Gene AXL (Mouse)

AXL

Species: Mouse
Alias: Axl, AXL
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Axl

Sequence

Name Sequence Type Origin Length Description Download
AXL.AA Protein Sugen 888 None Fasta, JSON
AXL.NA RNA Sugen 4119 None Fasta, JSON
AXL.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of AXL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG AXL.AA IG 35-124 16 1.4e-08 35.72 SMART 1-58 (58) Show / Hide 
Range on Protein: 35-124
Range on HMM: 1-58/58
Sequence Identity: 16% (16 aa)

PGNITGARGLTGTLRCELQVQGEPPEVVWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDA---GEYQCMVH---LEG--RTFVSQP
|. .|. .| | ||.|  .      .. |.                               |.|  .|..|.   |.|.|...    ..   | ..  
PP-VTVKEGETVTLTC-VS------QIWWY-------------------------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
V-set AXL.AA V-set 28-131 17 5e-06 22.65 Pfam 1-128 (128) Show / Hide 
Range on Protein: 28-131
Range on HMM: 1-128/128
Sequence Identity: 17% (23 aa)

GSPFVG-NPG----NITGARGLTGTLRCELQ---VQGEPP-EVVWLRDGQIL-------------ELADNTQTQVPLGEDWQDEWKVVSQ-----LRISA
 |.  . .|.     .|...| . ||.| ..    . |..  . | |. | .               ...... ..       .. .  .     |.|| 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

LQLSDAGEYQCMVHLEGRTFVSQPGFVGLEG
||.|| | | | |  .   ...  . . |  
LQPSDSGTYYCAVWNC--NEDYFGHGTRLTV
IGc2 AXL.AA IGc2 41-118 19 0.00011 19.8 SMART 1-56 (56) Show / Hide 
Range on Protein: 41-118
Range on HMM: 1-56/56
Sequence Identity: 19% (15 aa)

ARGLTGTLRCELQVQGEPPEVVWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGR
  | . ||.|.     . |.. |.. || |.                      . |.|.  ...|.|.|.| .  .  
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP--------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set AXL.AA I-set 29-68 36 0.067495 8.95 Pfam 1-39 (92) Show / Hide 
Range on Protein: 29-68
Range on HMM: 1-39/92
Sequence Identity: 36% (15 aa)

SPFVGNPGNITGARGLTGTLRCELQVQGEPP-EVVWLRDGQ
  |.  | ...   | | .. |  ||.|.|| .|.|..|||
PKFTQKPKDVEVQEGETARFEC--QVTGDPPPQVSWFKDGQ
I-set AXL.AA I-set 94-111 44 0.255182 6.99 Pfam 58-75 (92) Show / Hide 
Range on Protein: 94-111
Range on HMM: 58-75/92
Sequence Identity: 44% (8 aa)

SQLRISALQLSDAGEYQC
. |.||  | .|.|.| |
YTLTISNVQPDDEGKYTC
FN3 AXL.AA FN3 219-312 11 5e-08 33.9 SMART 1-69 (69) Show / Hide 
Range on Protein: 219-312
Range on HMM: 1-69/69
Sequence Identity: 11% (13 aa)

PQRPHH---LHVVSRQPT------ELEVAWTPGLSGIYPLTHCNLQAVLSDDGVGIWLGKSDPPEDPLTLQVSVPPHQLRLEKLLPH----TPYHIRISC
|  | .   |.|..  .|       ... |.|        ...                                    ... | |.    | |..|...
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------------------YTVTGLKPGQYPWTEYEFRVRA

SSS--QGPS
 ..  .|..
VNGNDAGEG
IG AXL.AA IG 139-218 15 0.000246 21.65 SMART 1-58 (58) Show / Hide 
Range on Protein: 139-218
Range on HMM: 1-58/58
Sequence Identity: 15% (13 aa)

PEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVTGHSSQHSLQTPGLNKT-----SSFSCEAHNAKGVTTS-RTATITVL
|.   | .  . .|.| ..      .. |.                 |.  .. .        . |.|.  .|...|  ..|.||.
PP-VTVKEGETVTLTC-VS------QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set AXL.AA I-set 133-163 32 0.006811 12.33 Pfam 1-31 (92) Show / Hide 
Range on Protein: 133-163
Range on HMM: 1-31/92
Sequence Identity: 32% (10 aa)

PYFLEEPEDKAVPANTPFNLSCQAQGPPEPV
|.|.  | |  |      ...||..| |.|.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQ
FN3 AXL.AA FN3 328-409 17 0.000115 22.74 SMART 1-69 (69) Show / Hide 
Range on Protein: 328-409
Range on HMM: 1-69/69
Sequence Identity: 17% (17 aa)

LGPPEN---VSAM-RNGS------QVLVRWQEPRVPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRPV----ANLTVSVTAYTS--AGDG
 |||.|   ...   . .      .| ..|..|        .|||                        ..| .|      . ...|.|...  || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase AXL.AA Axl 530-795 79 5.3e-211 707.27 In-house 1-267 (267) Show / Hide 
Range on Protein: 530-795
Range on HMM: 1-267/267
Sequence Identity: 79% (212 aa)

VALGKTLGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLY
..|||.|||||||.||||||.|.| |..|||||.|||.|||.||.|.|||||.|||||||||||||||||.|.|.|...|.|.||||||||||||.||||
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

SRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWS
|||||||..||.|||||||.|||.||||||...|||||||||||||.|.|.|||||||||||||.|||||||.||||||||||||||||||||||||||.
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSDVWA

FGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELRE
||||||||.||||||||||||.|.||||..|.|||||.||.|.||.||..|||..|.|||||..|||
FGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase AXL.AA TyrKc 530-797 40 5.9e-137 462.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 530-797
Range on HMM: 1-280/280
Sequence Identity: 40% (121 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEF--DHPNVMRLIGVCFQGSDREGF---PEPVVILPFMKHGDLHS
. |||.||||.|| |..|...     ..||||..|        .|||..||  |...  .|||. ||.||| |.. .  |   . . ... .|.||||..
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKD

FLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNG-------DYYRQGR--IAK--MPVKWIAIE
.| ..|       |... |..|. .||.|||||. |..||||||||||...||  | ..|||||..||..       ||||.     .|  .|..| |.|
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

SLADRVYTSKSDVWSFGVTMWEIATRGQTPYPG-----VENSEIYDYLRQGNRLKQPVD--------CLDGLYALMSRCWELNPRDRPSFAELREDL
.. ....|.|||||||||.|||| |.||.||||     ..|.|.. |..||.|..|| .        | | .| .|..||. .| |||.|.|..|..
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AXL.AA Pkinase_Tyr 530-797 44 8.99999999999e-133 450.29 Pfam 1-270 (270) Show / Hide 
Range on Protein: 530-797
Range on HMM: 1-270/270
Sequence Identity: 44% (122 aa)

VALGKTLGEGEFGAVMEGQLN--QDDSILKVAVKTMKIAICTRSE--LEDFLSEAVCMKEF-DHPNVMRLIGVCF-QGSDREGFPEPVVILPFMKHGDLH
. .||.||||.|| |..| ..  .|.  ..||||..|   .. ..  .|||..||  ||.. .|||. ||.|||  ||       .. .....|.||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDLL

SFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYY-RQGRIAKMPVKWIAIESLADRVYTS
..|   |  ...  |....|... ..||.|||||. |..||||||||||...||. | ..||||.. ||| ||| |..  .|.|.|| | |.......|.
DYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

KSDVWSFGVTMWEIATRGQTP-YPGVENSEIYDYL-RQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDL
|||||||||.|||| |.|..| |||. |.|.|.|. ..|.|...| .| | .| || .||. .| |||.|.|..|.|
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AXL.AA TK 530-797 26 4.4e-114 384.02 In-house 1-486 (486) Show / Hide 
Range on Protein: 530-797
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

VALGKTLGEGEFG---AVMEGQLNQDD-----------------------SILKVAVKTMK--IAICTRSELE----------DFLSEAVCMKEFD----
. |||.||||.||    |..|......                          .||||..|   |   . ...          |||.||  || ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVMRLIGVCFQGSDREGF------PEPVVILPFMKHGD----LHSFLLYSRLGDQP-----------------------------------------
 |||. ||.|||.||  . .|      . . ... .|.|||    |...|  .| . |.                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------VFLPTQMLVKFMADIASGMEYLSTK------RFIHRDLAARNCMLNENMS-----------VCVADFG---
                              .|... |. ....||.|||||. |      .|.|||||||||...||.            . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKKIYN------------------------GDYYRQGRIAKMPVKWIAIESLADRV---------YTSKSDVWSFGVTMWEIATRGQTPYPG-V
     |...||.                         |||||   .|.|..| | |.|.|||         .|.|||||||||.|||| |.||.||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EN---------SEIYDYLRQG--------------NRLKQPVDCL--------------DGLYALMSRCWELNPRDRPSFAELREDL
 |          |...|||.|              .|..||..|               . .| || .||...|.|||.|..|.| |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AXL.AA Met 531-791 40 1e-104 344.27 In-house 1-271 (271) Show / Hide 
Range on Protein: 531-791
Range on HMM: 1-271/271
Sequence Identity: 40% (114 aa)

ALGKTLGEGEFGAVMEGQLNQ-DDSILKVAVKTMK-IAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLY
.... .| | || |  |.. . |    ..|.|. .   | .  . . || |.. ||.||||||  |||.| . .       | |.||.|||||| .|   
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGH----MPWVVLPYMKHGDLKTFIR-

SRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKI-YNGDYY--RQGRI-AKMPVKWIAIESLA--------
    .    .    |. |  ..| ||.|.  ..|.|||||.||||| | . | ||||||. .. |   ||  .. .  |. |||| | |.|         
----NPQNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCP

DRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVEN-SEIYDYLRQG--NRLKQPVDCLDGLY-ALMSRCWELNPRDRPSFA
..  .|.||||||||| |||  ||| .||| | |   |  .| ||  .|| ||  | | ||  .| .||. || |||.| 
TYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase AXL.AA UTK 530-797 35 2e-100 339.96 In-house 1-296 (296) Show / Hide 
Range on Protein: 530-797
Range on HMM: 1-296/296
Sequence Identity: 35% (108 aa)

VALGKTLGEGEFGAVMEGQLNQDD---SILKVAVKTMKIAICTRSELE---DFLSEAV---CMKEFD-HPNVMRLIGVCFQGSDREGFPEPVVILPFMKH
|.||..||.|.|| | .. ..|..     ..||||. .    .. | |   ||. ||     || |. ||||.||.|||.|..       . ... .|. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP------WMIVTEYMEN

GDLHSFLLYSRL--GDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN-------MSVCVADFG---LSKKIY---------NGDYYR
||| |.| ..|   ...|..|    ......|||.||.||....|.||||||||| ....       |.. .||||   .|. ..         . .||.
GDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM

QGRIAKMPVKWIAIESLADR-VYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQG--NRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELRE
.    ..|..| | |.|...  .|.|||||||||..||| |.|..||||  | ..   .. |   |...| || . .| || |||. .|..||.| .|..
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQ

DL
 .
QM
Kinase AXL.AA InsR 530-799 38 5e-90 302.59 In-house 1-278 (278) Show / Hide 
Range on Protein: 530-799
Range on HMM: 1-278/278
Sequence Identity: 38% (109 aa)

VALGKTLGEGEFGAVMEG---QLNQDDSIL--KVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEP-VVILPFMKHGDLH
..|.. .|.| || | ||    . .|      ..|.|| . .   |  .| ||.||  ||||.. .| || ||| .|       .|  |.  .|..||| 
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIE-FLNEASVMKEFNCHHVVRLLGVCSRG-------QPMYVVMEMMTYGDLK

SFLLYSRLGDQ---PVFL------PTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
|.|.  |   .   |.        . . ..   |.|..|| ||  | |.|||||.|||| |.   | ..|||.   ||  |||| |.  ..|| | | ||
SYLRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPES

LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYL-RQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDLEN
| | |.|..|||||||| .||..| |  || |  | .. .|  . || |..|  | . ...|| .||  .|..||.| .. . | .
LKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase AXL.AA TK-Unique 530-797 32 6e-83 281.87 In-house 1-294 (294) Show / Hide 
Range on Protein: 530-797
Range on HMM: 1-294/294
Sequence Identity: 32% (98 aa)

VALGKTLGEGEFGAVMEGQLNQDD---SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD-HPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSF
. .|...|||.|| |  |.. ...   .  |... .|  .  |  .  |||.|.  ||| . |||. ...|.|   ...     .  |....  |.| ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEP-----WMIIMEYCPCGNLQHY

LLYSR-L-------------------GDQPVFLPTQMLVKFMADIASGMEYLST--KRFIHRDLAARNCMLNENMSVCVADFGLSKKIYN-GDYYRQGRI
| ..|                     .... ..  . |. |. .||.|||||.   |...||||.|||..|.|.  . ..|||.....|. |.| .... 
LRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQ

AKMPVKWIAIESLA--DRVY-TSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDC-LDGLYALMSRCWELNPRDRPSFAELREDL
 ..|..| | |||   ...| |.|||||||||.||||.| |..||||. ...| . .|.| |..||  |  . .| ||..|| ..| .||||....  |
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AXL.AA ALK 530-799 39 7.6e-82 278.21 In-house 1-273 (273) Show / Hide 
Range on Protein: 530-799
Range on HMM: 1-273/273
Sequence Identity: 39% (111 aa)

VALGKTLGEGEFGAVMEGQLNQ---DDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFL
. |.. || | || | .||      | . ..||.|| .   | . . |||. || .|  |.|.|| |.||.|||   .       ..| .|  ||. |||
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPE-DCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY------MIVLEYMEGGDMKSFL

LYSRLGDQ---PVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMS---VCVADFGLSKKI-YNGDYYRQGRIAKMPVKWIAIESLADRV
  .|   .   |  |  . | .   |.| |  || ...||||| ||||| |    .   . .|||| .. | |  |||| |  | |||||   | . | .
RECRPHPESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGI

YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDLEN
.|||.||||||| .|||   |  |||| .| |. . . .|.|.  | .|    | .|. ||   | |||.|. . | .. 
FTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase AXL.AA Src 530-797 39 7.2e-81 274.47 In-house 1-255 (255) Show / Hide 
Range on Protein: 530-797
Range on HMM: 1-255/255
Sequence Identity: 39% (107 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILP-FMKHGDLHSFLLY
. | . ||.| || | .|  |.     ||||||.| .     . |.|| ||  ||...|... .|  || |.       ||. |   .|.|| |  .|  
IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQE-------EPIYIVTEYMSHGSLLDYLKK

SRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNG-DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVW
.. | .   |. . |. . | .|.||.||. ...|||||||||   .||  . |||||| . | .. | |     ||.|.|| | | .  ...| |||||
DGEGRH---LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVW

SFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYA-LMSRCWELNPRDRPSFAELREDL
|||. ..|| |.|..|||| .| |  . . .| |. .|  | | ||  .| .||.  |..|| |. |.. |
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AXL.AA Abl 530-797 44 3.7e-80 267.05 In-house 1-252 (252) Show / Hide 
Range on Protein: 530-797
Range on HMM: 1-252/252
Sequence Identity: 44% (118 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYS
. . . || | .| | ||   . | .  |||||.|       |...|| ||  |||  |||...|.|||     ||  |   .|  || .| |  .|   
IMMKHKLGGGQYGEVYEGVWKRHDCT--VAVKTLKEDTM---EVHEFLKEAAIMKEMKHPNLVQLLGVCT----RE--PPFYIITEFMCYGNLLDYL---

RLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSF
|  |.   ||  .|.   . |||||.||  . |||||||||||.. |.  | ||||||. .. ..| |     || |.|| | ||||   . |||||| |
RECDR-EELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLA-RMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAF

GVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDL
|| .||||| | .||||.. |..|. | .| |. .|  | .  | || .||. .. |||||.|. . .
GVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AXL.AA FGFR 643-797 45 4.7e-68 231.03 In-house 138-293 (293) Show / Hide 
Range on Protein: 643-797
Range on HMM: 138-293/293
Sequence Identity: 45% (71 aa)

LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQT
||..   .| |||||  .. |||||||||    ..    ..||||.  | . ||||       |.|| | |.| |||||..|||||.|| .||| | |..
LVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQ

PYPGVE-NSEIYDYLRQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDL
|||..    |.|.||. | |.  |  |   .| .|  ||  .| .||.|..| |.|
PYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AXL.AA S_TKc 530-804 19 2e-41 144.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 530-804
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKH--GDLHSFLL
  .....|.| || |. .. .   .  .||.| .|         |....|  ..|. .|||. .|..|.          .  ... .. .  |||.... 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIK

YSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTS-KSDV
  . .  .. .|  .  ..|. |....||.  ...|||||   | .|.|   . ..||||....         .       ..| | |    |.  |.|.
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELRE--DLENTLKAL
||.|....| .. |..|.|  .  .... ..            . .  ....|.. .|..||.  |. .   . .    .
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AXL.AA Pkinase 530-797 19 1.3e-37 134.1 Pfam 1-293 (293) Show / Hide 
Range on Protein: 530-797
Range on HMM: 1-293/293
Sequence Identity: 19% (60 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELE---DFL-SEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHG----D
  .|...|.| || | ...   .    .||||..|    .... .   ... ||.  ||...|||. ||....         ... ...... .|    |
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMD

LHSFLLYSRLGDQPVFL--PTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSV----CVADFGLSKKIYNGDYYRQGRIAKMPV---KWIAI
|....      ..   .  . . . ..|  |..|.||.  ...|||||   |.....|. .    ...||||.|...    |  .. .. ..    ..| 
LFDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAP

ESLA-DRVYTSKSDVWSFGVTMWEIATRGQTPYPGV------ENSEIYDYLRQ-GNRLKQPVDCL-------------------DGLYALMSRCWELNPR
| .  .. |..|.|.||.|....| .. |..|.||       .  ....  ..  ..   | .|                    . .  ....|....| 
EVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

DRPSFAELRED--L
.||..... ..  .
KRPTAEQILQHPWF
Kinase AXL.AA FGFR 530-601 37 3.9e-10 30.69 In-house 1-77 (293) Show / Hide 
Range on Protein: 530-601
Range on HMM: 1-77/293
Sequence Identity: 37% (29 aa)

VALGKTLGEGEFGAVMEGQLN---QD--DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEF-DHPNVMRLIGVCFQG
  |||.|||| || |  .  .   .|  .   .|||| .| .  |  .| |  ||   ||    |.|...|.|.| |.
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLK-MNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQE