Gene IRAK-0_bj (S.moellendorffii)

IRAK-0_bj

Species: S.moellendorffii
Alias: IRAK-0_bj
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_bj.AA Protein None 363 None Fasta, JSON
IRAK-0_bj.NA RNA None 1092 None Fasta, JSON
IRAK-0_bj.kin_dom Protein Kinase Domain None 246 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_bj.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_bj.AA TKL 53-344 18 6.9e-42 145.47 In-house 1-364 (364) Show / Hide 
Range on Protein: 53-344
Range on HMM: 1-364/364
Sequence Identity: 18% (76 aa)

IDEGKFGELYKASVV-----CIFFFSNLSVANRSSCSLGFFYLQGELSDGTKFAVKKLSSKY----------------------HKEDHSVFASDVS---
| .| ||| ||.        |     .                     .|.  ||||..|..                      . .. | |        
IGSGGFGEVYKGKWRGWGGKC-----P------------------S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEI

-SIFAVEHPNLVKLMGCCIEADE-------------QFLLYEFLENGRPLSRLLFNPDNGECLSWQTRMTIAIGIARGVNYLHEEAH-------VIHGDI
 ..    |||.|..||.|.. .               .. .|. ..|  |..|.          |. |. .|..||||.|||| .         .|| |.
MMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDL

QASNIIIDENFT--------------PKISDFGLTSLL----PDEDSY--------------INSRFSGTLGYIAPEVAQ-----------------GKL
  .|| .|||.|              .||.||||   .     ..|.                ...  ||... |||| .                 .. 
KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY

TDKADVFSFGVLLLEIVSGRNNFEPDLPMETVFLVQWTWK----LYEQGKVLELVDPLLNND-------FPEEEV-FRAIHIALLCTQDSVKSRPHMVQV
. |.||.|||..| ||....       | .     .. .     ..  . ...   |.. .         |.. .  . . ..  | .   ..|| . ..
SEKCDVYSFGIVLWEILTRCR------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEI

RAML
   |
LKRL
Kinase IRAK-0_bj.AA IRAK 129-272 37 3.1e-39 136.67 In-house 62-221 (317) Show / Hide 
Range on Protein: 129-272
Range on HMM: 62-221/317
Sequence Identity: 37% (60 aa)

HPNLVKLMGCCIEADEQFLLYEFLENGRPLSRLLFNPDNGEC--LSWQTRMTIAIGIARGVNYLHEEA---HVIHGDIQASNIIIDENFTPKISDFGLTS
|||.| | | |.| ..  | |... ||    ||      .    |||..|  |..|.|.|...||.      .|||||  .||  |..|||||.||||  
HPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHR

------LLPDEDS--YINSRFSGTLGYIAPEVAQ---GKLTDKADVFSFGVLLLEIVSGR
       . .  .   . |.. ||. | .||      |.|| | ||.|||. |||...|.
FGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGC
Kinase IRAK-0_bj.AA TK 91-344 14 2.7e-34 111.79 In-house 20-486 (486) Show / Hide 
Range on Protein: 91-344
Range on HMM: 20-486/486
Sequence Identity: 14% (69 aa)

QGELSDG--------------------------TKFAVKKLSSKYHKEDHSVFA---------------SDVSSIFA---VEHPNLVKLMGCCIEADE--
.||. ..                          |. ||| | .. . ..   |.                 . ...     .|||.|.| |.| . ..  
KGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKP

----------QFLLYEFLENGR----PLSRLLFNPDNGEC------------------------------------------------------------
            .. |. ..|      .. |  ..... .                                                            
CFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQ

------------LSWQTRMTIAIGIARGVNYLHEEA-----HVIHGDIQASNIIIDENFT-----------PKISDFG--------LTSLLPDEDSYINS
            |. .... ..  ||.|  |||.       ...|.|. | |. ..|| .            ||.|||        |.  ....| |  .
MAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRK

RFSGTLG-------------------------YIAPEVAQ----------GKLTDKADVFSFGVLLLEIVS-GRNNFEPDLPMETVFL---VQWTWKLYE
.  || .                         . |||. .          || | | ||.|||||. ||.. |.  . .... . |     .|   .. .
SSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLR

Q------------GKVLELVDPLLNND------FPEEEVFRAIHI-ALLCTQDSVKSRPHMVQVRAML
.            |  ...  | .  |      .|...   ....  . | .   . || . |.. .|
RGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_bj.AA TK-Unique 47-270 22 7.8e-29 96.63 In-house 1-234 (294) Show / Hide 
Range on Protein: 47-270
Range on HMM: 1-234/294
Sequence Identity: 22% (60 aa)

FAPEKKIDEGKFGELYKASVVCIFFFSNLSVANRSSCSLGFFYLQGELSDGTKFAVKKLSSKYHKEDHSVFASDVSSIFAVE-HPNLVKLMGCCIEAD-E
.  ...|.||.||. ... |. |                      .. .. .. |||.|  . ...|.. | .  .   ..  |||.|...|||.. |  
LEVGDVIGEGAFGQVWRGEVWGIW---------------------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEP

QFLLYEFLENG---------RP--------------------------LS-RLLFNPDNGECLSWQTRMTIAIGIARGVNYLHE-EAHVIHGDIQASNII
.....|....|         ||                          .| ..|..              .|..||.| .||..   ...|.|. |.|. 
WMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH--------------FAWQIACGMEYLASQRKKIVHRDLCARNVL

IDENFTPKISDFGLTSLLPDEDSYINSRFSGTLG--YIAPEVAQ---GKL-TDKADVFSFGVLLLEIVS
. |... ||.|||..  . ..  |.... .|..   . |||. .   |   | | || |||||. ||..
LTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_bj.AA MLK 129-272 27 1.5e-26 89.23 In-house 64-233 (291) Show / Hide 
Range on Protein: 129-272
Range on HMM: 64-233/291
Sequence Identity: 27% (48 aa)

HPN----LVKLMGCCIEADEQ-FLLYEFLENGRPLSRLLFN-PDNGE----------CLSWQTRMTIAIGIARGVNYLHEEAH--VIHGDIQASNIIIDE
|||     ....|.|..   . ... |..|.| .|...| . .....            . .  |..|  .|||..|||..|   .|| |.  .|| |||
HPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG-SLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE

------NFTPKISDFGLTSLLPDEDSYINSRFSGTLGYIAPEV----AQGKLTDKADVFSFGVLLLEIVSGR
      . | ||.|||.   . . .      . ||. . ||||      .| . |.||.|.||.| |.....
ICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_bj.AA TKL-Unique 97-271 27 2.2e-25 86.59 In-house 20-224 (290) Show / Hide 
Range on Protein: 97-271
Range on HMM: 20-224/290
Sequence Identity: 27% (57 aa)

GTKFAVKKLS--SKYHKEDHSVFASDVSSIFAVE-HPNLVKLMGCCI----EADEQFLLYEFLENGRPLSRLLF-------NPDNGECLSWQTRMTIAIG
|.. |.|...  .. ..|    | . |. .   . |||.|..|| |.     . . ..  |... |  |  .|        |  |   |..| |...|| 
GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGG-SLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAID

IARGVNYLHEEAH-VIHGDIQASNIIIDEN-----FTPKISDFGLTSLLP--DEDSYINS------RFSGTLGYIAPEVAQG---KLTDKADVFSFGVLL
||.| .||| .   .||.|.  ||. .|.|     .  ||.||||  ..   .. .....       . |.. ..||||  .   . . |.||.|||. |
IAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL

LEIVSG
 ||...
WEIATR
Kinase IRAK-0_bj.AA HH498 128-272 27 2.4e-24 73.76 In-house 60-223 (284) Show / Hide 
Range on Protein: 128-272
Range on HMM: 60-223/284
Sequence Identity: 27% (45 aa)

EHPNLVKLMGCCIEADEQFLL-YEFLENGRPLSRL---------LFNPDNGEC-----LSWQTRMTIAIGIARGVNYLHE--EAHVIHGDIQASNIIIDE
.||. |. .. |..   ||..  .. .||   |.|           | ....      .. | .|||.. .|.| ||||.     .|| |    || |.|
NHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHE

NFTPKISDFGLTSLLPDEDSYINSRFSGTLGYIAPEVAQ--GKLTDKADVFSFGVLLLEIVSGR
.   .. |||    . | .        | | . ||||    .| . |.||||..  . |. ...
DGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTRE
Kinase IRAK-0_bj.AA Ciliate-E2 47-272 17 9.5e-24 78.38 In-house 1-293 (365) Show / Hide 
Range on Protein: 47-272
Range on HMM: 1-293/365
Sequence Identity: 17% (59 aa)

FAPEKKIDEGKFGELYKASV---------------------VCIFFFSNLSVANRSSCSLGFFYLQGELSDGTKFAVKKLSSKYHKEDHSVFASDVSSIF
.   ||| .| ||  ||..|                                                     |...|.   |. |..   . . . .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQ------------------------------EKVKIKIYAMKIMKKNQIEQIKQEIHIM

-AVE----------------HPNLVKLMGCCI--EADEQFLLYEFLENGRPLSRLLFNPDNG-------ECLSWQTRMTIAIGIAR--------------
  ..                |||..|.  | .    .  .|  |... |  ....  |. .        ...... . .|   |..              
REINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACII

-GVNYLHEEAHVIHGDIQASNIIIDENFTPKISDFGLTSLLPDE----------DSYINSR---------------------FSGTLGYIAPEVAQGK--
 ...|||.. ..|| ||  .||..     .||.||||   . |.            |.. .                     . ||.|| |||. .||  
LALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKY

--------LTDKADVFSFGVLLLEIVSGR
         . |.|..|.||.| | ..|.
DNQQKQKGYDYKCDIWSLGVILYEMLFGK
Kinase IRAK-0_bj.AA LRRK 128-276 27 1.7e-23 79.96 In-house 115-284 (351) Show / Hide 
Range on Protein: 128-276
Range on HMM: 115-284/351
Sequence Identity: 27% (47 aa)

EHPNLVKLMGCCIEADEQFLLYEFLENGRPLSRLLFNPDNGEC------LSWQTRMTIAIGIARGVNYLHEEA-HVIHGDIQASNIII---D--------
.|||.|.|.| ||.     .  |.. .|  |...|.|. . .       .||...  ||. ||.|..|||     .|| |    ||..   .        
NHPNIVSLKGFCIHP--LCMVMEYAPHGD-LYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYP

-ENFTPKISDFGLTSLLPDEDSY-INSRFSGTLGYIAPEVAQG----KLTDKADVFSFGVLLLEIVSGR-NNFE
 .. . ||.|||....    . . . ... |. |. |||. ..      |.|.|..|||..| |.....   |.
NAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_bj.AA Ciliate-E2-Unclassified 178-272 30 6.3e-22 72.86 In-house 147-267 (352) Show / Hide 
Range on Protein: 178-272
Range on HMM: 147-267/352
Sequence Identity: 30% (37 aa)

TIAIGIARGVNYLHEEAHVIHGDIQASNIIIDEN---FTPKISDFGLTS---LLPDEDSY------------INSRFSGTLGYI----APEVAQGKLTDK
...  |  | .|||.. ..|| ||. .||..|.|   . .||.|||. .     ...| .            . . |.||..|.    |||| ||.  |.
FYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDH

-----ADVFSFGVLLLEIVSGR
     .|..|.||.| |.. |.
SKAYKCDIWSLGVILYEMLFGY
Kinase IRAK-0_bj.AA Pkinase_Tyr 101-270 32 2.6e-21 72.78 Pfam 32-209 (270) Show / Hide 
Range on Protein: 101-270
Range on HMM: 32-209/270
Sequence Identity: 32% (59 aa)

AVKKLSSKYHKED--HSVFASDVSSIFAV-EHPNLVKLMGCCIEADEQ---FLLYEFLENGRPLSRLLFNP-DNGECLSWQTRMTIAIGIARGVNYLHEE
|||.|  ....|.  .  | . ..       |||.|.|.|.|.. .|.   ..  |. ..|  |   | .. .... |. ..   ... ||.| .|| |.
AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYL-ES

AHVIHGDIQASNIIIDENFTPKISDFGLTSLLPDEDSYINSRFSGTLGY--IAPE-VAQGKLTDKADVFSFGVLLLEIVS
 . || |. | |. ..||.. ||.||||. .. ..| |. .| .| |     |||  . || | | || |||||. ||..
KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_bj.AA Pkinase 129-272 30 7.8e-21 74.75 Pfam 59-209 (293) Show / Hide 
Range on Protein: 129-272
Range on HMM: 59-209/293
Sequence Identity: 30% (48 aa)

HPNLVKLMGCCIEADEQFLLYEFLENG---RPLSRLLFNPDNGECL--SWQTRMTIAIGIARGVNYLHEEAHVIHGDIQASNIIIDENFTP----KISDF
||| |.| ... . |.  .  |..|.|     |....   ... |.  |...   ..  |.||..|.|.   .|| |.  .|| ||.| ..    ||.||
HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDF

GLTSLL-PDEDSYINSRFSGTLGYIAPEV--AQGKLTDKADVFSFGVLLLEIVSGR
||  ..    .|  .. | ||..|.||||   . . . |.|..|.|..| | ..||
GLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_bj.AA TyrKc 47-344 22 4.7e-17 53.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 47-344
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

FAPEKKIDEGKFGELYKASVVCIFFFSNLSVANRSSCSLGFFYLQGELSDGTKFAVKKLSSKYHKEDHSVFASDVSSIFAV--EHPNLVKLMGCCIEA--
   .||. || ||| ||.                                 .. |||.| .      .  | .  .    .  .|||.|.| |.|..   
ITLGKKLGEGAFGEVYKGTWK------------------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGR

-----DEQFLLYEFLENGRPLSRLLFNPDNGECLSWQTRMTIAIGIARGVNYLHEEAHVIHGDIQASNIIIDENFTPKISDFGLTSLLPDE-------DS
     .  ... |. ..|  ...|  . ..   |....   ... ||.| .|||.  ..|| |. | |. ..||.| |||||||.  . |.       | 
NFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDY

YI-----NSRFSGTLGYIAPEVA-QGKLTDKADVFSFGVLLLEIVSGRNNFEPD-----LPMETVFLVQWTWKLYEQGKVLELVDPLLNNDF----PEEE
|      ....   .   |||.   || | | ||.||||.. || .      |.     .. . |.      .. .||. ..  .  .          .|
YRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI------EYVKQGYRMPQPPNDY-P-MSFVCCPDE

VFRAIHIALLCTQDSVKSRPHMVQVRAML
...   | . | .   ..|| . ...  .
MYQ---IMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_bj.AA S_TKc 47-344 18 3.5e-16 60.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 47-344
Range on HMM: 1-231/231
Sequence Identity: 18% (58 aa)

FAPEKKIDEGKFGELYKASVVCIFFFSNLSVANRSSCSLGFFYLQGELSDGTKFAVKKLSSKYHKEDHSVFASDVSSIFAVEHPNLVKLMGCCIEADEQF
.   .|| .| ||. ||.  .                            .| ..|.|...          . . ..      |||.||| ... . |. .
YEILRKIGKGAFGKVYKCRHKK---------------------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLY

LLYEFLEN--GRPLSRLLFNPDNGEC--LSWQTRMTIAIGIARGVNYLHEEAHVIHGDIQASNIIIDENFTPKISDFGLTSLLPDEDSYINSRFSGTLGY
.  |....  |  ....  .. .| .  ..  .   ..  |.....|.|.  ..|| |.  .|| .||  . ||.||||  .|        . | ||. |
MVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWY

IAPEVAQGKLTD-KADVFSFGVLLLEIVSGRNNFEPDLPMETVFLVQWTWKLYEQGKVLELVDPLLNNDFPEEEVFRAIHIALLCTQDSVKSRPHMVQVR
.||||   . .  |.|. |.|..| | ..|.  |.   ....  ..                               |...   | |   . ||   .. 
MAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

A---------ML
.          .
QDEWDIKCHPWF
Kinase IRAK-0_bj.AA IRAK 47-64 38 0.004093 7.08 In-house 1-18 (317) Show / Hide 
Range on Protein: 47-64
Range on HMM: 1-18/317
Sequence Identity: 38% (7 aa)

FAPEKKIDEGKFGELYKA
|... .| || ||. |..
FHKDNRIGEGGFGCVYRG