Gene GL50803_135970 (G.lamblia)
GL50803_135970
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_135970.AA | Protein | None | 797 | None | Fasta, JSON |
| GL50803_135970.kin_dom | Protein Kinase Domain | None | 261 | None | Fasta, JSON |
Protein domains of GL50803_135970.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_135970.AA | AGC | 179-268 | 21 | 1.4e-23 | 56.47 | In-house | 273-395 (395) | Show / Hide |
Range on Protein: 179-268 Range on HMM: 273-395/395 Sequence Identity: 21% (27 aa) YVAPEVLKSQAITTKADVWA--LGCIIYELCVQKQLFAAAS----------EEEMVARIL-----TPVSVTLP----------PQYSRDLVTVLRAMLEQ |.|||.| . .| |. |||..||. . . | . . ..|| .|. . |..| .. | ... .. .|. YMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCK DPFQRPGAVV----------LLGHPRF || .|.|. . || | DPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | GL50803_135970.AA | NEK | 177-268 | 33 | 2.4e-21 | 72.23 | In-house | 187-286 (286) | Show / Hide |
Range on Protein: 177-268 Range on HMM: 187-286/286 Sequence Identity: 33% (33 aa) TP-YVAPEVLKSQAITTKADVWALGCIIYELCVQ--KQLFAAA--SEEEMVARILTP-VSVTLPPQ--YSRDLVTVLRAMLEQDPFQRPGAVVLLGHPRF || | .|||.... . |.|.|.|||..||.| . | | | . .. . .| .|.. ||.|| ... || || ||| . .| .| TPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_135970.AA | Pkinase | 178-268 | 26 | 4e-21 | 75.79 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 178-268 Range on HMM: 176-293/293 Sequence Identity: 26% (31 aa) PYVAPEVLK-SQAITTKADVWALGCIIYELCVQKQLFAAA------SEEEMVARILT-PVSVTLPPQYS-------------------RDLVTVLRAMLE .|.||||.. .| ...|.|.|..|||.||.. . .| . .. .|..||. |.. | .| ... ... .|. WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC QDPFQRPGAVVLLGHPRF .|| .||.| .| || | KDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_135970.AA | NEK-Unclassified | 179-268 | 35 | 3.4e-19 | 59.94 | In-house | 163-258 (258) | Show / Hide |
Range on Protein: 179-268 Range on HMM: 163-258/258 Sequence Identity: 35% (35 aa) YVAPEVLKSQAITTKADVWALGCIIYELCVQKQLFAAASEEEMVARI----------LTPVSVTLPPQYSRDLVTVLRAMLEQDPFQRPGAVVLLGHPRF . .|||.. | . |||.|||||||.| | . . |. | | ||| | || || |.| ||.... ||| |. .. . WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKT----YSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
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| Kinase | GL50803_135970.AA | NEK11 | 179-268 | 37 | 1.2e-17 | 60.88 | In-house | 170-259 (259) | Show / Hide |
Range on Protein: 179-268 Range on HMM: 170-259/259 Sequence Identity: 37% (34 aa) YVAPEVLKSQAITTKADVWALGCIIYELCVQKQLFAAASEEEMVARILTPVSVTLPPQYSRDLVTVLRAMLEQDPFQRPGAVVLLGHPRF |..|| || | ||.|.|.| ||.||.| || .. .| .| || | |.| |.. || ..| || |. .| | . YMSPEALKHQGYDTKSDIWSLACILYEMCCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM |
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| Kinase | GL50803_135970.AA | NEK2 | 179-268 | 32 | 3.8e-17 | 54.19 | In-house | 230-319 (319) | Show / Hide |
Range on Protein: 179-268 Range on HMM: 230-319/319 Sequence Identity: 32% (29 aa) YVAPEVLKSQAITTKADVWALGCIIYELCVQKQLFAAASEEEMVARILTPVSVTLPPQYSRDLVTVLRAMLEQDPFQRPGAVVLLGHPRF | ||... | | |.|..||.|||.| . | | . . | ..| ||||.| . |.. |. .||. ..|.||. YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| Kinase | GL50803_135970.AA | NEK1 | 179-268 | 32 | 2.4e-16 | 53.32 | In-house | 187-276 (276) | Show / Hide |
Range on Protein: 179-268 Range on HMM: 187-276/276 Sequence Identity: 32% (29 aa) YVAPEVLKSQAITTKADVWALGCIIYELCVQKQLFAAASEEEMVARILTPVSVTLPPQYSRDLVTVLRAMLEQDPFQRPGAVVLLGHPRF |. || . . | |.|.|||. |||| | | |... .| .|. .|| ||..| . |. .| || . .| | YLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | GL50803_135970.AA | NEK4 | 179-268 | 31 | 2.9e-16 | 55.07 | In-house | 168-257 (257) | Show / Hide |
Range on Protein: 179-268 Range on HMM: 168-257/257 Sequence Identity: 31% (28 aa) YVAPEVLKSQAITTKADVWALGCIIYELCVQKQLFAAASEEEMVARILTPVSVTLPPQYSRDLVTVLRAMLEQDPFQRPGAVVLLGHPRF | ||. ... | |.|.||| .||. | | | .. .|. .||.|| || .. |||. | .|| .. | YMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI |
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| Kinase | GL50803_135970.AA | STE-Unique | 179-268 | 22 | 5.4e-15 | 49.17 | In-house | 514-616 (616) | Show / Hide |
Range on Protein: 179-268 Range on HMM: 514-616/616 Sequence Identity: 22% (23 aa) YVAPEVLKSQ-----AITTKADVWALGCIIYELCVQKQLFAAASEEEMVARILTPVSVTLP--------PQYSRDLVTVLRAMLEQDPFQRPGAVVLLGH | .|||. . . ||.|.| |||.. ..|.. ... . . . .. . .| |... ... ... ||..|..|| | || | YMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHH PRF . FWL |
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| Kinase | GL50803_135970.AA | Ciliate-E2 | 178-268 | 22 | 7.4e-15 | 47.42 | In-house | 252-365 (365) | Show / Hide |
Range on Protein: 178-268 Range on HMM: 252-365/365 Sequence Identity: 22% (27 aa) PYVAPEVLKSQA---------ITTKADVWALGCIIYELCVQKQLFAAASEEEMVARILT-PVSVTLP----------------PQYSRDLVTVLRA---- .|.|||.|... ..|.|.|.||.|.||.. | | |. ... | . | . .. GYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKR MLEQDPFQRPG-AVVLLGHPRF ||. || .|.. . .| || | MLQKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_135970.AA | Ciliate-B1 | 179-226 | 37 | 9.5e-14 | 44.61 | In-house | 194-244 (290) | Show / Hide |
Range on Protein: 179-226 Range on HMM: 194-244/290 Sequence Identity: 37% (19 aa) YVAPEVLK-SQAITTKADVWALGCIIYELCVQKQLFA--AASEEEMVARIL | |||.|. .| . | | |..|||.||. ..|||. . .. | . |. YMAPEILNFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIR |
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| S_TKc | GL50803_135970.AA | S_TKc | 8-268 | 17 | 3.2e-11 | -12.26 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 8-268 Range on HMM: 1-231/231 Sequence Identity: 17% (53 aa) YTYLQTLEDGVLRKLYTAARHD-GVSCLCEEVFVGPPPAPSASSLRACPALIARLDSPFLGKYILVQPDNQRRSVFLLSQHVQD--FSLFTLFTAHTGSR |. |... | | | . .. | . . .. . .| | . |.. |.. | | .... .. .||.. . . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG PY--TPEDDIWQILYGALQGLAYLHSP------------------------LAKPVLVHGAISPTSVYVSRDGAGLLRSLWSVRESGSPFTGDAYSPLTP .. || ... ..| ...|.|.|| ||. . | .| LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL----------------------------------TTFCGTP--W YVAPEVLKSQAITT-KADVWALGCIIYELCVQKQLFAAASEEEMVARILTPVSVTLPPQYSRDLVTVLRAMLEQDPFQRPGAVVLLG-------HPRF |.||||| .. |.|.|..|||.||... . .| ...|. ... |... .| .|. || .||.| .| || | YMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_135970.AA | STE-Unique | 108-128 | 47 | 0.151483 | 0.57 | In-house | 401-421 (616) | Show / Hide |
Range on Protein: 108-128 Range on HMM: 401-421/616 Sequence Identity: 47% (10 aa) PEDDIWQILYGALQGLAYLHS ||. . ..| .| || |||| PETEVIWYTYQILEGLEYLHS |
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| Ank | GL50803_135970.AA | Ank | 348-378 | 30 | 0.006123 | 14.86 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 348-378 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) NGYSSLMYAIVYQNTPMAKLLLK--SDAGLQDR .|.. |..|. . .| ..|.||. | .||. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_135970.AA | Ank | 379-402 | 25 | 0.015851 | 13.37 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 379-402 Range on HMM: 1-24/33 Sequence Identity: 25% (6 aa) TGRSALMYASSYDKLELVQELIRR |...|..|.... .| |..|. . DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_135970.AA | Ank | 410-431 | 22 | 0.138916 | 9.97 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 410-431 Range on HMM: 1-22/33 Sequence Identity: 22% (5 aa) AGRTALMHAAASDSLLSIRALI |.|.|. |. .... .. |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_135970.AA | Ank | 441-461 | 38 | 0.035889 | 12.09 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 441-461 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) EGSTALMIAIKSGAYRAVSML .| |.|..|...| .. |.|| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_135970.AA | Ank | 472-482 | 45 | 6.482788 | 3.95 | Pfam | 1-11 (33) | Show / Hide |
Range on Protein: 472-482 Range on HMM: 1-11/33 Sequence Identity: 45% (5 aa) LGKTALMLAAQ | |.|.||.. DGFTPLHLACR |
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| Ank | GL50803_135970.AA | Ank | 562-574 | 46 | 4.254111 | 4.61 | Pfam | 1-13 (33) | Show / Hide |
Range on Protein: 562-574 Range on HMM: 1-13/33 Sequence Identity: 46% (6 aa) QGNTSLMLAILEG |.| |.||.. | DGFTPLHLACRCG |
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| Ank | GL50803_135970.AA | Ank | 593-614 | 27 | 0.829999 | 7.17 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 593-614 Range on HMM: 1-22/33 Sequence Identity: 27% (6 aa) DSETALMLCAKKNLSGIAALLL | .|.|.| .... .. .|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_135970.AA | Ank | 633-658 | 38 | 0.003132 | 15.91 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 633-658 Range on HMM: 1-26/33 Sequence Identity: 38% (10 aa) VGMTALMHAAEANAVEVCKVLLTAEA |.|.|. |.. . .||.| || . | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_135970.AA | Ank | 664-684 | 33 | 2.956599 | 5.18 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 664-684 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) DGKTALILAAMADAKDAALVL || |.| ||.. . .. . | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_135970.AA | Ank | 697-722 | 34 | 0.000874 | 17.91 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 697-722 Range on HMM: 1-26/33 Sequence Identity: 34% (9 aa) NGFTALMGAVQHRNVDLAKLLLKKEA .|||.|. |... ... .|.||.. | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_135970.AA | Ank | 728-760 | 27 | 0.35508 | 8.5 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 728-760 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) DGTAAIHIAVFLEDVALVKLLFSYEKDLQLADG || . |.|.. .. ||.| .. |. . | DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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