Gene IRAK-0_c-1 (S.moellendorffii)

IRAK-0_c-1

Species: S.moellendorffii
Alias: IRAK-0_c-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_c-1.AA Protein None 543 None Fasta, JSON
IRAK-0_c-1.NA RNA None 1632 None Fasta, JSON
IRAK-0_c-1.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_c-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_c-1.AA TKL 199-464 21 8.7e-66 224.87 In-house 1-364 (364) Show / Hide 
Range on Protein: 199-464
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

LGEGGYGIVYKGKLPD---------GTPIAVKNLLNNRGQ---------------------------AEKEFRVEVEAIGRVRHKNLVRLLGYCVEGCH-
.|.||.|.|||||.           |...||| .  .  .                           .......|.  . | || |.|...||| .. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RMLVYEYVDNGNLEQWLHGPISRTKSLTWEARMKIVLGTAKALAYLHEAL-----EPKVVHRDIKSSNILIDSTYN------------
             ..|.||...|.|.  ||          |. |....|..|....|||         |...|||.||.|||.|. ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--ARISDFGLAKLLGAGKSHVTTR------------------VMGTFGYVAPEYAN----------------TGLLNERSDVYSFGVLLMEVVTGRDPVD
  . |.||||.. .   ..   |                   . ||... |||  .                 .  .|..||||||..| |..|.. | .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-YSRPPSEVNLVDWLKLMVGQRRSEEVADPNLEP-------KPASRALKRALLVALRCVDPDSSKRPKMGHVVHML
 |  .| ...  . ...|  .. ..    |  .         | . ....    . .| |.| .||| .  ... |
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_c-1.AA IRAK 193-401 36 3.8e-58 199.5 In-house 1-230 (317) Show / Hide 
Range on Protein: 193-401
Range on HMM: 1-230/317
Sequence Identity: 36% (85 aa)

FADCNVLGEGGYGIVYKGKLPDGT-PIAVKNLLNNR----GQAEKEFRV---EVEAIGRVRHKNLVRLLGYCVEGCHRMLVYEYVDNGNLEQWLHGPI-S
|.  |..||||.| ||.|..   | . ||| | ...    .. ...|.    |...  | ||.|.| |.||| |.    |||.|  || ||  |..   .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

RT-KSLTWEARMKIVLGTAKALAYLHEALEPK--VVHRDIKSSNILIDSTYNARISDFGLAKLL----GAGKSHV----TTRVMGTFGYVAPEYAN--TG
 . | |.|  | .| .|||... .||.. .|.  . |.||||.||| |   .. |.||||.       .  |. .    | .| ||  | .||. .  .|
CPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

LLNERSDVYSFGVLLMEVVTGRDPVDYSRPP
 |  ..||||||. |.||.||. .|.  ||.
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPE
Kinase IRAK-0_c-1.AA TKL-Unique 195-391 34 1.6e-45 157.52 In-house 1-224 (290) Show / Hide 
Range on Protein: 195-391
Range on HMM: 1-224/290
Sequence Identity: 34% (77 aa)

DCNVLGEGGYGIVYKGKLPDGTPIAVKNLL-NNRGQAE--KEFRVEVEAIGRVR-HKNLVRLLGYCV----EGCHRMLVYEYVDNGNLEQWLH--GPIS-
. |..|||||| ||||| . |.|.|.| .  |.    |  .||. ||  . . . |.|.|.. |||.       .. .| ||.. |.|   ||   . . 
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---RTKSLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDST-----YNARISDFGLAKLLGAG-KSHVT-------TRVMGTFGYVAPEYA
   . . |... |.|...  |... |||  .||.. |||.||||.|.|.      .|..|.||||.|..    |. ..       . ..|.| ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

NT--GLLNERSDVYSFGVLLMEVVTG
.    . .| |||||||. | | .|.
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_c-1.AA TK 193-464 17 8.1e-45 147.71 In-house 1-486 (486) Show / Hide 
Range on Protein: 193-464
Range on HMM: 1-486/486
Sequence Identity: 17% (84 aa)

FADCNVLGEGGYG---IVYKGKLPDG--------------------------TPIAVKNLLNNRGQAEKEFRV--------------EVEAIGRVR----
    ..|||| .|    ||||.. ..                          || ||| |    .....||.               |.|..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLVRLLGYCVEGC------------HRMLVYEYVDNGN----LEQWLHGPISRTKS-----------------------------------------
 |.|.|||.|.|..|             . |.| ||...|.    | ..|.    ...                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTWEARMKIVLGTAKALAYLHEA---LEPKVVHRDIKSSNILIDSTYN-----------ARISDFG---
                               || . .. . .  |....|||.    .....||||.   |.|... ..           ..|.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLGAGKSHVTTRVMGTFG-------------------------YVAPEYAN---------TGLLNERSDVYSFGVLLMEVVT-GRDPVDYSR
     ||. .. ..  ....  || .                         . |||  |         .|   . |||.|||||. |..| |. |     
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PP------SEVNLVDWLKLMVGQR-----RSEEVADPNLEPKPASRAL-------------KRALLVALRCVDPDSSKRPKMGHVVHML
.         .|     .|  |.|     . .|| . .  |.|.                 .   .. ..| ..| ..|| .  ....|
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGL-NEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_c-1.AA LISK 198-402 25 1.8e-41 132.37 In-house 1-248 (296) Show / Hide 
Range on Protein: 198-402
Range on HMM: 1-248/296
Sequence Identity: 25% (65 aa)

VLGEGGYGIVYKGKLP-DGTPIAVKNLLN-----NRGQAEKEFRVEVEAIGRVRHKNLVRLLGYCVE-GCHRMLVYEYVDNGNLEQWLHGPISRTKSLTW
..|.|..| |||| .  .|...|.| . .     |.  ..| .  ||. . . ||.| |.  | |..   . ..| ||.. |.|.| |. . .. . |.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILID----STYNARISDFGLAKLLGAGK-----------------------------------SHV
. |.|| |. |....|||.    ...||| || |.|..    . ..... |||.|...   .                                   .. 
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TTRVMGTFGYVAPEYANTGLLNERSDVYSFGVLLMEVVTGRDPVD--YSRPPS
|  . ||   .|||  .    .|..||.|||..| | .|....    . |.|.
T--ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQ
Kinase IRAK-0_c-1.AA Pkinase 193-392 26 4.4e-41 146.36 Pfam 1-209 (293) Show / Hide 
Range on Protein: 193-392
Range on HMM: 1-209/293
Sequence Identity: 26% (59 aa)

FADCNVLGEGGYGIVYKGKLPDG-TPIAVKNLLNNRGQAEKEFRV-----EVEAIGRVRHKNLVRLLGYCVEGCHRMLVYEYVDNG----NLEQWLHGPI
.    ..|.|..| |||..  .     |||  .. |.. ... .      |..   |..|.| |||.... .. |  .| ||...|     |  ....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK-IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

SRTKSL--TWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNA----RISDFGLAKLL-GAGKSHVTTRVMGTFGYVAPEYANTGLLN--
.| ...  ...   .... ....|.|.|.    ...|||.|..|||||....     .|.||||||..    .|  ||.. || .|.|||      ..  
WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEV-----IRGG

----ERSDVYSFGVLLMEVVTGR
     ..|..|.|..| |...||
QYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_c-1.AA LRRK 193-396 24 3.7e-39 136.18 In-house 1-284 (351) Show / Hide 
Range on Protein: 193-396
Range on HMM: 1-284/351
Sequence Identity: 24% (69 aa)

FADCNVLGEGGYG-IVYKGKLPD---------------------------GTPIAVKNLLN----------------------------------NRGQA
.   . .|.||.| .||..|. .                           ....|.| ..                                   ..  |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EKEFRVEVEAIGRVRHKNLVRLLGYCVEGCHRMLVYEYVDNGNLEQWLHGPISRT----K-SLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNI
  ||| ||  . . .| |.| |.|.| .  ....| ||...|.| . || . .      | ...|  . ||.|  ||...||| .  |...||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNI

LI---D---------STYNARISDFGLAKLLGAGKSHVTTRVMGTFGYVAPEYANTG---LLNERSDVYSFGVLLMEVVTGR-DPVD
|.   .          ...| |.|||.  .  . .. |. .. |..|..|||  . .     .| .|.||||..| | .|.. .| |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_c-1.AA Dicty4 197-394 32 7.5e-36 117.17 In-house 5-216 (277) Show / Hide 
Range on Protein: 197-394
Range on HMM: 5-216/277
Sequence Identity: 32% (69 aa)

NVLGEGGYGIVYKGKLPDGTPIAVKNL-LNNRG--QAE-KEFRVEVEAIGRVRHKNLVRLLGYCV----EGCHRMLVYEYVDNGNLEQWLHG-PISRTKS
. .|.|..| ||||.   |.  ||| | ..| .  ... .||| ||.  .  || |.. ..|.|     .    . | ||.  |||.  ||  |    .|
QRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQS

LTWE----AR-MKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLLGAGKSHVT--TRVMGTFGYVAPEYANTGLLNERSDVYS
 . .     | |.. . .|. ...||.   | ..|||.||.|.|.|  ... ..||||...   ...| .  . . || ...|||       || .||||
IKLDWPLIKRAMRMAFDAARGMNWLHCC-NPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYS

FGVLLMEVVTGRDP
|| .| | .|. .|
FGIVLWEILTRQEP
Kinase IRAK-0_c-1.AA TyrKc 193-464 23 9.8e-36 125.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 193-464
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

FADCNVLGEGGYGIVYKGKLPDGTPIAVKNLLNNRGQAEKEFRVEVEAIGRV--RHKNLVRLLGYCVEG-------CHRMLVYEYVDNGNLEQWLHGPIS
     .|||| .|.||||..   .. ||| | ..    ...|. | .   ..  .|.|.|||.|.|...          |.| ||...|.| . |. .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RTKSLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLLGAG------KSHVTT----RVM--GTFGYVAPEYANTGL
.   |...   .. .  |.  .|||.    ...|||.   |.|... . ..||||||.. .. .      |.  ..               |||  |.| 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

LNERSDVYSFGVLLMEVVTGRDPVDYSRPPSEVNLVDWLKLMVGQRRSEEVADPNLEPKPAS-------RALKRALLVALRCVDPDSSKRPKMGHVVHML
 .. |||.||||.. |. |  ..     |.... .      |  |.  | | . .  |.|..       .. .    . ..| . | ..|| .  ... .
FTTKSDVWSFGVCMWEIFTYGQQ-----PYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_c-1.AA MLK 193-394 25 5.6e-35 118.82 In-house 1-235 (291) Show / Hide 
Range on Protein: 193-394
Range on HMM: 1-235/291
Sequence Identity: 25% (60 aa)

FADCNVLGEGGYGIVYKGKLPDGTP-----IAVKNLLNNR---GQAE---KEFRVEVEAIGRVRHKN----LVRLLGYCVE-GCHRMLVYEYVDNGNLEQ
.    ..|.|..| |.||.   ..      .|||.   .    ....   ..|. |..   ...|.|     ....| | . .||  .| ||...| |  
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WLHG-PISRTKS---------LTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDS------TYNARISDFGLAKLLGAGKSHVTTRVMGTFG
 ||| ..    .          . .  |.. |  |....|||. . ....|||.||.|||||         ...|.|||... .   .    .  .||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YVAPEY---ANTGLLNERSDVYSFGVLLMEVVTGRDP
. |||    .  .  .| .||.|.||.| |..|.. |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_c-1.AA Pkinase_Tyr 198-394 30 6.3e-35 118.92 Pfam 6-214 (270) Show / Hide 
Range on Protein: 198-394
Range on HMM: 6-214/270
Sequence Identity: 30% (64 aa)

VLGEGGYGIVYKGKLP-----DGTPIAVKNLLNNRGQAE---KEFRVEVEAIGRV-RHKNLVRLLGYCV-EGCH--RMLVYEYVDNGNLEQWLHGPISRT
.|||| .| ||||..      ...| ||| | ..  . .   ..|  |..      .|.|.|||.| |. .| .   ..| ||. .|.|   |. . .  
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

KSLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLL-GAGKS-HVTTRVMGTFGYVAPEYANTGLLNERSDVYSFGV
..|| .   .. .  ||...||..    . .|||.   |.|....  ..|.|||||...   .   ....  .      |||  |.|  .. |||.||||
QPLTMKDLLQMCWQIAKGMEYLESK---NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGV

LLMEVVT-GRDP
|. |..| |. |
LMWEIFTYGEQP
Kinase IRAK-0_c-1.AA S_TKc 193-464 21 1.3e-34 122.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 193-464
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

FADCNVLGEGGYGIVYKGKLPD-GTPIAVKNLLNNRGQAEKEFRVEVEAIGRVRHKNLVRLLGYCVEGCHRMLVYEYVDN--GNLEQWLHGPISRT--KS
.   ...|.|..| |||..  . |   |.| .        . .| |..   . .|.|.|.|......  |  .| ||.|.  |.| . ..   ..   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLLGAGKSHVTTRVMGTFGYVAPEYANTGLLNE-RSDVYSFGVLLM
..     ...  ...||.|.|.    ...|||.| .|||.|.  .  |.|||||..|        | . ||  |.|||       .  ..|..|.|..| 
FPE-HARFYMYQICCALEYCHSH---GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EVVTGRDPVDYSRPPSEVNLVDWLKLMVGQRRSEEVADPNLEPKPASRALKRALLVALRCVDPDSSKRPKMGHVVH---------ML
| ..|. | .        ..   .|...                      . |.    .| . | .|||    . .          .
EMLCGYPPFP--------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_c-1.AA Dicty4-Unclassified 197-394 31 4.8e-33 110.48 In-house 5-207 (263) Show / Hide 
Range on Protein: 197-394
Range on HMM: 5-207/263
Sequence Identity: 31% (66 aa)

NVLGEGGYGIVYKGKLPDGTPIAVKNLLNNRGQAE----KEFRVEVEAIGRVRHKNLVRLLGYCVEG-CHR---MLVYEYVDNGNLEQWLH-GPISRTKS
  .|.|    |.||    |  .||| .  |. ..     ..|. |||  | . | |||.. |||.    |.   . | |    |||    |  |  . ..
QFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQP

LTWEA--RMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLLGAGKSHVTTRVMGTFGYVAPEYANTGLLNERSDVYSFGVLL
.  .    .|. .  |. ...||      ..||||||||||.|  .|..| |||..           | . ||    .||       | .|||||....|
IKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVIDF--NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMML

MEVVTGRDP
 | .||  |
YELATGDEP
Kinase IRAK-0_c-1.AA LISK-DD1 198-400 28 8.1e-30 105.06 In-house 1-236 (290) Show / Hide 
Range on Protein: 198-400
Range on HMM: 1-236/290
Sequence Identity: 28% (68 aa)

VLGEGGYGIVYKGKLPDGTPIAVKNLLN-----NRGQAEKEFRVEVEAIGR---VRHKNLVRLLGYCVE-------------GCHRMLVYEYVDNGNLEQ
  | |..|.|||| .  |||.|.| . .     |.   .|    |....      ||.|.|. .| |..             .   ..| |... |.| .
EIGKGSFGKVYKGCYF-GTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHW

WLHG-P--------ISRTKSLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDST----YNARISDFGLAKLLGAG-----KSHVTTRVMGT
 |   |        | . . ..|. |.|| |. |.| ||||.    ...||| || |||.|      . ... |||.|. .  .     ..| |    ||
YLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSK---NIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMT--ICGT

FGYVAPEYANTGLLNERSDVYSFGVLLMEVVTGRDPVDYSRP
 . .|||       ....||.|||..| |  |...|. . ..
DNWMAPEVILGMSYDWSCDVFSFGMVLLELITRKKPDKRMWQ
Kinase IRAK-0_c-1.AA MLK 445-464 35 0.004297 6.73 In-house 272-291 (291) Show / Hide 
Range on Protein: 445-464
Range on HMM: 272-291/291
Sequence Identity: 35% (7 aa)

RCVDPDSSKRPKMGHVVHML
.| ..|..|||.. ..|  |
QCWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_c-1.AA LISK 440-464 28 0.19865 0.17 In-house 272-296 (296) Show / Hide 
Range on Protein: 440-464
Range on HMM: 272-296/296
Sequence Identity: 28% (7 aa)

LLVALRCVDPDSSKRPKMGHVVHML
| ....|.. | ..||.  ..|. |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAK-0_c-1.AA TKL-Unique 445-464 35 0.265804 0.57 In-house 271-290 (290) Show / Hide 
Range on Protein: 445-464
Range on HMM: 271-290/290
Sequence Identity: 35% (7 aa)

RCVDPDSSKRPKMGHVVHML
.| ..|.|.||    ..| |
QCWHHDPSQRPSFDEIIHRL
Kinase IRAK-0_c-1.AA Pkinase_Tyr 444-464 23 3.098978 1.42 Pfam 250-270 (270) Show / Hide 
Range on Protein: 444-464
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

LRCVDPDSSKRPKMGHVVHML
..| ..| ..|| .  ....|
KQCWHYDPEDRPTFSEIHEQL