AlphaK2

Species: Mouse
Alias: AlphaK2, Hak-pending
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: Alpha-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
AlphaK2.AA Protein Sugen 2144 None Fasta, JSON
AlphaK2.NA RNA Sugen 7247 None Fasta, JSON
AlphaK2.kin_dom Protein Kinase Domain None 119 None Fasta, JSON

Protein domain

Protein domains of AlphaK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set AlphaK2.AA I-set 12-104 23 4.7e-13 46.8 Pfam 1-92 (92) Show / Hide
Range on Protein: 12-104
Range on HMM: 1-92/92
Sequence Identity: 23% (23 aa)

LCFLSTLLSQKVPEKSDVVLRCMIAGQPKPEVTWYKNGQAIDLGGTVS--SYEFFENQ-YIHLLHLSCCTQSDAAVYQVSARNCVGMICCSASLEV
 .|. .. ...| | ... . | . |.|.|.|.|.|.|| .      .   . . ... ... |  | ....|. .| . |.| .|   |.|.|.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP----DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IG AlphaK2.AA IG 18-105 16 4.6e-07 30.7 SMART 1-58 (58) Show / Hide
Range on Protein: 18-105
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

LLSQKVPEKSDVVLRCMIAGQPKPEVTWYKNGQAIDLGGTVSSYEFFENQYIHLLHLSCCTQSDA---AVYQVSARNCVGMICC--SASLEVQ
   . | | ..|.|.| ..     ...||                         |..   . .|.   ..|.  |.   |.. .  .. |.||
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

IGc2 AlphaK2.AA IGc2 24-94 28 5e-06 27.34 SMART 1-56 (56) Show / Hide
Range on Protein: 24-94
Range on HMM: 1-56/56
Sequence Identity: 28% (20 aa)

PEKSDVVLRCMIAGQPKPEVTWYKNGQAIDLGGTVSSYEFFENQYIHLLHLSCCTQSDAAVYQVSARNCVG
 |  .|.|.|  .| | |...||| || ..              .   |...  | .|. .|. .||| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG

IG AlphaK2.AA IG 1766-1849 15 6.1e-05 23.67 SMART 1-58 (58) Show / Hide
Range on Protein: 1766-1849
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

QAEMAPEHSGNIKLSCQFSEIHEDSTVCWTKDSKSIAQAKKSAGDNSSVSLAIVQAGQKDQ---GLYYCCLKNSYGKVTA--EFNLTAE
.  .     ....|.| .|      .. |.                    | | ..   |.   | |||  .  .|....  ...|| .
PP-VTVKEGETVTLTC-VS------QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

IGc2 AlphaK2.AA IGc2 1772-1838 19 0.000704 12.08 SMART 1-56 (56) Show / Hide
Range on Protein: 1772-1838
Range on HMM: 1-56/56
Sequence Identity: 19% (13 aa)

EHSGNIKLSCQFSEIHEDSTVCWTKDSKSIAQAKKSAGDNSSVSLAIVQAGQKDQGLYYCCLKNSYG
.  ... | |   .  .| .. |.| .....         .. .| |  .   | |.| |   |. |
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG

I-set AlphaK2.AA I-set 1815-1848 32 0.126003 8.03 Pfam 59-92 (92) Show / Hide
Range on Protein: 1815-1848
Range on HMM: 59-92/92
Sequence Identity: 32% (11 aa)

SLAIVQAGQKDQGLYYCCLKNSYGKVTAEFNLTA
.| | .. . | | | |  .||.|.......|| 
TLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

Kinase AlphaK2.AA Alpha-Unclassified 1980-2098 51 9.8e-84 272.96 In-house 87-215 (215) Show / Hide
Range on Protein: 1980-2098
Range on HMM: 87-215/215
Sequence Identity: 51% (66 aa)

EVPEIIPIFLIHRPENNIP-YATVEEELIGEFVKYSIRDGKEINFLRRDSEAGQKCCTFQHWVYQKTSGCLLVTDMQG-VG------MKLTDVGIATLAR
....|.|||||||...||. ...||..|||||||||...||||||.....||.|.|||.|||.||.|..|..|.|.|| |.      .|.||..|.|...
QIFYIPPIFLIHREDKNIKGCISVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIRQ

GYKGFKGNCSMTFIDQFRALH--QCNKYC
.|.|||.||.|.|||.. ..|  |||.||
RYQGFKTNCGMRFIDYWFNNHHVQCNHYC

Alpha_kinase AlphaK2.AA Alpha_kinase 1879-2098 24 2.2e-83 284.27 SMART 1-255 (255) Show / Hide
Range on Protein: 1879-2098
Range on HMM: 1-255/255
Sequence Identity: 24% (64 aa)

NDSYFGDHLRGQISTEELHFGEGVHRKAFRSKVMQGLMPVFQPGHACVLKVHNAVAHGTRNNDELVQRNYK----LAAQECYVQNTARYYAKIYAAEAQP
..... .... .| .|...|..| .|.... . . . |..|..|. ||.|...  ...|     ...|...    |..... .|......|... .||| 
DNKWTCQETCVKI-KEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTW----DEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQ-

LEGFGEVPEIIPIFLIHRP-------ENNIPY-----------------ATVEEELIGEFVKYSIRDGKEINFLRRDS------EAGQKCCTFQHWVYQK
..........||....|.|       ..||||                 ...|... ||||||. ..|..... |. .      |....|..|.|| |..
HNPCPKKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEW

TSGCLLVTDMQGV----GM--KLTDVGIATLAR-GYKGFKGNCSMTFIDQFRALHQCNKYC
.....||.|.|||    |.  ..||..|.|  . ||.. .||. .. |..| ..||||..|
SNHQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC

Kinase AlphaK2.AA Alpha 1980-2098 38 2.5e-76 216.67 In-house 91-215 (215) Show / Hide
Range on Protein: 1980-2098
Range on HMM: 91-215/215
Sequence Identity: 38% (48 aa)

EVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRDSEAGQKCCTFQHWVYQKTSGCLLVTDMQ-GVG-MKLTDVGIAT---LARGYK
.........|||....||.|..||....||..||....|... ||..|.|..|....|.||..|...|.|.|.|.| ||| .||||..|..   |..|.|
QFVHCYIYELIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVD-FLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMK

GFKGNCSMTFIDQFRALH--QCNKYC
...|||.......|.. |  |||.||
FGDGNCGYEGMFRFFYTHHVQCNHYC

Alpha_kinase AlphaK2.AA Alpha_kinase 1898-2098 22 2.9e-61 213.31 Pfam 1-225 (225) Show / Hide
Range on Protein: 1898-2098
Range on HMM: 1-225/225
Sequence Identity: 22% (52 aa)

FGEGVHRKAFRSKVMQGLMPVFQPGHACVLKVHNA----VAHGTRNNDELVQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRP
|..| .|..|| ...   .|...... ||.|...      . .    ...|..  ... |.|..|.......... ...|  . ..  .|..........
FAQGAMRWCFRMFDTW--DPNWRNNQNCVAKWYKKIKNYNQKQ----SIYVEE--DYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYEL

ENNIP-----------------YATVEEELIG-EFVKYSIRDGKEINFLRRDSEAGQKCCTFQHWVYQKTSGCLLVTDMQGVG--M---KLTDVGIATLA
|.. .                 |...|  . | |||||.  .|.  .  .|.....|....|.|. |... |...|.|.||||  .   .|||  | |  
EDHNKPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKD

RGY---K--GFKGNCSMTFIDQFRA-LHQCNKYC
. |   .  | .||..   |..| .  |.||..|
GNYEMDFDEG-MGNLGQEGIEKFFQNQHKCNHIC

Kinase AlphaK2.AA ChaK 2001-2098 37 1.1e-09 34.61 In-house 121-219 (219) Show / Hide
Range on Protein: 2001-2098
Range on HMM: 121-219/219
Sequence Identity: 37% (40 aa)

TVEEELIGEFVKYSIRDGKEINFLRRDSEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLARGYKGFKGNCSMTF---------IDQFRAL
|.|. . ||| ||    | ||       |       | || |  | | ||| |.||||  |||  .          |  | | |         |  ||| 
TIEKCMTGEFRKYNNNNGDEIIPTNTLEEI---MLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEE-----KQSCDMVFGPANLGEDAIRNFRAK

HQCNKYC
| ||  |
HHCNSCC

Kinase AlphaK2.AA VWL 2037-2103 36 1e-06 15.93 In-house 139-206 (206) Show / Hide
Range on Protein: 2037-2103
Range on HMM: 139-206/206
Sequence Identity: 36% (25 aa)

FQHWVYQKTSGCLLVTDMQGVG-MKLTDVGIATLARGYKGFKGNCSMTFIDQFRALHQCNKYCKMLGL
| |  .| . | ... |.||..   |||  | .| .  |   ||     .  |   |||||||. | |
FSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKYCQKLQL