SD2b2_k

Species: S.moellendorffii
Alias: SD2b2_k
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: SD2b2

Sequence

Name Sequence Type Origin Length Description Download
SD2b2_k.AA Protein None 200 None Fasta, JSON
SD2b2_k.NA RNA None 597 None Fasta, JSON
SD2b2_k.kin_dom Protein Kinase Domain None 42 None Fasta, JSON

Protein domain

Protein domains of SD2b2_k.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SD2b2_k.AA MLK 99-140 34 2.2e-07 21.82 In-house 177-226 (291) Show / Hide
Range on Protein: 99-140
Range on HMM: 177-226/291
Sequence Identity: 34% (17 aa)

FGLSK-L*QV---VTVMRGTPGYMAPEWL----HTKVTDKTDAYSFGIVL
||.|. . |     . ..||. .|||| .    ..|.. | | .|.|.||
FGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVL

Kinase SD2b2_k.AA IRAK 110-141 54 2.9e-07 21.98 In-house 181-215 (317) Show / Hide
Range on Protein: 110-141
Range on HMM: 181-215/317
Sequence Identity: 54% (19 aa)

VMRGTPGYMAPEWLH---TKVTDKTDAYSFGIVLL
. |||  ||.|| .     . | ||| ||||||||
HVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLL

Kinase SD2b2_k.AA IRAK 21-49 48 1e-06 19.81 In-house 62-90 (317) Show / Hide
Range on Protein: 21-49
Range on HMM: 62-90/317
Sequence Identity: 48% (14 aa)

HFNLVKLRGFCIQGPAALLVYEFMLNGSL
| |.| | |.|....   |||..| ||||
HPNIVPLYGYCTERQCHCLVYPYMPNGSL

Kinase SD2b2_k.AA TAK1 106-140 27 2e-06 17.43 In-house 158-215 (284) Show / Hide
Range on Protein: 106-140
Range on HMM: 158-215/284
Sequence Identity: 27% (16 aa)

QVVTVMRGTPGYMAPEW-----------------------LHTKVTDKTDAYSFGIVL
|  | .|||. .||||                         . | . | | ||.||..
QMMTCNRGTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRCEKYNMKCDIYSWGIIM

Kinase SD2b2_k.AA LRRK 99-140 37 3e-06 18.37 In-house 222-272 (351) Show / Hide
Range on Protein: 99-140
Range on HMM: 222-272/351
Sequence Identity: 37% (19 aa)

FGLSK----L*Q-VVTVMRGTPGYMAPEWLH----TKVTDKTDAYSFGIVL
||.|     .   |.  . |.||.|||| .        |.|.| ||||..|
FGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL

Kinase SD2b2_k.AA C8 113-140 32 3e-06 17.89 In-house 193-226 (226) Show / Hide
Range on Protein: 113-140
Range on HMM: 193-226/226
Sequence Identity: 32% (11 aa)

GTPGYMAPEWLHT------KVTDKTDAYSFGIVL
|| .|.||| .        . . . | .| |.||
GTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase SD2b2_k.AA TKL-ciliate1 113-140 32 4e-06 17.08 In-house 176-209 (279) Show / Hide
Range on Protein: 113-140
Range on HMM: 176-209/279
Sequence Identity: 32% (11 aa)

GTPGYMAPEWL------HTKVTDKTDAYSFGIVL
.|...|||| .         .. | | |..|||.
TTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVM

Kinase SD2b2_k.AA MOS 110-140 50 7e-06 15.24 In-house 197-228 (299) Show / Hide
Range on Protein: 110-140
Range on HMM: 197-228/299
Sequence Identity: 50% (16 aa)

VMRGTPGYMAPEWLHT-KVTDKTDAYSFGIVL
.. || .||||| |    .| | | ||||| .
YLKGTCTYMAPELLCGDTPTPKADIYSFGITM

Kinase SD2b2_k.AA TKL 99-140 25 8e-06 16.96 In-house 198-279 (364) Show / Hide
Range on Protein: 99-140
Range on HMM: 198-279/364
Sequence Identity: 25% (21 aa)

FGLSKL*Q-----------------------VVTVMRGTPGYMAPEWL-----------------HTKVTDKTDAYSFGIVL
||||.  .                            .|||..|||| |                 . . . |.| |||||||
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL

Kinase SD2b2_k.AA CAMK 99-140 18 8e-06 13.99 In-house 240-324 (425) Show / Hide
Range on Protein: 99-140
Range on HMM: 240-324/425
Sequence Identity: 18% (16 aa)

FGLSKL*QV---------------------------VTVMRGTPGYMA-PEWL---------------HTKVTDKTDAYSFGIVL
||...  .                             . . |||.||| ||.|               .. .. |.|  | |..|
FGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL

Kinase SD2b2_k.AA Pkinase 99-140 37 3e-05 19.64 Pfam 156-202 (293) Show / Hide
Range on Protein: 99-140
Range on HMM: 156-202/293
Sequence Identity: 37% (18 aa)

FGLSKL----*QVVTVMRGTPGYMAPEW-L-HTKVTDKTDAYSFGIVL
|||.|.     .  |.  |||.|||||. . ... . | | .|.|..|
FGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

TyrKc SD2b2_k.AA TyrKc 3-185 14 0.000153 -149.18 SMART 1-280 (280) Show / Hide
Range on Protein: 3-185
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

VE--------------------------IQGSSKGHSQFKAE------V--MHFNLVKLRGFCIQG-------PAALLVYEFMLNGSLDKLRLDIQVIPA
..                          .. ..  .  |  |      .   | |.|.| | |.|.       .  ..| |.| .|.|..   . .    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

ILR*VCESSSNIYRSRFADPPPLLSSFSV----------------------KIHLDENY------FGLSKL*QVV-------TVMR-----GTPG-----
                   ... | ||..                       . ..||.      ||||.             . |     |. .     
------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YMAPEWL-HTKVTDKTDAYSFGIVL---------LDPS-----APSSSILNHP----LPPHPPH---------PRFLGETALSMFHS-----GNVVELID
 |||| . . | | |.| .|||...           |       . . ....      .| ||.         |  . .  ..  |       .  |...
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

DL
..
CF

Kinase SD2b2_k.AA Pkinase_Tyr 23-51 37 0.000392 14.62 Pfam 65-96 (270) Show / Hide
Range on Protein: 23-51
Range on HMM: 65-96/270
Sequence Identity: 37% (12 aa)

NLVKLRGFCI-QGPA--ALLVYEFMLNGSLDK
|.|.| | |. ||     ..| |.| .|.|..
NIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

Kinase SD2b2_k.AA TKL-Unique 113-140 48 0.000476 10.38 In-house 188-218 (290) Show / Hide
Range on Protein: 113-140
Range on HMM: 188-218/290
Sequence Identity: 48% (15 aa)

GTPGYMAPEWLHT---KVTDKTDAYSFGIVL
|.. .|||| |     . . | | |||||||
GSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL

Kinase SD2b2_k.AA TKL 14-52 23 0.002793 7.68 In-house 71-129 (364) Show / Hide
Range on Protein: 14-52
Range on HMM: 71-129/364
Sequence Identity: 23% (14 aa)

QFKAEVM------HFNLVKLRGFCIQGPA-------------ALLVYEFMLNGS-LDKL
... |.|      | |.|.. |.|...|                .|.|.. .|| |. |
FEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYL

Kinase SD2b2_k.AA TKL-Unique 21-52 30 0.004404 6.93 In-house 55-90 (290) Show / Hide
Range on Protein: 21-52
Range on HMM: 55-90/290
Sequence Identity: 30% (11 aa)

HFNLVKLRGFCI----QGPAALLVYEFMLNGSLDKL
| |.|.. |.|.    . |   .| |..  |||...
HPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDV

Kinase SD2b2_k.AA MLK 21-49 32 0.039842 3.33 In-house 64-97 (291) Show / Hide
Range on Protein: 21-49
Range on HMM: 64-97/291
Sequence Identity: 32% (11 aa)

HFN----LVKLRGFCIQGPA-ALLVYEFMLNGSL
| |     ....| |.| |   ..| |.. .|||
HPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSL

Kinase SD2b2_k.AA Pkinase_Tyr 118-140 45 5.374567 0.61 Pfam 181-204 (270) Show / Hide
Range on Protein: 118-140
Range on HMM: 181-204/270
Sequence Identity: 45% (11 aa)

MAPE-WLHTKVTDKTDAYSFGIVL
|||| . . | | |.| .|||...
MAPECINYGKFTTKSDVWSFGVLM

Kinase SD2b2_k.AA Pkinase 17-68 12 5.955237 0.91 Pfam 55-119 (293) Show / Hide
Range on Protein: 17-68
Range on HMM: 55-119/293
Sequence Identity: 12% (8 aa)

AEVMHFNLVKLRGFCIQGPAALLVYEFMLNG----SLD-------KLRL--DIQVIPAILR*VCE
... | | |.|....  ..   .| |.. .|    .|        . ..  . ...  ... ...
KRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILR