Gene GL50803_22451 (G.lamblia)

GL50803_22451

Species: G.lamblia
Alias: GL50803_22451, GK201
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_22451.AA Protein None 1017 None Fasta, JSON
GL50803_22451.kin_dom Protein Kinase Domain None 230 None Fasta, JSON

Protein domain

Protein domains of GL50803_22451.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_22451.AA S_TKc 23-738 7 4.1e-10 -28.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-738
Range on HMM: 1-231/231
Sequence Identity: 7% (53 aa)

FKIANIVARSRRGREMVAAYIRTGELVLLKERYSNEMDVLENTLKEAETLLDLGPHRNILTIRGYAQEGTTGLIALEHLQH--KDMQRQMQRYKK--LSK
..| ... .   |. . .  ..||..| .|.         |....| . |     | || .. .. |. .   . .|.. .   |. . ......  | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

TFSEPFLWAILLDISSALQHIHDKGYVFRDIKLANIYLREVDYTNNSSVKLDLVEPNKQVRIANLQFVLSNFESCRKLPPPSRSNSKLMSNQFIPSDYAT
 |.|   . ..  | .||...|..| . ||.| .|| | |                         .  .. | ..|.|                      
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------------------HIKICDFGLARQL----------------------

DTASLPDTDYECTPGVDVTTPSQQPTISFLQALQNRIYYDITEDTHIDGRKKVMSTAAQKIYNEDHNLPYSARSPNKQMAIQKEYENVTGHMSDSTILNP
                                                                                                    
----------------------------------------------------------------------------------------------------

EIREELRAASRSGSLCGSNYGSQSMNTSRSASRSASPSISRTASRSISRSASPSLPIPRAISITVDRPINIPTDSRPDTLLVGSYVQSASPTFRRGLTDL
                                                                                                    
----------------------------------------------------------------------------------------------------

SNINRPDMSVPPMLSDSPGRHYIHSSRTSVSTRSQNSIDHGKFDYVQNMARFTRLDPFEKALRNHKIRKELEKRRNIFPEGTNMYATVESEDDIEFKLIK
                                                                                                    
----------------------------------------------------------------------------------------------------

PTLGKFGTRSISQTVALRPATTSSLGKVSQARLESSPKKNPFQIDRGKSAMPKINDEEQQLRDLEELWRREEISCNPNNPNYPTKLTTTLDQCNPRARDT
                                                                                                    
----------------------------------------------------------------------------------------------------

LPYYLEPPQNTYSTFKARSQKVLLPDGSGTITILGTPNYMPKEMAEGNNITAMDIYALGVSVLELMC----LEDYQQIDMERVQKQLSAIYSRDIRTLVL
                               |. |||.||. |.  | .  . |....|. . |..|     .  |.  | .. .      |.. . .. 
------------------------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------SPEAKDFIR

RMLG-PPDLRPSAEDIHE----SSLRAIL
..|   |. ||.| .. .      .   .
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_22451.AA ULK 96-156 25 6e-10 31.0 In-house 97-163 (329) Show / Hide 
Range on Protein: 96-156
Range on HMM: 97-163/329
Sequence Identity: 25% (17 aa)

IALEHLQHKDMQRQMQRYKKLS------KTFSEPFLWAILLDISSALQHIHDKGYVFRDIKLANIYL
| .|  .. | .  ....|||.      |..||.    .. .| ......|..... ||||..|| .
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILI
Kinase GL50803_22451.AA ULK 96-156 25 1.8e-09 29.85 In-house 94-159 (324) Show / Hide 
Range on Protein: 96-156
Range on HMM: 94-159/324
Sequence Identity: 25% (17 aa)

IALEHLQHKDMQRQMQRYKKLS-----KTFSEPFLWAILLDISSALQHIHDKGYVFRDIKLANIYL
| .|  .. | .  ....|||.     |..||.    .. .| ......|..... ||||..|| .
IIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI
Kinase GL50803_22451.AA WEE 120-156 44 3.3e-09 27.11 In-house 108-145 (297) Show / Hide 
Range on Protein: 120-156
Range on HMM: 108-145/297
Sequence Identity: 44% (17 aa)

FSEPFLWAILLDISSALQHIHDK-GYVFRDIKLANIYL
..|. .| ||.||. .|.|||.. | |  ||| .||..
LPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFI
Kinase GL50803_22451.AA AGC 132-154 40 1.2e-08 16.92 In-house 162-186 (395) Show / Hide 
Range on Protein: 132-154
Range on HMM: 162-186/395
Sequence Identity: 40% (10 aa)

ISSALQHIHD-KGYVFRD-IKLANI
| .||...|. .|.. || .|. ||
IVLALEYLHSHMGIIHRDYLKPENI
Kinase GL50803_22451.AA NEK 105-154 27 3.3e-08 25.44 In-house 93-150 (286) Show / Hide 
Range on Protein: 105-154
Range on HMM: 93-150/286
Sequence Identity: 27% (16 aa)

DMQRQ---MQRYKKLSKTFSEPFLWAILLDISSALQHIHDK-----GYVFRDIKLANI
|....    ...|.  | |.|   | ..  ...||...||.       . |||| .||
DLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNI
Kinase GL50803_22451.AA Ciliate-E6 128-156 34 8.2e-08 21.31 In-house 58-86 (154) Show / Hide 
Range on Protein: 128-156
Range on HMM: 58-86/154
Sequence Identity: 34% (10 aa)

ILLDISSALQHIHDKGYVFRDIKLANIYL
.......|....| |.||   |.| ||.|
FCCQLFHAVEYLHSKNYVLQNITLKNIFL
Kinase GL50803_22451.AA TK-Unique 66-149 18 1.5e-07 22.25 In-house 51-159 (294) Show / Hide 
Range on Protein: 66-149
Range on HMM: 51-159/294
Sequence Identity: 18% (20 aa)

LKEAETLLDLGPHRNILTIRGYAQEGT-TGLIALEHLQHK---DMQRQMQRY-------------------KKLSKTFSEPFLWAILLDISSALQHIHD-
|||.. .  ||.| ||... |. .. .   .|..|...     . .|.....                   |..  . |. .|  .. .| .......  
LKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ

-KGYVFRDI
 |. | ||.
RKKIVHRDL
Kinase GL50803_22451.AA NEK6 96-156 36 3.1e-07 19.58 In-house 76-136 (252) Show / Hide 
Range on Protein: 96-156
Range on HMM: 76-136/252
Sequence Identity: 36% (22 aa)

IALEHLQHKDMQRQMQRYKKLSKTFSEPFLWAILLDISSALQHIHDKGYVFRDIKLANIYL
| ||  .  || | .. .||  .   |  .|     ..|||.|.| |  . |||| ||...
IVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFI
Pkinase GL50803_22451.AA Pkinase 56-154 18 5e-07 25.93 Pfam 36-139 (293) Show / Hide 
Range on Protein: 56-154
Range on HMM: 36-139/293
Sequence Identity: 18% (20 aa)

SNEMDVLENTLK--EAETLLDLGPHRNILTIRGYAQEGTTGLIALEHLQHK----DMQRQMQ--RYKKLSKTFSEPFLWAILLDISSALQHIHDKGYVFR
......... ..  |.. .. |  | ||...... ....   . .|....     |  . ..  |.....  |||  .  ... | ..|...|..| . |
HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHR

DIKLANI
|.|..||
DLKPENI
Kinase GL50803_22451.AA Ciliate-E2 644-685 26 3e-06 17.35 In-house 227-291 (365) Show / Hide 
Range on Protein: 644-685
Range on HMM: 227-291/365
Sequence Identity: 26% (17 aa)

DGSGTIT-------------ILGTPNYMPKEMAEGNNI----------TAMDIYALGVSVLELMC
| |.|..             |.|||.||. |. .| ..          .. ||..|||   |...
DTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
Kinase GL50803_22451.AA TKL 78-158 17 2.1e-05 15.43 In-house 84-175 (364) Show / Hide 
Range on Protein: 78-158
Range on HMM: 84-175/364
Sequence Identity: 17% (18 aa)

