ChaK2

Species: Mouse
Alias: ChaK2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: ChaK

Sequence

Name Sequence Type Origin Length Description Download
ChaK2.AA Protein Sugen 2028 None Fasta, JSON
ChaK2.NA RNA Sugen 6520 None Fasta, JSON
ChaK2.kin_dom Protein Kinase Domain None 219 None Fasta, JSON

Protein domain

Protein domains of ChaK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ion_trans ChaK2.AA Ion_trans 880-1000 7 0.000176 18.93 Pfam 1-116 (199) Show / Hide
Range on Protein: 880-1000
Range on HMM: 1-116/199
Sequence Identity: 7% (10 aa)

LVIIYIFTNAIEKVREICISEP-SKFKQKVKMWLSEYWNLMETVAIGLFAVGFGLRWGHPPLQTAGRLIYCIDIIFWFSR---LMDFFAVNQH-AGPY-V
. .....  ..| .  .    . .    . .  .  .||..  ... .. ... ..  ..       ..  . .. |. |   .. .| . ..  ... |
FDYVFTVWFTFEMILKFWAFGFKF----HPFHYFRDWWNWFDFFVVIPSYIDLIWFFFNWD------WFRVLRVFRWL-RVLRPLRLFRRWPGWMRTLWV

TMIAKMAANMFYIVIIMAIVLLSFGVA
 |. .. ...|........... |...
WMLMRSMPSIFNVMLLCFFFWFIFAII

Kinase ChaK2.AA ChaK 1760-1978 86 3.6e-187 628.09 In-house 1-219 (219) Show / Hide
Range on Protein: 1760-1978
Range on HMM: 1-219/219
Sequence Identity: 86% (190 aa)

SMSSWSQHGRAAMIQVLSQEEMDGGLRKAMRVISTWSEDDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIP
||||||| ||.||||.||.||||||||.|||| .||||.|.||||.|.|.||||||||.|| ||.||.|||||||||||||||||||||||||.||||||
SMSSWSQRGRCAMIQFLSREEMDGGLRRAMRVQCTWSEHDILKPGHVYIIKSFLPEVVRTWHKIYQEDTVLHLCLREIQQQRAAQKLIYTFNQMKPQTIP

YTPRFLEVSLVYCHSANQWLTIEKYMTGEFRKYNNNNGDEIAPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEDKQSRGMVFGPAN
|||||||| |.||||||||.||||.|||||||||||||||| |||||||.||||||||||||||||||||||||||||||||||||| |||..|||||||
YTPRFLEVFLIYCHSANQWFTIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPAN

LGEDAIRSFIAKHRCNSCC
||||||| |.||| |||||
LGEDAIRNFRAKHHCNSCC

Kinase ChaK2.AA Alpha 1769-1978 37 5e-131 375.13 In-house 1-215 (215) Show / Hide
Range on Protein: 1769-1978
Range on HMM: 1-215/215
Sequence Identity: 37% (81 aa)

RAAMIQVLSQEEMDGGLRKAMRVISTWSEDDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVS
....||..|...|.|..|.||.. ..|.... .|.......||| ..|...| |......|.|.|.||..|....|.....|||.|||.|......... 
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSF-KYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYE

LVYCHSAN-QWLTIEKYMTGEFRKYNNNNGDE--IAPTNTLEELMLAFSHWTYEYTRGELLVLDLQ-GVG-ENLTDPSVIKPEDKQSRGMVFGPANLGED
| .||..| .. ..|.||.||..|||||.|..  . ..|....||.||||||..|..|.|.|.||| ||| ..||||....|  |...||.||..|.|..
LIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCP-AKLDQGMKFGDGNCGYE

AIRSFIAKH--RCNSCC
... |...|   ||..|
GMFRFFYTHHVQCNHYC

Kinase ChaK2.AA Alpha_kinase 1761-1978 28 5.8e-89 302.78 SMART 1-255 (255) Show / Hide
Range on Protein: 1761-1978
Range on HMM: 1-255/255
Sequence Identity: 28% (74 aa)

MSSWSQHGRAAMIQVLSQEEMDGGLRKAMRVISTWSEDDVL-KPGQVFIVKSFLPEVVQTW--YKIFQESTVLHLCLREIQQQRAAQKLIYTFNQ---VK
...|..     .|   ..  . |..|....   .|||.... ..|.....|.|..|...||   . | | | ||||||....|......   |||    .
DNKWTCQETCVKI-KEPKPFAKGAMRWCYW-GCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHE-T-LHLCLRDVEMQMMCKHWANEFNQEAQHN

P--QTIPYTPRFLEVSL-----VYCHSANQW----------------LTIEKYMTGEFRKYNNNNGDEIAPTNTLE---------ELMLAFSHWTYEYTR
|    | ..| .. . .     .|...  .|                ...| .|.|||.|||||||....... ..         |...||||||||...
PCPKKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSN

GELLVLDLQGV----GE--NLTDPSVIKPEDKQSRGMVFGPANLGEDAIRSFIAKHRCNSCC
...|| |.|||    |.  ..||| ... ...   |. ||..|||...|. |...|.||..|
HQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQN---GYGFGMGNLGQEGIEKFFQTHQCNQIC

Kinase ChaK2.AA Alpha_kinase 1780-1978 25 7.7e-70 242.98 Pfam 1-225 (225) Show / Hide
Range on Protein: 1780-1978
Range on HMM: 1-225/225
Sequence Identity: 25% (60 aa)

EMDGGLRKAMRVISTWSEDDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKP--QTIPYTPRFLEVSLVYCHSANQ
 ..|..|.. |.. ||  |......|....| ..... ... |. ..... .........|. .|...  ||| ..  . .|....|.....||... ..
FAQGAMRWCFRMFDTW--DPNWRNNQNCVAKWYKKIK-NYNQKQ-SIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHN

------------------WLTIEKYMTG-EFRKYNNNNG---DEIAPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVG--E---NLTDPSVIKPEDKQS
                  . ..| |..| ||.||||| |   |. .... ....| ||||.||....|...| |.||||  .    ||||..  .. .. 
KPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKD-GNY

RGMVF--GPANLGEDAIRSFIA-KHRCNSCC
. |.|  |..|||...|..|.. .|.|| .|
E-MDFDEGMGNLGQEGIEKFFQNQHKCNHIC

Kinase ChaK2.AA Alpha-Unclassified 1880-1978 30 2e-23 73.14 In-house 109-215 (215) Show / Hide
Range on Protein: 1880-1978
Range on HMM: 109-215/215
Sequence Identity: 30% (34 aa)

TIEKYMTGEFRKYNNNNGDEIAPTNTLEE---LMLAFSHWTYEYTRGELLVLDLQG-VG------ENLTDPSVIKPEDKQSRGMVFG--PANLGEDAIRS
..| |. |||.||.|| | ||    .  |   ......||||. | . ..| |||| |.        .||| .       .    ..    | |   |  
SVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIH------TIRQRYQGFKTNCGMRFIDY

FIAKH--RCNSCC
... |   ||  |
WFNNHHVQCNHYC

Kinase ChaK2.AA VWL 1881-1940 40 7.9e-20 55.86 In-house 107-167 (206) Show / Hide
Range on Protein: 1881-1940
Range on HMM: 107-167/206
Sequence Identity: 40% (25 aa)

IEKYMTGEFRKYNNNNGDEIAPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVG-ENLTDP
.|.|. |.. ||||| |  .  ..    |  |||| |. |. | ... ||||..   ||||
VENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDP

Kinase ChaK2.AA VWL 1972-1983 58 0.078355 1.35 In-house 195-206 (206) Show / Hide
Range on Protein: 1972-1983
Range on HMM: 195-206/206
Sequence Identity: 58% (7 aa)

HRCNSCCGKLRL
| ||  | || |
HQCNKYCQKLQL