Gene IRAK-0_br (S.moellendorffii)

IRAK-0_br

Species: S.moellendorffii
Alias: IRAK-0_br
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_br.AA Protein None 433 None Fasta, JSON
IRAK-0_br.NA RNA None 1302 None Fasta, JSON
IRAK-0_br.kin_dom Protein Kinase Domain None 86 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_br.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF26 IRAK-0_br.AA DUF26 76-132 33 2.3e-12 39.41 Pfam 1-55 (55) Show / Hide 
Range on Protein: 76-132
Range on HMM: 1-55/55
Sequence Identity: 33% (20 aa)

AYARGECYNNLSPQDCVLCLGMANQTI-RGQAPRTIGARLFSNSSDYSCYLRYENYD-F
.|. . |   |||.||  ||  | . . .   |. .|.| .      .|||||..|  |
VYGMAQCRPDLSPSDCRDCLATAVRQMLPQCCPNRQGGRIW----YDWCYLRYSDYPNF
Kinase IRAK-0_br.AA TKL 233-330 18 5.2e-21 72.41 In-house 1-138 (364) Show / Hide 
Range on Protein: 233-330
Range on HMM: 1-138/364
Sequence Identity: 18% (27 aa)

LGRGAFGTVFKGVLKD---------GSEVAVKQLDLHSKQGQ---------------------------REFVNELSIITSIQHKNLAKLRGYCLDRDD-
.|.|.||.|.||...          | .||||..  |. .                              ....|. .. ...| |. .. |||.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RILVYEFLENKS-LDQLLFESATGILLDWPTRFQIA
              .|.|. .. | |..|.          |. |...|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWA
Kinase IRAK-0_br.AA IRAK 227-331 31 8.2e-21 70.61 In-house 1-116 (317) Show / Hide 
Range on Protein: 227-331
Range on HMM: 1-116/317
Sequence Identity: 31% (36 aa)

FSDINKLGRGAFGTVFKGVLKDGS-EVAVK----QLDLHSKQGQREFVN---ELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENKSL-DQLLFESAT
|.  |..| |.||.|..|..|     .|||      |.  ..  ..|     || . ....|.|.  | |||..|..  |||... | || |.|    ..
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

GIL--LDWPTRFQIAW
. .  | |..|. |.|
CPPKPLSWHQRCSICW
Kinase IRAK-0_br.AA Pkinase_Tyr 227-331 27 1e-19 67.42 Pfam 1-118 (270) Show / Hide 
Range on Protein: 227-331
Range on HMM: 1-118/270
Sequence Identity: 27% (32 aa)

FSDINKLGRGAFGTVFKGVLK-----DGSEVAVKQL-DLHSKQG--QREFVNELSIITSI-QHKNLAKLRGYCLDRDDR---ILVYEFLENKSLDQLLFE
 . . |||.||||.|.||..|     .. .|||| | . ....   ...| .|..| ... .|.|. .| | |.|...    ..| |. .. .|.  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S-ATGILLDWPTRFQIAW
    .  |. ..  |..|
HREDKQPLTMKDLLQMCW
Kinase IRAK-0_br.AA TK 227-312 18 1.1e-18 58.53 In-house 1-150 (486) Show / Hide 
Range on Protein: 227-312
Range on HMM: 1-150/486
Sequence Identity: 18% (27 aa)

FSDINKLGRGAFG---TVFKGVLKDGS--------------------------EVAVKQLDLHSKQGQREFVN--------------ELSIITSIQ----
   ..|||.|.||   .|.|| .....                          .||||.| ... . |.||                |....   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLAKLRGYCLDRDD------------RILVYEFLENKS----LDQLL
 |.|. .| |.|.. .              ..| |. .. .    |.. |
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYL
Kinase IRAK-0_br.AA STE 227-312 20 3e-17 57.54 In-house 1-128 (359) Show / Hide 
Range on Protein: 227-312
Range on HMM: 1-128/359
Sequence Identity: 20% (26 aa)

FSDINKLGRGAFGTVFKGVLKD----------------GSEVAVKQLDLHSKQG-----------------QREFVNELSIITSIQ--HKNLAKLRGYCL
. .| |.|.||||||.|.. ..                |  .|.||..| ...                  . .. .|..|    .  |.|  |  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

D-------RDDRILVYEFLENKSLDQLL
.       .|.  .. |.... |||...
KEGHNHKNDDELWICMEYMDGGSLDDII
Kinase IRAK-0_br.AA TKL-Unique 229-312 30 5.7e-17 56.52 In-house 1-91 (290) Show / Hide 
Range on Protein: 229-312
Range on HMM: 1-91/290
Sequence Identity: 30% (28 aa)

DINKLGRGAFGTVFKGVLKDGSEVAVKQLDL---HSKQGQREFVNELSIITSIQ-HKNLAKLRGYCL----DRDDRILVYEFLENKSLDQLL
..||.|.|..|.|.||. . |..||.||. .    |..  .|| ||....  .. |.|. .. |||     .  ....| |...  ||. .|
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVL
Kinase IRAK-0_br.AA Pkinase 227-312 24 4.3e-16 57.98 Pfam 1-95 (293) Show / Hide 
Range on Protein: 227-312
Range on HMM: 1-95/293
Sequence Identity: 24% (23 aa)

FSDINKLGRGAFGTVFKGVLKDGSE-VAVKQLDLHSKQG--QREFVN--ELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENK----SLDQLL
.  . |.|.|.||.|.|.. |. .. ||||.......    ... ..  |..|  ...|.|  .|.... |.|.  .| |..|.     .|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI
Kinase IRAK-0_br.AA Fer 227-309 32 3.1e-15 48.42 In-house 1-97 (283) Show / Hide 
Range on Protein: 227-309
Range on HMM: 1-97/283
Sequence Identity: 32% (32 aa)

FSDINKLGRGAFGTVFKG--VLKDGS---------EVAVKQL--DLHSKQGQREFVNELSIITS-IQHKNLAKLRGYCLDRDDRILVYEFLENKSLD
. ...|||.||||.|.||  .|| .          .|.|| .  .. .|  ..|| .|  |. .  .|.|  |..|.| |.    .| ||  . |||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLD
Kinase IRAK-0_br.AA Jak 227-312 24 2.4e-14 47.0 In-house 1-102 (299) Show / Hide 
Range on Protein: 227-312
Range on HMM: 1-102/299
Sequence Identity: 24% (25 aa)

FSDINKLGRGAFGTVFKGVLKDGS----------E----VAVKQLDLHSKQGQREFVNELSIITSIQHKNLAKLRGYC--LDRDDRILVYEFLENKSLDQ
   .. ||.|.||.|..... .            |    |..| ..  ..| ...|  |.||  ...||.. |..| |    .|. ..| |... ..|| 
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

LL
 |
YL
Kinase IRAK-0_br.AA LRRK 227-330 15 3.4e-13 43.03 In-house 1-170 (351) Show / Hide 
Range on Protein: 227-330
Range on HMM: 1-170/351
Sequence Identity: 15% (27 aa)

FSDINKLGRGAFG-TVFKGVLKD---------------------------GSEVAVKQLDLH----------------------------------SKQG
.   ...|||.|| .|... ...                           ...||.|.....                                  .   
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QREFVNELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENKSLDQLLFESA-TG-----ILLDWPTRFQIA
 ||| .|..|. . .| |. .| |.|.  . ...| |.. . .|...|.... .|     . ..| .. .||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIA
Kinase IRAK-0_br.AA STE20 227-288 25 5.4e-13 44.12 In-house 1-71 (288) Show / Hide 
Range on Protein: 227-288
Range on HMM: 1-71/288
Sequence Identity: 25% (18 aa)

FSDINKLGRGAFGTVFKGVL-KDGSE----VAVKQLDLHSK----QGQREFVNELSIITSIQHKNLAKLRG
. .. |.|.|..|.|.|.   . | .    ||.|...| ..    . ... ..| ||    .|.|  |  |
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYG
Kinase IRAK-0_br.AA ULK 227-312 23 1.5e-12 40.92 In-house 1-108 (324) Show / Hide 
Range on Protein: 227-312
Range on HMM: 1-108/324
Sequence Identity: 23% (25 aa)

FSDINKLGRGAFG-TVFKGV-LKD---GSEVAVKQLD---LHSKQGQRE-------FVNELSIITSIQ---HKN--LAKLRGYCLDRDD--RILVYEFLE
.. ...|| |.|| .|.||   |.   .  ||.|. |   .  |. ..|       . || .|.  .    |.|    ||  .. . ..    ...|. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NKSLDQLL
   |.|..
GGDLEQYI
Kinase IRAK-0_br.AA TyrKc 227-384 13 3.8e-09 -74.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 227-384
Range on HMM: 1-280/280
Sequence Identity: 13% (38 aa)

FSDINKLGRGAFGTVFKGVLKDGSEVAVKQLDLHSKQGQREFVNELSIITSI--QHKNLAKLRGYCLDR-------DDRILVYEFLENKSLDQLLFESAT
 . . |||.||||.|.||..|   .|||| |  ..   ...| .|..| ...  .|.|. .| |.|..        .   .| |. .. .|.. | ..  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

GILLDWPTRFQIAW-------------------------ILHEN---------SSELEIA--------DQRL----DLE---------------------
   | ...  ...|                         . ...         | ...            |     .                       
K--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

----------------------------HNSEEILRVIQVA-------------------------LACTHENSASRPSMGDAVAML
                             . .|... ..                           . | ||. ..||.. . .  .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_br.AA S_TKc 227-388 12 6.9e-07 -75.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 227-388
Range on HMM: 1-231/231
Sequence Identity: 12% (32 aa)

FSDINKLGRGAFGTVFKGVLKD-GSEVAVKQLDLHSKQGQREFVNELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLEN--KSLDQLLFESATG-----
.  ..|.|.||||.|.|.. |. | .||.|...       . . .|..|  . .|.|. || ... | |.  .| |....   .| ... .  ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

----------------------------------------------------------------ILLDWPT-------------RFQIAWILHENSSELE
                                                                .|  . .              .     . .   . .
FPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQM

IADQRLDLEHNSEEILRVIQVALACTHENSASRPSMGDAVA-----MLSGYK
. .. .     |.| .  |.    | . . . ||.  .| .     ..  . 
MFKKIG-----SPEAKDFIR---KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_br.AA TK 361-384 20 0.005629 4.96 In-house 463-486 (486) Show / Hide 
Range on Protein: 361-384
Range on HMM: 463-486/486
Sequence Identity: 20% (5 aa)

QVALACTHENSASRPSMGDAVAML
.. . | |.. . ||.. . . .|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_br.AA IRAK 361-384 29 0.040953 3.49 In-house 294-317 (317) Show / Hide 
Range on Protein: 361-384
Range on HMM: 294-317/317
Sequence Identity: 29% (7 aa)

QVALACTHENSASRPSMGDAVAML
|.|. |.|.  . |..|  ... |
QCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_br.AA TKL 358-384 18 0.061449 2.78 In-house 338-364 (364) Show / Hide 
Range on Protein: 358-384
Range on HMM: 338-364/364
Sequence Identity: 18% (5 aa)

RVIQVALACTHENSASRPSMGDAVAML
.... .  | ...  .|||. . .  |
SMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_br.AA Fer 358-385 20 0.147003 1.21 In-house 255-283 (283) Show / Hide 
Range on Protein: 358-385
Range on HMM: 255-283/283
Sequence Identity: 20% (6 aa)

RVIQVAL-ACTHENSASRPSMGDAVAMLS
...|. .  | ...   ||.| ... .| 
EIMQIMMKQCWQKDPEDRPTMKEICQKLK