kinase.com explores the functions, evolution and diversity of protein kinases, the key controllers of cell behavior. We focus on the kinome, the full complement of protein kinases in any sequenced genome. This includes our extensive KinBase database, and papers and supporting material for our published work from Sugen and the Salk Institute.
New: Apr 2008: KinBase updates include improved display of protein domains, links to external databases, and sorting of tabular output. Several moderate edits to the kinase classification scheme have also been made.
New: Dec 2007: The Tetrahymena kinome has been updated, based on an unpubished analysis of both Tetrahymena and the related Paramecium kinomes.
For other recent updates, see our What's New page.
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KinBase holds information on over 3,000 protein kinase genes found in the genomes of human, and many other sequenced genomes. You may search the database by a variety of different gene names and accessions, or according to the sequence based classification. KinBase can also be searched by Blast.
We have also recently completed a comprehensive analysis of a wide variety of microbial kinases related to the eukaryotic protein kinase family, using genomic and metagenomic sequences.