Gene IRAK-0_k (S.moellendorffii)

IRAK-0_k

Species: S.moellendorffii
Alias: IRAK-0_k
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_k.AA Protein None 760 None Fasta, JSON
IRAK-0_k.NA RNA None 2283 None Fasta, JSON
IRAK-0_k.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_k.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TNFR_c6 IRAK-0_k.AA TNFR_c6 335-359 30 1.6e-05 22.29 Pfam 16-41 (41) Show / Hide 
Range on Protein: 335-359
Range on HMM: 16-41/41
Sequence Identity: 30% (8 aa)

CLECSACVG-GDFEISPCGADSDRKC
|| |. | . | ....|| . ....|
CLSCTRCHPMGQYMVQPCTWTQNTVC
Kinase IRAK-0_k.AA TKL 445-707 22 2.7e-66 226.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 445-707
Range on HMM: 1-364/364
Sequence Identity: 22% (87 aa)

LGRGAFGTVYKGVLQN---------GHQVAVKRANSSRCD-----------------------------AMFDKELELLARTHHSCLVNLFGYCKEEN--
.|.|.||.||||....         |  ||||. .|  .|                               . .|. .. |..|  .| . |||....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------VLVFEFMSRGTVHDNIFQSPTSRSGPLEWVSRIRIAAQAARGLEYLHKYAS-----PSIIHRDIKSANILIDFDWN-----------
              .| |....|. ....            |  |.|.| ..|||..|||         | |||||.||.|||.| .|.           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---AHISDFGISLCG-----PQDNATHLS-----------NMTIVGTPGYLDPEY----------------GTSSQLTLKSDVYSFGVVLLELLSGRKPV
   . |.|||.| .       .|..|.             .||..|||... ||                   ... . |.||||||.|| |.|....| 
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

D--LSRQIQ------NLVAWVIDLVGR----DEWSSVLDPRLAVPLQPEPLFRVLKLALECTRLKGKQRPSMTQVAKTL
.   .....         ..|.|   |    ..|....  . . .  |  . .. ||. .|   . ..|||.... |.|
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_k.AA IRAK 439-641 34 7.5e-51 175.25 In-house 1-225 (317) Show / Hide 
Range on Protein: 439-641
Range on HMM: 1-225/317
Sequence Identity: 34% (77 aa)

YSEEMILGRGAFGTVYKGVLQNGH-QVAVK---RANSSRCDAM---FDK---ELELLARTHHSCLVNLFGYCKEENV--LVFEFMSRGTVHDNIFQSPTS
....  .| |.||.||.|...|    .|||     ... .. .   |.    ||....| .|  .| | ||| |.    ||...|. |. .|      ..
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

RS-GPLEWVSRIRIAAQAARGLEYLHKYASP-SIIHRDIKSANILIDFDWNAHISDFGISLCG--PQDNATHLS--NMT--IVGTPGYLDPEYGT--SSQ
 .  ||.|  |. |.  .|.|...||   .  .|||.|||||||| | . .. |.|||   .|   ...  . .  .||  ..||  |. ||. .  . |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTLKSDVYSFGVVLLELLSGRKPVD
|| |.||||||.||||.|.|...|.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_k.AA Pkinase 439-637 29 5.8e-42 149.46 Pfam 1-209 (293) Show / Hide 
Range on Protein: 439-637
Range on HMM: 1-209/293
Sequence Identity: 29% (64 aa)

YSEEMILGRGAFGTVYKGVLQNGHQ-VAVKRANSSRCDAMFDK------ELELLARTHHSCLVNLFGYC--KEENVLVFEFMSRG----TVHDNIFQSPT
|  . ..|.|.||.|||.. ..  . ||||. . .. .  .|.      |.....| .| . | |....  | .  .|.|..  |      .| |     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

SRSGPL--EWVSRIRIAAQAARGLEYLHKYASPSIIHRDIKSANILIDFDWNA----HISDFGISLCGPQDNATHLSNMTIVGTPGYLDPEY-GTSSQLT
.|.|..  ..   .... | .|||||.|.    .|||||.|..||||| . .     .|.|||.. .    .     ..|..|||.|. ||   ...  .
WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

LKSDVYSFGVVLLELLSGR
 |.|..|.|..| |.|.||
PKVDMWSCGCILYEMLCGR
Kinase IRAK-0_k.AA TKL-Unique 444-636 30 6.6e-38 131.29 In-house 4-224 (290) Show / Hide 
Range on Protein: 444-636
Range on HMM: 4-224/290
Sequence Identity: 30% (68 aa)

ILGRGAFGTVYKGVLQNGHQVAVKRANS---SRCD--AMFDKELELLARTH-HSCLVNLFGYCK----EEN--VLVFEFMSRGTVHDNIFQ-SPTS----
 .|.|..|.||||.  .| .||.|. .    |. .    | .|. .. . | |  .| ..|||.     ..   .| |....|. .|.. |  . .    
KIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

RSGPLEWVSRIRIAAQAARGLEYLHKYASPSIIHRDIKSANILIDFD-----WNAHISDFGISLCGPQDNATHLSNM------TIVGTPGYLDPEYGTS-
.. .| .  |...| ..|.|..||| .  | |||||.|| |.|.| .     ||. |.|||.|    ..|.. ...       | .|.. .. ||  .. 
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-SQLTLKSDVYSFGVVLLELLSG
 .| . ||||||||.|| |....
FCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_k.AA Dicty4-Unclassified 442-639 34 3e-36 121.65 In-house 4-207 (263) Show / Hide 
Range on Protein: 442-639
Range on HMM: 4-207/263
Sequence Identity: 34% (74 aa)

EMILGRGAFGTVYKGVLQNGHQVAVKRANSSRCDAM------FDKELELLARTHHSCLVNLFGYCKEE------NVLVFEFMSRGTVHDNIFQSPTSRSG
   .|.|.|  |.||.   |  ||||  |. .  .       | || |.|    |  || . |||          . | ||| .|.    |   |  .  
DQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

PLEWVS--RIRIAAQAARGLEYLHKYASPSIIHRDIKSANILIDFDWNAHISDFGISLCGPQDNATHLSNMTIVG-TPGYLDPEYGTSSQLTLKSDVYSF
|.   .   |..|   |.|. .||   .  .|||||||.|||.| . |. | |||||     |.     ||| .. ||    ||       . ||||||.
PIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRV--IDFNF---NMTTIAGTPKWESPECLMHESYNQKSDVYSY

GVVLLELLSGRKP
...| ||. |  |
AMMLYELATGDEP
Kinase IRAK-0_k.AA Dicty4 439-634 33 3.9e-33 107.97 In-house 1-211 (277) Show / Hide 
Range on Protein: 439-634
Range on HMM: 1-211/277
Sequence Identity: 33% (72 aa)

YSEEMILGRGAFGTVYKGVLQNGHQVAVKRA---NS-SRCDAM--FDKELELLARTHHSCLVNLFGYCK------EENVLVFEFMSRGTVHDNIFQ--SP
.  | ..|.|.||.||||    | .|||| .   |  .. . .  | || ....   |  .. . |.|       .. . | |.|..|...  .    | 
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

TSRSGPLEWVSRIR---IAAQAARGLEYLHKYAS--PSIIHRDIKSANILIDFDWNAHISDFGISLCGPQDNATHLS-NMTIVGTPGYLDPEYGTSSQLT
   | .|.|  ..|   .|  ||||. .||   .  | |||||.||.|.|.| .|.. ..|||.|    .   .|    || .|||..  ||   .   .
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH---CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQY-MKKHEDHKDNQMTACGTPCWMAPEVMMHQPYN

LKSDVYSFGVVLLELL
 |.|||||| || |.|
EKADVYSFGIVLWEIL
Kinase IRAK-0_k.AA S_TKc 439-714 22 1.1e-32 115.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 439-714
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

YSEEMILGRGAFGTVYKGVLQN-GHQVAVKRANSSRCDAMFDKELELLARTHHSCLVNLFGYCK-EENVLVFEFMSR--GTVHDNIFQSPTSRSG-PLEW
|    ..|.||||.|||..  . |..||.|. .      .. .|...| . ||  .|.|....  ..  .|.|...   |...| | . .. . . |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

VSRIRIAAQAARGLEYLHKYASPSIIHRDIKSANILIDFDWNAHISDFGISLCGPQDNATHLSNMTIVGTPGYLDPEYGTSSQLTL-KSDVYSFGVVLLE
    ....| ...|||.|.     |||||.| .|||.|   .  |.|||..             .|..||| |. ||     . .  |.|..|.|..| |
-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLSGRKPVDLSRQIQNLVAWVIDLVGRDEWSSVLDPRLAVPLQPEPLFRVLKLALECTRLKGKQRPSMTQVAK--TLEEVLEAI
.|.|. | .   |.| .   .                            .. .   | .   ..||.  .. .   .    . .
MLCGYPPFP---QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_k.AA MLK 439-639 27 1.5e-32 110.32 In-house 1-235 (291) Show / Hide 
Range on Protein: 439-639
Range on HMM: 1-235/291
Sequence Identity: 27% (65 aa)

YSEEMILGRGAFGTVYKGVLQNGH----QVAVKRAN--------SSRCDAMFDKELELLARTHHSC----LVNLFGYCKEE-N--VLVFEFMSRGTVHDN
  .. ..| |.|| |.||. .|       |||||..        ..  .  |..| ..|..  |       . . | |... .  ..| |... |  .. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IFQSPTSRS---------GPLEWVSRIRIAAQAARGLEYLHKYASPSIIHRDIKSANILIDF------DWNAHISDFGISLCGPQDNATHLSNMTI-VGT
.   ..  .         .     . ...| | |||..|||. | . |||||.|| |||||       . .. |.|||.|      . .. .||.   ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR---DWHQMC-TNMMSNAGT

PGYLDPEY---GTSSQLTLKSDVYSFGVVLLELLSGRKP
. .  ||      ... . |.||.|.|||| |.|... |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_k.AA STE 439-637 21 8.5e-32 109.61 In-house 1-265 (359) Show / Hide 
Range on Protein: 439-637
Range on HMM: 1-265/359
Sequence Identity: 21% (59 aa)

YSEEMILGRGAFGTVYKGVLQN----------------GHQVAVKRANSSRCDA-------------------MFDKELELLARTH--HSCLVNLFGYCK
.    ..|.||||||||..  .                |  .|.|. | ..|..                    . ||.... . .  |   |. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------EENVLVFEFMSRGTVH---DNIFQSPTSRS------GPLEWVSRIRIAAQAARG-LEYLHKYASPSIIHRDIKSANILIDFDWNAHISDFG
         .|  .. |.|. |..    .. .  . . .      ....    ..|. |  .| |.|||.     |||||||.||||.     . ..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

ISLCGPQDNA------------THL-SNMTIVGTPGYLDPEYGTS------SQLTLKSDVYSFGVVLLELLSGR
.. .  ...|            |    . |.|||| .  ||  .       .. . |.|..|.| ...|.. |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_k.AA LRRK 439-641 24 1.8e-31 108.63 In-house 1-284 (351) Show / Hide 
Range on Protein: 439-641
Range on HMM: 1-284/351
Sequence Identity: 24% (72 aa)

YSEEMILGRGAFG-TVYKGVLQN---------------------------GHQVAVKRANS-------SRCD----------------------------
  .|  .|||.|| .||.. ...                           .  ||.|  |        . |.                            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDND-CNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

--AMFDKELELLARTHHSCLVNLFGYCKEENVLVFEFMSRGTVHDNIFQSPTSRSG------PLEWVSRIRIAAQAARGLEYLHKYASPSIIHRDIKSAN
    | .|. .. . .|...|.|.|.| .   .| |... |. .. .. .  ...|       . |  ...|| | |.|.||||. ..|.||||| || |
AFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNK--KQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPN

ILI-DF-----------DWNAHISDFGISLCGPQDNATHLS-NMTIVGTPGYLDPEYGT---SSQLTLKSDVYSFGVVLLELLSGR-KPVD
||.  .           . .|.|.|||||       ..| .  .. ||.||.. ||       .. | |.|.||||..| |||...  | |
ILLWSSPQNHSPNYPNAHVCAKIADFGISR--MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_k.AA TK 439-639 15 2.5e-30 98.28 In-house 1-394 (486) Show / Hide 
Range on Protein: 439-639
Range on HMM: 1-394/486
Sequence Identity: 15% (63 aa)

YSEEMILGRGAFG---TVYKGVLQNG--------------------------HQVAVKRAN---SSRCDAMFD----------------KELELLA--RT
   .  ||.|.||   .|||| ....                          ..||||      ..  ...||                 |....     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHSCLVNLFGYC--------------KEENVLVFEFMSRGT----VHDNIFQSPTSRSG-----------------------------------------
||  .|.|.|.|              .|   .| |.|. |      .|   ...  ..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------PLEWVSRIRIAAQAARGLEYLHKY----ASPSIIHRDIKSANILIDFDWN-----------AHISDFGIS
                              .|    .. ...|.|.|.||||.       . ..|||.   |.|.. . .           . |.||| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LCGPQDNATHLSNMTIVGTPG-------------------------YLDPEYGTSSQ---------LTLKSDVYSFGVVLLELLS-GRKP
      |.   .. .    ..  ||..                         .. ||  .. .          | ||||.||||.. |... |..|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAK-0_k.AA LISK 444-648 26 1.9e-28 89.38 In-house 1-249 (296) Show / Hide 
Range on Protein: 444-648
Range on HMM: 1-249/296
Sequence Identity: 26% (66 aa)

ILGRGAFGTVYKGVLQ-NGHQVAVKRAN-------SSRCDAMFDKELELLARTHHSCLVNLFGYCKE-ENVL--VFEFMSRGTVHDNIFQSPTSRSGPLE
..|.|.|| |||| .   |  .|.|                 ...|.... .  |   |. .| |.. .  |  | |... |..|. .. ..  .. || 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDK-HKIPLP

WVSRIRIAAQAARGLEYLHKYASPSIIHRDIKSANILID-F---DWNAHISDFGISLCGPQDN-------------------------------ATHLSN
|  |..||   |.|..|||   |  ||||| || |.|.. .   .|.. . |||      ..|                               ..  . 
WPQRVKIALDIACGMSYLH---SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRR

MTIVGTPGYLDPEYGTSSQLTLKSDVYSFGVVLLELLSGRKPVD--LSRQIQN
|||.|||    ||  . .. . ..||.|||.||.|.  ..|.    . |. |.
MTICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQH
Kinase IRAK-0_k.AA Pkinase_Tyr 439-584 28 1.9e-17 59.74 Pfam 1-158 (270) Show / Hide 
Range on Protein: 439-584
Range on HMM: 1-158/270
Sequence Identity: 28% (46 aa)

YSEEMILGRGAFGTVYKGVLQ-----NGHQVAVKRA--NSSRCD---AMFDKELELLART-HHSCLVNLFGYCK--EEN---VLVFEFMSRGTVHDNIFQ
 .    ||.||||.||||..      .. .||||    ...  .   ..| .|....    ||  .|.| | |   .|     .|.|.|  |  .|   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

SPTSRSGPLEWVSRIRIAAQAARGLEYLHKYASPSIIHRDIKSANILIDFDWNAHISDFGIS
   .  .||     . ...| |.|.|||.      .||||.   |.|.. .  . |.||| .
HR-EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLA
Kinase IRAK-0_k.AA TyrKc 439-707 24 1.8e-16 43.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 439-707
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

YSEEMILGRGAFGTVYKGVLQNGHQVAVKRANSSRCDAMFDKELELLART--HHSCLVNLFGYCK---------EENVLVFEFMSRGTVHDNI-FQSPTS
 . . .||.||||.||||..    |||||  ...   ..| .|.... .   || ..|.|.|.|          |   .|.|.|. |  .| .    |. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

RSGPLEWVSRIRIAAQAARGLEYLHKYASPSIIHRDIKSANILIDFDWNAHISDFGISLCGPQD-------NATH-----LSN--MTIVGTPGYLDPEYG
    | .   . .. |.|.| ||||.     .||||.   |.|.. .  . ||||| |  .  |          .      ..  . |  ..    ||  
----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA----PECI

TSSQLTLKSDVYSFGVVLLELLS-GRKPVDLS----RQIQNLVAWVIDLVGRDEWSSVLDPRLAVPLQPEPLFRVLKLALECTRLKGKQRPSMTQVAKTL
  .  | ||||.||||.. |... | .|           | ....| .   ..   ... | ..    ..    . .. ..| . . ..||..... . .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_k.AA Pkinase_Tyr 618-639 52 0.000155 15.99 Pfam 192-214 (270) Show / Hide 
Range on Protein: 618-639
Range on HMM: 192-214/270
Sequence Identity: 52% (12 aa)

TLKSDVYSFGVVLLELLS-GRKP
| ||||.||||.. |... |..|
TTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAK-0_k.AA LISK 683-707 32 0.000448 8.91 In-house 272-296 (296) Show / Hide 
Range on Protein: 683-707
Range on HMM: 272-296/296
Sequence Identity: 32% (8 aa)

LKLALECTRLKGKQRPSMTQVAKTL
|.|...|.... | ||| . . ..|
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAK-0_k.AA IRAK 683-707 24 0.000829 9.57 In-house 293-317 (317) Show / Hide 
Range on Protein: 683-707
Range on HMM: 293-317/317
Sequence Identity: 24% (6 aa)

LKLALECTRLKGKQRPSMTQVAKTL
. .|..|.  . . |..|..| ..|
CQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_k.AA Dicty4 695-709 29 0.003521 6.65 In-house 261-277 (277) Show / Hide 
Range on Protein: 695-709
Range on HMM: 261-277/277
Sequence Identity: 29% (5 aa)

KQRPSMTQVAKT--LEE
..|||. .. .   ||.
QHRPSFEEIIQRRILEH
Kinase IRAK-0_k.AA TK 685-707 26 0.006708 4.7 In-house 464-486 (486) Show / Hide 
Range on Protein: 685-707
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

LALECTRLKGKQRPSMTQVAKTL
| ..| ... ..||...|. . |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_k.AA LRRK 688-709 31 0.008876 5.64 In-house 330-351 (351) Show / Hide 
Range on Protein: 688-709
Range on HMM: 330-351/351
Sequence Identity: 31% (7 aa)

ECTRLKGKQRPSMTQVAKTLEE
.|   . |.||...|. |.|..
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-0_k.AA MLK 693-707 33 0.127832 1.55 In-house 277-291 (291) Show / Hide 
Range on Protein: 693-707
Range on HMM: 277-291/291
Sequence Identity: 33% (5 aa)

KGKQRPSMTQVAKTL
. ..|||. |. . |
DPHKRPSFRQIVQHL