Gene MLK-Un_ac (S.moellendorffii)

MLK-Un_ac

Species: S.moellendorffii
Alias: MLK-Un_ac
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_ac.AA Protein None 372 None Fasta, JSON
MLK-Un_ac.NA RNA None 1119 None Fasta, JSON
MLK-Un_ac.kin_dom Protein Kinase Domain None 128 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_ac.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-Un_ac.AA TKL 126-287 17 6.2e-19 64.82 In-house 1-244 (364) Show / Hide 
Range on Protein: 126-287
Range on HMM: 1-244/364
Sequence Identity: 17% (45 aa)

LGSGGQGSVYLGQWQRHG---------KVAVKCFRSPS-----------------------------LWRTEVKALALLQSRTSAHILHPYG-VLDGSI-
.|||| | || |.|. .|          |||| |.| .                             .  .|.. . .. ..   .|.. .| .....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VFPVMECH-----LQKLIDDVPTIPEPERLKWSYRFLSILVQAAKGVATMHSHG--------IPHRDLKPDNILILDAV---------
             . ||| .     |  |.             |. .....  ..|.|.. .||..        | |||||..|||. .           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WH-QRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYN

--GICLAKVADMGHAKIGFHSGP--------------------NSGGTSHLFYTPPEL
   .. .|..|.| ..  ..||                     ..    .. . .||.
PNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV
Kinase MLK-Un_ac.AA CMGC 120-247 17 6.3e-14 41.23 In-house 1-217 (513) Show / Hide 
Range on Protein: 120-247
Range on HMM: 1-217/513
Sequence Identity: 17% (38 aa)

IVLQRQLGSGGQGSVYLGQWQRHG---------------KVAVKCFRSP-SLWR---------------TEVKALALL--------------QSRTSAHI
    ...|.|  | || .. .| .               .||.| ...|   .                 |.| |  |              ...   .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

LHPYGVLDGS---------------------IVFPVMECHLQKLIDDVP---------TIPEPE--------RLKWSYRFLSIL------VQAAKGVA--
.. | ..  .                     .||  |.. | ..|.. .           .| .        ..   .   ...       |  .|..  
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPP---HNIKYFMIHIRYMYQILRGLKLK

TMHSHG--IPHRDLKPDNILI
 .|||.  | |||||| ||||
YCHSHWGNIIHRDLKPENILI
Kinase MLK-Un_ac.AA S_TKc 120-363 20 7.1e-14 26.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 120-363
Range on HMM: 1-231/231
Sequence Identity: 20% (54 aa)

IVLQRQLGSGGQGSVYLGQWQR-HGKVAVKCFRSPSLWRTEVKALALLQSRTSAHILHPYGVLD---GSIVFPVMEC---HLQKLIDDVPT------IPE
  . |..|.|. |.||.... . . .||.|. .     | |.. |         .| . |.| .     .|.  ..     | ..|.. ..      .||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK----HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

PERLKWSYRFLSILVQAAKGVATMHSHGIPHRDLKPDNILILDAVGICLAKVADMGHAKIGFHSGPNSGGTSHLFYTPPELRQPKGGATGMKPWYSKQSF
 .  .       .. | ..... .||||| ||||||.|||. .       |..| | |..       .     ..| .||.             |.| . 
-HARF-------YMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL-----------GYGKCKC

DCYALGAVVKSCIN--------TGIFECHPRATDHLKSIVEDCCQAAPGGRPSAKDVVA-----RLTEVL
| ...| ..  ..           .|.     .. .|.... |.|  |  ||.| .. .     .. . .
DWWSCGCILYEMLCGYPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK-Un_ac.AA CDK 184-247 32 1.4e-11 33.17 In-house 94-141 (284) Show / Hide 
Range on Protein: 184-247
Range on HMM: 94-141/284
Sequence Identity: 32% (21 aa)

