Gene GL50803_9354 (G.lamblia)
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_9354.AA | Protein | None | 1392 | None | Fasta, JSON |
| GL50803_9354.kin_dom | Protein Kinase Domain | None | 254 | None | Fasta, JSON |
Protein domains of GL50803_9354.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_9354.AA | Pkinase | 322-396 | 19 | 6e-06 | 22.17 | Pfam | 192-293 (293) | Show / Hide |
Range on Protein: 322-396 Range on HMM: 192-293/293 Sequence Identity: 19% (20 aa) KADVWAMGALLLCLCLGRPLNHRD-----------DCVHLATDLRKNSKLGSCLY----------------SYSLCSFICSCLQPDPVKRPALSILKERI |.|.|..| .| ....|||. . | . ..|. .. .. . | ....||..||..|| ||| ... KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP QI . WF |
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| Kinase | GL50803_9354.AA | NEK10 | 322-385 | 31 | 1.4e-05 | 14.15 | In-house | 200-265 (279) | Show / Hide |
Range on Protein: 322-385 Range on HMM: 200-265/279 Sequence Identity: 31% (21 aa) KADVWAMGALLLCLCLGRPLNHRDDCVHLATDLRKNSK--LGSCLYSYSLCSFICSCLQPDPVKRP ||||||.| | .| .| . ||. .. . ..| . | .|| ||| || KADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIVEHFYDPVNEGMWSDDVRFTITRCLTPDPEARP |
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| S_TKc | GL50803_9354.AA | S_TKc | 13-396 | 9 | 3e-05 | -99.94 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-396
Range on HMM: 1-231/231
Sequence Identity: 9% (42 aa)
FYDVESVAKTQFGASFYLVRDRSTGT--CLKLISIEFTDSWIRRQASKEASLDYCSSLTNPGLAKYQGWVKEQSSQVLYVKVVYPSS--PTILTLLARNH
. .. . | || |..|...|| .| |. ... .| .. | . |. .. . . ||. | . . .... ..
YEILRKIGKGAFGKV-YKCRHKKTGRIVAIKIIK---------EHIRREIQILKK---HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG
A------FLEDAIWDIATNLVELLVYLHKHHL----------------------LAWSGLSPSFVHLTTQNEPILDNYFASFRFRTLLSKVVDPFLAPEI
| | .. .. ... | |.|.|. ||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----------------------------------------
SSMYLSTSEKISDATYLDKECAISAEADAQFGTNGTSNRSTCTKNPLALNINSIDTSSFANCDNLSTPRNDRNDFTIEQGLGVFKSSVTPCLIHRLSPSH
----------------------------------------------------------------------------------------------------
ASSARQGDAPPPSSYSKEGSEEIQRVQHMI--------ELAGLSPSKQF-KADVWAMGALLLCLCLGRPLNHRDDCVHLATDLRKNSKLGSCLYSYSLCS
... |. . . |.|.|. | .| .. |.|. . ... .. . | ....
--------------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------SPEAKD
FICSCLQPDPVKRPALSILKE-------RIQI
||. ||| || ||| . . .
FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | GL50803_9354.AA | NEK | 364-396 | 36 | 5.3e-05 | 14.01 | In-house | 254-286 (286) | Show / Hide |
Range on Protein: 364-396 Range on HMM: 254-286/286 Sequence Identity: 36% (12 aa) LYSYSLCSFICSCLQPDPVKRPALSILKERIQI .|| | ..| ..||.|| .|| . . |. .| MYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_9354.AA | STE | 321-385 | 20 | 0.000271 | 11.21 | In-house | 247-346 (359) | Show / Hide |
Range on Protein: 321-385 Range on HMM: 247-346/359 Sequence Identity: 20% (21 aa) FKADVWAMGALLLCLCLGRPLN---HRD------------------------DCVHLATDLRKNSKLGS----------CLYSYSLCSFICSCLQPDPVK .|.|.| | ... .. |.| | .. | ..| .| . . .| ... || ||| || | TKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEM--ISYGGSGTTYPHKWSPEFKDFINKCLQKDPNK RP || RP |
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| Kinase | GL50803_9354.AA | MEK4 | 365-396 | 37 | 0.000547 | 8.71 | In-house | 244-275 (275) | Show / Hide |
Range on Protein: 365-396 Range on HMM: 244-275/275 Sequence Identity: 37% (12 aa) YSYSLCSFICSCLQPDPVKRPALSILKERIQI || ..|.|| || | .|| . ||. . YSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY |
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| Kinase | GL50803_9354.AA | Ciliate-B1 | 376-395 | 40 | 0.000727 | 9.55 | In-house | 271-290 (290) | Show / Hide |
Range on Protein: 376-395 Range on HMM: 271-290/290 Sequence Identity: 40% (8 aa) CLQPDPVKRPALSILKERIQ |||||| .|. .. ...|. CLQPDPENRITIDQIIDRLM |
