Gene CG4041 (Fruit Fly)
CG4041
Sequence
Protein domains of CG4041.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CG4041.AA | TBCK | 22-263 | 37 | 4e-152 | 511.68 | In-house | 2-346 (346) | Show / Hide |
Range on Protein: 22-263
Range on HMM: 2-346/346
Sequence Identity: 37% (130 aa)
HPGDVCGSNGLPLTPNSIAILGRAQKLKELQDEHLCQYLDVIRGK--HERTIVVSEYLGLSLED----YAMRHPPLAIAQILRIFYQVACGINVLSRHHL
. |.|..||||.|||.. .|||.|.||.||...||||||..||| |||.|||.|.....||| ||.||.|....|||.|.||..||......||.
EKHDRCCINGLPVTPNAKQMLGRFQYLKSLQHPNLCQYLDFSRGKIHHERMIVVMEHYKMNLEDQIEIYAKRHTPKDCSQILCIYYQILCGLSYMHKHHI
VAHNVEPKHILLSSDGQ---RVKLFNYGLHHMTKGGAYVPFPIGNIRYMAPERLLG-----------LN----------GNVKSDVWSLALVMVELILQI
|.....|..|.|...|. .|||.||||.|||..|..||||||..|||||||.|. .| .|.|||||||...|.|..|.|
VHRFLHPHNIYLDDNGNQKLHVKLANYGLYHMTNHGKDVPFPIGYPRYMAPERILQGEMKTTDHMPPTNPLPPKTTNLSSNPKSDVWSLGCIMLEICLGI
ELWPKLKLSNVVRKILAFG------------------------------------------------------------KSNGALEKIAREHQCHER---
.||..|.||.|..||...| ..|...|..|||||||.|
CLWQELTLSEVLNKIMHYGTHSTTQSFNSISKSFEQCELKKTIINEKQHEEYEEYDDDEDISEEEKEKRIKDIKLNDQDCMNHFMEDLAREHQCHQRSNS
----------YVQMDQRLRQLLESCLSVLPKRRPLPGELLEHPIF
|.||...|.|....||...|..||.|.||.|||.|
GSSNSNIGIPYHQMCEWLIQIIRKCLQMCPMKRPSPTELMEHPMF
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| Kinase | CG4041.AA | TKL | 73-261 | 16 | 1.8e-12 | 41.24 | In-house | 116-364 (364) | Show / Hide |
Range on Protein: 73-261
Range on HMM: 116-364/364
Sequence Identity: 16% (42 aa)
VSEYL-GLSLEDYAMRHPPLAIAQILRIFYQVACGINVLSRHH--------LVAHNVEPKHILLSSDGQ-------------RVKLFNYGLHHMTKGGAY
| || | ||..| . |..|. ...|.|.| | .. .. . .| ||. .... ..|. .|| . ..
VMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGN
--------------------VPFPIGNIRYMAPERLLGL----------------NGNVKSDVWSLALVMVELILQIELWPKLKLSNVVRK----ILAFG
..|..|.|||| | | . |.||.| ..|. |.. . . ... . .. . . .
MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMM
KSNGALEKIAR-----EHQCHERYV----QMDQRLRQLLESCLSVLPKRRPLPGELLEHP
.. | | . . ........|.. | . |. || |.|..
VCDKGLRPPIPPIWQNHH----K-MCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| S_TKc | CG4041.AA | S_TKc | 2-263 | 18 | 1.7e-11 | -8.33 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2-263 Range on HMM: 1-231/231 Sequence Identity: 18% (53 aa) GTRERE---------RECRLCA--VTFFAKLHPGDVCGSNGLPLTPNSIAILGRAQKLKELQDEHLCQYLDVIRGKHERTIVVSEYLGL---SLEDYAMR . |. . || . | . . |. | ||. . .......||.. .. .| ||.. .| || . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKK HPP------LAIAQILRIFYQVACGINVLSRHHLVAHNVEPKHILLSSDGQRVKLFNYGLHHMTKGGAYVPFPIGNIRYMAPERLLGLNGNVKSDVWSLA ... . .. ...||..|... . .|. . . | |||.. ..|. || .| ||||| | | |.|.||. RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCG LVMVELILQIELWPKLKLSNVVRKILAFGKSNGALEKIAREHQCHERYVQMDQRLRQLLESCLSVLPKRRPLPGELLE-------HPIF .. |.. ..| . . .||. .. ...... || . |..|| |.|. || | CILYEMLCGYPPFP--QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | CG4041.AA | Pkinase | 158-263 | 21 | 7.9e-11 | 39.37 | Pfam | 175-293 (293) | Show / Hide |
Range on Protein: 158-263 Range on HMM: 175-293/293 Sequence Identity: 21% (26 aa) IRYMAPERLL-GLNGNVKSDVWSLALVMVELILQIELWPKL----------KLSNVVRKILAFGKSNG------ALEKIAREHQCHERYVQMDQRLRQLL ..||||| .. | |.|.||. ... |... ..| .. .. ...| | .. .. . |. |.. . ... ..... PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTFHNWSEECKDFI ESCLSVLPKRRPLPGELLEHPIF ..|| . ||.|| . ..|.|| | KWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | CG4041.AA | TK-Unique | 90-187 | 27 | 4.6e-10 | 31.03 | In-house | 127-232 (294) | Show / Hide |
Range on Protein: 90-187 Range on HMM: 127-232/294 Sequence Identity: 27% (29 aa) PLAIAQILRIFYQVACGINVLSR--HHLVAHNVEPKHILLSSDGQRVKLFNYGLH-HMTKGGAYVPF-P--IGNIRYMAPERLL--GLNG-NVKSDVWSL |. . ... .|.||| . |.. .. | ... ...||..|. ..|. ..|. . ..|.|. ||.||||.|. . . . ||||||. PISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDK-VCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSF ALVMVEL . .| |. GVLMWEI |
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| Kinase | CG4041.AA | MEK5 | 98-263 | 25 | 7.5e-10 | 32.16 | In-house | 97-254 (254) | Show / Hide |
Range on Protein: 98-263 Range on HMM: 97-254/254 Sequence Identity: 25% (42 aa) RIFYQVACGINVLSRHHLVAHNVEPKHILLSSDGQRVKLFNYGLHHMTKGGAYVPFPIGNIRYMAPERLLGLNGNVKSDVWSLALVMVELILQIELWPKL |. . |.| | .. | | .| || .|| .| . || ||||||..| . . |||||| . ..|. . .|.. RMTVAIVKGLNYLWNLKIMHRDVKPSNMLVNTQGQ-IKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQI KLSNVVRKILAFGKSNGALEKIAREHQCHERYVQMDQRLRQLLESCLSVLPKRRPLPGELLEHPIF . .. | | || . . . .. |. || || | .|..|| QRDQGELMPIQL------LQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI |
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| Kinase | CG4041.AA | MEK1 | 112-189 | 34 | 4.4e-09 | 26.64 | In-house | 116-191 (297) | Show / Hide |
Range on Protein: 112-189 Range on HMM: 116-191/297 Sequence Identity: 34% (27 aa) RHHLVAHNVEPKHILLSSDGQRVKLFNYGLHHMTKGGAYVPFPIGNIRYMAPERLLGLNGNVKSDVWSLALVMVELIL .|... | | || | | .|| .| . | .| ||.|||| | |.||.||. | .||... KHKIMHRDVKPSNILVNSRGE-IKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAI |
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| Kinase | CG4041.AA | STE | 155-188 | 27 | 7.7e-08 | 23.9 | In-house | 224-262 (359) | Show / Hide |
Range on Protein: 155-188 Range on HMM: 224-262/359 Sequence Identity: 27% (11 aa) IGNIRYMAPERLLGLNGN------VKSDVWSLALVMVELI .| .||||.... ... .|.|.||| ....|.. VGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA |
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| Kinase | CG4041.AA | NZAK | 155-188 | 38 | 7.7e-08 | 21.87 | In-house | 233-266 (329) | Show / Hide |
Range on Protein: 155-188 Range on HMM: 233-266/329 Sequence Identity: 38% (13 aa) IGNIRYMAPERLLGLNGNVKSDVWSLALVMVELI .| . ||||| . . | ||||||. .. .... GGTHHYMAPENKNNHRINEKSDVWSFGCTVWQMF |
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| Kinase | CG4041.AA | STE7 | 160-187 | 53 | 9.3e-08 | 24.69 | In-house | 177-207 (288) | Show / Hide |
Range on Protein: 160-187 Range on HMM: 177-207/288 Sequence Identity: 53% (17 aa) YMAPERLLGLNG---NVKSDVWSLALVM-VEL ||||||. | | |.|||||| . | .|. YMAPERIDG-NKQHYDVRSDVWSLGITMGIEM |
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| Kinase | CG4041.AA | FRAY | 237-263 | 40 | 2.9e-07 | 18.25 | In-house | 251-277 (277) | Show / Hide |
Range on Protein: 237-263 Range on HMM: 251-277/277 Sequence Identity: 40% (11 aa) RQLLESCLSVLPKRRPLPGELLEHPIF ....|.|| |..||.. |||.| | KKMIEKCLQKDPSKRPTASELLKHKFF |
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| TyrKc | CG4041.AA | TyrKc | 21-263 | 18 | 6.3e-07 | -110.7 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 21-263 Range on HMM: 1-280/280 Sequence Identity: 18% (56 aa) LHPGDVCGS---------------------NGLPLTPNSIAILGRAQKLKEL--QDEHLCQYLDVIRGKH------ERTIVVSEYLGL-SLEDYAMRHPP .. |.. |. .. ... |. ...| . ... . . |.. . | .| || . .| || .| | ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -LAIAQILRIFYQVACGINVLSRHHLV-----AHNVEPKHILLSSDGQRVKLFNYGLHHMTKGG-------AYVPF-----PI--GNIRYMAPERLLGLN | .. | . .|.||| . |...... | | .|..... .|| || . . | || |||| . KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN-----CLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NY G--NVKSDVWSLALVMVELI-LQIELWPK-----LKLSNVVRKILAFGKSNGALEKIAR----EHQCHERYVQMDQRLRQLLESCLSVLPKRRPLPGELL | . |||||| .| |. . . .| .. . |.... |. . ... . .| . . . |. ..| |. || |. GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV----KQGYRMPQPPNDYPMS------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI- EHPIF | .| -HECF |
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| Kinase | CG4041.AA | STE7-Unclassified | 160-187 | 45 | 1e-05 | 16.27 | In-house | 186-218 (301) | Show / Hide |
Range on Protein: 160-187 Range on HMM: 186-218/301 Sequence Identity: 45% (15 aa) YMAPERLLGL-----NGNVKSDVWSLALVMVEL ||.|||. | ||||.||| |. |. YMSPERIQGQMPHRPSYSVKSDIWSLGLTIWEC |
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| Kinase | CG4041.AA | STE | 236-263 | 30 | 0.000156 | 12.07 | In-house | 330-359 (359) | Show / Hide |
Range on Protein: 236-263 Range on HMM: 330-359/359 Sequence Identity: 30% (9 aa) LRQLLESCLSVLPKRRPLPGELLE--HPIF ... .. || |. || . .||. || . FKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | CG4041.AA | STE7-Unclassified | 236-263 | 27 | 0.013259 | 5.12 | In-house | 273-301 (301) | Show / Hide |
Range on Protein: 236-263 Range on HMM: 273-301/301 Sequence Identity: 27% (8 aa) LRQLLESCLSVLPKRRPLPGELLE-HPIF .... . |. |..|| . .||. || FMDFISKCCKKHPRERPDIHQLLNEHPWI |
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| Kinase | CG4041.AA | STE7 | 236-263 | 27 | 0.050905 | 3.6 | In-house | 260-288 (288) | Show / Hide |
Range on Protein: 236-263 Range on HMM: 260-288/288 Sequence Identity: 27% (8 aa) LRQLLESCLSVLPKRRPLPGELLE-HPIF .... . || |. || . .|.. || . FQDFVNKCLQKDPNERPKYHQLMKEHPFI |
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| Kinase | CG4041.AA | Pkinase | 48-108 | 20 | 0.074896 | 7.63 | Pfam | 54-122 (293) | Show / Hide |
Range on Protein: 48-108 Range on HMM: 54-122/293 Sequence Identity: 20% (14 aa) LKELQDEHLCQYLDVIRGKHERTIVVSEYLGL-----SLEDYAM--RHPPL--AIAQILRIFYQVACGIN .|.|. .. ....|. . . . .| ||.. .| || . || .. .. ...||...|.. MKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE |
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| TBC | CG4041.AA | TBC | 434-634 | 22 | 8.3e-41 | 146.18 | Pfam | 1-240 (240) | Show / Hide |
Range on Protein: 434-634 Range on HMM: 1-240/240 Sequence Identity: 22% (55 aa) PLLRGPIWAALL--------------------EVVPNGSYAKIDKFTSTSTDRQIEVDIPRCHQ-YD--ELLSSPDGHR-KLRRLLKAWVTAHPQYVYWQ . ||. .| || . .. .. . .. . ..||| |..|... .. . .....|.. .||..|||. .|. |.| DQLRWQVWPYLLGYYPWMNGYYKRLYYQEKKQWYQMK-YQ-NNYHEPHPD-YHQIEKDVHRTFPNHHHFFFFQNGQGQQVQLRNILKAYSNYNPDVGYCQ GLDSLTAPFLYLNFNNEEL-----AFLSLFKFI--PKYLQWFFLKD-NSAVIKEYLS--KFSQLTAFHEPLLAQHLAS--ISFIPELFAIPWFLTMFSHV |. . |||||. ...|| || . ... ..|. ....| . ... .. | .| | | |..|. . . | .||..||...|.|. GMNFIAAPFLYMYMMDEEDFQAEDAFWCFCQLMNENYHLRDYYTHDMPG-HLQRDFYFQVFEELLKKHDPKLYKHFQKDCLNIDPSMFATQWFMCLFTHC FPLHKILHLWDKLML---GD--SSYPLFIGIA-IL-RQLRSTLL ||. .|..|| ... |. . . .....| || ...|. .| FPFETVLRIWDCFFFYCEGWNAKFFLFRFCLACILVKYHRQEIL |
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| TBC | CG4041.AA | TBC | 428-637 | 18 | 1.2e-35 | 125.68 | SMART | 1-310 (310) | Show / Hide |
Range on Protein: 428-637
Range on HMM: 1-310/310
Sequence Identity: 18% (58 aa)
AAVDVPPLLRGPIWAALLEVVP---------------------------NGSYAKIDKFTSTST--------------------------------DRQI
.|. .||..| ||. | .. | .. . ..... . ||
WWQGIPHHYRGWVWWLLLNCQPMNTSNWERMQYMWDGENCYFPVNWDRCKDYYDRMLNQHCPCDHHHDNWQDIMMNNNDHECCWMSYWHFFQDCWHWHQI
EVDIPRCHQYDELLSSP---------------DGHRKLRRLLKAWVTAHPQ--YVYWQGLDSLTAPFLYLNF-NNEELAFLSLFKFIPKYLQWFFL----
|.|..|... ... .. .....|||.|.|. .|. .|.||. ..||.|. . .|| || . |.. |..||.
EKDLRRTFPNHPFFQFRMRYNQHCIMLHDQNGPHQESLRRVLYAYSWHNPEHIVGYCQGMNFIAAPLLLHMPCYDEEDAFWCFCKLMERYCPWFYFCDDQ
---KDNSAVIKEYLSKFSQLTAFHEPLLAQHLASI------------SFIPELFAIPWFLTMFSHVFPLHKILHLWDKLMLG----DSSYPLFIGIAILR
. . . . . |..| | | |..|| . . |...|..||||.|.. |||. ....|| ... . ...|..|.|.
NCYTPDMMGMHWQMYQFDHLLQEHDPDLYKHLQEQDHHSMKWHFDHLEIDPSMYAFRWFLTCFAREFPLEDVCRIWDCYFFEYGRHGHPFLFCIALAMLK
QLRSTLLTSG
..| ||.
MHRQKLLQHD
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| RHOD | CG4041.AA | RHOD | 706-835 | 15 | 0.000201 | 21.94 | SMART | 1-94 (94) | Show / Hide |
Range on Protein: 706-835 Range on HMM: 1-94/94 Sequence Identity: 15% (20 aa) ISAKDVQFLLDNSPAELALIDLRSVVEFGRVHVPHSINIPFATVQLGEQRLEALQVPQLEAQLRGKIVVCVSNIHQHSVEVGHPLAQLKLLCKLKSFPIS . . ....|. . ... .|| |. |. . |.| .||||. .. ... ..|.|. . | . V-PEWWKMLQ--N-EDCVIIDCRWPYEYEGGHIPGAINIPWDELLDR------------LGIDKDKPVIVYCRSGNRS--------------------AP QFSHFLVACGVQRTCILHKGFNVLHSIEPN . .| ..| .. .||. |.. . | RAAWWLREAGYKNVYILDGGWKEWKRACPP |
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| Rhodanese | CG4041.AA | Rhodanese | 710-795 | 18 | 0.000714 | 13.93 | Pfam | 1-80 (102) | Show / Hide |
Range on Protein: 710-795 Range on HMM: 1-80/102 Sequence Identity: 18% (17 aa) DVQFLLDNSP-AELALIDLRSVVEFGRVHVPHS-INIPFATVQLGEQRLEAL--QVPQLEAQLRGKIV-VCVSNIHQHSVEVGHPLAQLKL ... |... .. .||.|. |. . |.| . .|||. ||.. . . ..| . |.. . | ... |....| TPEWLKEMMNDPDYVIIDVRPPEEYEKGHIPGAHVNIPW---------LEEEHDLEELGIKLDKDKPIIVVYC-HGNRSG-AWACLVWWML |
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