Gene 81529.m00535 (T.vaginalis)
81529.m00535
Species: T.vaginalis
Alias: TvagK0984, 81529.m00535
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 81529.m00535.AA | Protein | None | 276 | None | Fasta, JSON |
| 81529.m00535.kin_dom | Protein Kinase Domain | None | 175 | None | Fasta, JSON |
Protein domains of 81529.m00535.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | 81529.m00535.AA | S_TKc | 16-268 | 24 | 3.3e-40 | 140.8 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 16-268 Range on HMM: 1-231/231 Sequence Identity: 24% (65 aa) FKVTSLCESTQNSSTFFGYNTSDEQQVVLKVYKNNPRKYLREIAYLEKFNSNFILKPIQTFDIVNNLKCSVFPRAQE--KDLLDFLDKTPE----FPIPE ... . . .. . ...... ..| .|. | .. .|||. |.| . .| | . .|. . . |. . ||.|...| . ||.|| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE KKVRNIAYVLFKSVEYLNQNGVMHRDYKPENVVIMNSNLNVDDIKVIDLGMACEINDRLHQERVGSCYYAAPEVYDGAYSK-ECDIFSIGVTLCVACGGT .| ..| ... .||. ..|..||| ||||. . . ||..| |.|... .|. .| |||| |.| .||. |.|..| . | -HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGY VPFDCDSNKAMQASKKKRDYKLEGKIWNHFSNELKELIYKCLEPDPKKRITIDQIFS--------EYS ||. . .. .. . | |.|..| |||. ||.||.|. ... .. PPFP-QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 81529.m00535.AA | CAMK | 94-263 | 21 | 3.4e-38 | 120.18 | In-house | 150-419 (425) | Show / Hide |
Range on Protein: 94-263
Range on HMM: 150-419/425
Sequence Identity: 21% (57 aa)
DLLDFLDKTPE-------------FPIPEKKVRNIAYVLFKSVEYLNQNGVMHRDYKPENVVIMNSN-------------LNVDDIKVIDLGMACEIN--
||.|.. . . . ..|. .| . . |.|. .....||| ||||. . ..| .|. .||.|| |.|....
DLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPG
-----------------------DRLHQERVGSCYYAA-PEVYDGA---------------YSKECDIFSIGVTLCVACGGTVPFDCD------------
. . ....|. .|.| ||| | |...||. |.|| | . |. ||. |
ENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIG
-SNKAMQASKKKRDYKLEGKI------------WNHFSNE--------LKELIYKCLEPDPKKRITIDQI
. . . .| .| . . |.. |.| | || |.|..||.||.||.|.
MNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQC
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| Pkinase | 81529.m00535.AA | Pkinase | 33-264 | 23 | 3.2e-37 | 132.67 | Pfam | 18-288 (293) | Show / Hide |
Range on Protein: 33-264 Range on HMM: 18-288/293 Sequence Identity: 23% (64 aa) GYNTSDEQQVVLKVYKNNPRKYLR--------EIAYLEKFNSNFILKPIQTF-DIVNNLKCSVFPRAQEK----DLLDFLDKTPEFPI--PEKKVRNIAY ... .....|..|. | .| ||... ..|. .|.. . .| | .. . |.. .. || |.. . .. .|. .....| CHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY VLFKSVEYLNQNGVMHRDYKPENVVIMNSNLNV-DDIKVIDLGMAC---EINDRLHQERVGSCYYAAPEV--YDGAYSKECDIFSIGVTLCVACGGTVPF ... .||. ..|..||| ||||. | .| .. ...|..| | |. . |.. . ..|. .|.|||| . |....|..|.|..| . | || QILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF D-C----DSNKAMQASKKKRDYKLEGKIWNHFS-------------------NELKELIYKCLEPDPKKRITIDQIF . . . . || ..... .|. ... | |.|..|..||..|||||.|..||. PGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL |
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| Kinase | 81529.m00535.AA | Ciliate-E2 | 40-269 | 20 | 3.7e-34 | 114.65 | In-house | 48-365 (365) | Show / Hide |
Range on Protein: 40-269
Range on HMM: 48-365/365
Sequence Identity: 20% (69 aa)
QQVVLKVYKNNPRKYL-REIAYLEKFN----------------SNFILKPIQTFD-IVNNLKCSVFPRAQEKDLLDFLDKTPEF---------PIPEKKV
... .|..|.| ... .|| . . | ...|.| . .| . .| |. .| .||.|.. . . . .. ||..
KIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI
RNIAYVLFK---------------SVEYLNQNG-VMHRDYKPENVVIMNSNLNVDDIKVIDLGMACEINDR-----------------------------
..| . ... .||| ... ..||| ||||... ||.||.|.. ...|
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQI
----LHQERVGSCYYAAPEVYDGA----------YSKECDIFSIGVTLCVACGGTVPFDCDSNKAMQASKKKRDYKLEGK--------------IWNHFS
... .|. .| |||.. | |...|||.|.||.| . | || | .|. .... . .|.. |
IQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWS
NELKELIYK----CLEPDPKKRIT-IDQIFSEYSS
.| | || | .|. ||.|||| ..||.
QECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 81529.m00535.AA | CDPK | 108-263 | 35 | 1.8e-33 | 100.15 | In-house | 101-265 (271) | Show / Hide |
Range on Protein: 108-263 Range on HMM: 101-265/271 Sequence Identity: 35% (59 aa) PEKKVRNIAYVLFKSVEYLNQNGVMHRDYKPENVVIMNSNLNVD----DIKVIDLGMACEIND------RLHQERVGSCYYAAPEVYDGAYSKECDIFSI .||. ..| . .. | | .|...||| |||| . .|. . . .||||| | ... . . .|.| || ||||... | ..||| |. TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPEN-ILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSC GVTLCVACGGTVPFDCDSNKAMQASKKKRDYKLEGKIWNHFSNELKELIYKCLEPDPKKRITIDQI || | . |. || .. . ... || |..||. |.| |.| | || |.|..|||||.. .|. GVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQA |
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| Kinase | 81529.m00535.AA | Ciliate-E2a | 93-263 | 30 | 2.1e-31 | 89.71 | In-house | 84-269 (275) | Show / Hide |
Range on Protein: 93-263 Range on HMM: 84-269/275 Sequence Identity: 30% (57 aa) KDLLDFLDKTPEFPIPEKKVRNIAYVLF-KSVEYLNQNGVMHRDYKPENVVIM-NSNLNV--DDIKVIDLGMACEI----NDRLHQERVGSCYYAA---- ..|.| . . | ..... | |. . ..|. |...|||| ||||. . .| . |||.|| |.| | .....| ..|. .| | GELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQ-KCGTPGYVAPEVL --PEVYDGA-YSKECDIFSIGVTLCVACGGTVPFDCDSNKAMQASKKKRDYKLEGKI-WNHFSNELKELIYKCLEPDPKKRITIDQI .|| . |.. ||..|.|| . . |. ||. . . . || . ..... |. .|.| | |. | ||.|||||||. |. NNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQA |
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| Kinase | 81529.m00535.AA | CAMKL | 94-263 | 30 | 1.4e-29 | 91.47 | In-house | 109-291 (297) | Show / Hide |
Range on Protein: 94-263 Range on HMM: 109-291/297 Sequence Identity: 30% (57 aa) DLLDFLDKTPE--FPIPEKKVRNIAYVLFKSVEYLNQNGVMHRDYKPENVVIMNSNLNVDDIKVIDLGMACEIN------DRLHQERVGSCYYAAPEVYD ||.|...| .. ..||. | . . |.|. ..|. ||| ||||. . ... | ||.|| |.. .. ... .. || |.|||.. DLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQ G--A-YS-KECDIFSIGVTLCVACGGTVPFDCDSNK----AMQASKKKRDYKLEGK--IWNHFSNELKELIYKCLEPDPKKRITIDQI | | .. || |.||.| . |..|||.|... . ..... .. .. ||.| | ... || | |...|.||.||.|| GNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI |
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| Kinase | 81529.m00535.AA | ULK | 94-265 | 20 | 6e-29 | 98.23 | In-house | 106-325 (329) | Show / Hide |
Range on Protein: 94-265 Range on HMM: 106-325/329 Sequence Identity: 20% (45 aa) DLLDFLDKTPEFP--------IPEKKVRNIAYVLFKSVEYLNQNGVMHRDYKPENVVIMN-SNLNVDD--------IKVIDLGMACEINDR-----LHQE || ... | ..| ..|...... . . .|......||| ||.|. | | . |. .|. | | | ... . . DLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMT RV------GSCYYAAPEVYDGA-----YS-KECDIFSIGVTLCVACGGTVPFDCDSNKAMQASKKKRDYKL---------EGKIW-------NHFSNELK | |. .| ||.. | |. ..|||.|.|. . | .|| . . . .... ... .. ...|.|.| CVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECK ELIYKCLEPDPKKRITIDQIFS .||...|. |.|.||.....|. DLIRRMLQYDEKDRISWEELFN |
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| Kinase | 81529.m00535.AA | Ciliate-E2-Unclassified | 90-264 | 22 | 2.6e-28 | 95.29 | In-house | 103-347 (352) | Show / Hide |
Range on Protein: 90-264
Range on HMM: 103-347/352
Sequence Identity: 22% (55 aa)
AQEKDLLDFLDKTPE---------------FPIPEKKVR-----NIAYVLFKSVEYLNQNG-VMHRDYKPENVVIMNSNLNVDDIKVIDLGMACEIN---
.. .||.... | . ..|.... .... . . ||| ... . ||| ||||... |.. | ||.||.| . ...
CEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNY-YIKIIDFGISKKYQQNN
--------------DRLHQERVGSCYYA----APEVYDG-AYS----KECDIFSIGVTLCVACGGTVPFDCDSNKA----------------MQASKKKR
. . . ..|. .| ||||..| |. ..|||.| || | . |. ||.. . . .. .|..
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK
DYKLEGKIW----NHFSNELKELIY----KCLEPDPKKRITIDQIF
... | | |.| |..| |.|. .|.||||..||.
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
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| Kinase | 81529.m00535.AA | CAMK-Unique | 89-272 | 22 | 8.3e-28 | 88.72 | In-house | 116-363 (363) | Show / Hide |
Range on Protein: 89-272 Range on HMM: 116-363/363 Sequence Identity: 22% (56 aa) RAQEKDLLDFLDK------------------TPEFPIPE--KKVRNIAYVLFKSVEYLNQNGVMHRDYKPENVVIMNS------------NLNVDDIKVI ..|..||.| ..| . . | ...| | |.|. .... ||| |.||... .| ... .||.. YCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLC DLGMACEIN--DRLH--QERVGSCYYAAP--------------EVYD-GAYSKEC----DIFSIGVTLCVACGGTVPFDCDSNK--------AMQASKKK | |..|..| | |...|. .|.|| || . |. | || |.||.. | ||||.... .. .| DFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICK RDY-KLEGKIWNH---FSNELKELIYKCLEPDPKKRITIDQIFSEYSSLWS || ... | |. |.|.| .. .|.. ||..|... .. ... | GDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKEL---LEHQWI |
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| Kinase | 81529.m00535.AA | ULK | 94-265 | 21 | 6e-27 | 92.68 | In-house | 103-320 (324) | Show / Hide |
Range on Protein: 94-265 Range on HMM: 103-320/324 Sequence Identity: 21% (47 aa) DLLDFLDKTPEFP-------IPEKKVRNIAYVLFKSVEYLNQNGVMHRDYKPENVVIMN-SNLNVDD--------IKVIDLGMACEIND-----RLHQER || ... | ..| ..|...... . . .|......||| ||.| | | . |. .|. | | | ... . |. DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTC V------GSCYYAAPEVYDGA-----YS-KECDIFSIGVTLCVACGGTVPFDCDSNKAMQ----ASKKKR--------DYKLEGKIWN---HFSNELKEL | |. .| ||.. | |. ..|||.|.|. . | .|| .. . . .... . ... .. . ..|.|.|.| VNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL IYKCLEPDPKKRITIDQIFS |...|. |.|.||....||. IRRMLQYDEKDRISWEEIFN |
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| Kinase | 81529.m00535.AA | RSK | 94-263 | 28 | 7.1e-23 | 80.66 | In-house | 87-272 (278) | Show / Hide |
Range on Protein: 94-263 Range on HMM: 87-272/278 Sequence Identity: 28% (53 aa) DLLDFLDKTPEF-PIPEKKVRNIAYVLFKSVEYLNQNGVMHRDYKPENVVIMNSNLNVDDIKVIDLGMACE-IND--RLHQERVGSCYYAAPEVYD---- .|.. | | | . |. .. ... . . ||.| | |. ||| ||||.. .. . | ||..| | ... .| . . ... |.|||. ELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQ GA-YSKECDIFSIGVTLCVACGGTVPFDC-DSNKAMQASKKKRDYK--LEGKIWNHFSNELKELIYKCLEPDPKKRIT-----IDQI . ..| ||..| || . | .|| ..| . . .|. . | |....|. |.| |.|| |.|. ||.||.. ...| QGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEI |
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| TyrKc | 81529.m00535.AA | TyrKc | 1-270 | 15 | 2.6e-08 | -88.18 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-270 Range on HMM: 1-280/280 Sequence Identity: 15% (51 aa) MTLEKY--------VYPGRVINGFKVTSLCESTQNSSTFFGYNTSDEQQV---VLKVYKNNPRKYLREIAYLEKF--NSNFILKPIQTFDIVN------- ||.| || |. . .|| .|| .. . .||. . |. . |.. . . ITLGKKLGEGAFGEVYKGTWK--------------------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYI NLKCSVFPRAQEKDLLDFLDKTPEFPIPEKKVRNIAYVLFKSVEYLNQNGVMHRDYKPENVVIMNSNLNVDDIKVIDLGMACEINDR--------LH--- . |. . ||.|.| |. . .. |. .... . ||| .... ||| |. . . . .|. | |.. .| | EPLMIVMEYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKK ---QER-VGSCYYAAPEVY-DGAYSKECDIFSIGVTL--CVACGGTVPFD-----CDSNKAMQASKKK-RDYKLEG-----KIWNHFSNELKELIYKCLE ... . |||. .| .. . |..| ||.. |.. . . .. ... |. | . . . . |. ... .| . EHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWH PDPKKRITIDQIFSEYSSL ||..| | .| .. . EDPEDRPTFSEI---HECF |
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