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| Kinase | GL50803_9354.AA | TBCK | 322-341 | 50 | 0.001212 | 8.79 | In-house | 184-203 (346) | Show / Hide |
Range on Protein: 322-341 Range on HMM: 184-203/346 Sequence Identity: 50% (10 aa) KADVWAMGALLLCLCLGRPL |.|||. | .| .|||. | KSDVWSLGCIMLEICLGICL |
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| Kinase | GL50803_9354.AA | NEK10 | 100-131 | 31 | 0.061061 | 1.92 | In-house | 106-137 (279) | Show / Hide |
Range on Protein: 100-131 Range on HMM: 106-137/279 Sequence Identity: 31% (10 aa) ILTLLARNHAFLEDAIWDIATNLVELLVYLHK . .. ..| | |. || . .. | |||| FNSMKEKHHHFEEERIWHMFIQMCLALRYLHK |
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| Kinase | GL50803_9354.AA | TBCK | 368-396 | 37 | 0.110595 | 1.66 | In-house | 318-346 (346) | Show / Hide |
Range on Protein: 368-396 Range on HMM: 318-346/346 Sequence Identity: 37% (11 aa) SLCSFICSCLQPDPVKRPALSILKERIQI .| ..| .|||. | ||| | | . . WLIQIIRKCLQMCPMKRPSPTELMEHPMF |
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| Ank | GL50803_9354.AA | Ank | 481-503 | 39 | 0.000735 | 18.18 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 481-503 Range on HMM: 1-23/33 Sequence Identity: 39% (9 aa) GGRTALMFAAGNGHTKCIKSLIK |.|.|. |. .|||...| |.. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_9354.AA | Ank | 511-528 | 22 | 0.376079 | 8.41 | Pfam | 1-18 (33) | Show / Hide |
Range on Protein: 511-528 Range on HMM: 1-18/33 Sequence Identity: 22% (4 aa) QGLTALMYAVKNRYKDAI | |.|..|... ... . DGFTPLHLACRCGHTEVV |
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| Ank | GL50803_9354.AA | Ank | 542-576 | 28 | 1.6e-05 | 24.21 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 542-576 Range on HMM: 1-33/33 Sequence Identity: 28% (10 aa) QGFTALMYAAIDNNSEIVSILMKKAAGKELKKQNL |||.|..|.. .. |.|. |.. .| .. |. DGFTPLHLACRCGHTEVVKMLLQ--HGADVNAQDD |
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| Ank | GL50803_9354.AA | Ank | 577-599 | 30 | 0.042913 | 11.81 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 577-599 Range on HMM: 1-23/33 Sequence Identity: 30% (7 aa) KGETALMMATQYWNNEVADYLVK |.|.|..| .. . ||. .|.. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_9354.AA | Ank | 607-627 | 47 | 7e-05 | 21.86 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 607-627 Range on HMM: 1-21/33 Sequence Identity: 47% (10 aa) DGSTALMYAARNGNVNYVKLL || |.|..|.|.|... ||.| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_9354.AA | Ank | 638-658 | 28 | 79.445987 | 0.02 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 638-658 Range on HMM: 1-21/33 Sequence Identity: 28% (6 aa) NGDRALELALINSHADCADIL .|. .| || .. |.... | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_9354.AA | Ank | 667-720 | 18 | 1.113303 | 6.71 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 667-720 Range on HMM: 1-23/33 Sequence Identity: 18% (10 aa) AGETPLLYALKSGDKRLATISTPVYSQSHELSNTSHLSYAIKSNNAQAVKELLS |.||| .| ..| ... ||.||. DGFTPLHLACRCG-------------------------------HTEVVKMLLQ |
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| Ank | GL50803_9354.AA | Ank | 798-819 | 27 | 0.015953 | 13.36 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 798-819 Range on HMM: 1-22/33 Sequence Identity: 27% (6 aa) HGNTALMYAVRHRNRDATAALV .|.|.|..|.|. . . |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_9354.AA | Ank | 828-851 | 33 | 0.000441 | 18.98 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 828-851 Range on HMM: 1-24/33 Sequence Identity: 33% (8 aa) TGWSPLMVAAANGDADLVHELVEH |..||..|. .|... | .|..| DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_9354.AA | Ank | 859-889 | 27 | 0.039748 | 11.93 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 859-889 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) RKETALMVAVKGGSLPCVRLLAK--AEAKKQDI .|.|..|.. |.. .|..