SIVFPVMECHLQKLIDDVPTIPEPERLKWSYRFLSILVQAAKGVATMHSHGIPHRDLKPDNILI
..||. |.  | |..|                  ... |  .|.. .||..| |||||| ||||
YMVFEYMDHDLKKYMD----------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILI
Kinase MLK-Un_ac.AA Ciliate-B1 217-247 58 3.9e-11 35.36 In-house 121-151 (290) Show / Hide 
Range on Protein: 217-247
Range on HMM: 121-151/290
Sequence Identity: 58% (18 aa)

LSILVQAAKGVATMHSHGIPHRDLKPDNILI
|....| |||.   |.|.| ||||||.||||
LDFCIQIAKGIQYLHKHKICHRDLKPENILI
Kinase MLK-Un_ac.AA STE 219-286 27 3.9e-11 35.69 In-house 156-232 (359) Show / Hide 
Range on Protein: 219-286
Range on HMM: 156-232/359
Sequence Identity: 27% (24 aa)

ILVQAAKG-VATMHSHGIPHRDLKPDNILILDAVGICLAKVADMGHAKIGFHSGP-------------------NSGGTSHLFYTPPE
|..|  ||  .  |||.| |||.||.|||.        .| .| |....  .|..                      ||    .  ||
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP---WMAPE
Kinase MLK-Un_ac.AA TyrKc 120-359 19 1e-10 -49.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 120-359
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

IVLQRQLGSGGQGSVYLGQWQRHGKVAVKCFRSPS--LWRTEVKALALL--QSRTSAHILHPYGVLDGS-----------IVFPVMEC-----HLQKLID
|.| ..||.|  | ||.|.|    .||||. .. .    . | . .  |  .     .|.  |||   .           ||.  |.      .|.|  .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHP---NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

DVPTIPEPERLKWSYRFLSILVQAAKGVATMHSHGIPHRDLKPDNILILDAVGICLAKVADMGHAKIGFHS----------GPNS--GGT--SHLFYTPP
.         |...  .||. .|.|.| .  ||... ||||   |.|. .      .|..| | .. . .            . .  ||     .  ..|
K---------LCMK-DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

ELRQPKGG-------------------ATGMKPWYS--KQSFDCYALGAVVKSCINTGIFECHPRA---------TDHLKSIVEDCCQAAPGGRPSAKDV
|    . |                     |..|..   .|        . |  .. .|     |           .| . .| ..|... |  ||. ...
ECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

VARL
. ..
HECF
Kinase MLK-Un_ac.AA Ciliate-E2 217-266 25 8.1e-10 29.87 In-house 148-205 (365) Show / Hide 
Range on Protein: 217-266
Range on HMM: 148-205/365
Sequence Identity: 25% (17 aa)

LSILVQAAK---------------GVATMHSHG-IPHRDLKPDNILILDAVGICLAKVADMGHAKI
. |  | ..               ..  .|| . | |||.||.|||.         |..|.| .|.
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKK
Kinase MLK-Un_ac.AA Pkinase 224-287 36 9.9e-09 31.96 Pfam 118-182 (293) Show / Hide 
Range on Protein: 224-287
Range on HMM: 118-182/293
Sequence Identity: 36% (25 aa)

AKGVATMHSHGIPHRDLKPDNILILDAVGI--CLAKVADMGHAKI--GFHSGPNSGGTSHLFYTPPEL
..|.. .||.|| ||||||.|||| .   |  |. |..| | ||     ... ... .  ..| .||.
LRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV-KICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV
Kinase MLK-Un_ac.AA LRRK 221-247 55 3.1e-08 25.24 In-house 171-199 (351) Show / Hide 
Range on Protein: 221-247
Range on HMM: 171-199/351
Sequence Identity: 55% (16 aa)

VQAAKGVATMHSHG--IPHRDLKPDNILI
.| |||.. .|||   | |||||..|||.
LQIAKGMEYLHSHNPPIIHRDLKSPNILL
Kinase MLK-Un_ac.AA RAF 120-148 48 1.1e-07 20.66 In-house 1-27 (282) Show / Hide 
Range on Protein: 120-148
Range on HMM: 1-27/282
Sequence Identity: 48% (14 aa)

IVLQRQLGSGGQGSVYLGQWQRHGKVAVK
. .. . |||  |.|| |.|  ||.||||
VMVMTRIGSGSFGTVYRGHW--HGDVAVK
Kinase MLK-Un_ac.AA IKK 216-265 34 3.5e-07 20.86 In-house 115-166 (297) Show / Hide 
Range on Protein: 216-265
Range on HMM: 115-166/297
Sequence Identity: 34% (18 aa)

FLSILVQAAKGVATMH-SHGIPHRDLKPDNILIL-DAVGICLAKVADMGHAK
||... . ..|   .|   || |||.||.|| .. .  |    | .| | |.
FLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAR
Kinase MLK-Un_ac.AA MLK 221-251 44 5.5e-07 20.42 In-house 131-163 (291) Show / Hide 
Range on Protein: 221-251
Range on HMM: 131-163/291
Sequence Identity: 44% (15 aa)

VQAAKGVATMHSHG---IPHRDLKPDNILILDAV
.| |.|..  ||.    |.|||||. ||||.. .
LQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-I
Kinase MLK-Un_ac.AA Pkinase 120-151 39 3e-06 23.0 Pfam 1-33 (293) Show / Hide 
Range on Protein: 120-151
Range on HMM: 1-33/293
Sequence Identity: 39% (13 aa)

IVLQRQLGSGGQGSVYLGQWQRHGK-VAVKCFR
... |..|||. |.||.....  || ||||...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK
Kinase MLK-Un_ac.AA MLK 120-167 26 3e-06 17.9 In-house 1-63 (291) Show / Hide 
Range on Protein: 120-167
Range on HMM: 1-63/291
Sequence Identity: 26% (17 aa)

IVLQRQLGSGGQGSVYLGQWQRHG----KVAVKCFR----SPSL-------WRTEVKALALLQ
| ... .|||..|.|..|.|.        |||| .|    . |         ..|.. |. |.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILS
Kinase MLK-Un_ac.AA IKK 120-157 35 3e-06 17.42 In-house 1-39 (297) Show / Hide 
Range on Protein: 120-157
Range on HMM: 1-39/297
Sequence Identity: 35% (14 aa)

IVLQRQLGSGGQGSVYLGQWQRHG-KVAVKCFRSPSLWR
. ... ||.|. |.||... .  | ||||| ... |. |
WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMR
Kinase MLK-Un_ac.AA TKL 333-359 33 3.7e-05 14.52 In-house 338-364 (364) Show / Hide 
Range on Protein: 333-359
Range on HMM: 338-364/364
Sequence Identity: 33% (9 aa)

HLKSIVEDCCQAAPGGRPSAKDVVARL
..|.. .||... |  |||..... ||
SMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-Un_ac.AA Pkinase_Tyr 120-149 37 3.9e-05 18.02 Pfam 1-35 (270) Show / Hide 
Range on Protein: 120-149
Range on HMM: 1-35/270
Sequence Identity: 37% (13 aa)

IVLQRQLGSGGQGSVYLGQWQ-----RHGKVAVKC
|.. ..||.|  |.||.| |       . .||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKM
Kinase MLK-Un_ac.AA LRRK 120-148 19 0.00013 12.22 In-house 1-57 (351) Show / Hide 
Range on Protein: 120-148
Range on HMM: 1-57/351
Sequence Identity: 19% (11 aa)

IVLQRQLGSGGQG-SVYLGQWQR---------------------------HGKVAVK
.. ..|.|.|| | .|| . |..                             .||.|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIK
Kinase MLK-Un_ac.AA Ciliate-E2 120-138 31 0.000363 10.18 In-house 1-19 (365) Show / Hide 
Range on Protein: 120-138
Range on HMM: 1-19/365
Sequence Identity: 31% (6 aa)

IVLQRQLGSGGQGSVYLGQ
. .....|.|..||||...
YKFIKKIGQGNFGSVYKCK
Kinase MLK-Un_ac.AA RAF 219-266 31 0.000895 7.78 In-house 108-152 (282) Show / Hide 
Range on Protein: 219-266
Range on HMM: 108-152/282
Sequence Identity: 31% (15 aa)

ILVQAAKGVATMHSHGIPHRDLKPDNILILDAVGICLAKVADMGHAKI
|. | ..|   .|.  | |||||  ||.  . . .   |. | | ...
ISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTV---KIGDFGLMTV
Kinase MLK-Un_ac.AA RAF 334-361 25 0.001876 6.72 In-house 255-282 (282) Show / Hide 
Range on Protein: 334-361
Range on HMM: 255-282/282
Sequence Identity: 25% (7 aa)

LKSIVEDCCQAAPGGRPSAKDVVARLTE
..  .||| .  .  ||. . ...|.| 
MHRLMEDCWKFQREERPLFQQILKRITV
Kinase MLK-Un_ac.AA Ciliate-B1 120-148 30 0.003777 7.01 In-house 1-33 (290) Show / Hide 
Range on Protein: 120-148
Range on HMM: 1-33/290
Sequence Identity: 30% (10 aa)

IVLQRQLGSGGQGSVYLGQ----WQRHGKVAVK
.......|.|. . |..||     |    ||||
YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVK
Kinase MLK-Un_ac.AA LRRK 339-361 34 0.004554 6.68 In-house 329-351 (351) Show / Hide 
Range on Protein: 339-361
Range on HMM: 329-351/351
Sequence Identity: 34% (8 aa)

EDCCQAAPGGRPSAKDVVARLTE
..| |. |  ||.. ..| || .
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-Un_ac.AA MLK 332-359 32 0.008437 5.7 In-house 264-291 (291) Show / Hide 
Range on Protein: 332-359
Range on HMM: 264-291/291
Sequence Identity: 32% (9 aa)

DHLKSIVEDCCQAAPGGRPSAKDVVARL
.|.|.  ..| .. |. ||| . .|  |
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-Un_ac.AA STE 120-148 15 0.028776 3.96 In-house 1-45 (359) Show / Hide 
Range on Protein: 120-148
Range on HMM: 1-45/359
Sequence Identity: 15% (7 aa)

IVLQRQLGSGGQGSVYLGQWQRHG----------------KVAVK
  .....|.|. |.||..     .                 .|.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIK
Kinase MLK-Un_ac.AA Pkinase_Tyr 325-359 20 0.153529 5.84 Pfam 236-270 (270) Show / Hide 
Range on Protein: 325-359
Range on HMM: 236-270/270
Sequence Identity: 20% (7 aa)

ECHPRATDHLKSIVEDCCQAAPGGRPSAKDVVARL
.| . ..| . ..  .| .. |  ||. .... .|
PCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-Un_ac.AA Pkinase_Tyr 215-240 38 5.021382 0.71 Pfam 112-137 (270) Show / Hide 
Range on Protein: 215-240
Range on HMM: 112-137/270
Sequence Identity: 38% (10 aa)

RFLSILVQAAKGVATMHSHGIPHRDL
. |.. .| ||| .  .|... ||||
DLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MLK-Un_ac.AA Pkinase 328-359 17 6.827715 0.7 Pfam 260-293 (293) Show / Hide 
Range on Protein: 328-359
Range on HMM: 260-293/293
Sequence Identity: 17% (6 aa)

PRATDHLKSIVEDCCQAAPGGRPSAKDVVAR--L
..... .|.....|..  |  ||.|....    .
HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF