Gene IRAK-0_i-2 (S.moellendorffii)

IRAK-0_i-2

Species: S.moellendorffii
Alias: IRAK-0_i-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_i-2.AA Protein None 302 None Fasta, JSON
IRAK-0_i-2.NA RNA None 909 None Fasta, JSON
IRAK-0_i-2.kin_dom Protein Kinase Domain None 178 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_i-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_i-2.AA TKL 2-253 17 7.2e-51 175.31 In-house 11-364 (364) Show / Hide 
Range on Protein: 2-253
Range on HMM: 11-364/364
Sequence Identity: 17% (67 aa)

QGVLKD---------GSEVAVKQLDLHSKQGQ---------------------------REFVNELSIITSIQHKNLAKLRGYCLDRDD-----------
.|...          | .||||..  |. .                              ....|. .. ...| |. .. |||.. ..           
KGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPW

--RILVYEFLENKS-LDQLLFESATGILLDWPTRFQIVLGVANGLAYLHE-----GSQKQIIHRDIKASNILLDHRLH--------------PKISDFGI
    .|.|. .. | |..|.          |. |....|..| |..|||      .  ..|||||.| .|||.|  ..              .||.|||.
GQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGL

SKLFNQEKG------------------FTSTVIAGTMGYLAPEYVLGG----------------LLTVKADVYSFGVLTLEIVSGQRCSDRKDGRLLVHS
|. ..|...                   |.  . || ...|||   |                   . |.||||||..  ||....|             
SRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------------

AWILHENCSE------------LEIADQRLDLEHN------------SEEILRVIQVALACTHENSASRPSMGDAVAML
    ... ..              ..| .| ..              .    .... .  | ...  .|||. . .  |
--PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_i-2.AA IRAK 7-185 33 4.2e-45 156.17 In-house 21-222 (317) Show / Hide 
Range on Protein: 7-185
Range on HMM: 21-222/317
Sequence Identity: 33% (68 aa)

DGSE--VAVK----QLDLHSKQGQREFVN---ELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENKSL-DQLLFESATGIL--LDWPTRFQIVLGVAN
.. .  .|||      |.  ..  ..|     || . ....|.|.  | |||..|..  |||... | || |.|    ... .  | |..|. | .| |.
KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTAC

GLAYLHEGSQK-QIIHRDIKASNILLDHRLHPKISDFGISKL--FNQEKGFTST------VIAGTMGYLAPEYVL--GGLLTVKADVYSFGVLTLEIVSG
|. .||. . .  |||.||| .||||| .. |||.|||      . ..|  ..       .. ||  |..||.     | ||.| ||||||.  ||...|
GIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTG

QR
.|
CR
Kinase IRAK-0_i-2.AA Pkinase 6-184 26 3.9e-37 132.4 Pfam 22-209 (293) Show / Hide 
Range on Protein: 6-184
Range on HMM: 22-209/293
Sequence Identity: 26% (52 aa)

KDGSEVAVKQLDLHSKQG--QREFVN--ELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENK----SLDQLLF-ESATGILLDWPTRFQIVLGVANGL
..| .||||.......    ... ..  |..|  ...|.|  .|.... |.|.  .| |..|.     .|  ..  .. ....... .   ... .. ||
GTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGL

AYLHEGSQKQIIHRDIKASNILLDHRLHP----KISDFGISKLF-NQEKGFTSTVIAGTMGYLAPEYVL-GGLLTVKADVYSFGVLTLEIVSGQ
.|.|.     |||||.| .|||.|.. |.    ||.|||..|.| .  ..   |...|| .|.||| .. |   . |.|..|.|..  | ..|.
EYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_i-2.AA TKL-Unique 8-185 27 7.6e-33 113.23 In-house 20-226 (290) Show / Hide 
Range on Protein: 8-185
Range on HMM: 20-226/290
Sequence Identity: 27% (58 aa)

GSEVAVKQLDL---HSKQGQREFVNELSIITSIQ-HKNLAKLRGYCL----DRDDRILVYEFLENKSLDQLLF----ES---ATGILLDWPTRFQIVLGV
|..||.||. .    |..  .|| ||....  .. |.|. .. |||     .  ....| |...  ||. .|      .   .  . |..  | .... .
GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDI

ANGLAYLHEGSQKQIIHRDIKASNILLDHR-----LHPKISDFGISKLFNQE-KGFTS-------TVIAGTMGYLAPEYVLG--GLLTVKADVYSFGVLT
| |. |||  . . |||||.| ||.|.| .     .  ||.|||.||. ... |....       ..  |.  ..|||   .   . . |.||||||.  
AQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL

LEIVSGQR
 ||.....
WEIATRKI
Kinase IRAK-0_i-2.AA Dicty4-Unclassified 8-183 33 7e-31 102.98 In-house 22-204 (263) Show / Hide 
Range on Protein: 8-183
Range on HMM: 22-204/263
Sequence Identity: 33% (63 aa)

GSEVAVKQLDLHSKQGQ----REFVNELSIITSIQHKNLAKLRGYCLDR----DDRILVYEFLENKSLDQLLF----ESATGILLDWPTRFQIVLGVANG
| .|||| .   . .       .|  |  |  |||| || |..|||.         . | ||.    |  .      |    | ||      . . .| |
GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQG

LAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFGISKLFNQEKGFTSTVIAGTMGYLAPEYVLGGLLTVKADVYSFGVLTLEIVSG
...||    . .||||||.||||.|     || |||||        |. | ||||    .||   .   . |.||||....  | . |
MQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFN--FNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAK-0_i-2.AA STE 6-184 21 2.6e-30 104.28 In-house 37-265 (359) Show / Hide 
Range on Protein: 6-184
Range on HMM: 37-265/359
Sequence Identity: 21% (50 aa)

KDGSEVAVKQLDLHSKQG-----------------QREFVNELSIITSIQ--HKNLAKLRGYCLD-------RDDRILVYEFLENKSLDQLLFES-ATGI
. |  .|.||..| ...                  . .. .|..|    .  |.|  |  |....       .|.  .. |.... |||... .   .| 
ETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGK

LLD----------WPTRFQIVLGVANG-LAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFGISKLFNQ---------------EKGFTSTVIAGTMG
 |.           .    |.  .  | |.|||.     |||||||..||||      |..|||... ...                 .  .. ..||  
PLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-

YLAPEYVLG------GLLTVKADVYSFGVLTLEIVSGQ
. ||| ...      .  ..|.|..|.| . .| . |.
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_i-2.AA MLK 8-184 26 8.7e-29 97.06 In-house 22-233 (291) Show / Hide 
Range on Protein: 8-184
Range on HMM: 22-233/291
Sequence Identity: 26% (58 aa)

GSE-----VAVKQLD---LHSKQG----QREFVNELSIITSIQHKN----LAKLRGYCLDR-DDRILVYEFLENKSLDQLLFESATGIL-----------
. .     ||||. .     .|.     |..|  |  .   ..|.|      ...| ||.   .  .| |..|. ||  .| .  ...            
NKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRV

LDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDH------RLHPKISDFGISKLFNQEKGFTSTVIAGTMGYLAPEYVL----GGLLTVKAD
 |    ... | .|.|..|||.  .|.|||||.| .|||.|.       .. ||.|||.|. ..| .  . .  |||  . ||| |.    ..  . |.|
YDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPE-VIQQFRCEKYSEKCD

VYSFGVLTLEIVSGQ
|.|.||.  |.....
VWSWGVVLWEMLTRE
Kinase IRAK-0_i-2.AA TK 1-182 14 1.2e-28 92.57 In-house 19-389 (486) Show / Hide 
Range on Protein: 1-182
Range on HMM: 19-389/486
Sequence Identity: 14% (54 aa)

MQGVLKDGS--------------------------EVAVKQLDLHSKQGQREFVN--------------ELSIITSIQ-----HKNLAKLRGYCLDRDD-
..| .....                          .||||.| ... . |.||                |....   .     |.|. .| |.|.. .  
YKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPK

-----------RILVYEFLENKS----LDQLLFESATGIL------------------------------------------------------------
            ..| |. .. .    |.. | ..  .                                                              
PCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLL

-------------LDWPTRFQIVLGVANGLAYLHEGSQK-----QIIHRDIKASNILLDHRLH-----------PKISDFGIS--------KLFNQEKGF
             |. ...  . . .|.|..|||  |..     ...|||. | |.|......            ||.||| |        .  ....  
QMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH--SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDY

TSTVIAGTMG-------------------------YLAPEYVLGGL---------LTVKADVYSFGVLTLEIVS
...   ||..                         ..||| ....           | | ||.|||||  ||..
YRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_i-2.AA LRRK 2-185 22 6e-26 88.77 In-house 18-281 (351) Show / Hide 
Range on Protein: 2-185
Range on HMM: 18-281/351
Sequence Identity: 22% (60 aa)

QGVLKD---------------------------GSEVAVKQLDLH----------------------------------SKQGQREFVNELSIITSIQHK
.. ...                           ...||.|.....                                  .    ||| .|..|. . .| 
RAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRHEVWIMSHLNHP

NLAKLRGYCLDRDDRILVYEFLENKSLDQLLFESA-TG-----ILLDWPTRFQIVLGVANGLAYLHEGSQK-QIIHRDIKASNILL---D---------H
|. .| |.|.  . ...| |.. . .|...|.... .|     . ..| .. .|.| .| |..|||  |..  ||||| |  ||||   .          
NIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH--SHNPPIIHRDLKSPNILLWSSPQNHSPNYPNA

RLHPKISDFGISKLFNQEKGFT-STVIAGTMGYLAPEYVLGG----LLTVKADVYSFGVLTLEIVSGQ-R
  . ||.||||| .| |  . .      |. |..||| ....      | |.|.||||..  |....| .
HVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPE-IMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase IRAK-0_i-2.AA TK-Unique 11-182 23 1.1e-25 85.59 In-house 33-234 (294) Show / Hide 
Range on Protein: 11-182
Range on HMM: 33-234/294
Sequence Identity: 23% (49 aa)

VAVKQLD-LHSKQGQREFVNELSIITSIQ-HKNLAKLRGYCLDRD-DRILVYEFLENKSLDQLLFESATG-----------IL------------LDWPT
||||.|   .... ...| .|...  ..  |.|. .. |.| . | .  ...|.... .|. .| ... .           .             ..  .
VAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKD

RFQIVLGVANGLAYLHEGSQ--KQIIHRDIKASNILLDHRLHPKISDFGISKLFNQEKGFTSTVIAGTMG--YLAPEYVL--GGLL-TVKADVYSFGVLT
 ...  ..|.|..||.   .  |.|.|||. |.|.|| ...  ||.|||...  . ..   ..   |..   ..|||. .  .|   | | ||.||||| 
LYHFAWQIACGMEYLA---SQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM

LEIVS
 ||..
WEIFT
Kinase IRAK-0_i-2.AA Ciliate-E2-Unclassified 21-186 22 1.9e-25 85.21 In-house 44-269 (352) Show / Hide 
Range on Protein: 21-186
Range on HMM: 44-269/352
Sequence Identity: 22% (51 aa)

KQGQREFVNELSIITSIQ-----------------HKNLAKLRGYCLDRDD--RILVYEFLENKSLDQLLFESAT---------------GILLDWPTRF
.. . |..||. .. ...                 |... ... .  ..|.   ..|.|..|...| | . .. .                |. .  .. 
MNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY

----QIVLGVANGLAYLHEGSQKQ-IIHRDIKASNILLDHRL---HPKISDFGISK---LFNQEKGFT------------STVIAGTMGYL----APEYV
    ..   . .|| |||   .|. ||||||| .|||.|      ..||.||||||    .|... ..            .. ..|| .|.    |||. 
KKAKFYFAQILQGLEYLH---HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL

LGGLLT----VKADVYSFGVLTLEIVSGQRC
 |         |.|..|.||.  |.. |...
QGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase IRAK-0_i-2.AA Pkinase_Tyr 1-135 26 1.3e-23 80.62 Pfam 16-160 (270) Show / Hide 
Range on Protein: 1-135
Range on HMM: 16-160/270
Sequence Identity: 26% (39 aa)

MQGVLK-----DGSEVAVKQL-DLHSKQG--QREFVNELSIITSI-QHKNLAKLRGYCLDRDDR---ILVYEFLENKSLDQLLFES-ATGILLDWPTRFQ
..|..|     .. .|||| | . ....   ...| .|..| ... .|.|. .| | |.|...    ..| |. .. .|.  | .    .  |. ..  |
YKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQ

IVLGVANGLAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFGISKL
. . .|.|..||..   |..||||. | |.|... .. ||.||| ...
MCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-0_i-2.AA S_TKc 1-257 20 4.7e-18 67.23 SMART 16-231 (231) Show / Hide 
Range on Protein: 1-257
Range on HMM: 16-231/231
Sequence Identity: 20% (56 aa)

MQGVLKD-GSEVAVKQLDLHSKQGQREFVNELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLEN--KSLDQLLFESATG---ILLDWPTRFQIVLGVAN
.... |. | .||.|...       . . .|..|  . .|.|. || ... | |.  .| |....   .| ... .  ..     ..  .   ..  ...
YKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICC

GLAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFGISKLFNQEKGFTSTVIAGTMGYLAPEYVLGGLLTV-KADVYSFGVLTLEIVSGQR-CSDRKDG
.|.|.|.   ..|||||.| .|||||.  | ||.|||.....        | . ||  |.||| .     .  |.|..|.|..  | ..|.   .     
ALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----

RLLVHSAWILHENCSELEIADQRLDLEHNSEEILRVIQVALACTHENSASRPSMGDAVA-----MLSGYK
    . . ...  .               |.| .  |.    | . . . ||.  .| .     ..  . 
----QMQMMFKKIG---------------SPEAKDFIR---KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_i-2.AA TyrKc 1-253 22 1.9e-16 43.05 SMART 16-280 (280) Show / Hide 
Range on Protein: 1-253
Range on HMM: 16-280/280
Sequence Identity: 22% (64 aa)

MQGVLKDGSEVAVKQLDLHSKQGQREFVNELSIITSI--QHKNLAKLRGYCLDR-------DDRILVYEFLENKSLDQLLFESATGILLDWPTRFQIVLG
..|..|   .|||| |  ..   ...| .|..| ...  .|.|. .| |.|..        .   .| |. .. .|.. | ..     | ...  .. . 
YKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--LCMKDLLSFCWQ

VANGLAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFGISKLFNQE--KGFTSTVIA-----GTMG-----YLAPEYVLGGLLTVKADVYSFGVLTLE
.|.| .|||.    ..||||. | |.|...... |||||| |.    .  .|  . ..      |. .      .|||    |  | | ||.||||.  |
IACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWE

IVSGQRCSDRKDGRLLVHSAWILHENCSELEIADQRLDLEHN--------SEEILRVIQVALACTHENSASRPSMGDAVAML
| .  ..     |  .     .  .   |.  .  |..  .|          . .    . . | ||. ..||.. . .  .
IFT--YGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_i-2.AA Pkinase_Tyr 154-182 51 0.001728 12.44 Pfam 181-209 (270) Show / Hide 
Range on Protein: 154-182
Range on HMM: 181-209/270
Sequence Identity: 51% (15 aa)

LAPEYVLGGLLTVKADVYSFGVLTLEIVS
.|||    |  |.| ||.|||||  ||..
MAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_i-2.AA TK 230-253 20 0.005629 4.96 In-house 463-486 (486) Show / Hide 
Range on Protein: 230-253
Range on HMM: 463-486/486
Sequence Identity: 20% (5 aa)

QVALACTHENSASRPSMGDAVAML
.. . | |.. . ||.. . . .|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_i-2.AA IRAK 230-253 29 0.040953 3.49 In-house 294-317 (317) Show / Hide 
Range on Protein: 230-253
Range on HMM: 294-317/317
Sequence Identity: 29% (7 aa)

QVALACTHENSASRPSMGDAVAML
|.|. |.|.  . |..|  ... |
QCACCCGHHRANRRCDMAWVMQQL