| . |. || DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_9354.AA | Ank | 890-911 | 27 | 0.049701 | 11.58 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 890-911 Range on HMM: 1-22/33 Sequence Identity: 27% (6 aa) NGTTALMLAVILRNHPIAEVLM .| |.|.||.. .. ... |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_9354.AA | Ank | 921-946 | 34 | 0.002976 | 15.99 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 921-946 Range on HMM: 1-26/33 Sequence Identity: 34% (9 aa) NGMTTLMIAAQLGDVDMVRLLANHEA .|.| |..|.. |....|..| .| | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_9354.AA | Ank | 958-978 | 47 | 0.014682 | 13.49 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 958-978 Range on HMM: 1-21/33 Sequence Identity: 47% (10 aa) AGWTAMMYAAREGHCEVVAIL |.|. ..|.| || ||| | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_9354.AA | Ank | 989-1019 | 24 | 0.020333 | 12.98 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 989-1019 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) TGRTALMISAYAHNDSCVELLCT--IEREAQDE |.|.|.. .. . ..|..| . ||| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_9354.AA | Ank | 1020-1052 | 21 | 0.476283 | 8.04 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 1020-1052 Range on HMM: 1-22/33 Sequence Identity: 21% (7 aa) NGFTALMYAINSKYDSSDFMTRMQVQRCIQLLL .|||.|..|. . .....|| DGFTPLHLACRCG-----------HTEVVKMLL |
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| Ank | GL50803_9354.AA | Ank | 1061-1080 | 40 | 0.524148 | 7.89 | Pfam | 1-20 (33) | Show / Hide |
Range on Protein: 1061-1080 Range on HMM: 1-20/33 Sequence Identity: 40% (8 aa) GDTTPLSLAASVGNLDVIKL ||| ||.. |...|.|. DGFTPLHLACRCGHTEVVKM |
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| Ank | GL50803_9354.AA | Ank | 1097-1120 | 41 | 1.5e-05 | 24.27 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 1097-1120 Range on HMM: 1-24/33 Sequence Identity: 41% (10 aa) QGMTALMHAALQGHADCVKELLKY |.|.|. |.. ||...||.||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_9354.AA | Ank | 1139-1160 | 31 | 0.000143 | 20.74 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 1139-1160 Range on HMM: 1-22/33 Sequence Identity: 31% (7 aa) NGMTALMYASCNNRASCVDILL .|.|.|..|........| || DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_9354.AA | Ank | 1170-1202 | 27 | 0.000234 | 19.97 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 1170-1202 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) DGSTALMLAAQEGYINIVKKIVTGSSELGMANH || |.|.||.. |....|| . .. . . DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_9354.AA | Ank | 1203-1223 | 38 | 1.051141 | 6.8 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 1203-1223 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) NRLTALAAAASGGYTECVRFL . |.| |.. |.||.|..| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_9354.AA | Ank | 1237-1261 | 36 | 0.300773 | 8.76 | Pfam | 1-25 (33) | Show / Hide |
Range on Protein: 1237-1261 Range on HMM: 1-25/33 Sequence Identity: 36% (9 aa) QGFTNLMLAASLNDLDAVRMGIDEG ||| |.||.. .... |.| .. | DGFTPLHLACRCGHTEVVKMLLQHG |
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| Ank | GL50803_9354.AA | Ank | 1269-1289 | 38 | 0.010738 | 13.98 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 1269-1289 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) IGFTALMYAAINNSIESVLLL |||.|..|......| | .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_9354.AA | Ank | 1300-1330 | 36 | 1.4e-05 | 24.42 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 1300-1330 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) SGITALMLASKMGHVKCVKALIH--EEVGMQTV | |.|.||...||...|| |. .| .|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_9354.AA | Ank | 1331-1353 | 26 | 0.001383 | 17.19 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 1331-1353 Range on HMM: 1-23/33 Sequence Identity: 26% (6 aa) QGWSALMFAAFSNKPDCVELLLK |...|. |.... ...|..||. DGFTPLHLACRCGHTEVVKMLLQ |
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