Gene CG9746 (Fruit Fly)

CG9746

Species: Fruit Fly
Alias: CG9746, SFO036
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 85D1

Classification

Group: Other
Family: VPS15

Sequence

Name Sequence Type Origin Length Description Download
CG9746.AA Protein Various 1342 None Fasta, JSON
CG9746.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 289 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CG9746.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG9746.AA VPS15 28-319 60 2.9e-215 721.44 In-house 1-296 (296) Show / Hide 
Range on Protein: 28-319
Range on HMM: 1-296/296
Sequence Identity: 60% (179 aa)

IAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTLPLEDHKERLEGIKKTLSLANAVNCLPFQRVELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEK
.....|.|||||.||.|||..||.||||||||||.|..||..|.|.|.|||.|....|.||.|.|.|...|||||.||.||||.||||.||||||...||
CHYVKNLGSTRFMKVCKAKHHEGYIVVKVFVKHDDTYSLEPYKQRIEEIKKNLMQHPAFNCCPYQKVIETDKAAYMMRQYVKHNLYDRISTRPFLQMIEK

KWITFQILCALNQCHKQK-ICHGDIKLENILITSWNWILLSDFASFKPTYLPEDNPADYTYFFDTSRRRTCYIAPERFVKTLASDDDGGNGNMSVIHTDS
|||.||.||||.|||||. .||||||.||||.|||||..|.|||.|||.|||||||||.|.||||||||||||||||||.....|.|..||||..|||||
KWIAFQTLCALEQCHKQGNVCHGDIKSENILVTSWNWCYLTDFACFKPCYLPEDNPADFTFFFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHTDS

IIRLAPSYAGNTLLPAMDIFSAGCALLELWTEG-TAPFELSQLLAYRRGE-RDLVEKHLAGIENERLRNLLASMIDIH-SMNRKSAEDYLDQERGQ
|.|.........|.||||||||||...||..|| ..||..|||..||.|| ....|.....|..|..|||...||... .|.|.|.|.||...|| 
IDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPNREQIMEKIQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKWRGF
Kinase CG9746.AA NuaK 112-157 47 1.6e-15 36.72 In-house 86-131 (252) Show / Hide 
Range on Protein: 112-157
Range on HMM: 86-131/252
Sequence Identity: 47% (22 aa)

LYDRVSTRPFLTVLEKKWITFQILCALNQCHKQKICHGDIKLENIL
||| .| .  |.  | . .  ||  |.  ||| .||| | ||||||
LYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENIL
Kinase CG9746.AA AGC 133-169 41 1.6e-13 29.83 In-house 161-199 (395) Show / Hide 
Range on Protein: 133-169
Range on HMM: 161-199/395
Sequence Identity: 41% (16 aa)

QILCALNQCHK-QKICHGD-IKLENILITSWNWILLSDF
.|..||   |. ..| | | .|.||||...   | |.||
CIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF
Kinase CG9746.AA CAMK 106-169 22 2.3e-13 38.74 In-house 140-240 (425) Show / Hide 
Range on Protein: 106-169
Range on HMM: 140-240/425
Sequence Identity: 22% (23 aa)

EYVKH-----SLYDRVSTRPF---------------LTVLEKKWITFQILCALNQCHKQKICHGDIKLENILITSWN----------------W-ILLSD
||.        |.|..  ..                .|  | . .  ||..|.. ||...|.| |.|.||||... |                . | ..|
EYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIID

F
|
F
Kinase CG9746.AA CMGC 106-160 24 2.4e-13 39.3 In-house 135-219 (513) Show / Hide 
Range on Protein: 106-160
Range on HMM: 135-219/513
Sequence Identity: 24% (21 aa)

EYVKHSLYDRVSTRPF----------------------------LTVLEKKWITFQILCALN--QCHKQK--ICHGDIKLENILITS
||. |.||.     .|                            ...   . ...|||..|.   ||...  |.| |.| |||||..
EYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINH
Kinase CG9746.AA Ciliate-E2-Unclassified 130-169 38 1.8e-12 39.58 In-house 148-191 (352) Show / Hide 
Range on Protein: 130-169
Range on HMM: 148-191/352
Sequence Identity: 38% (17 aa)

ITFQILCALNQCHKQK-ICHGDIKLENILITSWN---WILLSDF
.. |||..|...|... |.| |||.||||... .    | ..||
YFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDF
Kinase CG9746.AA S_TKc 28-325 17 2.5e-12 3.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-325
Range on HMM: 1-231/231
Sequence Identity: 17% (54 aa)

IAFSSNMGSTRFFKVAKAKTDE--GQIVVKVFVKHDPTLPLEDHKERLEGIKKTLSLANAVNCLPFQRVELIDKAAYIMREYVKH---SLYDRVSTRPF-
  .    |.  | || |..  .   .  .|.              |...   . |.  .  |   .  |    .  |.  ||. .   .|.|.   |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LTVLEKKWITFQILCALNQCHKQKICHGDIKLENILITSWNWILLSDF--ASFKPTYLPEDNPADYTYFFDTSRRRTC----YIAPERFVKTLAS
     ..  . . .. ||.|||. ||...|.| |.| ||||...   | ..||  | .                     .  |    |.||| .      
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL------

DDDGGNGNMSVIHTDSIIRLAPSYAGNTLLP-AMDIFSAGCALLELWTEGTAPFELSQLLAYRRGERDLVEKHLAGIENERLRNLLASMIDIHSMNRKSA
                              . . |. | || | |. . |  ||.  . . ...               . .....  . .    .| .|
---------------------------GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA

EDYLDQERGQLFPEYF
 . |  |.     ..|
-EALQDEWDIKCHPWF
Kinase CG9746.AA Ciliate-E2 133-169 42 5.7e-12 37.35 In-house 168-200 (365) Show / Hide 
Range on Protein: 133-169
Range on HMM: 168-200/365
Sequence Identity: 42% (16 aa)

QILCALNQCHKQK-ICHGDIKLENILITSWNWILLSDF
.|..||. .|... |.| |||.||||.     | ..||
CIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF
Kinase CG9746.AA Ciliate-E1 32-170 21 7.7e-12 35.24 In-house 2-154 (202) Show / Hide 
Range on Protein: 32-170
Range on HMM: 2-154/202
Sequence Identity: 21% (33 aa)

SNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTLPLEDHKERLEGIKKTLSLANAVNCLPFQRVELIDKA--AYIMREYVKHSLYDRVS------------
.| .. ..||  . .. . |. .|..  ..     ....|  | .|    . .  . . .. .  ||..   .|  |....||.|  .            
GNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ

-TRPFLTVLEKKWITFQILCALNQCHKQKICHGDIKLENILITSWNWILLSDFA
 .   .| ..|  |.||.. .|.. | ..|.|.||| .||||.. .  ...||.
QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFG
Kinase CG9746.AA CDKL 130-169 51 1.2e-10 32.6 In-house 103-143 (286) Show / Hide 
Range on Protein: 130-169
Range on HMM: 103-143/286
Sequence Identity: 51% (21 aa)

ITFQILCALNQCHKQKICHGDIKLENILIT-SWNWILLSDF
...||| |.|.|||... | ||| |||||| .   . | ||
YMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDF
Kinase CG9746.AA CAMKL 133-160 53 3e-10 28.76 In-house 135-162 (297) Show / Hide 
Range on Protein: 133-160
Range on HMM: 135-162/297
Sequence Identity: 53% (15 aa)

QILCALNQCHKQKICHGDIKLENILITS
||..|.| ||...|.| |||.||||...
QIVSAVNYCHSHGIVHRDIKPENILLDE
Kinase CG9746.AA Pkinase 106-158 35 3.9e-08 29.86 Pfam 80-141 (293) Show / Hide 
Range on Protein: 106-158
Range on HMM: 80-141/293
Sequence Identity: 35% (22 aa)

EYVKH-----SLYDRVS--TRPFL--TVLEKKWITFQILCALNQCHKQKICHGDIKLENILI
||. .     .|.|..|   .  .  .  | | .  |||..|. ||...|.| |.|.|||||
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
WD40 CG9746.AA WD40 957-996 35 3.1e-11 34.94 Pfam 1-39 (39) Show / Hide 
Range on Protein: 957-996
Range on HMM: 1-39/39
Sequence Identity: 35% (14 aa)

GTLVAHLHEHSESVIKLASLRPHGSLFASGSIDGTVRLWD
..... . .|. .|  .|   ..|...|||| |||.|.||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 CG9746.AA WD40 956-996 29 1.4e-08 35.7 SMART 1-46 (46) Show / Hide 
Range on Protein: 956-996
Range on HMM: 1-46/46
Sequence Identity: 29% (14 aa)

TGTLVAHLHEHSE--SVIKLASLRPH-----GSLFASGSIDGTVRLWD
| ..|. .. |.   .|  ..    .     ....|||| |||.|.||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 CG9746.AA WD40 1006-1044 16 0.029383 10.03 SMART 1-46 (46) Show / Hide 
Range on Protein: 1006-1044
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

VNKSRQVYSANT---PIYALAACDSG------QSLAVGGKDGSMLMMR
  |  ..... |   ...... ...|      . ||.|. ||.  .  
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 CG9746.AA WD40 1007-1039 22 0.744056 5.08 Pfam 1-34 (39) Show / Hide 
Range on Protein: 1007-1039
Range on HMM: 1-34/39
Sequence Identity: 22% (8 aa)

NKSRQVYSAN-TPIYALAACDS-GQSLAVGGKDGS
 |  ... .   .....| ... |. || |. ||.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGT
WD40 CG9746.AA WD40 1102-1139 22 0.003965 15.52 SMART 1-46 (46) Show / Hide 
Range on Protein: 1102-1139
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

AWRLQNELR-HGV---ITTICADPTG------SWLATGTSGGKHICWD
  ..  ... |     .|..| .|.|      ..||.|   |.  .||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 CG9746.AA WD40 1111-1139 32 0.271487 6.34 Pfam 9-39 (39) Show / Hide 
Range on Protein: 1111-1139
Range on HMM: 9-39/39
Sequence Identity: 32% (10 aa)

H-GVITTICADPT-GSWLATGTSGGKHICWD
| . .| .. .|  |..||.|   |.   ||
HTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 CG9746.AA WD40 1155-1184 30 0.000596 13.99 Pfam 11-39 (39) Show / Hide 
Range on Protein: 1155-1184
Range on HMM: 11-39/39
Sequence Identity: 30% (9 aa)

SWIRKVACHPTEPSYLISASQSNNEVSVWN
.|.. .|.|| ...||.|.|   . . .|.
HWVTCCAWHPDMGHYLASGS-RDGTIRIWD
WD40 CG9746.AA WD40 1142-1184 26 0.001194 18.81 SMART 1-46 (46) Show / Hide 
Range on Protein: 1142-1184
Range on HMM: 1-46/46
Sequence Identity: 26% (13 aa)

FRLPIAEIK-HPADSWIRKVACHPTE-----PSYLISASQSNNEVSVWN
   .....| | . ||.. |. ||.      |.||.|.|  .. . .|.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGT-IRIWD
WD40 CG9746.AA WD40 1193-1240 16 0.002457 12.22 Pfam 16-39 (39) Show / Hide 
Range on Protein: 1193-1240
Range on HMM: 16-39/39
Sequence Identity: 16% (8 aa)

VLWASPVAALSSASPSDPATTCGILSGVVDGSPFILTGSSDQRIRYWD
. |. .                        .......|| |  || ||
CAWHPD------------------------MGHYLASGSRDGTIRIWD
WD40 CG9746.AA WD40 1187-1240 17 0.039629 9.21 SMART 1-46 (46) Show / Hide 
Range on Protein: 1187-1240
Range on HMM: 1-46/46
Sequence Identity: 17% (10 aa)

TGQRQTVLW--AS--PVAALSSASPSDPATTCGILSGVVDGSPFILTGSSDQRIRYWD
| .   ..    .  .| ...  . ...           |.. ....|| |  || ||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSD----------DYPNYLASGS-DGTIRIWD
WD40 CG9746.AA WD40 1302-1342 26 4.8e-05 17.14 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1302-1342
Range on HMM: 1-39/39
Sequence Identity: 26% (11 aa)

SGPDMPTASHHDAITDLLMCKDKGQIYIASASRNGVIKLWK
. .   .  | ...|..  . | .. |.||.|| | |..|.
WKCKHTF-GHTHWVTCCAWHPD-MGHYLASGSRDGTIRIWD
WD40 CG9746.AA WD40 1301-1342 20 0.002674 16.6 SMART 1-46 (46) Show / Hide 
Range on Protein: 1301-1342
Range on HMM: 1-46/46
Sequence Identity: 20% (10 aa)

RSGPDMPTASHHD--AITDLLMCKDK----GQIYIASASRNGVIKLWK
   . .    | .  ..|..  . |     .  |.||.| .| |..|.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD