNLVKLLGCCLETEVPLLVFEFVPN--GTLFEHLQHRRS----SI
..    .| |.||.|....  . .  ||||. .       .....|. ||.. .| |.|||.... . .   .|.|....  |.||.....|..    . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLEATHVSTTVHGTPGYIDPQYQQNYQLTD-KSDVYSFGVVLL
..  .   .. ....|. |.||   . | |||.|  ||||||  . |..|||.....        ||. ||| |. |      . .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELITGQKPVDFSRNSSDKNLTAFSLAYIQSSRIEDIIDKGLELGDERAKISSIQEVANLAIRCLEFNRENRPAMRSVAE--------ELM
|...|. | .                      .. ...| .            .|. ..  .||... |.||    . .        . .
EMLCGYPPFP---------------------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_b-2.AA Dicty4 98-297 30 1.7e-40 132.88 In-house 1-216 (277) Show / Hide 
Range on Protein: 98-297
Range on HMM: 1-216/277
Sequence Identity: 30% (67 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKA--NSTT--GPRIQQFLNEVTILSQVNHRNLVKLLGCCL----ETEVPLLVFEFVPNGTLFEHLQH----
 . |  .|.||||.|. |     . ||.||.  . ..    ... |..||.|...  | |.....| |.    . . .. | |..| |.|.. |      
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-RRSSILSWERRLQ---IAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLEATHVS--TTVHGTPGYIDPQYQQNYQLTDKS
   |  |.|.....   .|. .|  . .||..    | ||| || |.| |. ...||.|||.|..   . .|    .|. |||..  |   ..   . |.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVVLLELITGQKP
|||||| || |. |.| |
DVYSFGIVLWEILTRQEP
Kinase IRAK-0_b-2.AA Pkinase_Tyr 98-247 27 4.9e-38 129.43 Pfam 1-161 (270) Show / Hide 
Range on Protein: 98-247
Range on HMM: 1-161/270
Sequence Identity: 27% (45 aa)

FKAELMLGTGSFGTVFQGVLD-----DDTPVAIKKANSTTGPR---IQQFLNEVTILSQV-NHRNLVKLLGCCL-ETEV--PLLVFEFVPNGTLFEHLQH
 .   .|| |.||.|..|...     ...|||.|. . .. ..   .. |..|. |..|  .| |.|.|.|.|. . |   ...|.|..|.| | ..|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R--RSSILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLV
.      |. .. ||.... |.. .||.|   ... |||.   |.|..|....|..||| ....
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase IRAK-0_b-2.AA Pkinase 104-295 25 5.7e-38 135.33 Pfam 7-209 (293) Show / Hide 
Range on Protein: 104-295
Range on HMM: 7-209/293
Sequence Identity: 25% (54 aa)

LGTGSFGTVFQGVLDDD-TPVAIKKANSTTGPRIQQ---FLN--EVTILSQVNHRNLVKLLGCCLETEVPLLVFEFVPNG----TLFEHLQHRRSSIL--
.| ||||.|....  ..   ||.|. .   . . ..    ..  |. |.  .|| | |.|.... .   . .|.|....|     ||.... .|.  .  
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

SWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTA----KVADFGISKLVSLEATHVSTTVHGTPGYIDPQYQQ-NYQLTDKSDVYSFGV
|..    .. ...... |.||     | |||.|. |||.|.. .     |..|||..|....   .  ||. |||.|. |   . .   . |.|..|.|.
SEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC

VLLELITGQ
.| |...|.
ILYEMLCGR
Kinase IRAK-0_b-2.AA TK 98-297 16 7.8e-38 123.88 In-house 1-394 (486) Show / Hide 
Range on Protein: 98-297
Range on HMM: 1-394/486
Sequence Identity: 16% (66 aa)

FKAELMLGTGSFG---TVFQGVLDDD--------------------------TPVAIKKANSTTGPRIQQ--------------FLNEVTILSQVN----
 . .  || | ||   .|..| . ..                          ||||.|   ....   ..              ||.|. .... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVKLLGCCLET------------EVPLLVFEFVPNGT----LFEHLQHRRS---------------------------------------------
 | |.|.|.|.|..             | ...| |..|.|     | ..|. .|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------SILSWERRLQIAIETAEAISYLHSS----AAQPIYHRDVKSTNILLDEKFT-----------AKVADFGIS
                             ..|. ...| ..   |.. .||||       | . |||.   |.|..|. .           .|.|||| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

--------KLVSLEATHVSTTVHGTPG-------------------------YIDPQYQQ---------NYQLTDKSDVYSFGVVLLELIT-GQKP
        . .  .   .... .||..                         .  |   .         .   | ||||.||||.. |. | ||.|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAK-0_b-2.AA LRRK 98-299 28 3.8e-37 128.95 In-house 1-284 (351) Show / Hide 
Range on Protein: 98-299
Range on HMM: 1-284/351
Sequence Identity: 28% (83 aa)

FKAELMLGTGSFG-TVFQGVLDD---------------------------DTPVAIKKANST-----------TG-----------------------PR
.| | ..| |.|| .|... . .                           ...||||| | .           ..                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IQQFLNEVTILSQVNHRNLVKLLGCCLETEVPL-LVFEFVPNGTLFEHLQHRR-SSI------LSWERRLQIAIETAEAISYLHSSAAQ-PIYHRDVKST
 . | .||.|.|  || |.|.|.| |..   || .| |..|.|.| ..|.... ...      .||  .|.||.. |... ||||  .  || ||| || 
FREFRHEVWIMSHLNHPNIVSLKGFCIH---PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRDLKSP

NILL---D---------EKFTAKVADFGISKLVSLEATHVSTTVHGTPGYIDP---QYQ--QNYQLTDKSDVYSFGVVLLELITGQ-KPVD
||||   .         .  .||.|||||| . .   . |  .. |.||.  |   .|    .|  |.|.|.||||..| ||.|.|  | |
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEY--TEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_b-2.AA Dicty4-Unclassified 98-297 33 5.6e-37 124.15 In-house 1-207 (263) Show / Hide 
Range on Protein: 98-297
Range on HMM: 1-207/263
Sequence Identity: 33% (71 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKANSTT-GPR---IQQFLNEVTILSQVNHRNLVKLLGCCLET----EVPLLVFEFVPNGTLFEHLQ---HR
 .    .| | |  |  |.      ||.|| |.     |   || |. || ||  . | ||||. | |.           | || . |.|||        
IQIDQFIGKGHFSKVHKGNWKGKD-VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

RSSILSWER--RLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLEATHVSTTVHGTPGYIDPQYQQNYQLTDKSDVYSF
.   .. .    . .|.. |  . .||.     . |||.|| |||.|  | .|.||||||  ..   .   ||. |||    |        . ||||||.
QQQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNM--TTIAGTPKWESPECLMHESYNQKSDVYSY

GVVLLELITGQKP
...| ||.||  |
AMMLYELATGDEP
Kinase IRAK-0_b-2.AA Ciliate-E2 98-361 17 4.5e-36 121.3 In-house 1-353 (365) Show / Hide 
Range on Protein: 98-361
Range on HMM: 1-353/365
Sequence Identity: 17% (66 aa)

FKAELMLGTGSFGTVFQGVLDDD---------------------TPVAIKKANSTTGPRIQQFLNEVTILSQVN----------------HRNLVKLLGC
.|   ..|.|.||.|...  . .                     . . |.  ..     |.|...|  |. ..|                | |..|.  |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CL--ETEVPLLVFEFVPNGTLFEHLQHRRSSI---------LSWERRLQIAIETAE---------------AISYLHSSAAQPIYHRDVKSTNILLDEKF
     ..   ||.|..  |.||....... .          .... ...|  . ..               |. ||||     | ||| |  |||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

TAKVADFGISKLVSLE------------------------------ATHVSTTVHGTPGYIDPQYQQ--NYQ-------LTDKSDVYSFGVVLLELITGQ
  |..|||.|| .. .                                ..  |. |||||  |.  .  .|.        . |.|..|.||.| |...|.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

KPVDFSRNSSDKNLTAFSLAYIQSSRIEDIIDKGLELGDER-------------AKISSIQEVANLAIR----CLEFNRENRP
 |                        .. |... ...  .               . .  ||. .|  .    .|. . |.|.
PPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI
Kinase IRAK-0_b-2.AA MLK 98-245 28 2e-34 116.86 In-house 1-181 (291) Show / Hide 
Range on Protein: 98-245
Range on HMM: 1-181/291
Sequence Identity: 28% (52 aa)

FKAELMLGTGSFGTVFQGVLDDDT----PVAIKKAN------STTGPRIQQFLNEVTILSQVNHRN----LVKLLGCCLETEV-PLLVFEFVPNGTLFEH
.. .  .| |||| |. |.    .     ||.|...      | |.  ...|  |. .|. ..|.|     ....|.||...   ..| |....| |.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LQHRRS------------SILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDE------KFTAKVADFGISK
|  .||             . . .  ...|   |....|||| | .|| ||| || |||.||      . |.|..|||.|.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase IRAK-0_b-2.AA DRK 98-297 33 3.5e-32 106.33 In-house 1-201 (258) Show / Hide 
Range on Protein: 98-297
Range on HMM: 1-201/258
Sequence Identity: 33% (68 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKANSTTGP---RIQQFLNEVTILSQVNHRNLVKLLGCCLETEVPLLVFEFVPNGTLFEHLQHRRSSILSWE
 |     | |..| || |     | ||.|..          .. |  |.....|  | | .  .| |..   .. . |. | | |   | |  |  ..| 
IKIGNRIGRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNIL-HDESIEMDWP

RRLQIAIETAEAISYLHSSAAQP-IYHRDVKSTNILLDEKFTAKVADFGISK-LVSLEATHVSTTVHGTPGYIDPQYQQNYQLTDKSDVYSFGVVLLELI
...|...  |  . |||..   | | ||| || | | || .  |||||| |      .      |  |||. . |    |   | | |||||..|| |..
LMKQMMFDCAKGMIYLHCC--NPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV

TGQKP
| | |
TRQDP
Kinase IRAK-0_b-2.AA TyrKc 98-370 22 4.3e-30 107.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 98-370
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKANSTTGPRIQQFLNEVTILSQV--NHRNLVKLLGCCLET-------EVPLLVFEFVPNGTLFEHLQHRRS
 . . .|| | ||.|..|...  ..||.|. .. .   .. |..|  |....  .| |.|.|.|.|..        | ...|.|..|.| | ..|. .| 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLE--------ATHVSTTVHGT---------PGYIDPQYQQ
  |...  |....  |.  .||||    .. |||    |.|..|..|.|..||| |. .  .          ..... .|          |  |     .
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

NYQLTDKSDVYSFGVVLLELIT-GQKPVDF---SRNSSDKNLTAFSLAYIQSSRIED---IIDKGLELGDERAKISSIQEVANLAIRCLEFNRENRPAMR
 .  | ||||.||||.. |. | ||.|          |.. . ..  .     . ..   .                 .|. ..  .| ... |.|| ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS----------F-VCCPDEMYQIMKQCWHEDPEDRPTFS

SVAEEL
 . |..
EIHECF
Kinase IRAK-0_b-2.AA MLK 270-297 41 5.9e-07 20.31 In-house 207-235 (291) Show / Hide 
Range on Protein: 270-297
Range on HMM: 207-235/291
Sequence Identity: 41% (12 aa)

Q-QNYQLTDKSDVYSFGVVLLELITGQKP
| .. . . |.||.|.|||| |..|.. |
QFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_b-2.AA Pkinase_Tyr 276-297 56 0.00022 15.47 Pfam 192-214 (270) Show / Hide 
Range on Protein: 276-297
Range on HMM: 192-214/270
Sequence Identity: 56% (13 aa)

TDKSDVYSFGVVLLELIT-GQKP
| ||||.||||.. |..| |..|
TTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAK-0_b-2.AA IRAK 343-370 25 0.00253 7.83 In-house 290-317 (317) Show / Hide 
Range on Protein: 343-370
Range on HMM: 290-317/317
Sequence Identity: 25% (7 aa)

QEVANLAIRCLEFNRENRPAMRSVAEEL
.| . .|..|..    .|..|. | ..|
KEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_b-2.AA TK 343-370 28 0.007941 4.45 In-house 459-486 (486) Show / Hide 
Range on Protein: 343-370
Range on HMM: 459-486/486
Sequence Identity: 28% (8 aa)

QEVANLAIRCLEFNRENRPAMRSVAEEL
.|.. |  .| ... | || .. . |.|
EEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_b-2.AA Pkinase_Tyr 343-370 28 0.048005 7.55 Pfam 243-270 (270) Show / Hide 
Range on Protein: 343-370
Range on HMM: 243-270/270
Sequence Identity: 28% (8 aa)

QEVANLAIRCLEFNRENRPAMRSVAEEL
.|. .|  .| ... |.|| .. . |.|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL