Gene ATR (Mouse)

ATR

Species: Mouse
Alias: Atr, ATR
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: ATR

Sequence

Name Sequence Type Origin Length Description Download
ATR.NA RNA Sugen 8056 None Fasta, JSON
ATR.kin_dom Protein Kinase Domain None 337 None Fasta, JSON
ATR.AA Protein Sugen 2635 None Fasta, JSON

Protein domain

Protein domains of ATR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT ATR.AA HEAT 237-262 23 0.946313 6.46 Pfam 6-31 (31) Show / Hide 
Range on Protein: 237-262
Range on HMM: 6-31/31
Sequence Identity: 23% (6 aa)

CALLEHGSPKIRSLAISLLTELFELG
. .|.. ....|. |.. |..| |  
LKCLNDPDWEVREAACWCLGQLCEHC
HEAT ATR.AA HEAT 805-835 32 0.000855 17.0 Pfam 1-31 (31) Show / Hide 
Range on Protein: 805-835
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

VLGTLLNLMEDPDKDVRIAFSGNIKYILESL
.| .||....||| .|| |    .. ..| .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT ATR.AA HEAT 963-982 20 7.633352 3.32 Pfam 12-31 (31) Show / Hide 
Range on Protein: 963-982
Range on HMM: 12-31/31
Sequence Identity: 20% (4 aa)

DVAHHREMALNTLSEIANVF
.... ||.|...|.... ..
PDWEVREAACWCLGQLCEHC
UME ATR.AA UME 1119-1225 33 5.9e-47 163.23 SMART 1-115 (115) Show / Hide 
Range on Protein: 1119-1225
Range on HMM: 1-115/115
Sequence Identity: 33% (39 aa)

MADYLQPKLLGILAFFNMQLLSSS--VGIEDKKMALTSLMSLMKLMGPKHVSSVRVK---MMTTLRTGLRFKDDFPELCCRAWDCFVRCLDH---AY-LG
.||.||...|||...|||....|.    ...||.||.|.. ..|.|..||.||.|..   .|..|.|.|. .. ....|||.| ||...|..   .. .|
FADFLQDHFLGIMQWFNMIMHDSHGKKPYYEKKRALRSIEFMIKYMMGKHISSFRPQIIQIMACLQTALEIPE-LRHHCCRCWHCFIKHLNEVSCEHYIG

PLLSHVIVALLPLIHM
||........||....
PLIDQIFAIILPYWPT
UME ATR.AA UME 1119-1225 31 7.3e-45 153.67 Pfam 1-112 (112) Show / Hide 
Range on Protein: 1119-1225
Range on HMM: 1-112/112
Sequence Identity: 31% (35 aa)

MADYLQPKLLGILAFFNMQLLS--SSVGIEDKKMALTSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFK-DDFPELCCRAWDCFVRCLDH--AYLGPLLS
|||.||.. |||...|.|....  ..  ...||....|.. ..|.|. ||.||.|...|..|...|... ......|.|.| .|...||.  . ||||..
MADFLQDHFLGIITRFSMVMHDFQGRQPYFEKKRCIRSIEEMIKYMCGKHISSARPQIMACLQSALEIPEEELRYHCFRCWHVFIQTLDEVPEHLGPLID

HVIVALLPLIHM
...|...|....
QTFVIIIPYWDT
HEAT ATR.AA HEAT 1284-1314 19 43.232338 0.71 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1284-1314
Range on HMM: 1-31/31
Sequence Identity: 19% (6 aa)

TLQLSMKAIQHENVDVRIHALTSLKETLYKN
 |.. .|...... .||  |. .|.. . . 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT ATR.AA HEAT 1335-1365 25 0.018345 12.39 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1335-1365
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

LVTVILKGCQDANSQARLLCGECLGELGAID
.. ..||...| ... |. . .|||.|  . 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
FAT ATR.AA FAT 1765-2086 14 1.5e-73 246.47 Pfam 1-408 (408) Show / Hide 
Range on Protein: 1765-2086
Range on HMM: 1-408/408
Sequence Identity: 14% (61 aa)

NTYRVEAAWKLSQWDL--VENYLAADG------------KSTT----WSVRLGQLLLSA--KKRDTT--TFYDTLKLVRAEQIVPLSAASFERGSYQRGY
... .|||| |.|||.   ..|...              ....    |   . | .|.   .... .   ..   . .|   .  ..|.   . ||.| |
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTAC-LPGESYNRHY

EFIVRLHMLCELEHSLKPLFRKSPG-------DSCNEDSL--NWGARLEMT-QNSYRAKEPILALRRALLSLNK-------RPDYNEMVGECWLQSARVA
 ..||..||.|||.. .   . ...       .. . ...  .|  || .. |  ......||..|.  .|...       ..... .  ..|...|...
PVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLC

RKAGHHQTAYNALLNAGESR----------LAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENKSPS--------------------ESKHMLIHG-
||.|..| ....|... ..           ...  ....|..|..|. ..|.  |.. .. .. ..   .                    | . .  .. 
RKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTKLLAM

RATLLVGRFMEET--------ANFESNAVMKKYKDVTLFLPEWED-GHFYLAKYYDKLMPMVTDNKM-------EKQGDLIRYIVLHFGRSLQYGNQ-FI
|. .. |.....          . ....... |. .| | |.|.   ....|.|..... . .....       ........ .| .| .|. ...   .
RCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNS

YQSMPRMLS
.|...|.|.
RQDTLRLLW
Kinase ATR.AA ATR 2282-2548 73 3e-192 644.98 In-house 1-267 (267) Show / Hide 
Range on Protein: 2282-2548
Range on HMM: 1-267/267
Sequence Identity: 73% (196 aa)

AYLAGFDDVVEILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPIL
||.|||||.||||.|||||||||||||||||||||||||||||||||.|.||.|||. .|||.|.|||..|.||||||||||.|.|||||||||.|||||
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

TKIYKEKGVYMTGKELRQCMLPKSAALSEKLKVFQELLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGEC
.|..|||..||....|||||..||....||.|||.|.|||||||.||.||.|.||||..|||||..||||.||..|||||.||||||..|||.|. .|||
DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGEC

VHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTF
||||.||.||.||.||||||||||||||||.|||||.|.|||||||||....|||.|...|||...|
VHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase ATR.AA PIKK 2283-2548 45 6.5e-160 537.56 In-house 1-290 (290) Show / Hide 
Range on Protein: 2283-2548
Range on HMM: 1-290/290
Sequence Identity: 45% (132 aa)

YLAGFDDVVEILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILT
. ...|..|... ..||||||...|.|||.|...||...|||.|.|.|....|.|. |.||.|...|.||||||.|||....||.||||.|...|..|..
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

KIYKEKG------VYM-----------------TGKELRQCMLPKSAALSEKLKVFQELLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVG
. ...|.      ..|                 ......||| .....|.||..|| |.. ...|..|..||.|.||||..|...|..|.||.|||.|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHGENILFDSFTGECVHVDFNCLFN-KGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTF
|||||||||.|||..|. |||.||.||.|.|. ......|||.||||||.||||.|||||.||.|||.||.....||..||.||.|...|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase ATR.AA PI3Kc 2314-2624 31 4.90000000001e-126 425.93 SMART 1-336 (336) Show / Hide 
Range on Protein: 2314-2624
Range on HMM: 1-336/336
Sequence Identity: 31% (109 aa)

IMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKIYKEKGVYMTGKELRQ--------------
 ...|..||||.|.| |....|.|| ..||.|.||| ||.|.|..||....||.||||.|.. |..|. | .|.|...|.......              
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

----------CMLPKSAALSEKLKVFQELLLPRHPPVFHEWFLRTFPDP-TSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNC
          .| .. ....|.||.| . . | .|||...||...||||  .|...|. ..||.|...||.||||.||||..||..|  ||.|.|.||..
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

LFNKGETFEVP-----EIVPFRLTHNMVNGMG----PMGTEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPL-VEWSKPVKGHSKAPLNETGEVVNEK
.|..|......     | |||||||.||..||    |.| .|.||. |. ..|.|| ... .|... ....||.  .|..   ......|... .. .  
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLDH--

AKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLL
     |  |...| . .| ...  .. |.|.. . ..... . . .
-----LSDEEAAQYFMQT-MCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase ATR.AA PI3_PI4_kinase 2312-2558 30 2.2e-102 351.26 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2312-2558
Range on HMM: 1-300/300
Sequence Identity: 30% (90 aa)

FYIMMCKPKDDLR--KDCRLMEFN-----------------------SLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKIYK
 | ...| .||||  .|.|.|..                        .|.|| ..||...|||......| .||....||.||||.|. ....|. . ..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

EKGVYMTGKELRQCMLPKSAALS----EKLKVFQELLLPRHPPVFHEWFLRTFPDP-TSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILF--DSFTG
...  .  ||....|... ....    .|..|| . . . ..|....||....||. . | ..|. ..|| |.|..|.||||.||||..||..  | .||
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

ECVHVDFNCLFN--KGETFEVPEIVPFRLTH------NMVNGM------GPMGTEGLFRRACEVTLRLMRDQREPLMSVL-------KTFLHDPLVEWSK
...|.||.. |.  |...|..|| ||||.||      .||..|      .|.| .|.||. |....|..| . . .|..|        ...||.|..|..
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase ATR.AA ATM 2425-2556 48 7.6e-47 147.49 In-house 117-248 (304) Show / Hide 
Range on Protein: 2425-2556
Range on HMM: 117-248/304
Sequence Identity: 48% (64 aa)

PVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFR
|||  . .  | ||  |.  | || || |  |.|||||||||||  |||      | ||.|    | .|     || ||||||  .| |||  | || ||
PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR

RACEVTLRLMRDQREPLMSVLKTFLHDPLVEW
| || |.  ||   | |. .    | ||| .|
RCCEKTMEVMRNSQETLLTIVEVLLYDPLFDW
Kinase ATR.AA FRAP 2441-2558 46 5.8e-37 129.11 In-house 133-251 (251) Show / Hide 
Range on Protein: 2441-2558
Range on HMM: 133-251/251
Sequence Identity: 46% (55 aa)

WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFE-VPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQRE
|.  |  | || |.|||.||||||||||  ||. . .||  ||.||   |    . |  || .|||||  .|| |   | || .| .||. .. .|...|
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

PLMSVLKTFLHDPLVEWSK
 .| ||  |  |||  |  
SVMAVLEAFVYDPLFYWRL
Kinase ATR.AA SMG1 2438-2500 57 2.8e-26 83.96 In-house 180-242 (242) Show / Hide 
Range on Protein: 2438-2500
Range on HMM: 180-242/242
Sequence Identity: 57% (36 aa)

PTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPE
|  |.    .| ||||||||||||.|||||| .|.| |  ||| ||.|..  | ||    |||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase ATR.AA DNAPK 2445-2558 31 3.2e-23 81.25 In-house 187-301 (301) Show / Hide 
Range on Protein: 2445-2558
Range on HMM: 187-301/301
Sequence Identity: 31% (36 aa)

RSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFN-KGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQREPLMS
|. . |. ||    ..||| |||| .| .    .|. . .||   |   .    |||  |||||   .| | ||.  |...      .. .| .|  |. 
REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTN

VLKTFLHDPLVEWSK
    |  ||.. | .
FCDVFINDPSFDWKN
Kinase ATR.AA DNAPK 2282-2388 36 3.8e-19 66.18 In-house 2-108 (301) Show / Hide 
Range on Protein: 2282-2388
Range on HMM: 2-108/301
Sequence Identity: 36% (39 aa)

AYLAGFDDVVEILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPIL
  .||||. | .. || .||.| ..| | .    . |   ||| | |        |  .  |     |||  ||| .||.    | ||||.||  |. ||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL

TKIYKEK
 . . .|
NNEMQQK
Kinase ATR.AA FATC 2603-2635 60 9.9e-18 59.83 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2603-2635
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

LPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM
.|||.|..|  |||||||.. ||||| || |..
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase ATR.AA FRAP 2313-2388 35 4.1e-15 52.09 In-house 2-76 (251) Show / Hide 
Range on Protein: 2313-2388
Range on HMM: 2-76/251
Sequence Identity: 35% (27 aa)

YIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKIYKEK
|. . | ..|.| | | |    |||. |. ..|.....| |. |..|||  . |.| ||..   |. || . |..|
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLH-ILIRDYRKK
Kinase ATR.AA SMG1 2291-2371 38 1.2e-13 41.44 In-house 1-81 (242) Show / Hide 
Range on Protein: 2291-2371
Range on HMM: 1-81/242
Sequence Identity: 38% (31 aa)

VEILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWV
. ||    ||||.   ||||| |  . |  .||  | |.| | |..|              | | |.| ||    |.| ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV
Kinase ATR.AA ATM 2315-2370 37 3.5e-11 31.55 In-house 2-57 (304) Show / Hide 
Range on Protein: 2315-2370
Range on HMM: 2-57/304
Sequence Identity: 37% (21 aa)

MMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEW
 . | .||||.|  .     . |  | .  | |.| | | || |.||    |..||
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW