kinase.com explores the functions, evolution and diversity of protein kinases, the key controllers of cell behavior. We focus on the kinome, the full complement of protein kinases in any sequenced genome. This includes our extensive KinBase database, and papers and supporting material for our published work from Sugen and the Salk Institute.
New: Aug 2010: The sponge kinome provides a remarkable picture of the emergence of massive kinase complexity in early animal development, including the first occurrence of human-style tyrosine kinases and many other key control pathways.
New: June 2010: A detailed kinome search of the mushroom (Coprinopsis cinerea) shows a massive expansion in novel kinase families, and provides a distant fungal comparator for yeast kinases.
New: April 2009: KinBase includes new analysis and visualization tools for protein domains, including novel domains, and the clustering of similar domain models into families.
KinBase holds information on over 3,000 protein kinase genes found in the genomes of human, and many other sequenced genomes. You may search the database by a variety of different gene names and accessions, or according to the sequence based classification. KinBase can also be searched by Blast.
We have also recently completed a comprehensive analysis of a wide variety of microbial kinases related to the eukaryotic protein kinase family, using genomic and metagenomic sequences.