kinase.com explores the functions, evolution and diversity of protein kinases, the key controllers of cell behavior. We focus on the kinome, the full complement of protein kinases in any sequenced genome. This includes our extensive KinBase database, and papers and supporting material for our published work from Sugen and the Salk Institute.
New: Jan 2009: We explore the first crystal structure of a pseudokinase, a kinase domain that has lost catalytic activity (these account for almost 10% of all human kinase domains). In collaboration with the Knapp group, we looked at the structures and seqeunce evolution of the VRK3 pseudokinase and its active relative VRK2, to understand what happens when a kinase loses function, and what aspects are still conserved for non-catalytic functions.
KinBase holds information on over 3,000 protein kinase genes found in the genomes of human, and many other sequenced genomes. You may search the database by a variety of different gene names and accessions, or according to the sequence based classification. KinBase can also be searched by Blast.
We have also recently completed a comprehensive analysis of a wide variety of microbial kinases related to the eukaryotic protein kinase family, using genomic and metagenomic sequences.