HRNILTIRGYAQEGTTG-------------LIALEHLQHKDMQRQMQRYKKLSKTFSEPFLWAILLDISSALQHIHD--------KGYVFRDIKLANIYL
| ||. . ||..... |              |  |  .. .   ...           . .  . |||...... |         .. . ||.| .|| .
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV

RE
 |
DE
Kinase GL50803_22451.AA TKL 648-733 16 5.5e-05 13.91 In-house 230-364 (364) Show / Hide 
Range on Protein: 648-733
Range on HMM: 230-364/364
Sequence Identity: 16% (22 aa)

TITILGTPNYMPKEMAEGNNI-----------------TAMDIYALGVSVLELMCLE-DYQQID--------------MERVQKQLS-------------
|.|. |||..|. |. .|..                  ...|.|. |.   |... .  |....              | ...|.|              
TMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKM

---AIYSRDIRTLVLRMLGP-PDLRPSAEDIHESS
       .... |  .   . |. |||...| .  
CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_22451.AA Ciliate-E2 132-154 28 9.1e-05 12.27 In-house 154-192 (365) Show / Hide 
Range on Protein: 132-154
Range on HMM: 154-192/365
Sequence Identity: 28% (11 aa)

ISS---------------ALQHIHDKG-YVFRDIKLANI
| .               ||...| |.  . ||||. ||
ILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENI
TyrKc GL50803_22451.AA TyrKc 28-255 13 0.000173 -150.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-255
Range on HMM: 1-280/280
Sequence Identity: 13% (41 aa)

IVARSRRGR----EMVAAYIRTGELVL---LKERYSNEMDVLENTLKEAETLLDLG-PHRNILTIRGYAQEG-------TTGLIALEHLQHKDMQRQMQR
|.     |.    | . .  .  . |    |||        .|  ..||. .  ||  | ||. . |.. ..          .| .|.  | | .   ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

YKKLSKTFSEPFLWAILLDISSALQHIHDKGYVFRDIKLANIYLREVDYTNNSSVKLDLVEPNKQVRIANLQFVLSNFESCR-------KLPPPS-RSNS
...    .. . |  . ..|..  ...|.|... ||.   |. . |                  .|.|.   | || .           .   .. ....
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------TVKISD--FGLSRDIYDDDQQGESKDYYRKKEHKGG

K------------LMSN-----------------------QFIPS-----DYATDTASLPDTDYECTPGVD---------------------VTTPSQQP
|            .. .                       |  |        ...   . .. |   .  .                        |.. |
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TISFLQALQNRI
| | .     ..
TFSEI---HECF
Kinase GL50803_22451.AA NEK 704-735 36 0.000267 11.5 In-house 254-286 (286) Show / Hide 
Range on Protein: 704-735
Range on HMM: 254-286/286
Sequence Identity: 36% (12 aa)

IYSRDIRTLVLRMLGP-PDLRPSAEDIHESSLR
.||.| . |. .|| . |..|||...| | .. 
MYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_22451.AA WEE 692-735 19 0.000811 8.77 In-house 252-297 (297) Show / Hide 
Range on Protein: 692-735
Range on HMM: 252-297/297
Sequence Identity: 19% (9 aa)

IDMERVQ-KQLSAIYSRDIRTLVLRMLGP-PDLRPSAEDIHESSLR
.| ..    ....|.|.. . |.  |. | |..||..... .... 
FDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase GL50803_22451.AA WEE 657-688 33 0.001753 7.63 In-house 199-234 (297) Show / Hide 
Range on Protein: 657-688
Range on HMM: 199-234/297
Sequence Identity: 33% (12 aa)

YMPKEMAEG--NNITA--MDIYALGVSVLELMCLED
||..|   |  .....   ||..||  ..||.| .|
YMAPEILQGYYHYTHLYKADIFSLGITIYELACNMD